Papers by camilo esteban jimenez muñoz
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2011
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2013
TO THE EDITOR: A gomelatine is an antidepressant approved to treat major depressive disorder in E... more TO THE EDITOR: A gomelatine is an antidepressant approved to treat major depressive disorder in Europe and Australia, but is not available in the United States. It is an agonist of melatonergic receptors MT1 and MT2, and an antagonist of the 5-HT2C receptor. Its structure is highly similar to melatonin and is classified as a norepinephrine-dopamine disinhibitor. Agomelatine acts by antagonizing the 5-HT2C receptor, which normally acts to inhibit norepinephrine and dopamine release, promoting outflow of these neurotransmitters. Frequent neurologic and psychiatric adverse effects are headache, drowsiness, insomnia, and anxiety. There have been no reports of delirium. We report 2 cases of delirium syndrome in patients who used agomelatine for short periods of time with symptom recurrence upon rechallenge.
50th AIAA/ASME/SAE/ASEE Joint Propulsion Conference, 2014
Revista Colombiana …, 2011
Coagulation alterations in patients with chronic liver disease occur frequently, although they ar... more Coagulation alterations in patients with chronic liver disease occur frequently, although they are usually described as auto-anticoagulation phenomena. Changes in hemostasis are broad and diffuse. They include changes in procoagulant and anticoagulant substances, hemodynamic modifi cations, endothelial dysfunction and platelet malfunction which are the causes of different clinical conditions varying from hemorrhaging to thrombosis. Given the complexity of theses alterations, laboratory tests do not correlate well with the clinical events. Treatment for these patients has been controversial. Currently we do not have objective methods for determining the hemostatic balance between bleeding and thrombosis in patients with chronic liver disease. In addition to this, the medical literature does not include guidelines for dealing with this special population. Also, the risk of thrombosis indicates the need to consider the use of thromboprophylaxis.
Coagulation alterations in patients with chronic liver disease occur frequently, although they ar... more Coagulation alterations in patients with chronic liver disease occur frequently, although they are usually described as auto-anticoagulation phenomena. Changes in hemostasis are broad and diffuse. They include changes in procoagulant and anticoagulant substances, hemodynamic modifi cations, endothelial dysfunction and platelet malfunction which are the causes of different clinical conditions varying from hemorrhaging to thrombosis. Given the complexity of theses alterations, laboratory tests do not correlate well with the clinical events. Treatment for these patients has been controversial. Currently we do not have objective methods for determining the hemostatic balance between bleeding and thrombosis in patients with chronic liver disease. In addition to this, the medical literature does not include guidelines for dealing with this special population. Also, the risk of thrombosis indicates the need to consider the use of thromboprophylaxis.
Physical Review D, 2011
We report on the high statistics two-pion correlation functions from pp collisions at √ s = 0.9 T... more We report on the high statistics two-pion correlation functions from pp collisions at √ s = 0.9 TeV and √ s = 7 TeV, measured by the ALICE experiment at the Large Hadron Collider. The correlation functions as well as the extracted source radii scale with event multiplicity and pair momentum. When analyzed in the same multiplicity and pair transverse momentum range, the correlation is similar at the two collision energies. A threedimensional femtoscopic analysis shows an increase of the emission zone with increasing event multiplicity as well as decreasing homogeneity lengths with increasing transverse momentum. The latter trend gets more pronounced as multiplicity increases. This suggests the development of space-momentum correlations, at least for collisions producing a high multiplicity of particles. We consider these trends in the context of previous femtoscopic studies in high-energy hadron and heavy-ion collisions, and discuss possible underlying physics mechanisms. Detailed analysis of the correlation reveals an exponential shape in the outward and longitudinal directions, while the sideward remains a Gaussian. This is interpreted as a result of a significant contribution of strongly decaying resonances to the emission region shape. Significant non-femtoscopic correlations are observed, and are argued to be the consequence of "mini-jet"-like structures extending to low p T. They are well reproduced by the Monte-Carlo generators and seen also in π + π − correlations.
Physical Review C, 2002
The centrality dependence of the charged-particle multiplicity density at mid-rapidity in Pb-Pb c... more The centrality dependence of the charged-particle multiplicity density at mid-rapidity in Pb-Pb collisions at √ s NN = 2.76 TeV is presented. The charged-particle density normalized per participating nucleon pair increases by about a factor of two from peripheral (70-80%) to central (0-5%) collisions. The centrality dependence is found to be similar to that observed at lower collision energies. The data are compared with models based on different mechanisms for particle production in nuclear collisions.
Journal of Neuropsychiatry, 2007
Catatonia is a common neuropsychiatric syndrome which may arise from GABA-A hypoactivity, dopamin... more Catatonia is a common neuropsychiatric syndrome which may arise from GABA-A hypoactivity, dopamine (D2) hypoactivity,and possibly glutamate NMDA hyperactivity. Amantadine and memantine have been reported as effective treatments for catatonia in selected cases, and probably mediate the presence of catatonic signs and symptoms through complex pathways involving glutamate antagonism. The authors identified 25 cases of catatonia treated with either agent. This article provides indirect evidence that glutamate antagonists may improve catatonic signs in some patients who fail to respond to established treatment, including lorazepam or electroconvulsive therapy. Further study of glutamate antagonists in the treatment of catatonia is needed.
Journal of Neuropsychiatry, 2008
FEMS Immunology & Medical Microbiology, 2008
We aimed at determining involvement of extracellular matrix proteins (ECMp) and an ECM-binding ad... more We aimed at determining involvement of extracellular matrix proteins (ECMp) and an ECM-binding adhesin (32-kDa protein) from Paracoccidioides brasiliensis, in the course of experimental paracoccidioidomycosis. BALB/c mice were infected with P. brasiliensis conidia previously incubated with soluble laminin, fibronectin and fibrinogen or a mAb against the fungal adhesin. Inflammatory response, chitin levels and cytokine production at different postinfection periods were determined. Chitin was significantly decreased in lungs of mice infected with ECMp-treated conidia when compared with controls at week 8, especially with laminin and fibrinogen. Contrariwise, when animals were infected with mAb-treated conidia no differences in chitin content were found. The observed inflammatory reaction in lungs was equivalent in all cases. IFN-g increased significantly in lungs from mice infected with soluble ECMp-(at day 4 and week 12) or mAb-treated conidia (at week 12) when compared with animals infected with untreated conidia. Significant increased levels of tumour necrosis factor-a were observed at 8 weeks in animals infected with ECMp-treated conidia while no differences were observed during the remaining periods. These findings point toward an inhibitory effect of ECMp on P. brasiliensis conidia infectivity and suggest that these proteins may interfere with conidia initial adhesion to host tissues probably modulating the immune response in paracoccidioidomycosis.
Durante los ultimos anos, la produccion de crudo pesado en Colombia ha aumentando, estos crudos t... more Durante los ultimos anos, la produccion de crudo pesado en Colombia ha aumentando, estos crudos tienen alto contendido de acidos naftenicos, lo cual genera graves problemas en las refinerias. Cuando se procesa crudo pesado, se produce Jet 1A con alto TAN (Numero Total de Acidos). Las resinas de intercambio ionico son una alternativa de solucion para disminuir la acidez de este turbocombustible. En este trabajo se estudio la viabilidad de utilizar columnas de intercambio ionico para la remocion de acidos naftenicos y se determino las dimensiones de dicha columna a nivel industrial; para estas pruebas se diseno y construyo una columna de intercambio ionico a nivel de laboratorio. Se realizaron pruebas de desorcion con etanol analitico y con una solucion de etanol-MEA al 0.16% V/V, se demostro que la regeneracion de la resina es mas efectiva con la monoetanolamina, se calculo el grado de hinchamiento de la resina despues de la regeneracion y las dimensiones de una columna de intercambio ionico para procesar 14000 BPD de Jet 1A con un periodo de saturacion de 35 dias. Se determino que a nivel industrial se debe operar con un sistema de 3 columnas para obtener un proceso continuo y permitir que el tiempo de regeneracion sea el adecuado. Se concluyo que es viable utilizar las resinas de intercambio ionico a nivel industrial y se recomienda determinar costos reales de operacion.
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Papers by camilo esteban jimenez muñoz