One of the major health consequences of the Chernobyl Nuclear Power Plant accident in 1986 was a ... more One of the major health consequences of the Chernobyl Nuclear Power Plant accident in 1986 was a dramatic increase in incidence of thyroid cancer among those who were aged less than 18 years at the time of the accident. This increase has been directly linked in several analytic epidemiological studies to iodine-131 (131I) thyroid doses received from the accident. However, there remains limited understanding of factors that modify the 131I-related risk. Focusing on post-Chernobyl pediatric thyroid cancer in Belarus, we reviewed evidence of the effects of radiation, thyroid screening, and iodine deficiency on regional differences in incidence rates of thyroid cancer. We also reviewed current evidence on content of nitrate in groundwater and thyroid cancer risk drawing attention to high levels of nitrates in open well water in several contaminated regions of Belarus, i.e. Gomel and Brest, related to the usage of nitrogen fertilizers. In this hypothesis generating study, based on ecological data and biological plausibility, we suggest that nitrate pollution may modify the radiation-related risk of thyroid cancer contributing to regional differences in rates of pediatric thyroid cancer in Belarus. Analytic epidemiological studies designed to evaluate joint effect of nitrate content in groundwater and radiation present a promising avenue of research and may provide useful insights into etiology of thyroid cancer.
Neuroepithelial tumor cells were cultured in vitro. The biopsy material was taken from 93 childre... more Neuroepithelial tumor cells were cultured in vitro. The biopsy material was taken from 93 children at removal of the brain tumors during neurosurgical operations. The individual features of the cells sensitivity of primary cultures in respect to protocol-approved chemotherapy drugs and changes in the Interleukin-6 (Il-6) level in the culture medium after the application of chemotherapy were established. The initial level of Il-6 exceeded 600.0 pg/ml in the cultural medium with histologically verified pilomyxoid astrocytoma cells, and ranged from 100.0 to 200.0 pg/ml in the medium at cultivation of ganglioneuroblastoma and pilocytic astrocytoma. A decrease in the Il-6 level in the medium culture of primary tumors cells was observed after the application of chemotherapeutic agents on the cells of pilomyxoid astrocytoma, astrocytomas, and pilocytic desmoplastic/nodular medulloblastoma.
Thyroid cancer in children is usually rare, but in the individuals exposed to radiation risk of d... more Thyroid cancer in children is usually rare, but in the individuals exposed to radiation risk of disease increases considerably. After the Chernobyl acci- dent in 1986, an over 10-fold maximal elevation in the incidence of thyroid cancer was registered about a decade later, cumulatively resulting in more than a thousand of newly diagnosed cases in children who lived in the ter- ritories of Belarus, Russia, and Ukraine affected by radioactive fallouts. Experience from the epidemic substantially promoted knowledge in clini- cal pediatric oncology, pathology and basic sciences. This article overviews epidemiology, clinical features, results of treatment and follow- up of childhood patients with radiation-induced Chernobyl thyroid cancer in comparison to sporadic cases diagnosed at present. In addition, we dis- cuss general issues of pathology and molecular findings in childhood thy- roid carcinomas
клинико-МорФологиЧЕскиЕ осоБЕнносТи пАпиллЯрного рАкА ЩиТоВиДноЙ ЖЕлЕЗы У ДЕТЕЙ и поДросТкоВ В рЕ... more клинико-МорФологиЧЕскиЕ осоБЕнносТи пАпиллЯрного рАкА ЩиТоВиДноЙ ЖЕлЕЗы У ДЕТЕЙ и поДросТкоВ В рЕспУБликЕ БЕлАрУсЬ: АнАлиЗ 936 посТ-ЧЕрноБылЬскиХ кАрЦиноМ 1 Белорусская медицинская академия последипломного образования 2 Институт физиологии НАН Беларуси 3 Объединенный институт проблем информатики НАН Беларуси, Минск представлена клинико-морфологическая характеристика пост-чернобыльского папиллярного рака щитовидной железы у 936 детей и подростков. В целом, карцинома у данных пациентов отличалась местно-распространенным ростом -в 57,4% (387 из 674 пациентов, у которых этот признак можно было оценить), метастазами в регионарных лимфатических узлах -в 73,7% (N1b у 40,7%) и внутренних органах -11,1%. средняя продолжительность периода наблюдения составила 12,4±3,5 лет (от 4,3 до 19,6 лет), в том числе у детей 14,6±2,7 лет (от 8,8 до 19,6 лет), а у подростков -10,1±3,1 лет (от 4,3 до 18,8 лет). общая выживаемость за 20-летней период равнялась 96,6%±1,2%. причиной смерти стали суициды (7), травмы и несчастные случаи (5), вторые злокачественные опухоли (1), соматические заболевания (2). Только у двух больных летальный исход был связан с основным заболеванием -метастатическим поражением легких. Безрецидивная выживаемость для когорты пост-чернобыльских карцином составила 92,7%±1,0%. ключевые слова: папиллярный рак, щитовидная железа, дети и подростки, Чернобыльская авария
клинико-МорФологиЧЕскиЕ осоБЕнносТи пАпиллЯрного рАкА ЩиТоВиДноЙ ЖЕлЕЗы У ДЕТЕЙ и поДросТкоВ В рЕ... more клинико-МорФологиЧЕскиЕ осоБЕнносТи пАпиллЯрного рАкА ЩиТоВиДноЙ ЖЕлЕЗы У ДЕТЕЙ и поДросТкоВ В рЕспУБликЕ БЕлАрУсЬ: АнАлиЗ 936 посТ-ЧЕрноБылЬскиХ кАрЦиноМ 1 Белорусская медицинская академия последипломного образования 2 Институт физиологии НАН Беларуси 3 Объединенный институт проблем информатики НАН Беларуси, Минск представлена клинико-морфологическая характеристика пост-чернобыльского папиллярного рака щитовидной железы у 936 детей и подростков. В целом, карцинома у данных пациентов отличалась местно-распространенным ростом -в 57,4% (387 из 674 пациентов, у которых этот признак можно было оценить), метастазами в регионарных лимфатических узлах -в 73,7% (N1b у 40,7%) и внутренних органах -11,1%. средняя продолжительность периода наблюдения составила 12,4±3,5 лет (от 4,3 до 19,6 лет), в том числе у детей 14,6±2,7 лет (от 8,8 до 19,6 лет), а у подростков -10,1±3,1 лет (от 4,3 до 18,8 лет). общая выживаемость за 20-летней период равнялась 96,6%±1,2%. причиной смерти стали суициды (7), травмы и несчастные случаи (5), вторые злокачественные опухоли (1), соматические заболевания (2). Только у двух больных летальный исход был связан с основным заболеванием -метастатическим поражением легких. Безрецидивная выживаемость для когорты пост-чернобыльских карцином составила 92,7%±1,0%. ключевые слова: папиллярный рак, щитовидная железа, дети и подростки, Чернобыльская авария
Several studies reported an increased risk of thyroid cancer in children and adolescents exposed ... more Several studies reported an increased risk of thyroid cancer in children and adolescents exposed to radioactive iodines, chiefly iodine-131 ((131)I), after the 1986 Chornobyl (Ukrainian spelling) nuclear power plant accident. The risk of benign thyroid tumors following such radiation exposure is much less well known. We have previously reported a novel finding of significantly increased risk of thyroid follicular adenoma in a screening study of children and adolescents exposed to the Chornobyl fallout in Ukraine. To verify this finding, we analyzed baseline screening data from a cohort of 11,613 individuals aged ≤18 years at the time of the accident in Belarus (mean age at screening = 21 years). All participants had individual (131)I doses estimated from thyroid radioactivity measurements and were screened according to a standardized protocol. We found a significant linear dose response for 38 pathologically confirmed follicular adenoma cases. The excess odds ratio per gray of 2.22 (95% confidence interval: 0.41, 13.1) was similar in males and females but decreased significantly with increasing age at exposure (P < 0.01), with the highest radiation risks estimated for those exposed at <2 years of age. Follicular adenoma radiation risks were not significantly modified by most indicators of past and current iodine deficiency. The present study confirms the (131)I-associated increases in risk of follicular adenoma in the Ukrainian population and adds new evidence on the risk increasing with decreasing age at exposure.
The aims were to analyse the features of papillary thyroid carcinoma in a large cohort of childre... more The aims were to analyse the features of papillary thyroid carcinoma in a large cohort of children and adolescents in Belarus and to study the influence of radiation exposure as well as the source of irradiation on the morphological and clinical presentations of tumours. The clinical and pathological features of 1086 young patients (age range=4 to 18 inclusive, followed up for ≥18years) with papillary thyroid carcinoma diagnosed during the years 1990 to 2010 were reviewed. The patients were divided into three groups: "external radiation-related", "post-Chernobyl" (internal irradiation-related) and "sporadic". Besides, patients from "post-Chernobyl" cohort (n=936) were further divided into the three equal subgroups according to the dates of surgery, which were corresponding to the early (4-9years), intermediate (10-12years) and long (14-18years) latency periods. Patients in the "external radiation-related" group often showed extra-thy...
There is presented clinical and morphological characteristics of post-Chernobyl papillary thyroid... more There is presented clinical and morphological characteristics of post-Chernobyl papillary thyroid cancer in 936 children and adolescents. In general, carcinoma of these patients featured by locally advanced growth - 57.4% (387 of 674 patients with this sign could be assessed), metastases in regional lymph nodes - 73,7% (N1b in 40.7%) and internal organs - 11.1%. The mean duration of follow-up was 12,4 +/- 3,5 years (range 4.3 to 19.6 years) including children 14,6 +/- 2,7 years (range 8.8 to 19.6 years) and adolescents - 10,1 +/- 3,1 years (range 4.3 to 18.8 years). Overall survival for the 20-year period was 96,6% +/- 1,2%. The causes of death were suicide (7), injuries and accidents (5), secondary malignancies (1), somatic diseases (2). Only in two patients the death was related to the main disease - lung metastases. Free-recurrence survival for the cohort of post-Chernobyl carcinomas was 92,7% +/- 1,0%.
The Journal of clinical endocrinology and metabolism, 2014
The aim of this population-based study was to evaluate the clinical and pathological characterist... more The aim of this population-based study was to evaluate the clinical and pathological characteristics and outcome of papillary thyroid carcinoma (PTC) that have arisen in the Belarusian childhood population exposed to the radioactive fallout from the Chernobyl accident within a long-term period. The long-term treatment results were investigated in 1078 children and adolescents (<19 years old) with PTC who were surgically treated during the years 1990 through 2005. Patients had high rates of metastatic PTC at presentation, with 73.8% of cases having lymph node involvement and 11.1% having distant spread. The most influential factor for lymph node metastases at initial treatment was lymphatic vessel invasion (P < .0001) and for distant metastases, lateral lymph node involvement (P < .0001). The overall survival was 96.9% ± 0.9% with a median follow-up of 16.21 years, and 20-year event-free survival and relapse-free survival were 87.8% ± 1.6% and 92.3% ± 0.9%, respectively. Pat...
The Journal of clinical endocrinology and metabolism, 2014
The aim of this population-based study was to evaluate the clinical and pathological characterist... more The aim of this population-based study was to evaluate the clinical and pathological characteristics and outcome of papillary thyroid carcinoma (PTC) that have arisen in the Belarusian childhood population exposed to the radioactive fallout from the Chernobyl accident within a long-term period. The long-term treatment results were investigated in 1078 children and adolescents (<19 years old) with PTC who were surgically treated during the years 1990 through 2005. Patients had high rates of metastatic PTC at presentation, with 73.8% of cases having lymph node involvement and 11.1% having distant spread. The most influential factor for lymph node metastases at initial treatment was lymphatic vessel invasion (P < .0001) and for distant metastases, lateral lymph node involvement (P < .0001). The overall survival was 96.9% ± 0.9% with a median follow-up of 16.21 years, and 20-year event-free survival and relapse-free survival were 87.8% ± 1.6% and 92.3% ± 0.9%, respectively. Pat...
The purpose of the present study was to analyze the thyroid cancer incidence risk after the Chern... more The purpose of the present study was to analyze the thyroid cancer incidence risk after the Chernobyl accident and its degree of dependence on time and age. Data were analyzed for 1034 settlements in Ukraine and Belarus, in which more than 10 measurements of the (131)I content in human thyroids had been performed in May/June 1986. Thyroid doses due to the Chernobyl accident were assessed for the birth years 1968-1985 and related to thyroid cancers that were surgically removed during the period 1990-2001. The central estimate for the linear coefficient of the EAR dose response was 2.66 (95% CI: 2.19; 3.13) cases per 10(4) PY-Gy; for the quadratic coefficient, it was -0.145 (95% CI: -0.171; -0.119) cases per 10(4) PY-Gy(2). The EAR was found to be higher for females than for males by a factor of 1.4. It decreased with age at exposure and increased with age attained. The central estimate for the linear coefficient of the ERR dose response was 18.9 (95% CI: 11.1; 26.7) Gy(-1); for the q...
The International Conference on Digital Technologies 2013, 2013
ABSTRACT Authors report a method for ovarian cancer relapse prediction based on image analysis of... more ABSTRACT Authors report a method for ovarian cancer relapse prediction based on image analysis of lymphangiogenesis D2-40 stained tumor samples. The described approach to forecasting the clinical event of cancer recurrence has sensitivity and specificity of 70%.
Journal of radiological protection : official journal of the Society for Radiological Protection, 2006
Our objective is to assess the regional and temporal dependences of the baseline cases contributi... more Our objective is to assess the regional and temporal dependences of the baseline cases contributing to thyroid cancer incidence among those exposed in childhood or during adolescence in Belarus and Ukraine after the Chernobyl accident. Data are analysed for Kyiv and Sevastopol City and the 25 oblasts (regions) in Ukraine, and for Minsk and Gomel City and the 6 oblasts in Belarus. Average thyroid doses due to the Chernobyl accident were assessed for every birth year in the period from 1968 to 1985. Case data pertain to people who underwent surgical removal of thyroid cancers during the period 1986 to 2001 and who were allocated to their place of residence at the time of the accident. The 35 oblasts/cities were subdivided into an upper, middle and lower group of baseline thyroid cancer incidence. Poisson regressions were performed to estimate age, time and gender dependences of the baseline incidence rates in the three groups. The majority of oblasts/cities with high average doses and...
BACKGROUND: Recent studies of children and adolescents who were exposed to radioactive iodine-131... more BACKGROUND: Recent studies of children and adolescents who were exposed to radioactive iodine-131 (I-131) after the 1986 Chernobyl nuclear accident in Ukraine exhibited a significant dose-related increase in the risk of thyroid cancer, but the association of radiation doses with tumor histologic and morphologic features is not clear.
One of the major health consequences of the Chernobyl Nuclear Power Plant accident in 1986 was a ... more One of the major health consequences of the Chernobyl Nuclear Power Plant accident in 1986 was a dramatic increase in incidence of thyroid cancer among those who were aged less than 18 years at the time of the accident. This increase has been directly linked in several analytic epidemiological studies to iodine-131 (131I) thyroid doses received from the accident. However, there remains limited understanding of factors that modify the 131I-related risk. Focusing on post-Chernobyl pediatric thyroid cancer in Belarus, we reviewed evidence of the effects of radiation, thyroid screening, and iodine deficiency on regional differences in incidence rates of thyroid cancer. We also reviewed current evidence on content of nitrate in groundwater and thyroid cancer risk drawing attention to high levels of nitrates in open well water in several contaminated regions of Belarus, i.e. Gomel and Brest, related to the usage of nitrogen fertilizers. In this hypothesis generating study, based on ecological data and biological plausibility, we suggest that nitrate pollution may modify the radiation-related risk of thyroid cancer contributing to regional differences in rates of pediatric thyroid cancer in Belarus. Analytic epidemiological studies designed to evaluate joint effect of nitrate content in groundwater and radiation present a promising avenue of research and may provide useful insights into etiology of thyroid cancer.
Neuroepithelial tumor cells were cultured in vitro. The biopsy material was taken from 93 childre... more Neuroepithelial tumor cells were cultured in vitro. The biopsy material was taken from 93 children at removal of the brain tumors during neurosurgical operations. The individual features of the cells sensitivity of primary cultures in respect to protocol-approved chemotherapy drugs and changes in the Interleukin-6 (Il-6) level in the culture medium after the application of chemotherapy were established. The initial level of Il-6 exceeded 600.0 pg/ml in the cultural medium with histologically verified pilomyxoid astrocytoma cells, and ranged from 100.0 to 200.0 pg/ml in the medium at cultivation of ganglioneuroblastoma and pilocytic astrocytoma. A decrease in the Il-6 level in the medium culture of primary tumors cells was observed after the application of chemotherapeutic agents on the cells of pilomyxoid astrocytoma, astrocytomas, and pilocytic desmoplastic/nodular medulloblastoma.
Thyroid cancer in children is usually rare, but in the individuals exposed to radiation risk of d... more Thyroid cancer in children is usually rare, but in the individuals exposed to radiation risk of disease increases considerably. After the Chernobyl acci- dent in 1986, an over 10-fold maximal elevation in the incidence of thyroid cancer was registered about a decade later, cumulatively resulting in more than a thousand of newly diagnosed cases in children who lived in the ter- ritories of Belarus, Russia, and Ukraine affected by radioactive fallouts. Experience from the epidemic substantially promoted knowledge in clini- cal pediatric oncology, pathology and basic sciences. This article overviews epidemiology, clinical features, results of treatment and follow- up of childhood patients with radiation-induced Chernobyl thyroid cancer in comparison to sporadic cases diagnosed at present. In addition, we dis- cuss general issues of pathology and molecular findings in childhood thy- roid carcinomas
клинико-МорФологиЧЕскиЕ осоБЕнносТи пАпиллЯрного рАкА ЩиТоВиДноЙ ЖЕлЕЗы У ДЕТЕЙ и поДросТкоВ В рЕ... more клинико-МорФологиЧЕскиЕ осоБЕнносТи пАпиллЯрного рАкА ЩиТоВиДноЙ ЖЕлЕЗы У ДЕТЕЙ и поДросТкоВ В рЕспУБликЕ БЕлАрУсЬ: АнАлиЗ 936 посТ-ЧЕрноБылЬскиХ кАрЦиноМ 1 Белорусская медицинская академия последипломного образования 2 Институт физиологии НАН Беларуси 3 Объединенный институт проблем информатики НАН Беларуси, Минск представлена клинико-морфологическая характеристика пост-чернобыльского папиллярного рака щитовидной железы у 936 детей и подростков. В целом, карцинома у данных пациентов отличалась местно-распространенным ростом -в 57,4% (387 из 674 пациентов, у которых этот признак можно было оценить), метастазами в регионарных лимфатических узлах -в 73,7% (N1b у 40,7%) и внутренних органах -11,1%. средняя продолжительность периода наблюдения составила 12,4±3,5 лет (от 4,3 до 19,6 лет), в том числе у детей 14,6±2,7 лет (от 8,8 до 19,6 лет), а у подростков -10,1±3,1 лет (от 4,3 до 18,8 лет). общая выживаемость за 20-летней период равнялась 96,6%±1,2%. причиной смерти стали суициды (7), травмы и несчастные случаи (5), вторые злокачественные опухоли (1), соматические заболевания (2). Только у двух больных летальный исход был связан с основным заболеванием -метастатическим поражением легких. Безрецидивная выживаемость для когорты пост-чернобыльских карцином составила 92,7%±1,0%. ключевые слова: папиллярный рак, щитовидная железа, дети и подростки, Чернобыльская авария
клинико-МорФологиЧЕскиЕ осоБЕнносТи пАпиллЯрного рАкА ЩиТоВиДноЙ ЖЕлЕЗы У ДЕТЕЙ и поДросТкоВ В рЕ... more клинико-МорФологиЧЕскиЕ осоБЕнносТи пАпиллЯрного рАкА ЩиТоВиДноЙ ЖЕлЕЗы У ДЕТЕЙ и поДросТкоВ В рЕспУБликЕ БЕлАрУсЬ: АнАлиЗ 936 посТ-ЧЕрноБылЬскиХ кАрЦиноМ 1 Белорусская медицинская академия последипломного образования 2 Институт физиологии НАН Беларуси 3 Объединенный институт проблем информатики НАН Беларуси, Минск представлена клинико-морфологическая характеристика пост-чернобыльского папиллярного рака щитовидной железы у 936 детей и подростков. В целом, карцинома у данных пациентов отличалась местно-распространенным ростом -в 57,4% (387 из 674 пациентов, у которых этот признак можно было оценить), метастазами в регионарных лимфатических узлах -в 73,7% (N1b у 40,7%) и внутренних органах -11,1%. средняя продолжительность периода наблюдения составила 12,4±3,5 лет (от 4,3 до 19,6 лет), в том числе у детей 14,6±2,7 лет (от 8,8 до 19,6 лет), а у подростков -10,1±3,1 лет (от 4,3 до 18,8 лет). общая выживаемость за 20-летней период равнялась 96,6%±1,2%. причиной смерти стали суициды (7), травмы и несчастные случаи (5), вторые злокачественные опухоли (1), соматические заболевания (2). Только у двух больных летальный исход был связан с основным заболеванием -метастатическим поражением легких. Безрецидивная выживаемость для когорты пост-чернобыльских карцином составила 92,7%±1,0%. ключевые слова: папиллярный рак, щитовидная железа, дети и подростки, Чернобыльская авария
Several studies reported an increased risk of thyroid cancer in children and adolescents exposed ... more Several studies reported an increased risk of thyroid cancer in children and adolescents exposed to radioactive iodines, chiefly iodine-131 ((131)I), after the 1986 Chornobyl (Ukrainian spelling) nuclear power plant accident. The risk of benign thyroid tumors following such radiation exposure is much less well known. We have previously reported a novel finding of significantly increased risk of thyroid follicular adenoma in a screening study of children and adolescents exposed to the Chornobyl fallout in Ukraine. To verify this finding, we analyzed baseline screening data from a cohort of 11,613 individuals aged ≤18 years at the time of the accident in Belarus (mean age at screening = 21 years). All participants had individual (131)I doses estimated from thyroid radioactivity measurements and were screened according to a standardized protocol. We found a significant linear dose response for 38 pathologically confirmed follicular adenoma cases. The excess odds ratio per gray of 2.22 (95% confidence interval: 0.41, 13.1) was similar in males and females but decreased significantly with increasing age at exposure (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01), with the highest radiation risks estimated for those exposed at &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;2 years of age. Follicular adenoma radiation risks were not significantly modified by most indicators of past and current iodine deficiency. The present study confirms the (131)I-associated increases in risk of follicular adenoma in the Ukrainian population and adds new evidence on the risk increasing with decreasing age at exposure.
The aims were to analyse the features of papillary thyroid carcinoma in a large cohort of childre... more The aims were to analyse the features of papillary thyroid carcinoma in a large cohort of children and adolescents in Belarus and to study the influence of radiation exposure as well as the source of irradiation on the morphological and clinical presentations of tumours. The clinical and pathological features of 1086 young patients (age range=4 to 18 inclusive, followed up for ≥18years) with papillary thyroid carcinoma diagnosed during the years 1990 to 2010 were reviewed. The patients were divided into three groups: "external radiation-related", "post-Chernobyl" (internal irradiation-related) and "sporadic". Besides, patients from "post-Chernobyl" cohort (n=936) were further divided into the three equal subgroups according to the dates of surgery, which were corresponding to the early (4-9years), intermediate (10-12years) and long (14-18years) latency periods. Patients in the "external radiation-related" group often showed extra-thy...
There is presented clinical and morphological characteristics of post-Chernobyl papillary thyroid... more There is presented clinical and morphological characteristics of post-Chernobyl papillary thyroid cancer in 936 children and adolescents. In general, carcinoma of these patients featured by locally advanced growth - 57.4% (387 of 674 patients with this sign could be assessed), metastases in regional lymph nodes - 73,7% (N1b in 40.7%) and internal organs - 11.1%. The mean duration of follow-up was 12,4 +/- 3,5 years (range 4.3 to 19.6 years) including children 14,6 +/- 2,7 years (range 8.8 to 19.6 years) and adolescents - 10,1 +/- 3,1 years (range 4.3 to 18.8 years). Overall survival for the 20-year period was 96,6% +/- 1,2%. The causes of death were suicide (7), injuries and accidents (5), secondary malignancies (1), somatic diseases (2). Only in two patients the death was related to the main disease - lung metastases. Free-recurrence survival for the cohort of post-Chernobyl carcinomas was 92,7% +/- 1,0%.
The Journal of clinical endocrinology and metabolism, 2014
The aim of this population-based study was to evaluate the clinical and pathological characterist... more The aim of this population-based study was to evaluate the clinical and pathological characteristics and outcome of papillary thyroid carcinoma (PTC) that have arisen in the Belarusian childhood population exposed to the radioactive fallout from the Chernobyl accident within a long-term period. The long-term treatment results were investigated in 1078 children and adolescents (<19 years old) with PTC who were surgically treated during the years 1990 through 2005. Patients had high rates of metastatic PTC at presentation, with 73.8% of cases having lymph node involvement and 11.1% having distant spread. The most influential factor for lymph node metastases at initial treatment was lymphatic vessel invasion (P < .0001) and for distant metastases, lateral lymph node involvement (P < .0001). The overall survival was 96.9% ± 0.9% with a median follow-up of 16.21 years, and 20-year event-free survival and relapse-free survival were 87.8% ± 1.6% and 92.3% ± 0.9%, respectively. Pat...
The Journal of clinical endocrinology and metabolism, 2014
The aim of this population-based study was to evaluate the clinical and pathological characterist... more The aim of this population-based study was to evaluate the clinical and pathological characteristics and outcome of papillary thyroid carcinoma (PTC) that have arisen in the Belarusian childhood population exposed to the radioactive fallout from the Chernobyl accident within a long-term period. The long-term treatment results were investigated in 1078 children and adolescents (<19 years old) with PTC who were surgically treated during the years 1990 through 2005. Patients had high rates of metastatic PTC at presentation, with 73.8% of cases having lymph node involvement and 11.1% having distant spread. The most influential factor for lymph node metastases at initial treatment was lymphatic vessel invasion (P < .0001) and for distant metastases, lateral lymph node involvement (P < .0001). The overall survival was 96.9% ± 0.9% with a median follow-up of 16.21 years, and 20-year event-free survival and relapse-free survival were 87.8% ± 1.6% and 92.3% ± 0.9%, respectively. Pat...
The purpose of the present study was to analyze the thyroid cancer incidence risk after the Chern... more The purpose of the present study was to analyze the thyroid cancer incidence risk after the Chernobyl accident and its degree of dependence on time and age. Data were analyzed for 1034 settlements in Ukraine and Belarus, in which more than 10 measurements of the (131)I content in human thyroids had been performed in May/June 1986. Thyroid doses due to the Chernobyl accident were assessed for the birth years 1968-1985 and related to thyroid cancers that were surgically removed during the period 1990-2001. The central estimate for the linear coefficient of the EAR dose response was 2.66 (95% CI: 2.19; 3.13) cases per 10(4) PY-Gy; for the quadratic coefficient, it was -0.145 (95% CI: -0.171; -0.119) cases per 10(4) PY-Gy(2). The EAR was found to be higher for females than for males by a factor of 1.4. It decreased with age at exposure and increased with age attained. The central estimate for the linear coefficient of the ERR dose response was 18.9 (95% CI: 11.1; 26.7) Gy(-1); for the q...
The International Conference on Digital Technologies 2013, 2013
ABSTRACT Authors report a method for ovarian cancer relapse prediction based on image analysis of... more ABSTRACT Authors report a method for ovarian cancer relapse prediction based on image analysis of lymphangiogenesis D2-40 stained tumor samples. The described approach to forecasting the clinical event of cancer recurrence has sensitivity and specificity of 70%.
Journal of radiological protection : official journal of the Society for Radiological Protection, 2006
Our objective is to assess the regional and temporal dependences of the baseline cases contributi... more Our objective is to assess the regional and temporal dependences of the baseline cases contributing to thyroid cancer incidence among those exposed in childhood or during adolescence in Belarus and Ukraine after the Chernobyl accident. Data are analysed for Kyiv and Sevastopol City and the 25 oblasts (regions) in Ukraine, and for Minsk and Gomel City and the 6 oblasts in Belarus. Average thyroid doses due to the Chernobyl accident were assessed for every birth year in the period from 1968 to 1985. Case data pertain to people who underwent surgical removal of thyroid cancers during the period 1986 to 2001 and who were allocated to their place of residence at the time of the accident. The 35 oblasts/cities were subdivided into an upper, middle and lower group of baseline thyroid cancer incidence. Poisson regressions were performed to estimate age, time and gender dependences of the baseline incidence rates in the three groups. The majority of oblasts/cities with high average doses and...
BACKGROUND: Recent studies of children and adolescents who were exposed to radioactive iodine-131... more BACKGROUND: Recent studies of children and adolescents who were exposed to radioactive iodine-131 (I-131) after the 1986 Chernobyl nuclear accident in Ukraine exhibited a significant dose-related increase in the risk of thyroid cancer, but the association of radiation doses with tumor histologic and morphologic features is not clear.
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Papers by Yuri Demidchik