Background: Quiescin Q6-Sulfydryl Oxidase 2 (QSOX2), an enzyme that can be directly secreted into... more Background: Quiescin Q6-Sulfydryl Oxidase 2 (QSOX2), an enzyme that can be directly secreted into the extracellular space, is known to be associated with oxidative protein folding. However, whether QSOX2 is abnormally expressed in non-small cell lung cancer (NSCLC) and its role in tumor growth remains unclear. Methods: Real-time quantitative PCR (qPCR), immunohistochemistry (IHC), bioinformatics analyses were applied to analyze the expression pattern and prognostic significance of QSOX2 in NSCLC. Xenografts model, enzyme-linked immunosorbent assays (ELISA), western blot analysis (WB), and IHC were preformed to examine in vivo tumor suppression and intracellular and extracellular expression of QSOX2. Flow cytometry, WB and qPCR analyses were used to elucidate the role of QSOX2 in cell cycle regulation. Chromatin immunoprecipitation assay (ChIP) assay and Dual-Luciferase reporter assay were employed to investigate transcriptional regulation of QSOX2 by E2F Transcription Factor 1 (E2F1) Results: QSOX2 was significantly overexpressed in NSCLC and associated with poor survival in advanced-stage patients. The intracellular and extracellular expression of QSOX2 by tumor cells markedly decreased after anti-cancer therapy in vitro, in vivo and in the clinic. Moreover, QSOX2 silencing in NSCLC cell lines resulted in inhibition of cancer cell proliferation, induction of apoptosis, and decreased expression of cell division-related genes ( CENPF and NUSAP1) and Wnt pathway activators (PRRX2 and Nuc-β-catenin). Mechanically, QSOX2 was expressed periodically during cell cycle and directly regulated by E2F1. Conclusions: Our findings demonstrate that QSOX2 is directly regulated by E2F1 in the cell cycle is essential for the proliferation of NSCLC cells. Furthermore, QSOX2 is an inferior prognostic indicator for NSCLC and may be developed into a biomarker for monitoring tumor burden and therapeutic progress. Funding Statement: This work was supported by the National Natural Science Foundation of China (81660467 to Chao Shi, and 81860427 to Jianping Xiong) and the Youth Science Foundation of Jiangxi Province ( 20171BAB215081 to Chao Shi). Declaration of Interests: The authors have no conflicts of interest to declare. Ethics Approval Statement: This work was approved by the Ethics Committee of the First Affiliated Hospital of Nanchang University (no. MR2018-83).
BackgroundEarly diagnosis of colorectal cancer could significantly improve the prognosis and redu... more BackgroundEarly diagnosis of colorectal cancer could significantly improve the prognosis and reduce mortality. However, indeterminate diagnosis is often met in pathology diagnosis in biopsy samples. Abnormal expression of long non-coding RNA (lncRNA) is associated with the initiation and progression of colorectal cancer. It is of great value and clinical significance to explore lncRNAs as candidate diagnostic biomarkers in colorectal cancer.MethodsBased on the within-sample relative expression levels of lncRNA pairs, we identified a group of candidate diagnostic biomarkers for colorectal cancer. In addition, we validated it in independent datasets produced by different laboratories and different platforms. We also tested it in colorectal cancer tissue samples using quantitative real-time polymerase chain reaction (RT-qPCR).ResultsA biomarker consisting of six lncRNA pairs including nine lncRNAs was identified for the diagnosis of colorectal cancer. For a total of 950 cancer samples ...
To remove the phobic psychological situation of Chinese college students who were in school lockd... more To remove the phobic psychological situation of Chinese college students who were in school lockdowns during the COVID-19 outbreak, and to provide a theoretical basis for college student psychological intervention. Methods: Online survey conducted from December 9, 2021, to December 11, 2021. The seven-item Fcv-19s was employed to assess fear of COVID-19 on a Likert five-point scale. Categorical data were reported as number and percentage, whereas continuous data were reported as mean AE standard deviation. Multivariate logistic regression models were used to assess the association between different factors and anxiety symptoms. Results: The study population consisted of 26.02% (268) male and 73.98% (762) female, of whom approximately 84% were undergraduates. The overall mean score of the questionnaire was 16.04 AE 5.28. Significantly more study populations reported high levels of fear (54.8%), while age, cost of life, professional category, education background (P < 0.05) revealed significant differences based on fear levels. Conclusions: More than half of the Chinese college students developed fear symptoms during the COVID-19 epidemic. Appropriate psychological interventions for college students should be implemented promptly to reduce the psychological harm induced by the COVID-19 epidemic.
This study attempted to investigate the influence of values on appearance perception and scalp & ... more This study attempted to investigate the influence of values on appearance perception and scalp & hair care behavior against Chinese women. An online survey was conducted through WEN JUAN XING from September 11 to 30, 2021 among adult women in their 20-30s in Liaoning Province, China. Among 430 questionnaires distributed, 328 copies were collected. Then, 289 copies were used for the final analysis, excluding 39 poorly answered ones. The collected data were analyzed, using SPSS WIN 21.0. The above results confirm that ‘self-achievement orientation’, ‘sensitivity orientation’, and ‘social-relationship orientation’ are important factors affecting appearance perception. In addition, ‘material orientation’ was a key factor that affected ‘appearance perception’. Furthermore, ‘practice orientation’, ‘sensitivity orientation’, and ‘social-relationship orientation’ influenced ‘scalp & hair care behavior’. In particular, ‘sensitivity orientation’ and ‘social-relationship orientation’ were key ...
Due to the self-renewal characteristics and tumorigenic abilities of cancer stem cells (CSCs), CS... more Due to the self-renewal characteristics and tumorigenic abilities of cancer stem cells (CSCs), CSCs have been demonstrated to play vital roles in carcinogenesis and antitumor therapy. Our previous report found that Krüppel-like family members (KLFs) and zinc finger protein 32 (ZNF32) play oncogenic roles in carcinogenesis. However, the roles and mechanism of ZNF32 in CSCs are still unknown. Our study demonstrated that ZNF32 was highly expressed in colorectal CSCs, which promoted their self-renewal capacity and tumorigenicity. Overexpression of ZNF32 in colorectal cancer (CRC) cells increased their self-renewal capacity. Furthermore, we identified the leptin receptor (LEPR) as the downstream target gene of ZNF32 and verified that the ZNF32-mediated regulation of CRC self-renewal is achieved via the LEPR- signal transducer and activator of transcription 3 (STAT3) pathway. Moreover, ZNF32 regulated the expression of SOX2, a core transcription factor in stem cells. Finally, we demonstra...
Purpose. To examine the effects of fluid contamination on the reverse torque value (RTV) of abutm... more Purpose. To examine the effects of fluid contamination on the reverse torque value (RTV) of abutment screws. 484 titanium fixtures were mounted into the stainless-steel holders. Methods. 11 groups (44 specimens in each group) of implants were mounted in acrylic resin. Ten groups of fixture screw holes were contaminated with chlorhexidine, saliva, blood, fluoride, or combination groups, and one group served as a control without contamination. To simulate the oral environment, samples were subjected to thermal cycling and cyclic loading. Results. The RTV means were less than the initial torque in both control and contamination groups. The maximum RTV mean was observed in the fluoride group ( 26.00 ± 1.02 Ncm). In other groups, this rate for control, blood, saliva, and chlorhexidine groups were 18.00 ± 1.78 Ncm, 22.12 ± 1.56 Ncm, 21.56 ± 1.43 Ncm, and 21.89 ± 1.02 Ncm, respectively. In combination groups, the maximum RTV mean was observed in the saliva+CHX group ( 23.89 ± 1.92 Nc...
This is an open access article under the terms of the Creative Commons Attribution License, which... more This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
The development of detection method for aflatoxin gene cluster in Aspergillus flavus and Aspergil... more The development of detection method for aflatoxin gene cluster in Aspergillus flavus and Aspergillus parasiticusis is an effective approach to prevent the widespread of aflatoxins, which are considered as extremely, toxic substances. Herein, a hairpin DNA-assisted fluorescence probe switch based on Förster resonant energy transfer (FRET) was designed. In this work, the two terminals of hairpin DNA probe were combined with CdTe/CdS quantum dots as donor and gold nanoparticles (AuNPs) as acceptor respectively to fabricate the FRET hairpin probe switch, which were utilized to detect the aflatoxigenic fragment of aflD genes for the first time. In the absence of target DNA, the hairpin probe formed the double stem loops state to trigger the FRET to induce the fluorescence-quenching (turning off). With the addition of target DNA, the specific interaction between target and hairpin probe switch brought about the separation of fluorescent energy donor–acceptor pairs to create an increasing fluorescence response (turning on). Consequently, the fluorescence intensity recovers can be employed to detect aflD genes in homogenous phase through optical responses. This proposed FRET hairpin probe switch performed a great limit of detection of 0.02 nM with a linear range of 0.05–200 nM under optimal conditions. Furthermore, the feasibility of the fabricated strategy was demonstrated in fermented soybean paste with the advantages of simplicity, rapidity, and sensitivity, which indicated that this method exhibited the potential and practicability in foodborne biological samples.
With the improvement of national living standard, consumers have higher yearning and pursuit for ... more With the improvement of national living standard, consumers have higher yearning and pursuit for the quality of life. it is the mainstream idea of contemporary consumption to make more consumers eat healthier food by using the logistics mode of fresh cold chain, and the development of intelligent logistics platform has promoted the upgrading and innovation development of enterprises, better completed the development of the current intelligent logistics platform, minimized the cost and improved the transportation efficiency, and promoted the rapid development of fresh cold chain.
2019 34th IEEE/ACM International Conference on Automated Software Engineering (ASE), 2019
Smart pointers are widely used to prevent memory errors in modern C++ code. However, improper usa... more Smart pointers are widely used to prevent memory errors in modern C++ code. However, improper usage of smart pointers may also lead to common memory errors, which makes the code not as safe as expected. To avoid smart pointer errors as early as possible, we present a coding style checker to detect possible bad smart pointer usages during compile time, and notify programmers about bug-prone behaviors. The evaluation indicates that the currently available state-of-the-art static code checkers can only detect 25 out of 116 manually inserted errors, while our tool can detect all these errors. And we also found 521 bugs among 8 open source projects with only 4 false positives.
Delay discounting is the decline in the present value of a reward with delay to its receipt. (Maz... more Delay discounting is the decline in the present value of a reward with delay to its receipt. (Mazur,1987). The delay discounting task is used to measure delay discounting rate, which requires the participants to choose between two options: one involves immediate delivery of a reward, and other involves delivery after a delay, and the immediate rewards are adjusted in value until the subject feels there is no difference between the immediate and the delayed reward. Some previous studies (Robles and Vargas, 2007; 2008; Robles et al., 2009) found that the order of presentation of the immediate rewards (ascending or descending) significantly influenced the estimated delay discounting rate, which is known as the order effect. Uncertainty about the future and impulsivity could explain delay discounting behavior. The purpose of this study was to explore the order effect in delay discounting assessment. The current study found that the order effect in the delay discounting task can be explained by risk aversion, loss aversion and impulsivity. In the current study, the two kinds of fixed procedure (ascending and descending), and the titrating delay discounting task were used to estimate the degree of delay discounting. Also, two gambling tasks were applied to measure risk and loss aversion indices. The BIS-11 scale was used to assess the level of trait impulsivity. The results indicated that impulsivity biases individuals to choose the immediate small reward rather than the large delayed reward, resulting in lower area under the discounting curve (AUC) when estimated with the ascending-sequence delay discounting task. Also, impulsivity moderated the relationship between loss aversion and AUC estimated with the descending-sequence delay discounting task.
We propose the novel use of a generative adversarial network (GAN) (i) to make predictions in tim... more We propose the novel use of a generative adversarial network (GAN) (i) to make predictions in time (PredGAN) and (ii) to assimilate measurements (DA-PredGAN). In the latter case, we take advantage of the natural adjoint-like properties of generative models and the ability to simulate forwards and backwards in time. GANs have received much attention recently, after achieving excellent results for their generation of realistic-looking images. We wish to explore how this property translates to new applications in computational modelling and to exploit the adjoint-like properties for efficient data assimilation. To predict the spread of COVID-19 in an idealised town, we apply these methods to a compartmental model in epidemiology that is able to model space and time variations. To do this, the GAN is set within a reduced-order model (ROM), which uses a low-dimensional space for the spatial distribution of the simulation states. Then the GAN learns the evolution of the low-dimensional st...
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery, 2016
OBJECTIVE To investigate the impact of the weekday of surgery on the prognosis of patients with c... more OBJECTIVE To investigate the impact of the weekday of surgery on the prognosis of patients with colorectal cancer. METHODS A retrospective analysis was conducted in patients with colorectal cancer who underwent radical resection in Fudan University Shanghai Cancer Center(FUSCC) between January 2007 and December 2013, and 4 971 patients were identified eligible. Statistical analyses were carried out between patients who received surgery on Monday to Thursday and those who received surgery on Friday. Chi-square test was used to analyze the relationship between clinicopathological parameters and day of surgery. T test was used to compare continuous variables between groups. The 5-year overall survival (OS) and disease-free survival (DFS) were calculated by the Kaplan-Meier method, and compared by log-rank test. RESULTS There were no statistically significant differences between two groups in age, gender and pathological grade et al (all P>0.05). However, the number of dissected lymp...
Background: Quiescin Q6-Sulfydryl Oxidase 2 (QSOX2), an enzyme that can be directly secreted into... more Background: Quiescin Q6-Sulfydryl Oxidase 2 (QSOX2), an enzyme that can be directly secreted into the extracellular space, is known to be associated with oxidative protein folding. However, whether QSOX2 is abnormally expressed in non-small cell lung cancer (NSCLC) and its role in tumor growth remains unclear. Methods: Real-time quantitative PCR (qPCR), immunohistochemistry (IHC), bioinformatics analyses were applied to analyze the expression pattern and prognostic significance of QSOX2 in NSCLC. Xenografts model, enzyme-linked immunosorbent assays (ELISA), western blot analysis (WB), and IHC were preformed to examine in vivo tumor suppression and intracellular and extracellular expression of QSOX2. Flow cytometry, WB and qPCR analyses were used to elucidate the role of QSOX2 in cell cycle regulation. Chromatin immunoprecipitation assay (ChIP) assay and Dual-Luciferase reporter assay were employed to investigate transcriptional regulation of QSOX2 by E2F Transcription Factor 1 (E2F1) Results: QSOX2 was significantly overexpressed in NSCLC and associated with poor survival in advanced-stage patients. The intracellular and extracellular expression of QSOX2 by tumor cells markedly decreased after anti-cancer therapy in vitro, in vivo and in the clinic. Moreover, QSOX2 silencing in NSCLC cell lines resulted in inhibition of cancer cell proliferation, induction of apoptosis, and decreased expression of cell division-related genes ( CENPF and NUSAP1) and Wnt pathway activators (PRRX2 and Nuc-β-catenin). Mechanically, QSOX2 was expressed periodically during cell cycle and directly regulated by E2F1. Conclusions: Our findings demonstrate that QSOX2 is directly regulated by E2F1 in the cell cycle is essential for the proliferation of NSCLC cells. Furthermore, QSOX2 is an inferior prognostic indicator for NSCLC and may be developed into a biomarker for monitoring tumor burden and therapeutic progress. Funding Statement: This work was supported by the National Natural Science Foundation of China (81660467 to Chao Shi, and 81860427 to Jianping Xiong) and the Youth Science Foundation of Jiangxi Province ( 20171BAB215081 to Chao Shi). Declaration of Interests: The authors have no conflicts of interest to declare. Ethics Approval Statement: This work was approved by the Ethics Committee of the First Affiliated Hospital of Nanchang University (no. MR2018-83).
BackgroundEarly diagnosis of colorectal cancer could significantly improve the prognosis and redu... more BackgroundEarly diagnosis of colorectal cancer could significantly improve the prognosis and reduce mortality. However, indeterminate diagnosis is often met in pathology diagnosis in biopsy samples. Abnormal expression of long non-coding RNA (lncRNA) is associated with the initiation and progression of colorectal cancer. It is of great value and clinical significance to explore lncRNAs as candidate diagnostic biomarkers in colorectal cancer.MethodsBased on the within-sample relative expression levels of lncRNA pairs, we identified a group of candidate diagnostic biomarkers for colorectal cancer. In addition, we validated it in independent datasets produced by different laboratories and different platforms. We also tested it in colorectal cancer tissue samples using quantitative real-time polymerase chain reaction (RT-qPCR).ResultsA biomarker consisting of six lncRNA pairs including nine lncRNAs was identified for the diagnosis of colorectal cancer. For a total of 950 cancer samples ...
To remove the phobic psychological situation of Chinese college students who were in school lockd... more To remove the phobic psychological situation of Chinese college students who were in school lockdowns during the COVID-19 outbreak, and to provide a theoretical basis for college student psychological intervention. Methods: Online survey conducted from December 9, 2021, to December 11, 2021. The seven-item Fcv-19s was employed to assess fear of COVID-19 on a Likert five-point scale. Categorical data were reported as number and percentage, whereas continuous data were reported as mean AE standard deviation. Multivariate logistic regression models were used to assess the association between different factors and anxiety symptoms. Results: The study population consisted of 26.02% (268) male and 73.98% (762) female, of whom approximately 84% were undergraduates. The overall mean score of the questionnaire was 16.04 AE 5.28. Significantly more study populations reported high levels of fear (54.8%), while age, cost of life, professional category, education background (P < 0.05) revealed significant differences based on fear levels. Conclusions: More than half of the Chinese college students developed fear symptoms during the COVID-19 epidemic. Appropriate psychological interventions for college students should be implemented promptly to reduce the psychological harm induced by the COVID-19 epidemic.
This study attempted to investigate the influence of values on appearance perception and scalp & ... more This study attempted to investigate the influence of values on appearance perception and scalp & hair care behavior against Chinese women. An online survey was conducted through WEN JUAN XING from September 11 to 30, 2021 among adult women in their 20-30s in Liaoning Province, China. Among 430 questionnaires distributed, 328 copies were collected. Then, 289 copies were used for the final analysis, excluding 39 poorly answered ones. The collected data were analyzed, using SPSS WIN 21.0. The above results confirm that ‘self-achievement orientation’, ‘sensitivity orientation’, and ‘social-relationship orientation’ are important factors affecting appearance perception. In addition, ‘material orientation’ was a key factor that affected ‘appearance perception’. Furthermore, ‘practice orientation’, ‘sensitivity orientation’, and ‘social-relationship orientation’ influenced ‘scalp & hair care behavior’. In particular, ‘sensitivity orientation’ and ‘social-relationship orientation’ were key ...
Due to the self-renewal characteristics and tumorigenic abilities of cancer stem cells (CSCs), CS... more Due to the self-renewal characteristics and tumorigenic abilities of cancer stem cells (CSCs), CSCs have been demonstrated to play vital roles in carcinogenesis and antitumor therapy. Our previous report found that Krüppel-like family members (KLFs) and zinc finger protein 32 (ZNF32) play oncogenic roles in carcinogenesis. However, the roles and mechanism of ZNF32 in CSCs are still unknown. Our study demonstrated that ZNF32 was highly expressed in colorectal CSCs, which promoted their self-renewal capacity and tumorigenicity. Overexpression of ZNF32 in colorectal cancer (CRC) cells increased their self-renewal capacity. Furthermore, we identified the leptin receptor (LEPR) as the downstream target gene of ZNF32 and verified that the ZNF32-mediated regulation of CRC self-renewal is achieved via the LEPR- signal transducer and activator of transcription 3 (STAT3) pathway. Moreover, ZNF32 regulated the expression of SOX2, a core transcription factor in stem cells. Finally, we demonstra...
Purpose. To examine the effects of fluid contamination on the reverse torque value (RTV) of abutm... more Purpose. To examine the effects of fluid contamination on the reverse torque value (RTV) of abutment screws. 484 titanium fixtures were mounted into the stainless-steel holders. Methods. 11 groups (44 specimens in each group) of implants were mounted in acrylic resin. Ten groups of fixture screw holes were contaminated with chlorhexidine, saliva, blood, fluoride, or combination groups, and one group served as a control without contamination. To simulate the oral environment, samples were subjected to thermal cycling and cyclic loading. Results. The RTV means were less than the initial torque in both control and contamination groups. The maximum RTV mean was observed in the fluoride group ( 26.00 ± 1.02 Ncm). In other groups, this rate for control, blood, saliva, and chlorhexidine groups were 18.00 ± 1.78 Ncm, 22.12 ± 1.56 Ncm, 21.56 ± 1.43 Ncm, and 21.89 ± 1.02 Ncm, respectively. In combination groups, the maximum RTV mean was observed in the saliva+CHX group ( 23.89 ± 1.92 Nc...
This is an open access article under the terms of the Creative Commons Attribution License, which... more This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
The development of detection method for aflatoxin gene cluster in Aspergillus flavus and Aspergil... more The development of detection method for aflatoxin gene cluster in Aspergillus flavus and Aspergillus parasiticusis is an effective approach to prevent the widespread of aflatoxins, which are considered as extremely, toxic substances. Herein, a hairpin DNA-assisted fluorescence probe switch based on Förster resonant energy transfer (FRET) was designed. In this work, the two terminals of hairpin DNA probe were combined with CdTe/CdS quantum dots as donor and gold nanoparticles (AuNPs) as acceptor respectively to fabricate the FRET hairpin probe switch, which were utilized to detect the aflatoxigenic fragment of aflD genes for the first time. In the absence of target DNA, the hairpin probe formed the double stem loops state to trigger the FRET to induce the fluorescence-quenching (turning off). With the addition of target DNA, the specific interaction between target and hairpin probe switch brought about the separation of fluorescent energy donor–acceptor pairs to create an increasing fluorescence response (turning on). Consequently, the fluorescence intensity recovers can be employed to detect aflD genes in homogenous phase through optical responses. This proposed FRET hairpin probe switch performed a great limit of detection of 0.02 nM with a linear range of 0.05–200 nM under optimal conditions. Furthermore, the feasibility of the fabricated strategy was demonstrated in fermented soybean paste with the advantages of simplicity, rapidity, and sensitivity, which indicated that this method exhibited the potential and practicability in foodborne biological samples.
With the improvement of national living standard, consumers have higher yearning and pursuit for ... more With the improvement of national living standard, consumers have higher yearning and pursuit for the quality of life. it is the mainstream idea of contemporary consumption to make more consumers eat healthier food by using the logistics mode of fresh cold chain, and the development of intelligent logistics platform has promoted the upgrading and innovation development of enterprises, better completed the development of the current intelligent logistics platform, minimized the cost and improved the transportation efficiency, and promoted the rapid development of fresh cold chain.
2019 34th IEEE/ACM International Conference on Automated Software Engineering (ASE), 2019
Smart pointers are widely used to prevent memory errors in modern C++ code. However, improper usa... more Smart pointers are widely used to prevent memory errors in modern C++ code. However, improper usage of smart pointers may also lead to common memory errors, which makes the code not as safe as expected. To avoid smart pointer errors as early as possible, we present a coding style checker to detect possible bad smart pointer usages during compile time, and notify programmers about bug-prone behaviors. The evaluation indicates that the currently available state-of-the-art static code checkers can only detect 25 out of 116 manually inserted errors, while our tool can detect all these errors. And we also found 521 bugs among 8 open source projects with only 4 false positives.
Delay discounting is the decline in the present value of a reward with delay to its receipt. (Maz... more Delay discounting is the decline in the present value of a reward with delay to its receipt. (Mazur,1987). The delay discounting task is used to measure delay discounting rate, which requires the participants to choose between two options: one involves immediate delivery of a reward, and other involves delivery after a delay, and the immediate rewards are adjusted in value until the subject feels there is no difference between the immediate and the delayed reward. Some previous studies (Robles and Vargas, 2007; 2008; Robles et al., 2009) found that the order of presentation of the immediate rewards (ascending or descending) significantly influenced the estimated delay discounting rate, which is known as the order effect. Uncertainty about the future and impulsivity could explain delay discounting behavior. The purpose of this study was to explore the order effect in delay discounting assessment. The current study found that the order effect in the delay discounting task can be explained by risk aversion, loss aversion and impulsivity. In the current study, the two kinds of fixed procedure (ascending and descending), and the titrating delay discounting task were used to estimate the degree of delay discounting. Also, two gambling tasks were applied to measure risk and loss aversion indices. The BIS-11 scale was used to assess the level of trait impulsivity. The results indicated that impulsivity biases individuals to choose the immediate small reward rather than the large delayed reward, resulting in lower area under the discounting curve (AUC) when estimated with the ascending-sequence delay discounting task. Also, impulsivity moderated the relationship between loss aversion and AUC estimated with the descending-sequence delay discounting task.
We propose the novel use of a generative adversarial network (GAN) (i) to make predictions in tim... more We propose the novel use of a generative adversarial network (GAN) (i) to make predictions in time (PredGAN) and (ii) to assimilate measurements (DA-PredGAN). In the latter case, we take advantage of the natural adjoint-like properties of generative models and the ability to simulate forwards and backwards in time. GANs have received much attention recently, after achieving excellent results for their generation of realistic-looking images. We wish to explore how this property translates to new applications in computational modelling and to exploit the adjoint-like properties for efficient data assimilation. To predict the spread of COVID-19 in an idealised town, we apply these methods to a compartmental model in epidemiology that is able to model space and time variations. To do this, the GAN is set within a reduced-order model (ROM), which uses a low-dimensional space for the spatial distribution of the simulation states. Then the GAN learns the evolution of the low-dimensional st...
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery, 2016
OBJECTIVE To investigate the impact of the weekday of surgery on the prognosis of patients with c... more OBJECTIVE To investigate the impact of the weekday of surgery on the prognosis of patients with colorectal cancer. METHODS A retrospective analysis was conducted in patients with colorectal cancer who underwent radical resection in Fudan University Shanghai Cancer Center(FUSCC) between January 2007 and December 2013, and 4 971 patients were identified eligible. Statistical analyses were carried out between patients who received surgery on Monday to Thursday and those who received surgery on Friday. Chi-square test was used to analyze the relationship between clinicopathological parameters and day of surgery. T test was used to compare continuous variables between groups. The 5-year overall survival (OS) and disease-free survival (DFS) were calculated by the Kaplan-Meier method, and compared by log-rank test. RESULTS There were no statistically significant differences between two groups in age, gender and pathological grade et al (all P>0.05). However, the number of dissected lymp...
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