International journal of clinical and experimental pathology, 2015
Hydrogen sulfide (H2S) has been reported to be interwined in multiple systems, specifically in th... more Hydrogen sulfide (H2S) has been reported to be interwined in multiple systems, specifically in the cardiovascular system. However, the mechanisms underlying remain controversial. In the present study, we assessed the cardio-protective effects of H2S in the rat hemorrhagic shock model. Hemorrhagic shock was induced in adult male Sprague-Dawley rats by drawing blood from the femoral artery to maintain the mean arterial pressure at 35-40 mmHg for 1.5 h. The rats were assigned to four groups and the H2S donor, NaHS (28 μmol/kg, i.p.), was injected before the resuscitation in certain groups. After resuscitation the animals were observed and then killed to harvest the hearts. The morphological investigation and ultrastructural analyses were done and apoptotic cells were detected. The levels of relevant proteins were examined using Western blotting and immunohistochemical analyses. Resuscitated hemorrhagic shock induced heart injury and significantly increased the levels of serum myocardia...
2012 International Symposium on Network Coding (NetCod), 2012
Functional dependence graph (FDG) is an important class of directed graph that captures the domin... more Functional dependence graph (FDG) is an important class of directed graph that captures the dominance relationship among a set of variables. FDG is frequently used in calculating network coding capacity bounds. However, the order of FDG is usually much larger than the original network and the computational complexity of many bounds grows exponentially with the order of FDG. In this paper, we introduce the concept of reduced FDG, which is obtained from the original FDG by keeping only those "essential" edges. It is proved that the reduced FDG gives the same capacity region/bounds with the original FDG, but requiring much less computation. The applications of reduced FDG in the algebraic formulation of scalar linear network coding is also discussed.
A series of JMJD2A inhibitors had been designed by analyzing the binding mode of 5-carboxy-8-hydr... more A series of JMJD2A inhibitors had been designed by analyzing the binding mode of 5-carboxy-8-hydroxyquinoline (5-carboxy-8-HQ) with JMJD2A. The inhibitory activity of the synthesized compounds against JMJD2A was determined, followed by docking simulations to understand the structure-activity relationships. Compounds with potent JMJD2A inhibitory activity demonstrated outstanding selectivity for JMJD2A over PHD2. Several potent compounds were selected to evaluate their anti-proliferative activity on tumor cell lines. Among them, compound 6p displayed the best anti-proliferative activity. Based on these in vitro biological data, seven compounds were chosen to determine their physicochemical properties. Compound 6p displayed good aqueous solubility and better permeability than 5-carboxy-8-HQ. Our data recognized that compound 6p could be considered as a starting point for development of new JmjC inhibitors.
Candida albicans is the leading cause of fungal infections; but it is also a member of the human ... more Candida albicans is the leading cause of fungal infections; but it is also a member of the human microbiome, an ecosystem of thousands of microbial species potentially influencing the outcome of host-fungal interactions. Accordingly, antibacterial therapy raises the risk of candidiasis, yet the underlying mechanism is currently not fully understood. We hypothesize the existence of bacterial-derived metabolites that normally control C. albicans growth and of fungal resistance mechanisms against these metabolites. Among the most abundant microbiota-derived metabolites found on human mucosal surfaces are weak organic acids (WOAs), such as acetic, propionic, butyric and lactic acid. Here we used quantitative growth assays to investigate the dose-dependent fungistatic property of WOAs on C. albicans growth and found it to occur at physiologically relevant concentrations and pH. This effect was conserved across distantly related fungal species both inside and outside the CTG clade. We nex...
The aim of the present study was to evaluate the incidences of margin involvement, disease relaps... more The aim of the present study was to evaluate the incidences of margin involvement, disease relapse, and complications in patients who had undergone conization using an electrosurgical knife (EKC) for cervical intraepithelial neoplasia (CIN) or microinvasive carcinomas (micro-CAs). A retrospective case series analysis was performed with a total of 1359 patients who underwent EKC in Fudan University Shanghai Cancer Center between June 2004 and July 2010. The median age of the patients was 39 years old (range: 19-72). Conization revealed the presence of CIN in 1113 (81.9%) patients, micro-CA in 72 (5.3%) patients and invasive carcinomas in 44 (3.2%) patients. The remaining 130 (9.6%) patients were free of diseases in the cone specimens. Positive surgical margins, or endocervical curettages (ECCs) were found in 90 (7.6%) patients with CINs or micro-CAs. Three factors were associated with positive margins and ECCs and included age (>50 years; odds ratio (OR), 3.0, P<0.01), postmenopausal status (OR, 3.1, P<0.01) and microinvasive disease (OR, 2.7, P<0.01). One thousand and eighty-nine (92.0%) patients were followed-up regularly for a median follow-up duration of 46 months (range: 24-106 months). Disease relapse was documented in 50 (4.6%) patients. Eighty-two (6.0%) cases experienced surgical complications that needed to be addressed, including early or late hemorrhages, infections, cervical stenosis, etc. Our patients demonstrated that EKC was an alternative technique for diagnosis and treatment of CIN or micro-CAs with relatively low rate of recurrence and acceptable rate of complications. A randomized clinical trial is warranted to compare EKC, CKC and LEEP in the management of CIN or micro-CA.
Explicit characterization of network coding capacity for multi-source multi-sink networks is an e... more Explicit characterization of network coding capacity for multi-source multi-sink networks is an extremely hard problem. The linear programming bound is an explicit outer bound on network coding capacity but it is computationally very intensive. An edge-cut bound called functional dependence bound is an easily computable relaxation of the linear programming bound. However, the functional dependence bound is still very loose, even for two source unicast networks. In this paper, we characterize a set of Shannon-type inequalities for a given network that leads to new weighted bounds providing strict improvement over the functional dependence bound.
We provide inner and outer bounds for the degrees of freedom (DoF) of the 3-user $M_T\times M_R$ ... more We provide inner and outer bounds for the degrees of freedom (DoF) of the 3-user $M_T\times M_R$ multiple-input multiple-output (MIMO) interference channel (IC) with \emph{rank-deficient} channel matrices, where each transmitter is equipped with $M_T$ antennas and each receiver with $M_R$ antennas, and the interfering channel matrices from each transmitter to the other two receivers are of ranks $D_1$ and $D_2$, respectively. The inner and outer bounds for the \emph{spatially-normalized} DoF are tight when $D_1+D_2\leq 2N-M$, where $N\triangleq \max(M_T, M_R)$ and $M\triangleq \min(M_T,M_R)$. A key step for both the inner and outer bounds is \emph{change of basis}, which explores the rank deficiency of the interfering channels to zero-force as many interfering links as possible by applying invertible linear transformations at both the transmitters and receivers. The outer bound is derived by combining the user-cooperation and the genie-aided signaling techniques, and achievability i...
Abstract A single injector with one ion source has been constructed, which is provided for resear... more Abstract A single injector with one ion source has been constructed, which is provided for researching the stability effect of the sloshing ion distribution in the magnetic mirror experiment facility (MM-2U) by oblique injection of neutral beam. The neutral beam ...
Proceedings of ICSSSM '05. 2005 International Conference on Services Systems and Services Management, 2005., 2005
... dominant conceptualization and measurement of service quality has been SERVQUAL instrument de... more ... dominant conceptualization and measurement of service quality has been SERVQUAL instrument developed by Parasuman et al. ... 1. The proposed integrative model. III. ... To measure service quality, therefore, some items of SERVQUAL are modified, added or even deleted when ...
International journal of clinical and experimental pathology, 2014
Carcinoma arising in microglandular adenosis (MGACA) is an extremely rare subtype of breast carci... more Carcinoma arising in microglandular adenosis (MGACA) is an extremely rare subtype of breast carcinoma. In this study, clinicopathological analysis of MGACA from 11 Chinese patients was conducted. Microscopically, all cases showed a spectrum of structure and glandular proliferations ranging from microglandular adenosis (MGA) to atypical MGA (AMGA) to MGACA. Carcinoma components were composed of high grade ductal carcinoma in situ (DCIS) in 1 case and invasive carcinoma in 10 cases. Invasive carcinomas were grade 3 in 10 tumors and grade 2 in 1. Invasive components in 5 of 10 cases were composed of invasive carcinoma of no special type (NST), and 1 case showed partially acinic cell differentiation. In 5 cases, invasive components were mixed of NST and matrix-producing carcinoma (MPC). All epitheliums in 11 cases were triple negative (ER-, PR-, HER2-), and diffuse positive for CK and S-100 protein. No myoepithelial cells were demonstrable from MGA to invasive components with immunohist...
Burns : journal of the International Society for Burn Injuries, Jan 13, 2015
The potential of acellular dermal matrix (ADM) to improve cosmetic and functional outcomes has be... more The potential of acellular dermal matrix (ADM) to improve cosmetic and functional outcomes has been demonstrated; however, there have been few clinical comparative studies assessing the long-term morphological, histological and functional changes after ADM placement. This study was designed to retrospectively evaluate the long-term outcomes of the cograft acellular dermal matrix with autologous thin split-thickness skin for the coverage of wounds in extensively burned patients. Thirty burn patients treated with a composite graft of ADM with autologous split-thickness skin from January 2007 to December 2009 were enrolled in this study. Another group of thirty patients who received only an autogenous split-thickness skin implant served as the control. Our study revealed that the collagen in the dermis treated with ADM were ordered, and the proportion of collagen III/I was much higher in the control group than in the ADM group. The basement membrane was prominent and continuous. Meanwh...
The most common cause of death from paraquat (PQ) poisoning is respiratory failure from pulmonary... more The most common cause of death from paraquat (PQ) poisoning is respiratory failure from pulmonary fibrosis, which develops through pathological overproduction of extracellular matrix proteins such as collagens. In this study, a MicroCT system was used to observe dynamic changes of pulmonary fibrosis in rats with PQ poisoning, and find the characteristics of interstitial lung diseases via density-based and texture-based analysis of CT images of the lung structure. A total of 15 male SD rats were randomly divided into a control group (n=5) and a PQ poisoning group (n=10). The rats in the poisoning group were intraperitoneally administered with 4 mg/ mL PQ at 14 mg/kg, and the rats in the control group were administered with the same volume of saline. The signs of pulmonary fibrosis observed by the MicroCT included ground-glass opacity, nodular pattern, subpleural interstitial thickening, consolidation honeycomb-like shadow of the lung. Compared with the control group, the rats with ac...
Zhonghua bing li xue za zhi Chinese journal of pathology, 2014
To investigate the clinicopathologic characteristics and differential diagnosis of the metastases... more To investigate the clinicopathologic characteristics and differential diagnosis of the metastases to the breast from non-mammary malignancies. Twenty-eight cases were collected from 2004 to 2012;microscopic pathologic examinations and immunohistochemistry (EnVision method) were performed. (1) All except one patients were female, ranging from 16 to 77 years old (average 45.8 years). Twenty-six (92.9%) patients initially presented with the primary site lesions; while the other two (7.1%) patients initially presented with breast lesions. The mean interval from primary diagnosis to detection of metastatic breast lesions was 32 months (0-228 months). Fifteen patients (53.6%) had other metastases detected simultaneously or preceded the breast lesions. (2) Macroscopically, all the tumors were relatively circumscribed, with a mean diameter of 4.0 cm (0.6-12.0 cm). The histological types of the corresponding primary tumors were as follows: eight (28.6%) cases from lung adenocarcinoma, five (...
2009 9th International Conference on Electronic Measurement & Instruments, 2009
Multi-level recursive method is an adaptive and data-driven fault prediction process. In terms of... more Multi-level recursive method is an adaptive and data-driven fault prediction process. In terms of input-output equivalence, a nonlinear model can be modified into a multi-level linearized model using the multi-level recursive method. The time-varying characteristics of model parameters are accounted for at the same time. Therefore, the proposed approach obtained satisfied results when utilized in prediction issues. The fault prediction for CSTR(Continuous Stirred Tank Reactor) system has been studied based on the integrated multi-level recursive forecasting method which considering the CSTR system's dynamic & time-variable characteristics. The optimal match of models and the algorithm of multi-level recursive method have been investigated through simulation. Through used in digital simulation experiments, the proposed method which is specific for CSTR system fault prediction has been validated and proved to be effective. This method can be used to predict the faults in such a class of nonlinear time-varying systems. Hence applying the proposed method in engineering and industry is proved to be feasible.
Others have demonstrated the presence of an autocrine prolactin (PRL) growth loop in the normal h... more Others have demonstrated the presence of an autocrine prolactin (PRL) growth loop in the normal human prostate. In this study we have used three human prostate cancer cell lines but have focused on the androgen-independent human prostate cancer cell line, DU145, to ask: (a) whether this autocrine growth loop is maintained beyond the loss of androgen sensitivity in the progression of prostate cancer; and (b) whether interruption of this growth loop by a PRL receptor antagonist, an S179D mutant PRL, could inhibit the formation of DU145-derived tumors. The autocrine loop was examined in most detail in the DU145 cell line but was demonstrated to be functional in all three of the lines by the reversible inhibition of growth in vitro by the S179D PRL receptor antagonist. To investigate the effect of S179D PRL on the growth of DU145 tumors in nude mice two sets of experiments were performed. In the first set, Alzet minipumps containing no PRL, wild-type (WT) PRL, or the S179D PRL (the last...
American journal of physiology. Endocrinology and metabolism, 2000
The purpose of the current study was to determine whether maternal prolactin (PRL) had any effect... more The purpose of the current study was to determine whether maternal prolactin (PRL) had any effects on bone formation in the developing rat pup. Because the most prevalent forms of PRL in rats are unmodified and phosphorylated PRL, both recombinant PRL and a molecular mimic of phosphorylated PRL (PP-PRL) were administered to pregnant animals. Blood samples from the dams showed normal estrogen and progesterone and no effect of extra PRL on parathyroid hormone (PTH), calcium, or alkaline phosphatase (AP). In newborn pups, however, there was a 30% decrease in blood AP in both PRL-treated groups, whereas PTH and calcium levels were not different from controls. When primary rat osteoblasts were exposed to both PRLs, AP activity was reduced, with PP-PRL being the more potent form of the hormone. Histological examination of pup bone formation showed reduced calvarial bone and reduced endochondral ossification in pups exposed to PP-PRL. These results are the first to show a direct inhibitory...
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000
Semaphorin 6A (Sema6A) (previously named Semaphorin VIa) is the originally described member of th... more Semaphorin 6A (Sema6A) (previously named Semaphorin VIa) is the originally described member of the vertebrate semaphorin class 6, a group of transmembrane semaphorins homologous to the insect semaphorin class 1. Although Sema-1a (previously named semaphorin I) has been implicated in axon guidance in insects, the function of Sema6A is currently unknown. We have expressed the extracellular domain of Sema6A in mammalian cells as either a monomeric or a dimeric fusion protein and tested for potential axon guidance effects on two populations of embryonic neurons in growth cone collapse and collagen matrix chemorepulsion assays. Sema6A was observed to induce growth cone collapse of sympathetic neurons with an EC50 of approximately 200 pM, although a 10-fold higher (EC50 of approximately 2 nM) concentration was necessary to induce growth cone collapse of dorsal root ganglion neurons. The activity of Sema6A is likely to depend on protein dimerization or oligomerization. Although Sema6A mRNA...
Domain structures in ferroelastic neodymium pentaphosphate NdP5O14 of small a and b dimensions ha... more Domain structures in ferroelastic neodymium pentaphosphate NdP5O14 of small a and b dimensions have been observed to be nearly periodic domain arrays of quasi-one-dimension sandwiched by parallel domain walls along the (001) lattice plane. Based on a continuous order-parameter profile along the wall normal, a positive temperature-dependent wall energy was obtained from Landau's theory of second-order phase transitions. Then a one-dimensional spin system, with the spins corresponding to the shear strains of the two orientation states of NdP5O14, has been developed to describe statistically the effect of thermal energy exciting the fluctuation of the wall number. The theoretical deductions were well consistent with the actual drastic increase of walls on approaching the phase transition temperature and the dynamical behavior of the domains in external stress fields.
White-beam synchrotron-radiation topography is applied to an investigation of the second-order fe... more White-beam synchrotron-radiation topography is applied to an investigation of the second-order ferroelastic-paraelastic phase transition in NdP5O14 single crystals. The displacements of images of adjacent domains in the 200 reflection topographs and their variation during the transition are directly observed with a television recording system. The spontaneous deformation, a monoclinic shear strain e5, is calculated from the image displacements at different temperatures. The temperature dependence of e5 and the evolution of domains are well consistent with the Landau theory of second-order phase transitions. The transition process is also observed under a polarizing microscope.
2010 4th International Conference on Bioinformatics and Biomedical Engineering, 2010
In this paper, a new stochastic model based on cellular automata is established to simulate the o... more In this paper, a new stochastic model based on cellular automata is established to simulate the occurrence and development of Schistosoma japonicum (S. japonicum) infection in an endemic population. We included the process of the pathogen invasion from exposure to worm development and till worm death when the infection is cleared in the model. We further utilized the model to
International journal of clinical and experimental pathology, 2015
Hydrogen sulfide (H2S) has been reported to be interwined in multiple systems, specifically in th... more Hydrogen sulfide (H2S) has been reported to be interwined in multiple systems, specifically in the cardiovascular system. However, the mechanisms underlying remain controversial. In the present study, we assessed the cardio-protective effects of H2S in the rat hemorrhagic shock model. Hemorrhagic shock was induced in adult male Sprague-Dawley rats by drawing blood from the femoral artery to maintain the mean arterial pressure at 35-40 mmHg for 1.5 h. The rats were assigned to four groups and the H2S donor, NaHS (28 μmol/kg, i.p.), was injected before the resuscitation in certain groups. After resuscitation the animals were observed and then killed to harvest the hearts. The morphological investigation and ultrastructural analyses were done and apoptotic cells were detected. The levels of relevant proteins were examined using Western blotting and immunohistochemical analyses. Resuscitated hemorrhagic shock induced heart injury and significantly increased the levels of serum myocardia...
2012 International Symposium on Network Coding (NetCod), 2012
Functional dependence graph (FDG) is an important class of directed graph that captures the domin... more Functional dependence graph (FDG) is an important class of directed graph that captures the dominance relationship among a set of variables. FDG is frequently used in calculating network coding capacity bounds. However, the order of FDG is usually much larger than the original network and the computational complexity of many bounds grows exponentially with the order of FDG. In this paper, we introduce the concept of reduced FDG, which is obtained from the original FDG by keeping only those "essential" edges. It is proved that the reduced FDG gives the same capacity region/bounds with the original FDG, but requiring much less computation. The applications of reduced FDG in the algebraic formulation of scalar linear network coding is also discussed.
A series of JMJD2A inhibitors had been designed by analyzing the binding mode of 5-carboxy-8-hydr... more A series of JMJD2A inhibitors had been designed by analyzing the binding mode of 5-carboxy-8-hydroxyquinoline (5-carboxy-8-HQ) with JMJD2A. The inhibitory activity of the synthesized compounds against JMJD2A was determined, followed by docking simulations to understand the structure-activity relationships. Compounds with potent JMJD2A inhibitory activity demonstrated outstanding selectivity for JMJD2A over PHD2. Several potent compounds were selected to evaluate their anti-proliferative activity on tumor cell lines. Among them, compound 6p displayed the best anti-proliferative activity. Based on these in vitro biological data, seven compounds were chosen to determine their physicochemical properties. Compound 6p displayed good aqueous solubility and better permeability than 5-carboxy-8-HQ. Our data recognized that compound 6p could be considered as a starting point for development of new JmjC inhibitors.
Candida albicans is the leading cause of fungal infections; but it is also a member of the human ... more Candida albicans is the leading cause of fungal infections; but it is also a member of the human microbiome, an ecosystem of thousands of microbial species potentially influencing the outcome of host-fungal interactions. Accordingly, antibacterial therapy raises the risk of candidiasis, yet the underlying mechanism is currently not fully understood. We hypothesize the existence of bacterial-derived metabolites that normally control C. albicans growth and of fungal resistance mechanisms against these metabolites. Among the most abundant microbiota-derived metabolites found on human mucosal surfaces are weak organic acids (WOAs), such as acetic, propionic, butyric and lactic acid. Here we used quantitative growth assays to investigate the dose-dependent fungistatic property of WOAs on C. albicans growth and found it to occur at physiologically relevant concentrations and pH. This effect was conserved across distantly related fungal species both inside and outside the CTG clade. We nex...
The aim of the present study was to evaluate the incidences of margin involvement, disease relaps... more The aim of the present study was to evaluate the incidences of margin involvement, disease relapse, and complications in patients who had undergone conization using an electrosurgical knife (EKC) for cervical intraepithelial neoplasia (CIN) or microinvasive carcinomas (micro-CAs). A retrospective case series analysis was performed with a total of 1359 patients who underwent EKC in Fudan University Shanghai Cancer Center between June 2004 and July 2010. The median age of the patients was 39 years old (range: 19-72). Conization revealed the presence of CIN in 1113 (81.9%) patients, micro-CA in 72 (5.3%) patients and invasive carcinomas in 44 (3.2%) patients. The remaining 130 (9.6%) patients were free of diseases in the cone specimens. Positive surgical margins, or endocervical curettages (ECCs) were found in 90 (7.6%) patients with CINs or micro-CAs. Three factors were associated with positive margins and ECCs and included age (>50 years; odds ratio (OR), 3.0, P<0.01), postmenopausal status (OR, 3.1, P<0.01) and microinvasive disease (OR, 2.7, P<0.01). One thousand and eighty-nine (92.0%) patients were followed-up regularly for a median follow-up duration of 46 months (range: 24-106 months). Disease relapse was documented in 50 (4.6%) patients. Eighty-two (6.0%) cases experienced surgical complications that needed to be addressed, including early or late hemorrhages, infections, cervical stenosis, etc. Our patients demonstrated that EKC was an alternative technique for diagnosis and treatment of CIN or micro-CAs with relatively low rate of recurrence and acceptable rate of complications. A randomized clinical trial is warranted to compare EKC, CKC and LEEP in the management of CIN or micro-CA.
Explicit characterization of network coding capacity for multi-source multi-sink networks is an e... more Explicit characterization of network coding capacity for multi-source multi-sink networks is an extremely hard problem. The linear programming bound is an explicit outer bound on network coding capacity but it is computationally very intensive. An edge-cut bound called functional dependence bound is an easily computable relaxation of the linear programming bound. However, the functional dependence bound is still very loose, even for two source unicast networks. In this paper, we characterize a set of Shannon-type inequalities for a given network that leads to new weighted bounds providing strict improvement over the functional dependence bound.
We provide inner and outer bounds for the degrees of freedom (DoF) of the 3-user $M_T\times M_R$ ... more We provide inner and outer bounds for the degrees of freedom (DoF) of the 3-user $M_T\times M_R$ multiple-input multiple-output (MIMO) interference channel (IC) with \emph{rank-deficient} channel matrices, where each transmitter is equipped with $M_T$ antennas and each receiver with $M_R$ antennas, and the interfering channel matrices from each transmitter to the other two receivers are of ranks $D_1$ and $D_2$, respectively. The inner and outer bounds for the \emph{spatially-normalized} DoF are tight when $D_1+D_2\leq 2N-M$, where $N\triangleq \max(M_T, M_R)$ and $M\triangleq \min(M_T,M_R)$. A key step for both the inner and outer bounds is \emph{change of basis}, which explores the rank deficiency of the interfering channels to zero-force as many interfering links as possible by applying invertible linear transformations at both the transmitters and receivers. The outer bound is derived by combining the user-cooperation and the genie-aided signaling techniques, and achievability i...
Abstract A single injector with one ion source has been constructed, which is provided for resear... more Abstract A single injector with one ion source has been constructed, which is provided for researching the stability effect of the sloshing ion distribution in the magnetic mirror experiment facility (MM-2U) by oblique injection of neutral beam. The neutral beam ...
Proceedings of ICSSSM '05. 2005 International Conference on Services Systems and Services Management, 2005., 2005
... dominant conceptualization and measurement of service quality has been SERVQUAL instrument de... more ... dominant conceptualization and measurement of service quality has been SERVQUAL instrument developed by Parasuman et al. ... 1. The proposed integrative model. III. ... To measure service quality, therefore, some items of SERVQUAL are modified, added or even deleted when ...
International journal of clinical and experimental pathology, 2014
Carcinoma arising in microglandular adenosis (MGACA) is an extremely rare subtype of breast carci... more Carcinoma arising in microglandular adenosis (MGACA) is an extremely rare subtype of breast carcinoma. In this study, clinicopathological analysis of MGACA from 11 Chinese patients was conducted. Microscopically, all cases showed a spectrum of structure and glandular proliferations ranging from microglandular adenosis (MGA) to atypical MGA (AMGA) to MGACA. Carcinoma components were composed of high grade ductal carcinoma in situ (DCIS) in 1 case and invasive carcinoma in 10 cases. Invasive carcinomas were grade 3 in 10 tumors and grade 2 in 1. Invasive components in 5 of 10 cases were composed of invasive carcinoma of no special type (NST), and 1 case showed partially acinic cell differentiation. In 5 cases, invasive components were mixed of NST and matrix-producing carcinoma (MPC). All epitheliums in 11 cases were triple negative (ER-, PR-, HER2-), and diffuse positive for CK and S-100 protein. No myoepithelial cells were demonstrable from MGA to invasive components with immunohist...
Burns : journal of the International Society for Burn Injuries, Jan 13, 2015
The potential of acellular dermal matrix (ADM) to improve cosmetic and functional outcomes has be... more The potential of acellular dermal matrix (ADM) to improve cosmetic and functional outcomes has been demonstrated; however, there have been few clinical comparative studies assessing the long-term morphological, histological and functional changes after ADM placement. This study was designed to retrospectively evaluate the long-term outcomes of the cograft acellular dermal matrix with autologous thin split-thickness skin for the coverage of wounds in extensively burned patients. Thirty burn patients treated with a composite graft of ADM with autologous split-thickness skin from January 2007 to December 2009 were enrolled in this study. Another group of thirty patients who received only an autogenous split-thickness skin implant served as the control. Our study revealed that the collagen in the dermis treated with ADM were ordered, and the proportion of collagen III/I was much higher in the control group than in the ADM group. The basement membrane was prominent and continuous. Meanwh...
The most common cause of death from paraquat (PQ) poisoning is respiratory failure from pulmonary... more The most common cause of death from paraquat (PQ) poisoning is respiratory failure from pulmonary fibrosis, which develops through pathological overproduction of extracellular matrix proteins such as collagens. In this study, a MicroCT system was used to observe dynamic changes of pulmonary fibrosis in rats with PQ poisoning, and find the characteristics of interstitial lung diseases via density-based and texture-based analysis of CT images of the lung structure. A total of 15 male SD rats were randomly divided into a control group (n=5) and a PQ poisoning group (n=10). The rats in the poisoning group were intraperitoneally administered with 4 mg/ mL PQ at 14 mg/kg, and the rats in the control group were administered with the same volume of saline. The signs of pulmonary fibrosis observed by the MicroCT included ground-glass opacity, nodular pattern, subpleural interstitial thickening, consolidation honeycomb-like shadow of the lung. Compared with the control group, the rats with ac...
Zhonghua bing li xue za zhi Chinese journal of pathology, 2014
To investigate the clinicopathologic characteristics and differential diagnosis of the metastases... more To investigate the clinicopathologic characteristics and differential diagnosis of the metastases to the breast from non-mammary malignancies. Twenty-eight cases were collected from 2004 to 2012;microscopic pathologic examinations and immunohistochemistry (EnVision method) were performed. (1) All except one patients were female, ranging from 16 to 77 years old (average 45.8 years). Twenty-six (92.9%) patients initially presented with the primary site lesions; while the other two (7.1%) patients initially presented with breast lesions. The mean interval from primary diagnosis to detection of metastatic breast lesions was 32 months (0-228 months). Fifteen patients (53.6%) had other metastases detected simultaneously or preceded the breast lesions. (2) Macroscopically, all the tumors were relatively circumscribed, with a mean diameter of 4.0 cm (0.6-12.0 cm). The histological types of the corresponding primary tumors were as follows: eight (28.6%) cases from lung adenocarcinoma, five (...
2009 9th International Conference on Electronic Measurement & Instruments, 2009
Multi-level recursive method is an adaptive and data-driven fault prediction process. In terms of... more Multi-level recursive method is an adaptive and data-driven fault prediction process. In terms of input-output equivalence, a nonlinear model can be modified into a multi-level linearized model using the multi-level recursive method. The time-varying characteristics of model parameters are accounted for at the same time. Therefore, the proposed approach obtained satisfied results when utilized in prediction issues. The fault prediction for CSTR(Continuous Stirred Tank Reactor) system has been studied based on the integrated multi-level recursive forecasting method which considering the CSTR system's dynamic & time-variable characteristics. The optimal match of models and the algorithm of multi-level recursive method have been investigated through simulation. Through used in digital simulation experiments, the proposed method which is specific for CSTR system fault prediction has been validated and proved to be effective. This method can be used to predict the faults in such a class of nonlinear time-varying systems. Hence applying the proposed method in engineering and industry is proved to be feasible.
Others have demonstrated the presence of an autocrine prolactin (PRL) growth loop in the normal h... more Others have demonstrated the presence of an autocrine prolactin (PRL) growth loop in the normal human prostate. In this study we have used three human prostate cancer cell lines but have focused on the androgen-independent human prostate cancer cell line, DU145, to ask: (a) whether this autocrine growth loop is maintained beyond the loss of androgen sensitivity in the progression of prostate cancer; and (b) whether interruption of this growth loop by a PRL receptor antagonist, an S179D mutant PRL, could inhibit the formation of DU145-derived tumors. The autocrine loop was examined in most detail in the DU145 cell line but was demonstrated to be functional in all three of the lines by the reversible inhibition of growth in vitro by the S179D PRL receptor antagonist. To investigate the effect of S179D PRL on the growth of DU145 tumors in nude mice two sets of experiments were performed. In the first set, Alzet minipumps containing no PRL, wild-type (WT) PRL, or the S179D PRL (the last...
American journal of physiology. Endocrinology and metabolism, 2000
The purpose of the current study was to determine whether maternal prolactin (PRL) had any effect... more The purpose of the current study was to determine whether maternal prolactin (PRL) had any effects on bone formation in the developing rat pup. Because the most prevalent forms of PRL in rats are unmodified and phosphorylated PRL, both recombinant PRL and a molecular mimic of phosphorylated PRL (PP-PRL) were administered to pregnant animals. Blood samples from the dams showed normal estrogen and progesterone and no effect of extra PRL on parathyroid hormone (PTH), calcium, or alkaline phosphatase (AP). In newborn pups, however, there was a 30% decrease in blood AP in both PRL-treated groups, whereas PTH and calcium levels were not different from controls. When primary rat osteoblasts were exposed to both PRLs, AP activity was reduced, with PP-PRL being the more potent form of the hormone. Histological examination of pup bone formation showed reduced calvarial bone and reduced endochondral ossification in pups exposed to PP-PRL. These results are the first to show a direct inhibitory...
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000
Semaphorin 6A (Sema6A) (previously named Semaphorin VIa) is the originally described member of th... more Semaphorin 6A (Sema6A) (previously named Semaphorin VIa) is the originally described member of the vertebrate semaphorin class 6, a group of transmembrane semaphorins homologous to the insect semaphorin class 1. Although Sema-1a (previously named semaphorin I) has been implicated in axon guidance in insects, the function of Sema6A is currently unknown. We have expressed the extracellular domain of Sema6A in mammalian cells as either a monomeric or a dimeric fusion protein and tested for potential axon guidance effects on two populations of embryonic neurons in growth cone collapse and collagen matrix chemorepulsion assays. Sema6A was observed to induce growth cone collapse of sympathetic neurons with an EC50 of approximately 200 pM, although a 10-fold higher (EC50 of approximately 2 nM) concentration was necessary to induce growth cone collapse of dorsal root ganglion neurons. The activity of Sema6A is likely to depend on protein dimerization or oligomerization. Although Sema6A mRNA...
Domain structures in ferroelastic neodymium pentaphosphate NdP5O14 of small a and b dimensions ha... more Domain structures in ferroelastic neodymium pentaphosphate NdP5O14 of small a and b dimensions have been observed to be nearly periodic domain arrays of quasi-one-dimension sandwiched by parallel domain walls along the (001) lattice plane. Based on a continuous order-parameter profile along the wall normal, a positive temperature-dependent wall energy was obtained from Landau's theory of second-order phase transitions. Then a one-dimensional spin system, with the spins corresponding to the shear strains of the two orientation states of NdP5O14, has been developed to describe statistically the effect of thermal energy exciting the fluctuation of the wall number. The theoretical deductions were well consistent with the actual drastic increase of walls on approaching the phase transition temperature and the dynamical behavior of the domains in external stress fields.
White-beam synchrotron-radiation topography is applied to an investigation of the second-order fe... more White-beam synchrotron-radiation topography is applied to an investigation of the second-order ferroelastic-paraelastic phase transition in NdP5O14 single crystals. The displacements of images of adjacent domains in the 200 reflection topographs and their variation during the transition are directly observed with a television recording system. The spontaneous deformation, a monoclinic shear strain e5, is calculated from the image displacements at different temperatures. The temperature dependence of e5 and the evolution of domains are well consistent with the Landau theory of second-order phase transitions. The transition process is also observed under a polarizing microscope.
2010 4th International Conference on Bioinformatics and Biomedical Engineering, 2010
In this paper, a new stochastic model based on cellular automata is established to simulate the o... more In this paper, a new stochastic model based on cellular automata is established to simulate the occurrence and development of Schistosoma japonicum (S. japonicum) infection in an endemic population. We included the process of the pathogen invasion from exposure to worm development and till worm death when the infection is cleared in the model. We further utilized the model to
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Papers by Xiaoli Xu