Papers by Vygantas Gruslys
The search for biological markers, which allow a relatively accurate assessment of the individual... more The search for biological markers, which allow a relatively accurate assessment of the individual course of pulmonary sarcoidosis at the time of diagnosis remains one of the research priorities in this field of pulmonary medicine. The aim of our study was to investigate possible prognostic factors for pulmonary sarcoidosis with a special focus on cellular immune inflammation markers. 2 years follow-up of the study population after initial prospective and simultaneous analysis of lymphocyte activation markers expression in the blood, as well as bronchoalveolar lavage fluid (BALF), and lung biopsy tissue of patients with newly diagnosed pulmonary sarcoidosis, was done. We found that some blood and BAL fluid immunological markers and lung computed tomography (CT) patterns have been associated with a different course of sarcoidosis. We revealed five markers that had a significant negative association with the course of sarcoidosis (worsening pulmonary function tests and/or the chest CT ...
Vilnius : Vaistų žinios, 2020
Pneumologia
Cryptogenic organising pneumonia (COP) is a rare interstitial lung disease with different onset o... more Cryptogenic organising pneumonia (COP) is a rare interstitial lung disease with different onset of symptoms, which responds rapidly to glucocorticoid treatment. We present a case of COP which manifested as progressive 3-year dyspnoea that has led ultimately to acute respiratory failure. Moreover, treatment with prednisone for this patient exhibits slow onset of the effect.
The treatment of esophageal perforation is difficult and controversial because of small amount of... more The treatment of esophageal perforation is difficult and controversial because of small amount of cases. Usually patients condition is bad and proper diagnosis is delayed. We present our experience with 29 year old male, who was operated 14 days after spontaneous esophageal perforation, case
Lietuvos chirurgija, 2007
Saulius Cicėnas, Pranas Naujokaitis, Dainius Piščikas, Arnoldas Krasauskas, Renatas AškinisVilnia... more Saulius Cicėnas, Pranas Naujokaitis, Dainius Piščikas, Arnoldas Krasauskas, Renatas AškinisVilniaus universiteto Onkologijos instituto Krūtinės chirurgijos ir onkologijos skyrius,Santariškių g. 1, LT-08660 VilniusEl paštas: [email protected] Tikslas Išanalizuoti ir įvertinti piktybinės pleuros mezoteliomos diagnostikos ir chirurginio gydymo metodus, pateikti operuotų ligonių gydymo rezultatus. Ligoniai ir metodai Vilniaus universiteto Onkologijos instituto Krūtinės chirurgijos ir onkologijos skyriuje 1992–2005 m. buvo gydomi 138 ligoniai, kuriems morfologiškai patvirtinta piktybinės pleuros mezoteliomos (PPM) diagnozė: 113 (81,9%) ligonių buvo operuoti, 25 (18,1%) ligoniams atliktas konservatyvusis gydymas (radioterapija ir chemoterapija). Prieš operaciją buvo taikomi neinvaziniai PPM tyrimo metodai: rentgeninis tyrimas – 138 (100%) ligoniams, krūtinės ląstos KT – 62 (44,9%), krūtinės rentgeninis tyrimas ir KT – 56 (40,5%), krūtinės ląstos KT ir BMR – 10 (7,2%) ir krūtinės ultragarsini...
Geriatrics
Introduction: Bronchoscopic lung biopsy (BLB) is a widely used procedure. As the world’s populati... more Introduction: Bronchoscopic lung biopsy (BLB) is a widely used procedure. As the world’s population is ageing, more BLBs are performed for older people with comorbidities. The aim of the study was to investigate if an older age is a risk factor for BLB related complications. Materials and Methods: A prospective study at the Centre of Pulmonology and Allergology of Vilnius University Hospital Santaros klinikos was conducted. Seven hundred and eighty-six patients (male 60.6%), mean age 57 ± 16, who underwent BLB, were included. The complications that occurred due to BLB were evaluated. Bleeding and pneumothorax were classified into I° or II° grades depending on their severity. Potential determinants, which may increase the risk of complications, emphasizing on age, were analyzed. Results: Fifty-seven (7.2%) BLB-related complications occurred. There were 27 (3.4%) pneumothoraxes, and 19 (70%) of them required thoracic drainage. Thirty (3.8%) bleeding complications occurred, and four (1...
Interventional pulmonology, 2020
Vytautas Jovaiðas, Vygantas Gruslys, Þygimantas Jagelavièius, Gintautas Kiðkis, Rièardas Janilion... more Vytautas Jovaiðas, Vygantas Gruslys, Þygimantas Jagelavièius, Gintautas Kiðkis, Rièardas Janilionis Vilniaus universiteto ligoninës Santariðkiø klinikø Centro filialo Krûtinës chirurgijos centras, Þygimantø g. 3, Vilnius El. paðtas: [email protected] Vilnius University Hospital „Santariðkiø klinikos“ General Thoracic Surgery Centre, Þygimantø str. 3, Vilnius, Lithuania E-mail: [email protected]
1 Vilniaus universiteto Medicinos fakultetas, M. K. Čiurlionio g. 21, LT-03101 Vilnius, Lietuva 2... more 1 Vilniaus universiteto Medicinos fakultetas, M. K. Čiurlionio g. 21, LT-03101 Vilnius, Lietuva 2 Vilniaus universiteto Medicinos fakulteto Infekcinių, krūtinės ligų, dermatovenerologijos ir alergologijos klinika, Krūtinės chirurgijos centras, Santariškių g. 2, Vilnius, Lietuva 3 Vilniaus universiteto ligoninės Santariškių klinikos, Krūtinės chirurgijos skyrius, Santariškių g. 2, Vilnius, Lietuva El. paštas: [email protected]
In Vivo, 2021
Background/Aim: The objectives of this study were to evaluate systemic inflammation using differe... more Background/Aim: The objectives of this study were to evaluate systemic inflammation using different sclerosing agents and to estimate the prediction of systemic inflammation for the efficacy of pleurodesis. Patients and Methods: Ninety-six patients with recurrent and symptomatic malignant pleural effusion were enrolled in this retrospective study. We used serum C-reactive protein (CRP) levels, serum leukocyte counts and neutrophil-to-lymphocyte ratios (NLRs) as parameters of systemic inflammatory reactions. Evaluations of these parameters were performed before and 24 h after pleurodesis. Results: Pleurodesis was successful in 81 (84.4%) patients. The non-graded talc induced the highest changes in serum CRP levels, total white blood cell and neutrophil counts compared to other agents, while mitoxantrone induced the lowest. Graded talc and bleomycin induced the same levels of changes in serum CRP levels and serum leukocyte counts. The change in serum NLR was the same for all agent gro...
Journal of thoracic disease, 2021
Background The mechanisms driving the transition from inflammation to fibrosis in sarcoidosis pat... more Background The mechanisms driving the transition from inflammation to fibrosis in sarcoidosis patients are poorly understood; prognostic features are lacking. Immune cell profiling may provide insights into pathogenesis and prognostic factors of the disease. This study aimed to establish associations in simultaneous of lymphocyte subset profiles in the blood, bronchoalveolar lavage fluid (BALF), and lung biopsy tissue in the patients with newly diagnosed sarcoidosis. Methods A total of 71 sarcoid patients (SPs) and 20 healthy controls (HCs) were enrolled into the study. CD31, CD38, CD44, CD103 positive T lymphocytes in blood and BALF were analysed. Additionally, the densities of CD4, CD8, CD38, CD44, CD103 positive cells in lung tissue biopsies were estimated by digital image analysis. Results Main findings: (I) increase of percentage of CD3+CD4+CD38+ in BALF and blood, and increase of percentage of CD3+CD4+CD44+ in BALF in Löfgren syndrome patients comparing with patients without L...
Background: Penetrating cardiac injuries are a dramatic and lethal form of trauma. They are usual... more Background: Penetrating cardiac injuries are a dramatic and lethal form of trauma. They are usually sustained by young people. The majority of victims die before reaching the hospital. Aim of the study: The aim of the study was to establish prognostic criteria for the outcome of penetrating cardiac injury. Material and methods: We retrospectively reviewed the records of 186 patients with penetrating cardiac injuries who were operated on during the first 24 hours after admission. Results: The mean age was 33 (interquartile range (IQR): 26-44) years. 88.7% of victims were male. The mean time from the moment of trauma to arrival at the hospital in Vilnius city was 60 minutes (IQR: 50-91), whereas from the Vilnius region it was 240 (IQR: 82-390) minutes. The vast majority of patients (176/186, 94.6%) sustained stab wounds. Hemopericardium or cardiac tamponade (142/186, 76.3%) usually was found at the operation. Right ventricle was the most often injured heart chamber (75/186, 40.3%). As...
Medicina, 2002
UNLABELLED The purpose of this study was to analyze results of pneumatic dilatation due to esopha... more UNLABELLED The purpose of this study was to analyze results of pneumatic dilatation due to esophageal achalasia at the Clinic of General Thoracic Surgery of Vilnius University. MATERIAL AND METHODS During 25-year period (1973-1998) we have treated 133 achalasia patients. On 125 patients pneumatic dilatation was performed. One hundred five (84%) patients recovered fully. Single course of pneumatic dilatations was sufficient. Recurrence rate was 16% - 3 courses of pneumatic dilatations were performed on 2 (1.6%), 2 - on 18 (14.4%) patients. Complications. The major complication of pneumatic dilatation is esophageal perforation. Most series report its incidence at about 2%. In our study 2 cases (1.6%) of esophageal perforation occurred. Both patients were operated immediately. One (0.8%) died because of purulent complications. CONCLUSION Pneumatic dilatation is safe and effective method of treatment. In our opinion, it would be the best initial approach. If it failed, then myotomy woul...
Medicina, 2021
Background and objective: According to the World Health Organization (WHO), more than 100 million... more Background and objective: According to the World Health Organization (WHO), more than 100 million people have already recovered from SARS-CoV-2 infection. Therefore, it is imperative to understand the possible outcomes of COVID-19. The aim of our study was to evaluate pulmonary function, exercise capacity, residual radiological changes, and health-related quality of life (HRQoL) at follow-up in a cohort of SARS-CoV-2 pneumonia survivors. Materials and Methods: Patients with SARS-CoV-2 infection and radiologically confirmed lung injury, with no chronic lung disease prior to this infection, were included in the study. Patients’ evaluation 2 months after their discharge from hospital included spirometry (FVC, FEV1, FEV1/FVC), determination of lung volume (TLC, VC, RV) and diffusing capacity of lung for carbon monoxide (DLCO, adjusted for hemoglobin), 6-Minute Walk Test (6MWT), chest CT scan, and 36-Item Short Form General Health Survey (SF-36). Results: Fifty-one patients (25 men, 26 w...
Pulmonology, 2021
The World Health Organization (WHO) recommends countries introduce new anti-TB drugs in the treat... more The World Health Organization (WHO) recommends countries introduce new anti-TB drugs in the treatment of multidrug-resistant tuberculosis. The aim of the study is to prospectively evaluate the effectiveness of bedaquiline (and/or delamanid)-containing regimens in a large cohort of consecutive TB patients treated globally. This observational, prospective study is based on data collected and provided by Global Tuberculosis Network (GTN) centres and analysed twice a year. All consecutive patients (including children/adolescents) treated with bedaquiline and/or delamanid were enrolled, and managed according to WHO and national guidelines. Overall, 52 centres from 29 countries/regions in all continents reported 883 patients as of January 31st 2021, 24/29 countries/regions providing data on 100% of their consecutive patients (10-80% in the remaining 5 countries). The drug-resistance pattern of the patients was severe (>30% with extensively drug-resistant-TB; median number of resistant drugs 5 (3−7) in the overall cohort and 6 (4−8) among patients with a final outcome). For the patients with a final outcome (477/883, 54.0%) the median (IQR) number of months of anti-TB treatment was 18 (13−23) (in days 553 (385-678)). The proportion of patients achieving sputum smear and culture conversion ranged from 93.4% and 92.8% respectively (whole cohort) to 89.3% and 88.8% respectively (patients with a final outcome), a median (IQR) time to sputum smear and culture conversion of 58 (30−90) days for the whole cohort and 60 (30−100) for patients with a final outcome and, respectively, of 55 (30−90) and 60 (30−90) days for culture conversion. Of 383 patients treated with bedaquiline but not delamanid, 284 (74.2%) achieved treatment success, while 25 (6.5%) died, 11 (2.9%) failed and 63 (16.5%) were lost to follow-up.
Lietuvos chirurgija, 2007
Vygantas Gruslys, Ričardas Janilionis, Arūnas ŽilinskasVilniaus universiteto ligoninės Santariški... more Vygantas Gruslys, Ričardas Janilionis, Arūnas ŽilinskasVilniaus universiteto ligoninės Santariškių klinikų Centro filialas, Krūtinės chirurgijos centras,VšĮ VUL SK Centro filialas, Žygimantų g. 3, VilniusEl paštas: [email protected] Tikslas – pasitelkiant du panašius klinikinius atvejus pagrįsti mintį, kad gydant pooperacinę ezofagopleurinę fistulę, greitai ir radikaliai jos pašalinti dažniausiai negalima; būtina nuosekliai siekti rezultato, o gydymo taktika kiekvienu konkrečiu atveju turi būti individuali.Stemplės stentavimo ištakos – XIX amžiaus pabaiga. Per praėjusį šimtmetį stemplės stentai buvo gerokai ištobulinti. Tačiau vis dar tebesama eksperimentinės stadijos. Esant neoperabiliai navikinės kilmės stemplės stenozei ar stemplės ir kvėpavimo takų jungčiai, stemplės arba mišrus – stemplės ir trachėjos (broncho) – stentavimas tapo pirmojo pasirinkimo gydymo būdu. Santūraus optimizmo teikia ir pirmieji silikoninių solidinių (ne savaime išsiskleidžiančių) stentų naudojimo, esa...
Lietuvos chirurgija, 2007
Arūnas Žilinskas, Vygantas Gruslys, Vytautas Jovaišas, Ričardas JanilionisVilniaus universiteto l... more Arūnas Žilinskas, Vygantas Gruslys, Vytautas Jovaišas, Ričardas JanilionisVilniaus universiteto ligoninės Santariškių klinikų Centro filialas, Krūtinės chirurgijos centras,Žygimantų g. 3, VilniusEl paštas: [email protected] Stemplės perforacijos gydymas yra sudėtingas ir diskusinis, nes tokių ligonių yra mažai, jų būklė dažniausiai būna sunki, liga vėlai diagnozuota. Šiame darbe pabandėme panagrinėti 29 metų vyro, operuoto praėjus 14 dienų po savaiminio stemplės plyšimo, ligos eigą. Pagrindiniai žodžiai: stemplės perforacija Spontaneous esophageal perforation: case report Arūnas Žilinskas, Vygantas Gruslys, Vytautas Jovaišas, Ričardas JanilionisVilnius University Hospital, Department of General Thoracic Surgery,Žygimantų str. 3, Vilnius, LithuaniaE-mail: [email protected] The treatment of esophageal perforation is difficult and controversial because of small amount of cases. Usually patients condition is bad and proper diagnosis is delayed. We present our experience with 29 ...
Lietuvos chirurgija, 2010
Žymantas Jagelavičius, Vytautas Jovaišas, Arūnas Žilinskas, Algis Kybartas, Gintaras Kiškis, Vyga... more Žymantas Jagelavičius, Vytautas Jovaišas, Arūnas Žilinskas, Algis Kybartas, Gintaras Kiškis, Vygantas Gruslys, Irena Liubertienė, Ričardas JanilionisVilniaus universiteto Krūtinės ligų, alergologijos ir radiologijos klinika, Krūtinės chirurgijos centras; Vilniaus universiteto ligoninės „Santariškių klinikų“ centro filialas, Krūtinės chirurgijos skyrius,Žygimantų g. 3, LT-01102 VilniusEl paštas: [email protected] Įvadas / tikslasŠirdies sužalojimai yra viena letališkiausių traumų, ją patiria jaunesnio amžiaus žmonės. Dauguma sužeistųjų į širdį miršta nepasiekę ligoninės. Pateikiame Vilniaus universiteto ligoninės Santariškių klinikų Centro filialo Krūtinės chirurgijos skyriaus patirtį gydant širdies traumą patyrusius asmenis. Ligoniai ir metodaiRetrospektyviai išanalizavome 170 ligonių, gydytų dėl įtariamo širdies sužalojimo ir operuotų per pirmas 24 valandas po traumos, 1983–2007 metų duomenis. Įvertinome veiksnius, turėjusius įtakos išgyvenamumui. RezultataiVidutinis ligonių amžius ...
In Vivo, 2018
Background/Aim: The prognostic role of thyroid transcription factor-1 (TTF1) in advanced lung can... more Background/Aim: The prognostic role of thyroid transcription factor-1 (TTF1) in advanced lung cancer is not clearly established. The present study aimed to evaluate the associations between clinicopathological characteristics, TTF1 expression, and overall survival (OS) of patients with advanced lung adenocarcinoma. Materials and Methods: One hundred and seventy-two patients were enrolled in this retrospective study. OS was assessed according to immunohistochemical TTF1 expression in lung adenocarcinoma tissue, age, gender, performance status (PS), smoking history and status, disease stage, tumor differentiation, epidermal growth factor receptor (EGFR) mutation and EGFR tyrosine kinase inhibitor (TKI) treatment status. Results: The OS time was longer (p<0.001) for patients with TTF1 expression than for patients without TTF1 expression (13.0 vs. 5.0 months, respectively). A multivariate analysis confirmed that worse PS [hazard ratio (HR)=2.13, p<0.001], poor histological differentiation (HR=2.02, p=0.001), wild-type EGFR status (HR=3.08, p<0.001) and negative TTF1 expression (HR=1.97, p=0.001) were independent predictors of worse prognosis. Conclusion: TTF1 expression is an independent predictor of survival of patients with advanced lung adenocarcinoma.
Medicina, Feb 1, 2002
Empyema thoracis has been recognized as a disease entity since the time of Hippocrates and histor... more Empyema thoracis has been recognized as a disease entity since the time of Hippocrates and historically has been associated with high mortality. Over 30 years ago, the American Thoracic Society described three stages in the natural course of empyema, namely the exudative, fibrinopurulent, and organizing phases. Decortication and suction drainage usually result in lung re-expansion, otherwise pleurocutaneous window, intrathoracic transposition of skeletal muscle, or thoracoplasty remain life-saving but now uncommon options for treating a closed-space infection. During last 9 years (1993-2001) 50 patients underwent empyemectomy due to pleural empyema. Three patients died (6%). In 4 cases we had complications-hydropneumothorax. They received punction (3 patients) and 1 received tube toracostomy. In one case urgent retoracotomy was performed due to acute intrapleural bleeding. After successful empyemectomy 47 patients stay at hospital 14 days approximately.
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Papers by Vygantas Gruslys