Papers by Vuyo Mavumengwana
Aflatoxin (AF) contamination presents one of the most insidious challenges to combat, in food saf... more Aflatoxin (AF) contamination presents one of the most insidious challenges to combat, in food safety. Its adulteration of agricultural commodities presents an important safety concern as evident in the incidences of its health implication and economic losses reported widely. Due to the overarching challenges presented by the contamination of aflatoxins (AFs) in foods and feeds, there is an urgent need to evolve cost-effective and competent strategies to combat this menace. In our review, we tried to appraise the cost-effective methods for decontamination of aflatoxins (AFs). We identified the missing links in adopting microbial degradation as a palliative
to decontamination of aflatoxins AFs and its commercialization in food industries. Cogent areas of further research were also highlighted in the review paper.
Archives of Environmental Contamination and Toxicology, 2016
The bioaccumulation and quantitative variations of cyanobacterial peptide hepatotoxin intracellul... more The bioaccumulation and quantitative variations of cyanobacterial peptide hepatotoxin intracellular microcystin in floating scums of cyanobacterium microcystis flos aquae collected from predetermined sampling sites in the Swartspruit River was investigated. Three distinct MCs variants (MC-YR, MC-LR, and MC-RR) were isolated, identified, and quantified. Additionally, two minor microcystin congeners (MC-(H4) YR), (D-Asp(3), Dha(7))MC-RR) also were identified but were not quantified. Quantitative analysis was achieved using peak areas substituted on linear regression equations: Y = 10085x - 19698 (R (2) = 0.9998), Y = 201387x + 20328 (R (2) = 0.9929), Y = 2506x + 15659 (R (2) = 0.9999), and 9859x + 208694 (R (2) = 0.9929) of standard curves for 0.5, 1.0, 2.0, 4.0, 6.0, 8.0, and 10.0 μg/mL MC-LR, MC-RR, MC-YR respectively. Variant dominance followed the order MC-LR > MC-RR > MC-YR across the sampling sites. Analysis of maximum and minimum concentrations of quantified MCs variants showed 270.7, 14.10 (µg/g), 141.5, 1.43 (µg/g), and 72.28, 0.15 (µg/g) for MC-LR, MC-RR, and MC-YR, respectively. This implies there was quantitative variations of microcystin congeners across the sampled sites. Significant differences between means were assessed by an analysis of variance with P < 0.05 being considered significant. Results showed that there were no significant difference between mean MCs concentrations across the sampling periods (P > 0.05) and significant difference between mean MCs concentrations across sampling sites (P < 0.05).
African Journal of Science, Technology, Innovation and Development, 2015
Bioorganic & Medicinal Chemistry, 2010
a b s t r a c t N-Acetylglucosaminylinositol (GlcNAc-Ins)-deacetylase (MshB) and mycothiol-S-conj... more a b s t r a c t N-Acetylglucosaminylinositol (GlcNAc-Ins)-deacetylase (MshB) and mycothiol-S-conjugate amidase (Mca), structurally related amidases present in mycobacteria and other Actinomycetes, are involved in the biosynthesis of mycothiol and in the detoxification of xenobiotics as their mycothiol-S-conjugates, respectively. With substrate analogs of GlcNAc-Ins, MshB showed a marked preference for inositol as the aglycon present in GlcNAc-Ins. The inhibition of MshB and Mca by 10 thioglycosides, 7 cyclohexyl-2-deoxy-2-C-alkylglucosides, and 4 redox cyclers was evaluated. The latter contained plumbagin tethered via 2 to 5 methylene carbons and an amide linkage to phenyl-2-deoxy-2-amino-1-thio-a-D-glucopyranoside. These proved to be the most potent amongst the 21 compounds tested as inhibitors of MshB. Their inhibitory potency varied with the length of the spacer, with the compound with longest spacer being the most effective.
Food Control, 2016
Effects associated with aflatoxins (AFs), principally aflatoxin B 1 (AFB 1 ) have necessitated st... more Effects associated with aflatoxins (AFs), principally aflatoxin B 1 (AFB 1 ) have necessitated strategies to eliminate their occurrence in commodities along the food chain. This study therefore, investigated the AFB 1 biodegradation ability of Staphylococcus warneri, Sporosarcina sp. and Lysinibacillus fusiformis liquid cultures and cell lysates (disrupted in the presence or absence of protease inhibitors to obtain lysates).
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Papers by Vuyo Mavumengwana
to decontamination of aflatoxins AFs and its commercialization in food industries. Cogent areas of further research were also highlighted in the review paper.
to decontamination of aflatoxins AFs and its commercialization in food industries. Cogent areas of further research were also highlighted in the review paper.