AIDS is a collection of symptoms and infections resulting from the specific damage to the immune ... more AIDS is a collection of symptoms and infections resulting from the specific damage to the immune system caused by the human immunodeficiency virus (HIV). The late stage of the condition leaves individuals prone to opportunistic infections and tumors. Although treatments for AIDS and HIV exist to slow the virus’s progression, there is no known cure. HIV is transmitted through direct contact of a mucous membrane or the blood stream with a bodily fluid containing HIV, such as blood, semen, vaginal fluid, preseminal fluid and breast milk .Most researchers believe that HIV originated in sub–Saharan Africa during the twentieth century, it is now pandemic, with an estimated 38.6 million people now living with the disease worldwide. As of January 2006, the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the World Health Organization (WHO) estimate that AIDS has killed more than 25 million people since it was first recognized on June 5, 1981, making it one of the most destructive epidemics in recorded history. In 2005 alone, AIDS claimed an estimated 2.4–3.3 million lives, of which more than 570,000 were children. A third of these deaths are occurring in sub-Saharan Africa, retarding economic growth and destroying human capital. Antiretroviral treatment reduces both the mortality and the morbidity of HIV infection, but routine access to antiretroviral medication is not available in all countries. The absorption of drugs through the transdermal route improves bioavailability of drugs that might otherwise be metabolized by first-pass effect (pre- systemic drug elimination) during their passage through the gastrointestinal tract. Drug absorption from the transdermal route is mainly via passive diffusion through the lipoidal membrane. Thus, transdermal route of drug delivery has attracted the attention worldwide for optimizing the drug delivery.
Supplementary Material Available: A listing of atomic parameters (Table I) and the structure ampl... more Supplementary Material Available: A listing of atomic parameters (Table I) and the structure amplitude table (6 pages). Ordering information is given on any current masthead page. Synthesis and Structure of a Mononuclear Copper(1) Complex Containing the Copper(I) +Phenyl Functionality
The coordination of organochalcogen (especially Se and Te) substituted Schiff-bases LH, LH, LH, a... more The coordination of organochalcogen (especially Se and Te) substituted Schiff-bases LH, LH, LH, and LH toward Zn(II) and Hg(II) has been studied. Reactions of these ligands with ZnCl2 in 1 : 1 molar ratio gave binuclear complexes [{2-[PhX(CH2)nN = C(Ph)]-6-[PhCO]-4-MeC6H2O}2Zn2Cl2] (where X = Se, n = 2 (1); X = Se, n = 3 (2); X = Te, n = 2 (3); and X = Te, n = 3 (4)) with partial hydrolytic cleavage of proligands. In these complexes, two
AIDS is a collection of symptoms and infections resulting from the specific damage to the immune ... more AIDS is a collection of symptoms and infections resulting from the specific damage to the immune system caused by the human immunodeficiency virus (HIV). The late stage of the condition leaves individuals prone to opportunistic infections and tumors. Although treatments for AIDS and HIV exist to slow the virus’s progression, there is no known cure. HIV is transmitted through direct contact of a mucous membrane or the blood stream with a bodily fluid containing HIV, such as blood, semen, vaginal fluid, preseminal fluid and breast milk .Most researchers believe that HIV originated in sub–Saharan Africa during the twentieth century, it is now pandemic, with an estimated 38.6 million people now living with the disease worldwide. As of January 2006, the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the World Health Organization (WHO) estimate that AIDS has killed more than 25 million people since it was first recognized on June 5, 1981, making it one of the most destructive epidemics in recorded history. In 2005 alone, AIDS claimed an estimated 2.4–3.3 million lives, of which more than 570,000 were children. A third of these deaths are occurring in sub-Saharan Africa, retarding economic growth and destroying human capital. Antiretroviral treatment reduces both the mortality and the morbidity of HIV infection, but routine access to antiretroviral medication is not available in all countries. The absorption of drugs through the transdermal route improves bioavailability of drugs that might otherwise be metabolized by first-pass effect (pre- systemic drug elimination) during their passage through the gastrointestinal tract. Drug absorption from the transdermal route is mainly via passive diffusion through the lipoidal membrane. Thus, transdermal route of drug delivery has attracted the attention worldwide for optimizing the drug delivery.
Supplementary Material Available: A listing of atomic parameters (Table I) and the structure ampl... more Supplementary Material Available: A listing of atomic parameters (Table I) and the structure amplitude table (6 pages). Ordering information is given on any current masthead page. Synthesis and Structure of a Mononuclear Copper(1) Complex Containing the Copper(I) +Phenyl Functionality
The coordination of organochalcogen (especially Se and Te) substituted Schiff-bases LH, LH, LH, a... more The coordination of organochalcogen (especially Se and Te) substituted Schiff-bases LH, LH, LH, and LH toward Zn(II) and Hg(II) has been studied. Reactions of these ligands with ZnCl2 in 1 : 1 molar ratio gave binuclear complexes [{2-[PhX(CH2)nN = C(Ph)]-6-[PhCO]-4-MeC6H2O}2Zn2Cl2] (where X = Se, n = 2 (1); X = Se, n = 3 (2); X = Te, n = 2 (3); and X = Te, n = 3 (4)) with partial hydrolytic cleavage of proligands. In these complexes, two
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Papers by Vinay Verma