The Journal of Cardiovascular Aging
The Journal of Cardiovascular Aging (JCA, online ISSN 2768-5993, https://cardiovascularaging.com/) is an international peer-reviewed, open access, online journal.
Aims and Scope
To establish JCA as a premier, most desirable, and entirely transparent international platform for dissemination of the state-of-the-art basic, translational, and clinical studies in aging and cardiovascular disease. The journal aims to publish state-of-the-art scientific discoveries pertaining to the broad spectrum of cardiovascular consequences of aging. The Editors aim to provide timely, fair, and balanced considerations to all manuscripts submitted and seek the opinions of the external experts in prioritizing the meritorious manuscripts.
JCA aims to publish clinical, translational, and basic science discoveries that pertain to all aspects of aging and cardiovascular disease. All aspects of basic and clinical sciences relating to aging in the context of cardiovascular disease are considered to be within the scope of the journal. Examples include clinical trials, diet, treatment, genetics, epigenetics, genomics, stem cells, immunology, inflammation, cell cycle regulation, senescence, signaling pathways, and pharmacology, among others. The primary focus of the journal is to publish original research articles that provide novel insights into cardiovascular aging. Studies confirming and validating previous findings, whenever providing unequivocal findings, are also within the scope of the journal. Review manuscripts on topics of broad interest to the readership of the journal, Editorials, and Commentaries on timely and important topics will also be considered.
Aims and Scope
To establish JCA as a premier, most desirable, and entirely transparent international platform for dissemination of the state-of-the-art basic, translational, and clinical studies in aging and cardiovascular disease. The journal aims to publish state-of-the-art scientific discoveries pertaining to the broad spectrum of cardiovascular consequences of aging. The Editors aim to provide timely, fair, and balanced considerations to all manuscripts submitted and seek the opinions of the external experts in prioritizing the meritorious manuscripts.
JCA aims to publish clinical, translational, and basic science discoveries that pertain to all aspects of aging and cardiovascular disease. All aspects of basic and clinical sciences relating to aging in the context of cardiovascular disease are considered to be within the scope of the journal. Examples include clinical trials, diet, treatment, genetics, epigenetics, genomics, stem cells, immunology, inflammation, cell cycle regulation, senescence, signaling pathways, and pharmacology, among others. The primary focus of the journal is to publish original research articles that provide novel insights into cardiovascular aging. Studies confirming and validating previous findings, whenever providing unequivocal findings, are also within the scope of the journal. Review manuscripts on topics of broad interest to the readership of the journal, Editorials, and Commentaries on timely and important topics will also be considered.
less
Uploads
Papers by The Journal of Cardiovascular Aging
Aim: Therefore, here we reassessed an estimated 500 putative genes in the Chinese Han population by whole exome sequencing (WES) to describe the landscape of variants in these genes and to confirm their genetic contribution to DCM and HCM.
Methods and Results: WES was performed in 1059 DCM patients, 1175 HCM patients and 514 controls. Approximately 500 candidate genes were selected for evaluation. Truncating variants of TTN and MYBPC3 were the most burdensome for both groups. Gene-based association tests identified 35 and 35 genes associated with DCM and HCM, respectively. Except for the known genes of cardiomyopathy, the top three genes associated with DCM were MUC16, KMT2C, and FBN1, while the top three genes associated with HCM were KMT2C, RYR2, and SCN5A. After filtering for pathogenicity, FBN1 is still significantly associated with DCM and SCN5A and RYR2 remains significantly enriched in HCM patients. However, after adjustment, only TTN with DCM and MYBPC3 and MYH7 with HCM remains significant.
Conclusion: We described the genetic landscape of Chinese patients with DCM and HCM and developed a website (www.cardioexome.cn) to enable open access to this information. Furthermore, the gene-based association test confirmed the contribution of TTN to DCM and MYBPC3 and MYH7 to HCM in Chinese Han. In addition, the website, www.cardioexome.cn, was developed to store these sequencing results.
Aim: Therefore, here we reassessed an estimated 500 putative genes in the Chinese Han population by whole exome sequencing (WES) to describe the landscape of variants in these genes and to confirm their genetic contribution to DCM and HCM.
Methods and Results: WES was performed in 1059 DCM patients, 1175 HCM patients and 514 controls. Approximately 500 candidate genes were selected for evaluation. Truncating variants of TTN and MYBPC3 were the most burdensome for both groups. Gene-based association tests identified 35 and 35 genes associated with DCM and HCM, respectively. Except for the known genes of cardiomyopathy, the top three genes associated with DCM were MUC16, KMT2C, and FBN1, while the top three genes associated with HCM were KMT2C, RYR2, and SCN5A. After filtering for pathogenicity, FBN1 is still significantly associated with DCM and SCN5A and RYR2 remains significantly enriched in HCM patients. However, after adjustment, only TTN with DCM and MYBPC3 and MYH7 with HCM remains significant.
Conclusion: We described the genetic landscape of Chinese patients with DCM and HCM and developed a website (www.cardioexome.cn) to enable open access to this information. Furthermore, the gene-based association test confirmed the contribution of TTN to DCM and MYBPC3 and MYH7 to HCM in Chinese Han. In addition, the website, www.cardioexome.cn, was developed to store these sequencing results.