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Papers by Tan Tan

The Forecasting Power of Digital Transformation on Future Corporate Innovation Evidence from Digital Transformation Certification

SSRN Electronic Journal

Understanding Russian and Turkish State-National Interests in the Syrian Conflict through the Neo-Realism Paradigm

Open Journal of Political Science, 2021

The study is devoted to the analysis of Russian-Turkish interaction in the Syrian conflict under ... more The study is devoted to the analysis of Russian-Turkish interaction in the Syrian conflict under neo-realism concept. The Syrian crisis has become a kind of Russian-Turkish relations "barometer" in recent years. On the Syrian battlefield, Moscow and Ankara as unitary and rational actors both try to increase their relative power, which enables them to achieve their objectives mainly connected with prospects for national interests. The detailed analyses of the Russian-Turkish diplomatic negotiations and dynamics of joint military-political activities lead to the conclusion that despite competing for military-strategic, energy and geopolitical interests, both parties opt to jointly balance against common challenges. Being aware of the mutual necessity and adhering to the principles of "realpolitik", Russia and Turkey prefer to negotiate and act within the framework of widespread interests, where real and potential mutual benefits prevail over disagreements.

Combining multi-criteria decision making (MCDM) methods with building information modelling (BIM): A review

Automation in Construction, 2021

Integrating building information to support decision-making has been a key challenge in the Archi... more Integrating building information to support decision-making has been a key challenge in the Architecture, Engineering, and Construction (AEC) industry. The synergy of Building Information Modelling (BIM) and Multi-Criteria Decision Making (MCDM) is expected to improve information integration and decision-making. The aim of this paper is to identify strategies to improve the synergy between MCDM and BIM. From the earliest literature (2009) to the present, this study examines 45 articles combining MCDM with BIM. We find that the five major application domains are sustainability, retrofit, supplier selection, safety, and constructability. Five established strategies for improving the synergy between MCDM and BIM were discussed and can be used as a benchmark for evaluating the application of decision techniques in practice. This study points out gaps of combining MCDM and BIM in the current literature. It also sheds new light into combining MCDM with BIM for practitioners, as to promote integrated decision-making.

Association between IKZF1 related gene polymorphism, DNA methylation and rheumatoid arthritis in Han Chinese: A case-control study

Background: Rheumatoid arthritis (RA) is a systematic autoimmune disease with evidence of genetic... more Background: Rheumatoid arthritis (RA) is a systematic autoimmune disease with evidence of genetic predisposition. The IKZF1 (IKAROS family zinc finger 1 (Ikaros)) gene is located at chromosome 7, encodes a transcription factor related tochromatin remodeling, regulates lymphocyte differentiation, and is associated with some autoimmune diseases. However, there were few studies reported the association between IKZF1 and the risk of RA in China. For this, we determined to investigate the possibility of association between the IKZF1 locus and RA. Methods: we selected one single nucleotide polymorphisms (SNP) in the IKZF1 locus, rs1456893, based on a detailed analysis of genome-wide association study (GWAS) data and performed genotyping in 410 RA patients and 421 healthy controls in Han Chinese. We studied the systematic genome-wide interrogation of DNA methylation between RA group and control group and we also studied the association between CpGs and RA. Results: The results showed that the rs1456893 locus was correlated with RA in different models(P¡0.05). Through comparison with methylation levels determined in their equivalent healthy counterparts we have identified and validated a restricted set of CpGs that show distinct methylation differences between patients with RA and control group. The Multiple logistic regression results showed CpG 3 (OR=3.17,95%CI=1.05-9.60,P=0.041) and CpG 13.14(OR=4.96,95%CI=1.77-13.86,P=0.002)were associated with RA. Conclusion: IKZF1 can be used as a marker for the diagnosis of RA. Higher CpG 3 and CpG 13.14 methylation levels would increase the risk of RA.

Deletion of CD163 Exon 7 Confers Resistance to Highly Pathogenic Porcine Reproductive and Respiratory Viruses on Pigs

International Journal of Biological Sciences, 2019

Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) is a severe inf... more Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) is a severe infectious disease in the swine industry. PRRSV infection is mediated by porcine CD163 (pCD163). Scavenger receptor cysteine-rich domain 5 coded by exon 7 of pCD163 is essential for PRRSV infection. In this study, we generated CD163 exon 7 deleted (CD163E7D) pigs using CRISPR/Cas9 mediated homologous recombination and somatic cell nuclear transfer (SCNT). The deletion of exon 7 had no adverse effects on CD163-associated functions. Pigs were further challenged with a highly pathogenic PRRSV (HP-PRRSV) strain. The CD163E7D pigs exhibited mild clinical symptoms and had decreased viral loads in blood. All CD163E7D pigs survived the viral challenge, while all the WT pigs displayed severe symptoms, and 2 out of 6 WT pigs died during the challenge. Our results demonstrated that CD163 exon 7 deletion confers resistance to HP-PRRSV infection without impairing the biological functions of CD163.

Changes in the position and volume of inactive X chromosomes during the G0/G1 transition

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, Sep 21, 2018

In female mammals, each cell silences one X chromosome by converting it into transcriptionally in... more In female mammals, each cell silences one X chromosome by converting it into transcriptionally inert heterochromatin. The inactivation is concomitant with epigenetic changes including methylation of specific histone residues and incorporation of macroH2A. Such epigenetic changes may exert influence on the positioning of the inactive X chromosome (Xi) within the nucleus beyond the level of chromatin structure. However, the dynamic positioning of the inactive X chromosome during cell cycle remains unclear. Here, we show that H3K27me3 is a cell-cycle-independent marker for the inactivated X chromosomes in WI38 cells. By utilizing this marker, three types of Xi locations in the nuclei are classified, which are envelope position (associated with envelope), mid-position (between the envelope and nucleolus), and nucleolus position (associated with the nucleolus). Moreover, serial-section analysis revealed that the inactive X chromosomes in the mid-position appear to be sparser and less con...

Association of interleukin 22 gene polymorphisms and serum IL-22 level with risk of systemic lupus erythematosus in a Chinese population

Clinical and experimental immunology, Jan 30, 2018

The aim of this study was to investigate the association between the single-nucleotide polymorphi... more The aim of this study was to investigate the association between the single-nucleotide polymorphisms (SNPs) of interleukin 22 (IL-22) gene and systemic lupus erythematosus (SLE) in a Chinese population. Three IL-22 SNPs (rs2227485, rs2227513 and rs2227491) were genotyped using Snapshot SNP genotyping assays and identified by sequencing in 314 SLE patients and 411 healthy controls. IL-22 level of serum was assessed by enzyme-linked immunosorbent assay (ELISA) kits. Data were analyzed by SPSS 17.0 software. We found that rs2227513 was associated with an increased risk of SLE (AG vs. AA: adjusted OR=2.24, 95%CI, 1.22-4.12, P=0.010; G vs. A: adjusted OR=2.18, 95%CI, 1.20-3.97, P=0.011). Further analysis in patients with SLE showed that AG genotype and G allele were associated with an increased risk of renal disorder in SLE (G vs. A: adjusted OR=3.09, 95%CI, 1.30-7.33, P=0.011; AG vs. AA: adjusted OR=3.25, 95%CI, 1.35-7.85, P=0.009). In addition, the concentration of IL-22 was significan...

Preprocessing Digital Retinal Images for Vessel Segmentation

Research Journal of Applied Sciences, Engineering and Technology, 2017

The information contained in the retinal vasculature is used to diagnose the onset of retinal dis... more The information contained in the retinal vasculature is used to diagnose the onset of retinal diseases such as diabetic retinopathy. However, due to non-uniform illumination and variations in imaging modalities, the contrast between the retinal blood vessels network and the background is very low, encumbering the analysis and the diagnosis processes. This prompts the need for preprocessing digital fundus images to remove noise and improve contrast thus increasing the segmentation accuracy of the retinal vasculature. In this study, we address issues of nonuniform illumination and low contrast by developing a framework that implements shade correction, image enhancement and prepares the digital fundus images for the next stage.

Analysis and Prediction for the Chaotic Characteristic of Phase Difference VLF

Advanced Materials Research, 2012

By analyzing the nonlinear characteristic of phase difference of receiving VLF signal in Xinxiang... more By analyzing the nonlinear characteristic of phase difference of receiving VLF signal in Xinxiang. Research on it's chaotic characteristic and probability of predicting it take advantage of the chaotic theory. The numerical results show that the phase difference of propagation has chaotic characteristic on the position that has specified latitude and longitude. Predicting the phase difference by using the method that based on the lyapunov exponent. The standard deviation and variance of Prediction results are 1.6240 cec and 2.6375 cec, respectively.

Crashworthiness analysis and structural optimisation of multi-cell square tubes under axial and oblique loads

International Journal of Crashworthiness, 2016

ABSTRACT Square tubes have been widely used as energy absorption components. To investigate the i... more ABSTRACT Square tubes have been widely used as energy absorption components. To investigate the influences of multi-cell configuration and loading arrangement on the crashworthiness of square tubes, eight kinds of multi-cell square tubes were numerically analysed under axial and oblique loads. Validation was performed against experimental data. According to the complex proportional assessment method, the T5-1 tube is found to have the best crashworthiness performance. Next, a parameter study was performed to analyse the effect of geometric parameters of the T5-1 tube on the crashworthiness. It was found that the s/b ratio and thickness have a significant influence on the energy absorption. The critical loading angle lies in the range of 10°–11°. Finally, a structural improvement design, with the straight tube changed to the taper tube, was implemented and the taper T5-1 tube was proposed. The results show that the taper T5-1 tube has better crashworthiness performance, compared with the original T5-1 tube.

Study on near-field image extraction in high power lasers

Optik - International Journal for Light and Electron Optics, 2016

Abstract The accurate measurement of high-power laser near-field fluence distribution leads to a ... more Abstract The accurate measurement of high-power laser near-field fluence distribution leads to a correct assessment of the output beam quality. In this paper, the nearfield fluence distribution is measured by a scientific-grade CCD in a hundred-Joule-level laser system. The experimental method of filtering the background noise in original near-field image is studied. Compared with the other method of filtering background noise, the experimental method is simple and accurate. Results show that this method can measure and correctly extract the image of near-field distribution in high-power lasers.

Erratum to: Genetic variants of ESR1 and SGSM3 are associated with the susceptibility of breast cancer in the Chinese population

Breast cancer (Tokyo, Japan), May 11, 2016

The correct name of the corresponding author should be given as Wenjun Chen, not Wenjun Chen Sun.

Generation of high-energy 284 ps laser pulse without tail modulation by stimulated Brillouin scattering

Chinese Optics Letters, 2016

We obtain the output of a 284 ps pulse duration without tail modulation based on stimulated Brill... more We obtain the output of a 284 ps pulse duration without tail modulation based on stimulated Brillouin scattering (SBS) pulse compression pumped by an 8 ns-pulse-duration, 1064 nm-wavelength Q-switched Nd:YAG laser. To suppress the tail modulation in SBS pulse compression, proper attenuators, which can control the pump energy within a rational range, are added in a generator-amplifier setup. The experimental result shows that the effective energy conversion efficiency triples when the pump energy reaches 700 mJ to 51%, compared with the conventional generator-amplifier setup.

Chromatin remodeling factor LSH drives cancer progression by suppressing the activity of fumarate hydratase

Cancer research, Oct 14, 2016

Chromatin modification is pivotal to the epithelial-mesenchymal transition (EMT) which confers po... more Chromatin modification is pivotal to the epithelial-mesenchymal transition (EMT) which confers potent metastatic potential to cancer cells. Here we report a role for the chromatin remodeling factor LSH in nasopharyngeal carcinoma (NPC), a prevalent cancer in China. LSH expression was increased in NPC, where it was controlled by the Epstein-Barr virus-encoded protein LMP1. In NPC cells in vitro and in vivo, LSH promoted cancer progression in part by regulating expression of fumarate hydratase (FH), a core component of the tricarboxylic acid (TCA) cycle. LSH bound to the FH promoter, recruiting the epigenetic silencer factor G9a to repress FH transcription. Clinically, we found that the concentration of TCA intermediates in NPC patient sera was deregulated in the presence of LSH. RNAi-mediated silending of FH mimicked LSH overexpression, establishing FH as downstream mediator of LSH effects. The TCA intermediates α-KG and citrate potentiated the malignant character of NPC cells, in pa...

Low expression of Aldo-keto reductase 1B10 is a novel independent prognostic indicator for nasopharyngeal carcinoma

Cell & bioscience, 2016

Nasopharyngeal carcinoma (NPC) is one of the most common human head and neck cancers with high in... more Nasopharyngeal carcinoma (NPC) is one of the most common human head and neck cancers with high incidence in Southern China, Southeast Asia and North Africa. Because of its nonspecific symptoms, the early diagnosis of NPC is very difficult. The 5-year survival rate is not ideal in spite of great innovations in radiation and chemotherapy treatments. Highly sensitive and specific prognostic biomarkers are eager for NPC clinical diagnosis. To find specific target molecules is very important for individualized treatment. Aldo-keto reductase B10 (AKR1B10) is closely related to tumorigenesis and tumor development, and however, its expression level in NPC tissues is not clear. AKR1B10 expression levels were validated in benign, para-cancerous nasopharyngeal and NPC tissues by immunohistochemical evaluation. AKR1B10 was positively expressed in 42 (82.4 %) of 51 benign specimens, and 235 (98.7 %) of 238 para-carcinoma specimens. This percentage was significantly higher than 44.5 % (133/299) i...

Dynamically Evolving Annotation-Based Variability for Runtime Adaptation

2015 IEEE International Conference on Computer and Information Technology; Ubiquitous Computing and Communications; Dependable, Autonomic and Secure Computing; Pervasive Intelligence and Computing, 2015

Software applications are increasingly desirable to adapt to varying execution environments and d... more Software applications are increasingly desirable to adapt to varying execution environments and diverse user requirements to support runtime adaptation. Behavioral variations are generally modularized to handle variability. Depending on activating or deactivating relevant variations dynamically due to continuous context changes, a required behavioral variant specific to contexts is subsequently generated and has to evolve over time, to remain higher availability. However, since the potential amount of behavioral variants to be formed is huge, it is substantially unlikely to ensure all of them are type safe due to the unnecessary variants which are not used at all. To address this problem, we propose an annotation-based approach to variability. It can type check the entire program consisting of base program and many variations only once, without resulting from each variant individually. We extend the Featherweight Java to formally prove that all the expected variants are still well typed. Moreover, the type system guarantees type safety of the updated program as one variant evolves to another and type correctness that no run-time errors occur.

Radioimmunotherapy of human colorectal carcinoma xenografts using 90Y-labeled monoclonal antibody CO17-1A prepared by two bifunctional chelate techniques

Cancer research, 1990

Monoclonal antibody CO17-1A, which has specificity for colorectal and pancreatic carcinomas, was ... more Monoclonal antibody CO17-1A, which has specificity for colorectal and pancreatic carcinomas, was radiolabeled with the pure beta emitter, 90Y, by either the cyclic diethylenetriaminepentaacetic acid (DTPA) anhydride technique or by a site-specific bifunctional chelate technique using 1-(p-aminobenzyl)DTPA (p-NH2-Bz-DTPA). Female nude mice bearing SW 948 human colorectal carcinoma xenografts were given injections i.v. of 90Y-labeled monoclonal antibody CO17-1A at dosages of 100, 150, and 200 muCi/25 g body weight. Unlabeled CO17-1A (100 micrograms/25 g body weight) was coadministered. In animals receiving 90Y-CO17-1A prepared by the cyclic DTPA anhydride technique, tumor volume was unchanged from base line at a dose of 200 microCi/25 g. As the dosage of 90Y-CO17-1A increased, the rate of tumor growth decreased, but all experimental animals in this group died between 14 and 21 days. In contrast, CO17-1A radiolabeled with 90Y by the site-specific p-NH2-Bz-DTPA bifunctional chelate tech...

Growth and characterization of the interface

Surface Science, 1996

The structure and electronic properties of the interfaces formed by Re evaporation on clean Si(11... more The structure and electronic properties of the interfaces formed by Re evaporation on clean Si(111)-7 X 7 and subsequent annealing were investigated by low energy electron diffraction (LEED), Photoelectron spectroscopy (XPS/XAES, UPS) and work function (WF) measurements. Rhenium was deposited from submonolayer up to 50 ML coverages and gradually annealed up to 1100 K. Deposition causes rapid disappearance of the 7 X 7 reconstruction and the substrate UPS features, a gradual increase in the WF from 4.5 to 5.1 eV and negligible chemical shift in the XPS/XAES peaks. The interface remained abrupt with no intermixing, as metallic Re grew in a simultaneous mulfilayers fashion above 0.8 ML coverage. Annealing of 50 ML of Re causes a Si enrichment of the overlayer above 600 K and the formation at around 950 K of a continuous layer of silicide which remains stable up to 1100 K, whereas annealing of Re layers close to 1 ML creates ReSi 2 islands on the substrate surface.

Screening for methylation-silenced genes in acute myeloid leukemia HL-60 cell line by a quantitative proteomic approach

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2010

To screen for new methylation association genes in HL-60 to reveal the pathogenesis of leukemia, ... more To screen for new methylation association genes in HL-60 to reveal the pathogenesis of leukemia, and provide important theoretical and scientific basis for the prevention and cure of leukemia. Two-dimensional fluorescence difference gel electrophoresis (F-2D-DIGE) was performed to separate the total proteins from acute myelogenous leukemia (AML) cell line HL-60 cells with or without 5-aza-2-deoxycytidine (5-aza-2-dC) treatment. Imaging software Decyder 6.5 and PDQuest were used to detect the differential expression protein spots, and matrix-assisted laser desorption/ionizaion time-of-flight mas spectrometer (MALDI-TOF MS) was adopted to identify the differential expression proteins. F-2D-DIGE maps of 5-aza-2-dC-untreated HL-60 and-treated HL-60 cells were established. A total of 53 differential protein spots were detected, and 35 differential proteins were successfully identified. Of the identified proteins, 32 proteins were up-regulated, and 3 proteins were down-regulated in HL-60 ...

Potassium adsorption on β-FeSi2 thin films

Surface Science Letters, 1991

Potassium adsorption on thin fl-FeSi 2 epitaxiaUy grown on Si(111) was studied with ultraviolet p... more Potassium adsorption on thin fl-FeSi 2 epitaxiaUy grown on Si(111) was studied with ultraviolet photoemission spectroscopy (UPS), Auger electron spectroscopy (AES) and work function (WF) measurements. A value of (4.65 + 0.03) eV was measured for the absolute WF of the silicide surface. A combination of the experimental results upon K deposition indicates a plausible mode of K adsorption on fl-FeSi 2. Initially K adsorbs on Si triangular sites with a Fe atom underneath up to a coverage of-2 x 1014 atoms cm-2 and then on Si triangular sites with no Fe underneath up to a saturation coverage of-2 x 1014 atoms cm-2.

The Forecasting Power of Digital Transformation on Future Corporate Innovation Evidence from Digital Transformation Certification

SSRN Electronic Journal

Understanding Russian and Turkish State-National Interests in the Syrian Conflict through the Neo-Realism Paradigm

Open Journal of Political Science, 2021

The study is devoted to the analysis of Russian-Turkish interaction in the Syrian conflict under ... more The study is devoted to the analysis of Russian-Turkish interaction in the Syrian conflict under neo-realism concept. The Syrian crisis has become a kind of Russian-Turkish relations "barometer" in recent years. On the Syrian battlefield, Moscow and Ankara as unitary and rational actors both try to increase their relative power, which enables them to achieve their objectives mainly connected with prospects for national interests. The detailed analyses of the Russian-Turkish diplomatic negotiations and dynamics of joint military-political activities lead to the conclusion that despite competing for military-strategic, energy and geopolitical interests, both parties opt to jointly balance against common challenges. Being aware of the mutual necessity and adhering to the principles of "realpolitik", Russia and Turkey prefer to negotiate and act within the framework of widespread interests, where real and potential mutual benefits prevail over disagreements.

Combining multi-criteria decision making (MCDM) methods with building information modelling (BIM): A review

Automation in Construction, 2021

Integrating building information to support decision-making has been a key challenge in the Archi... more Integrating building information to support decision-making has been a key challenge in the Architecture, Engineering, and Construction (AEC) industry. The synergy of Building Information Modelling (BIM) and Multi-Criteria Decision Making (MCDM) is expected to improve information integration and decision-making. The aim of this paper is to identify strategies to improve the synergy between MCDM and BIM. From the earliest literature (2009) to the present, this study examines 45 articles combining MCDM with BIM. We find that the five major application domains are sustainability, retrofit, supplier selection, safety, and constructability. Five established strategies for improving the synergy between MCDM and BIM were discussed and can be used as a benchmark for evaluating the application of decision techniques in practice. This study points out gaps of combining MCDM and BIM in the current literature. It also sheds new light into combining MCDM with BIM for practitioners, as to promote integrated decision-making.

Association between IKZF1 related gene polymorphism, DNA methylation and rheumatoid arthritis in Han Chinese: A case-control study

Background: Rheumatoid arthritis (RA) is a systematic autoimmune disease with evidence of genetic... more Background: Rheumatoid arthritis (RA) is a systematic autoimmune disease with evidence of genetic predisposition. The IKZF1 (IKAROS family zinc finger 1 (Ikaros)) gene is located at chromosome 7, encodes a transcription factor related tochromatin remodeling, regulates lymphocyte differentiation, and is associated with some autoimmune diseases. However, there were few studies reported the association between IKZF1 and the risk of RA in China. For this, we determined to investigate the possibility of association between the IKZF1 locus and RA. Methods: we selected one single nucleotide polymorphisms (SNP) in the IKZF1 locus, rs1456893, based on a detailed analysis of genome-wide association study (GWAS) data and performed genotyping in 410 RA patients and 421 healthy controls in Han Chinese. We studied the systematic genome-wide interrogation of DNA methylation between RA group and control group and we also studied the association between CpGs and RA. Results: The results showed that the rs1456893 locus was correlated with RA in different models(P¡0.05). Through comparison with methylation levels determined in their equivalent healthy counterparts we have identified and validated a restricted set of CpGs that show distinct methylation differences between patients with RA and control group. The Multiple logistic regression results showed CpG 3 (OR=3.17,95%CI=1.05-9.60,P=0.041) and CpG 13.14(OR=4.96,95%CI=1.77-13.86,P=0.002)were associated with RA. Conclusion: IKZF1 can be used as a marker for the diagnosis of RA. Higher CpG 3 and CpG 13.14 methylation levels would increase the risk of RA.

Deletion of CD163 Exon 7 Confers Resistance to Highly Pathogenic Porcine Reproductive and Respiratory Viruses on Pigs

International Journal of Biological Sciences, 2019

Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) is a severe inf... more Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) is a severe infectious disease in the swine industry. PRRSV infection is mediated by porcine CD163 (pCD163). Scavenger receptor cysteine-rich domain 5 coded by exon 7 of pCD163 is essential for PRRSV infection. In this study, we generated CD163 exon 7 deleted (CD163E7D) pigs using CRISPR/Cas9 mediated homologous recombination and somatic cell nuclear transfer (SCNT). The deletion of exon 7 had no adverse effects on CD163-associated functions. Pigs were further challenged with a highly pathogenic PRRSV (HP-PRRSV) strain. The CD163E7D pigs exhibited mild clinical symptoms and had decreased viral loads in blood. All CD163E7D pigs survived the viral challenge, while all the WT pigs displayed severe symptoms, and 2 out of 6 WT pigs died during the challenge. Our results demonstrated that CD163 exon 7 deletion confers resistance to HP-PRRSV infection without impairing the biological functions of CD163.

Changes in the position and volume of inactive X chromosomes during the G0/G1 transition

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, Sep 21, 2018

In female mammals, each cell silences one X chromosome by converting it into transcriptionally in... more In female mammals, each cell silences one X chromosome by converting it into transcriptionally inert heterochromatin. The inactivation is concomitant with epigenetic changes including methylation of specific histone residues and incorporation of macroH2A. Such epigenetic changes may exert influence on the positioning of the inactive X chromosome (Xi) within the nucleus beyond the level of chromatin structure. However, the dynamic positioning of the inactive X chromosome during cell cycle remains unclear. Here, we show that H3K27me3 is a cell-cycle-independent marker for the inactivated X chromosomes in WI38 cells. By utilizing this marker, three types of Xi locations in the nuclei are classified, which are envelope position (associated with envelope), mid-position (between the envelope and nucleolus), and nucleolus position (associated with the nucleolus). Moreover, serial-section analysis revealed that the inactive X chromosomes in the mid-position appear to be sparser and less con...

Association of interleukin 22 gene polymorphisms and serum IL-22 level with risk of systemic lupus erythematosus in a Chinese population

Clinical and experimental immunology, Jan 30, 2018

The aim of this study was to investigate the association between the single-nucleotide polymorphi... more The aim of this study was to investigate the association between the single-nucleotide polymorphisms (SNPs) of interleukin 22 (IL-22) gene and systemic lupus erythematosus (SLE) in a Chinese population. Three IL-22 SNPs (rs2227485, rs2227513 and rs2227491) were genotyped using Snapshot SNP genotyping assays and identified by sequencing in 314 SLE patients and 411 healthy controls. IL-22 level of serum was assessed by enzyme-linked immunosorbent assay (ELISA) kits. Data were analyzed by SPSS 17.0 software. We found that rs2227513 was associated with an increased risk of SLE (AG vs. AA: adjusted OR=2.24, 95%CI, 1.22-4.12, P=0.010; G vs. A: adjusted OR=2.18, 95%CI, 1.20-3.97, P=0.011). Further analysis in patients with SLE showed that AG genotype and G allele were associated with an increased risk of renal disorder in SLE (G vs. A: adjusted OR=3.09, 95%CI, 1.30-7.33, P=0.011; AG vs. AA: adjusted OR=3.25, 95%CI, 1.35-7.85, P=0.009). In addition, the concentration of IL-22 was significan...

Preprocessing Digital Retinal Images for Vessel Segmentation

Research Journal of Applied Sciences, Engineering and Technology, 2017

The information contained in the retinal vasculature is used to diagnose the onset of retinal dis... more The information contained in the retinal vasculature is used to diagnose the onset of retinal diseases such as diabetic retinopathy. However, due to non-uniform illumination and variations in imaging modalities, the contrast between the retinal blood vessels network and the background is very low, encumbering the analysis and the diagnosis processes. This prompts the need for preprocessing digital fundus images to remove noise and improve contrast thus increasing the segmentation accuracy of the retinal vasculature. In this study, we address issues of nonuniform illumination and low contrast by developing a framework that implements shade correction, image enhancement and prepares the digital fundus images for the next stage.

Analysis and Prediction for the Chaotic Characteristic of Phase Difference VLF

Advanced Materials Research, 2012

By analyzing the nonlinear characteristic of phase difference of receiving VLF signal in Xinxiang... more By analyzing the nonlinear characteristic of phase difference of receiving VLF signal in Xinxiang. Research on it's chaotic characteristic and probability of predicting it take advantage of the chaotic theory. The numerical results show that the phase difference of propagation has chaotic characteristic on the position that has specified latitude and longitude. Predicting the phase difference by using the method that based on the lyapunov exponent. The standard deviation and variance of Prediction results are 1.6240 cec and 2.6375 cec, respectively.

Crashworthiness analysis and structural optimisation of multi-cell square tubes under axial and oblique loads

International Journal of Crashworthiness, 2016

ABSTRACT Square tubes have been widely used as energy absorption components. To investigate the i... more ABSTRACT Square tubes have been widely used as energy absorption components. To investigate the influences of multi-cell configuration and loading arrangement on the crashworthiness of square tubes, eight kinds of multi-cell square tubes were numerically analysed under axial and oblique loads. Validation was performed against experimental data. According to the complex proportional assessment method, the T5-1 tube is found to have the best crashworthiness performance. Next, a parameter study was performed to analyse the effect of geometric parameters of the T5-1 tube on the crashworthiness. It was found that the s/b ratio and thickness have a significant influence on the energy absorption. The critical loading angle lies in the range of 10°–11°. Finally, a structural improvement design, with the straight tube changed to the taper tube, was implemented and the taper T5-1 tube was proposed. The results show that the taper T5-1 tube has better crashworthiness performance, compared with the original T5-1 tube.

Study on near-field image extraction in high power lasers

Optik - International Journal for Light and Electron Optics, 2016

Abstract The accurate measurement of high-power laser near-field fluence distribution leads to a ... more Abstract The accurate measurement of high-power laser near-field fluence distribution leads to a correct assessment of the output beam quality. In this paper, the nearfield fluence distribution is measured by a scientific-grade CCD in a hundred-Joule-level laser system. The experimental method of filtering the background noise in original near-field image is studied. Compared with the other method of filtering background noise, the experimental method is simple and accurate. Results show that this method can measure and correctly extract the image of near-field distribution in high-power lasers.

Erratum to: Genetic variants of ESR1 and SGSM3 are associated with the susceptibility of breast cancer in the Chinese population

Breast cancer (Tokyo, Japan), May 11, 2016

The correct name of the corresponding author should be given as Wenjun Chen, not Wenjun Chen Sun.

Generation of high-energy 284 ps laser pulse without tail modulation by stimulated Brillouin scattering

Chinese Optics Letters, 2016

We obtain the output of a 284 ps pulse duration without tail modulation based on stimulated Brill... more We obtain the output of a 284 ps pulse duration without tail modulation based on stimulated Brillouin scattering (SBS) pulse compression pumped by an 8 ns-pulse-duration, 1064 nm-wavelength Q-switched Nd:YAG laser. To suppress the tail modulation in SBS pulse compression, proper attenuators, which can control the pump energy within a rational range, are added in a generator-amplifier setup. The experimental result shows that the effective energy conversion efficiency triples when the pump energy reaches 700 mJ to 51%, compared with the conventional generator-amplifier setup.

Chromatin remodeling factor LSH drives cancer progression by suppressing the activity of fumarate hydratase

Cancer research, Oct 14, 2016

Chromatin modification is pivotal to the epithelial-mesenchymal transition (EMT) which confers po... more Chromatin modification is pivotal to the epithelial-mesenchymal transition (EMT) which confers potent metastatic potential to cancer cells. Here we report a role for the chromatin remodeling factor LSH in nasopharyngeal carcinoma (NPC), a prevalent cancer in China. LSH expression was increased in NPC, where it was controlled by the Epstein-Barr virus-encoded protein LMP1. In NPC cells in vitro and in vivo, LSH promoted cancer progression in part by regulating expression of fumarate hydratase (FH), a core component of the tricarboxylic acid (TCA) cycle. LSH bound to the FH promoter, recruiting the epigenetic silencer factor G9a to repress FH transcription. Clinically, we found that the concentration of TCA intermediates in NPC patient sera was deregulated in the presence of LSH. RNAi-mediated silending of FH mimicked LSH overexpression, establishing FH as downstream mediator of LSH effects. The TCA intermediates α-KG and citrate potentiated the malignant character of NPC cells, in pa...

Low expression of Aldo-keto reductase 1B10 is a novel independent prognostic indicator for nasopharyngeal carcinoma

Cell & bioscience, 2016

Nasopharyngeal carcinoma (NPC) is one of the most common human head and neck cancers with high in... more Nasopharyngeal carcinoma (NPC) is one of the most common human head and neck cancers with high incidence in Southern China, Southeast Asia and North Africa. Because of its nonspecific symptoms, the early diagnosis of NPC is very difficult. The 5-year survival rate is not ideal in spite of great innovations in radiation and chemotherapy treatments. Highly sensitive and specific prognostic biomarkers are eager for NPC clinical diagnosis. To find specific target molecules is very important for individualized treatment. Aldo-keto reductase B10 (AKR1B10) is closely related to tumorigenesis and tumor development, and however, its expression level in NPC tissues is not clear. AKR1B10 expression levels were validated in benign, para-cancerous nasopharyngeal and NPC tissues by immunohistochemical evaluation. AKR1B10 was positively expressed in 42 (82.4 %) of 51 benign specimens, and 235 (98.7 %) of 238 para-carcinoma specimens. This percentage was significantly higher than 44.5 % (133/299) i...

Dynamically Evolving Annotation-Based Variability for Runtime Adaptation

2015 IEEE International Conference on Computer and Information Technology; Ubiquitous Computing and Communications; Dependable, Autonomic and Secure Computing; Pervasive Intelligence and Computing, 2015

Software applications are increasingly desirable to adapt to varying execution environments and d... more Software applications are increasingly desirable to adapt to varying execution environments and diverse user requirements to support runtime adaptation. Behavioral variations are generally modularized to handle variability. Depending on activating or deactivating relevant variations dynamically due to continuous context changes, a required behavioral variant specific to contexts is subsequently generated and has to evolve over time, to remain higher availability. However, since the potential amount of behavioral variants to be formed is huge, it is substantially unlikely to ensure all of them are type safe due to the unnecessary variants which are not used at all. To address this problem, we propose an annotation-based approach to variability. It can type check the entire program consisting of base program and many variations only once, without resulting from each variant individually. We extend the Featherweight Java to formally prove that all the expected variants are still well typed. Moreover, the type system guarantees type safety of the updated program as one variant evolves to another and type correctness that no run-time errors occur.

Radioimmunotherapy of human colorectal carcinoma xenografts using 90Y-labeled monoclonal antibody CO17-1A prepared by two bifunctional chelate techniques

Cancer research, 1990

Monoclonal antibody CO17-1A, which has specificity for colorectal and pancreatic carcinomas, was ... more Monoclonal antibody CO17-1A, which has specificity for colorectal and pancreatic carcinomas, was radiolabeled with the pure beta emitter, 90Y, by either the cyclic diethylenetriaminepentaacetic acid (DTPA) anhydride technique or by a site-specific bifunctional chelate technique using 1-(p-aminobenzyl)DTPA (p-NH2-Bz-DTPA). Female nude mice bearing SW 948 human colorectal carcinoma xenografts were given injections i.v. of 90Y-labeled monoclonal antibody CO17-1A at dosages of 100, 150, and 200 muCi/25 g body weight. Unlabeled CO17-1A (100 micrograms/25 g body weight) was coadministered. In animals receiving 90Y-CO17-1A prepared by the cyclic DTPA anhydride technique, tumor volume was unchanged from base line at a dose of 200 microCi/25 g. As the dosage of 90Y-CO17-1A increased, the rate of tumor growth decreased, but all experimental animals in this group died between 14 and 21 days. In contrast, CO17-1A radiolabeled with 90Y by the site-specific p-NH2-Bz-DTPA bifunctional chelate tech...

Growth and characterization of the interface

Surface Science, 1996

The structure and electronic properties of the interfaces formed by Re evaporation on clean Si(11... more The structure and electronic properties of the interfaces formed by Re evaporation on clean Si(111)-7 X 7 and subsequent annealing were investigated by low energy electron diffraction (LEED), Photoelectron spectroscopy (XPS/XAES, UPS) and work function (WF) measurements. Rhenium was deposited from submonolayer up to 50 ML coverages and gradually annealed up to 1100 K. Deposition causes rapid disappearance of the 7 X 7 reconstruction and the substrate UPS features, a gradual increase in the WF from 4.5 to 5.1 eV and negligible chemical shift in the XPS/XAES peaks. The interface remained abrupt with no intermixing, as metallic Re grew in a simultaneous mulfilayers fashion above 0.8 ML coverage. Annealing of 50 ML of Re causes a Si enrichment of the overlayer above 600 K and the formation at around 950 K of a continuous layer of silicide which remains stable up to 1100 K, whereas annealing of Re layers close to 1 ML creates ReSi 2 islands on the substrate surface.

Screening for methylation-silenced genes in acute myeloid leukemia HL-60 cell line by a quantitative proteomic approach

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2010

To screen for new methylation association genes in HL-60 to reveal the pathogenesis of leukemia, ... more To screen for new methylation association genes in HL-60 to reveal the pathogenesis of leukemia, and provide important theoretical and scientific basis for the prevention and cure of leukemia. Two-dimensional fluorescence difference gel electrophoresis (F-2D-DIGE) was performed to separate the total proteins from acute myelogenous leukemia (AML) cell line HL-60 cells with or without 5-aza-2-deoxycytidine (5-aza-2-dC) treatment. Imaging software Decyder 6.5 and PDQuest were used to detect the differential expression protein spots, and matrix-assisted laser desorption/ionizaion time-of-flight mas spectrometer (MALDI-TOF MS) was adopted to identify the differential expression proteins. F-2D-DIGE maps of 5-aza-2-dC-untreated HL-60 and-treated HL-60 cells were established. A total of 53 differential protein spots were detected, and 35 differential proteins were successfully identified. Of the identified proteins, 32 proteins were up-regulated, and 3 proteins were down-regulated in HL-60 ...

Potassium adsorption on β-FeSi2 thin films

Surface Science Letters, 1991

Potassium adsorption on thin fl-FeSi 2 epitaxiaUy grown on Si(111) was studied with ultraviolet p... more Potassium adsorption on thin fl-FeSi 2 epitaxiaUy grown on Si(111) was studied with ultraviolet photoemission spectroscopy (UPS), Auger electron spectroscopy (AES) and work function (WF) measurements. A value of (4.65 + 0.03) eV was measured for the absolute WF of the silicide surface. A combination of the experimental results upon K deposition indicates a plausible mode of K adsorption on fl-FeSi 2. Initially K adsorbs on Si triangular sites with a Fe atom underneath up to a coverage of-2 x 1014 atoms cm-2 and then on Si triangular sites with no Fe underneath up to a saturation coverage of-2 x 1014 atoms cm-2.