Books by Sujata Maiti Choudhury
Kripa-Drishti Publications, Pune., 2021
Environmental degradation means the disintegration or deterioration of the environment and
its co... more Environmental degradation means the disintegration or deterioration of the environment and
its components affecting through the consumption or destruction of the valuable assets of
the earth due to scarcity of resources, accelerated soil erosion, landslides, droughts, floods,
declines of forest cover, decline in agricultural yields, siltation problem, shrinking of biodiversity etc. These results in the destruction of environment along with the abolition of
wildlife and then environment become unsupportive to its living components. The major
causes behind the environmental degradation are urbanization, industrialization, overpopulation, deforestation etc. Environmental pollution refers to the degradation of both the
quality and quantity of natural resources.
Some undesirable and detrimental human activities are responsible for the environmental
degradation producing different types of degrading particles and substances in the
environment. The exposure of these degrading particles and substances affect air, water and
soil throughout the world making the earth environment unsuitable for the living species.
Deterioration of the agricultural land is being affected by the quality of soil and climate
change and these factors are facilitating this incident. The overall impacts of environmental
degradation are forcing to destabilize the ecosystem as well as the global climate.
Environmental degradation can be prevented by framing effective relevant policies related
to the use of renewable sources of energy instead of non-renewable sources, protection of
species from their extinction, conservation of water resources from the polluted materials
and chemicals from industries, factories, formulation of energy saving plan for community.
Though the government has launched many programmes and policies but still there are more
needs for drastic interventions from national and international levels as well as individual
awareness which is necessary to maintain and continue the ecological balance and
sustainability.
Keywords: Environmental degradation, Deterioration of natural resources, Environmental
pollution, Ecological balance and sustainability.
Papers by Sujata Maiti Choudhury
KDPublications, Jul 15, 2021
Anacardium occidentale of family Anacardiaceae is a tropical tree and used traditionally for the ... more Anacardium occidentale of family Anacardiaceae is a tropical tree and used traditionally for the treatment of different diseases. In the present study, we have evaluated the anti-mitotic and cytotoxic activities of ethanolic (EEAOL), methanolic (MEAOL) and water (WEAOL) extracts of Anacardium occidentaleleaf in Allium cepa root tip cells and against Sarcoma-180 cell lines. Ethanol, methanol, and water extracts were prepared from pulverized powder obtained from shed-dried leaves of Anacardium occidentale. The antimitotic activity was measured using Allium cepa root meristematic cells. The studies were extended to Sarcoma-180 cell lines to obtain the cytotoxic potential of the plant. Anacardium occidentaleextracts were found to be antimitotic for Allium cepa root tip cells at the concentration of 100mg/ml and also exhibited in vitro cytotoxicity against Sarcoma-180 cell lines at100 μg/ml concentration. These findings reveal that Anacardium occidentale leaf possesses pronounced antimit...
VirusDisease
The third SARS-CoV-2 pandemic wave causing Omicron variant has comparatively higher replication r... more The third SARS-CoV-2 pandemic wave causing Omicron variant has comparatively higher replication rate and transmissibility than the second wave-causing Delta variant. The exact mechanism behind the differential properties of Delta and Omicron in respect to infectivity and virulence is not properly understood yet. This study reports the analysis of different mutations within the receptor binding domain (RBD) of spike glycoprotein and non-structural protein (nsp) of Delta and Omicron strains. We have used computational studies to evaluate the properties of Delta and Omicron variants in this work. Q498R, Q493R and S375F mutations of RBD showed better docking scores for Omicron compared to Delta variant of SARS-CoV-2, whereas nsp3_L1266I with PARP15 (7OUX), nsp3_L1266I with PARP15 (7OUX), and nsp6_G107 with ISG15 (1Z2M) showed significantly higher docking score. The findings of the present study might be helpful to reveal the probable cause of relatively milder form of COVID-19 disease manifested by Omicron in comparison to Delta variant of SARS-CoV-2 virus.
Toxicology and Forensic Medicine – Open Journal, 2021
Aim The present study investigated the effects of cypermethrin exposure on humoral and cellular i... more Aim The present study investigated the effects of cypermethrin exposure on humoral and cellular immune response in rat and its attenuation by zinc and alpha-lipoic acid. Methods Cypermethrin at the dose levels of 40 mg and 80 mg/kg body weight were orally administered and pre-treatment of zinc (227 mg/L in drinking water) and alpha-lipoic acid (35 mg/kg body wt.) were done. Total leukocyte and differential leukocyte counts (DLC), phagocytic index, serum nitric oxide (NO) activity, total immunoglobulin concentration, quantitative hemolysis, proliferation assay of blood mononuclear cells were estimated and histological examination of spleen was accomplished. Results Total white blood cell (WBC) count and percentage of lymphocyte, serum nitric oxide activity (p<0.001) and quantitative hemolysis were increased significantly increased whereas neutrophil %, total serum immunoglobulin, and blood mononuclear cell proliferation (p<0.001) and the phagocytic function of peritoneal macrop...
Journal of Drug Delivery Science and Technology
Industrial & Engineering Chemistry Research, 2018
Amide linkage containing two nicotinic acid amphiphiles have been investigated for their gelemuls... more Amide linkage containing two nicotinic acid amphiphiles have been investigated for their gelemulsion and glucose sensing properties. In emulsions, the synthesized materials were used as stabilizers in water medium, whereas organic solvents and/or mineral oils as dispersed phase and water acts as a continuous phase. The gel-emulsions were prepared at room temperature by stirring or shaking and no heating-cooling arrangement or addition of any other co-solvents, active agents are mandatory. Rheological investigation of these amphiphiles showed mechanical stability of gel-emulsions and its viscoelasticity. Optical images confirmed the existence of network structures in gel-emulsion phase for both the amphiphiles. FE-SEM measurement suggests the morphology depends on the solvent:water composition. XRD study proposed that the arrangements of the amphiphiles in the emulsion state are different. The gel-emulsions formed by the studied amphiphiles are able to entrap and release bio-molecule, anticancer drug
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2021
Abstract Gelation performances of three synthesized short tripeptide based amphiphiles [11-(2-ter... more Abstract Gelation performances of three synthesized short tripeptide based amphiphiles [11-(2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-undecanoylamino]-acetic acid TBMBUA (A), [11-(2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-undecanoylamino]-acetic acid TBMPUA (B) and [11-(2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-undecanoylamino]-acetic acid TBPPUA (C) have been investigated. The results recommended that these can act as good hydrogelators. Various instrumental techniques like Field Emission Scanning Electron Microscopic (FE-SEM) and high resolution Transmission Electron Microscopic (HR-TEM) imaging for morphological analyses of hydrogel, X-ray Diffraction analyses to know packing pattern of gelators in the assembled state, Fourier Transformed Infrared Spectroscopic (FT-IR) measurements to execute role of hydrogen bonding in the gel morphology and rheological experiments for investigation of mechanical stability were carried out to characterize the hydrogels. Prepared hydrogels were employed for entrapment and release of Vitamin B12 and Doxorubicin, an anticancer drug molecule. The study revealed that the release capacity is dependent on pH of the medium. Synthesized hydrogelators (TBMBUA, TBMPUA and TBPPUA) showed anticancer activity by exhibiting in vitro cytotoxicity against the human breast cancer cell line (MCF-7 cell) as well as in-vivo cancer cell line (EAC cell) using MTT assay. The gelators did not exhibit any notable lethality towards normal human lymphocytes up to the concentration of 25 µg/ml. These results propose that the utilization of hydrogelators for localized breast cancer therapy may have a high therapeutic potential.
New Journal of Chemistry, 2022
An azo armed Schiff base chemosensor was synthesized based on naphthalene fluorophore, which tran... more An azo armed Schiff base chemosensor was synthesized based on naphthalene fluorophore, which transduces greenish-yellow emission by complexing with Al3+. It emits greenish-yellow fluorescent through restricted C=N isomerization, chelation-enhanced fluorescence,...
Asian Journal of Medical Sciences, 2022
The sudden outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the year 2... more The sudden outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the year 2020, has had an impact on different fields of the human life including health sciences, economics, societies and international relations. Science and technology play a crucial role in fighting this ‘war without smoke’. The enormous power of science to manage the critical situation, arises during a pandemic and reminds us that by promoting scientific cultures we can overcome the situation. We must have faith on science in high regard. Although technology will not be able to restrict the onset of a pandemic; nevertheless, it can assist in dealing the emergency more effectively. During this time of sheer uncertainty and constant anxiety, our preparedness to adopt technology has been our lifeline. Certain applications of innovative approach of science and technology include distance learning, contact tracing applications, contactless online deliveries, dissemination of information, technolog...
Current Protein & Peptide Science, 2022
Background: COVID-19 is a worldwide threat because of the incessant spread of SARS-CoV-2 which ur... more Background: COVID-19 is a worldwide threat because of the incessant spread of SARS-CoV-2 which urges the development of suitable antiviral drug to secure our society. Already, a group of peptides have been recommended for SARS-CoV-2, but not yet established. SARS-CoV-2 is an enveloped virus with hydrophobic fusion protein and spike glycoproteins. Methods: Here, we have summarized several reported amphiphilic peptides and their in-silico docking analysis with spike glycoprotein of SARS-CoV-2. Result: The result revealed the complex formation of spike protein and amphiphilic peptides with higher binding affinity. It was also observed that PalL1 (ARLPRTMVHPKPAQP), 10AN1 (FWFTLIKTQAKQPARYRRFC), THETA defensin (RCICGRGICRLL) and mucroporin M1 (LFRLIKSLIKRLVSAFK) showed the binding free energy more than -1000 kcal/mol. Molecular pI and hydrophobicity are also important factors of peptides to enhance the binding affinity with spike protein of SARS-CoV-2 Conclusion: In the light of these fi...
Antineoplastic activities of MT81 and its structural analogue in ehrlich ascites carcinoma-bearin... more Antineoplastic activities of MT81 and its structural analogue in ehrlich ascites carcinoma-bearing swiss albino mice
We investigated several global behaviors of the weak KAM solutions uc(x, t) parametrized by c ∈ H... more We investigated several global behaviors of the weak KAM solutions uc(x, t) parametrized by c ∈ H 1 (T, R). For the suspended Hamiltonian H(x, p, t) of the exact symplectic twist map, we could find a family of weak KAM solutions uc(x, t) parametrized by c(σ) ∈ H 1 (T, R) with c(σ) continuous and monotonic and such that sequence of weak KAM solutions {uc} c∈H 1 (T,R) is 1/2-Hölder continuity of parameter σ ∈ R. Moreover, for each generalized characteristic (no matter regular or singular) solving we evaluate it by a uniquely identified rotational number ω(c) ∈ H 1 (T, R). This property leads to a certain topological obstruction in the phase space and causes local transitive phenomenon of trajectories. Besides, we discussed this applies to high-dimensional cases.
International Journal of Phytomedicine, 2015
Eupatorium ayapana of Asteraceae family was found to possess useful therapeutic properties like h... more Eupatorium ayapana of Asteraceae family was found to possess useful therapeutic properties like hypoglycaemic, antimicrobial, hematoprotective, hepatoprotective, and antioxidant activities. The present study was aimed to evaluate the antimitotic, cytotoxic and apoptotic potential of the ethanolic and water extracts of Eupatorium ayapana leaf on Ehrlich’s ascites carcinoma. Antimitotic study was done by using Allium cepa root tips model. In vitro cytotoxicity was determined by MTT assay, apoptosis was determined by fluorescence microscopy, and cell cycle progression was analysed using flow cytometry; in vivo antitumor activity was performed in Ehrlich’s ascites carcinoma bearing mice. Ethanolic and water extracts of Eupatorium ayapana leaf showed significant decrease in mitotic index. The IC 50 value of ethanolic, and water extracts were 100.6 𝜇g/mL, 112.7 𝜇g/ml respectively in Ehrlich’s ascites carcinoma cells. Fluorescence microscopy analysis showed significant increase in apoptoti...
Cypermethrin, a type II synthetic pyrethroid, is widely used in agricultural field, animal husban... more Cypermethrin, a type II synthetic pyrethroid, is widely used in agricultural field, animal husbandry and public health sector. This study was conducted to investigate the effects of cypermethrin on antioxidant enzyme activities and lipid peroxidation (LPO) in female rats and the protective effect of zinc and α-lipoic acid. In this study, cypermethrin was orally administered at 34.33 and 51.5 mg/kg dose levels for consecutive 14 days alone or along withpre-administration of zinc (1-2mg/kg body wt) and αlipoic acid (35 mg/kg body wt). Cypermethrin caused significant increase in LPO and decrease in reducedglutathione (GSH) level, superoxide dismutase, and glutathione peroxidase activity. Co-administration of zinc and α-lipoic acid attenuated cypermethrin induced ovarian oxidative stress by decreasing LPO in ovary. In addition to this, zinc and α-lipoic acid increased ovarian GSH level and superoxide dismutase, glutathione peroxidase activity. From the findings, it can be concluded that...
Medicinal plants have gained significant importance in the potential management of cancer. Eupato... more Medicinal plants have gained significant importance in the potential management of cancer. Eupatorium ayapana , belonging to the Asteraceae, is therapeutically used as an antiseptic, antidysenteric, antibacterial and haemostatic agent. The present study was aimed to evaluate the antioxidant potential of ethanolic (EEEAL) and water extracts (WEEAL) of Eupatorium ayapana leaf in Ehrlich’s ascites carcinoma-bearing Swiss albino mice. EEEAL, WEEAL were administered intraperitoneally at the dose level of 150 mg/kg b ody weight/day for consecutive 14 days after 24 hours of EAC cell inoculation (1×10 6 cell) to mice using 5fluorouracil as standard drug. Treatment with the extracts decreased the levels of hepatic and renal malon-dialdehyde (MDA), oxidized glutathione (GSSG) and increased reduced glutathione (GSH) level, catalase (CAT) and super oxide dismutase (SOD) activity in EAC-bearing mice. The study reveals that the extracts of Eupatorium ayapana leaf exhibit antioxidant activities in...
International Journal of Research in Medical Sciences, 2020
Background: Wasting, a form of malnutrition is a major public health burden in developing countri... more Background: Wasting, a form of malnutrition is a major public health burden in developing countries including India. Since, food and diet diversity have direct impact on nutritional status of children. The aim of the study was to assess the dietary consumption pattern and malnutrition based on mid upper arm circumference (MUAC) of Lodha tribal children of Paschim Medinipur and Jhargram districts of West Bengal, India.Methods: A total of 1043 Lodha preschool children (1-5 years) was selected for the present study. MUAC of the children was made and recorded by standard method. A questionnaire for 24-hour dietary recall method was applied to collect dietary information. Dietary diversity was calculated by standard techniques. All statistical analyses were performed by using Statistical package for social sciences (SPSS) software.Results: The mean±SD of MUAC was 129.7±11.3 mm. The results showed that the mean MUAC increased steadily with the advancement of age in both genders. Prevalenc...
International Journal of Nutrition, 2020
Aim To assess the sanitation and hygienic practices of women and its effects on the nutritional s... more Aim To assess the sanitation and hygienic practices of women and its effects on the nutritional status of the mother and preschool children of the Lodha tribal community in two districts of West Bengal. Methods A cross-sectional study was conducted during November, 2014 - December, 2018 of 941 Lodha mothers and 1043 of their preschool children in Paschim Medinipur and Jhargram districts. All information was collected by using KAP questionnaire following interview and group discussion. Mother nutritional status was assessed based on body mass index (BMI) and mid upper arm circumference (MUAC). A child was classified as underweight, stunting and wasting as weight-for-age, height-for-age and weight-of -height Z-score below -2 standard deviation of WHO standard. Results This study found 35% of the households used safe drinking water. Almost 97.2% of the mother had the low hand wash score and about 67.1% of them had an average WaSH score. Overall, 41.6% and 1.6% mothers were suffered fro...
Journal of Photochemistry and Photobiology A: Chemistry, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Uploads
Books by Sujata Maiti Choudhury
its components affecting through the consumption or destruction of the valuable assets of
the earth due to scarcity of resources, accelerated soil erosion, landslides, droughts, floods,
declines of forest cover, decline in agricultural yields, siltation problem, shrinking of biodiversity etc. These results in the destruction of environment along with the abolition of
wildlife and then environment become unsupportive to its living components. The major
causes behind the environmental degradation are urbanization, industrialization, overpopulation, deforestation etc. Environmental pollution refers to the degradation of both the
quality and quantity of natural resources.
Some undesirable and detrimental human activities are responsible for the environmental
degradation producing different types of degrading particles and substances in the
environment. The exposure of these degrading particles and substances affect air, water and
soil throughout the world making the earth environment unsuitable for the living species.
Deterioration of the agricultural land is being affected by the quality of soil and climate
change and these factors are facilitating this incident. The overall impacts of environmental
degradation are forcing to destabilize the ecosystem as well as the global climate.
Environmental degradation can be prevented by framing effective relevant policies related
to the use of renewable sources of energy instead of non-renewable sources, protection of
species from their extinction, conservation of water resources from the polluted materials
and chemicals from industries, factories, formulation of energy saving plan for community.
Though the government has launched many programmes and policies but still there are more
needs for drastic interventions from national and international levels as well as individual
awareness which is necessary to maintain and continue the ecological balance and
sustainability.
Keywords: Environmental degradation, Deterioration of natural resources, Environmental
pollution, Ecological balance and sustainability.
Papers by Sujata Maiti Choudhury
its components affecting through the consumption or destruction of the valuable assets of
the earth due to scarcity of resources, accelerated soil erosion, landslides, droughts, floods,
declines of forest cover, decline in agricultural yields, siltation problem, shrinking of biodiversity etc. These results in the destruction of environment along with the abolition of
wildlife and then environment become unsupportive to its living components. The major
causes behind the environmental degradation are urbanization, industrialization, overpopulation, deforestation etc. Environmental pollution refers to the degradation of both the
quality and quantity of natural resources.
Some undesirable and detrimental human activities are responsible for the environmental
degradation producing different types of degrading particles and substances in the
environment. The exposure of these degrading particles and substances affect air, water and
soil throughout the world making the earth environment unsuitable for the living species.
Deterioration of the agricultural land is being affected by the quality of soil and climate
change and these factors are facilitating this incident. The overall impacts of environmental
degradation are forcing to destabilize the ecosystem as well as the global climate.
Environmental degradation can be prevented by framing effective relevant policies related
to the use of renewable sources of energy instead of non-renewable sources, protection of
species from their extinction, conservation of water resources from the polluted materials
and chemicals from industries, factories, formulation of energy saving plan for community.
Though the government has launched many programmes and policies but still there are more
needs for drastic interventions from national and international levels as well as individual
awareness which is necessary to maintain and continue the ecological balance and
sustainability.
Keywords: Environmental degradation, Deterioration of natural resources, Environmental
pollution, Ecological balance and sustainability.