Papers by Spilios Argyropoulos
EThOS - Electronic Theses Online ServiceGBUnited Kingdo
Journal of Psychopharmacology, 2003
The inhalation of carbon dioxide (CO 2) is commonly used in patients and volunteers as a means of... more The inhalation of carbon dioxide (CO 2) is commonly used in patients and volunteers as a means of producing anxiety or panic. It is generally believed that patients with panic disorder are more vulnerable to the effects of CO 2 than patients with other anxiety disorders or healthy volunteers and there is speculation and debate as to the mechanism for this apparent sensitivity. Recent work from our group has shown that a single inhalation of 35% CO 2 activates the hypothalamic-pituitary-adrenocortical (HPA) axis, increases blood pressure (BP) and increases subjective fear responses in healthy volunteers. Correlation analyses reveal a relationship between the changes in BP and the cortisol increase. These findings led us to postulate that a common mechanism may mediate these and the subjective responses to inhalation of CO 2. We propose that the noradrenergic system, particularly the locus coeruleus (LC), but including the A1 and A2 cell groups, may be a key mediator of these responses. This article examines the evidence and discusses the results of studies from our laboratory in relation to a neuroanatomical model centring on the LC. K Ke ey y w wo or rd ds s: : a an nx xi ie et ty y, , b bl lo oo od d p pr re es ss su ur re e, , c ca ar rb bo on n d di io ox xi id de e, , c co or rt ti is so ol l, , l lo oc cu us s c co oe er ru ul le eu us s, , n no or ra ad dr re en na al li in ne e ((n no or re ep pi in ne ep ph hr ri in ne e)
Journal of Psychopharmacology, Oct 6, 2008
1. The Concept of Generalized Anxiety Disorder: Historical Introduction 2. Diagnosis, Classificat... more 1. The Concept of Generalized Anxiety Disorder: Historical Introduction 2. Diagnosis, Classification and Epidemiology of GAD 3. Course, Prognosis, Disability and Costs 4. Causation and Mechanisms of GAD 5. Depression and Generalized Anxiety 6. GAD and Panic Disorder 7. GAD and Obsessive-compulsive Disorder 8. Treatment 9. References 10. Index
Journal of Psychopharmacology, 2016
The 2002 paper “Does 5-HT restrain panic? A tryptophan depletion study in panic disorder patients... more The 2002 paper “Does 5-HT restrain panic? A tryptophan depletion study in panic disorder patients recovered on paroxetine” by Bell and colleagues – reprinted in this issue of the Journal – reports on a study undertaken in the halcyon days of David Nutt’s Psychopharmacology Unit at the University of Bristol, England. In this invited commentary authors of the original work discuss the impact of this paper on the field of acute tryptophan depletion research (especially in the field of clinical anxiety disorders) and the development of disorder-specific anxiogenic provocations over the past decade.
BMJ (Clinical research ed.), Jan 25, 2001
We may not be able to make you love reading, but pharmacogenetics of psychotropic drugs will lead... more We may not be able to make you love reading, but pharmacogenetics of psychotropic drugs will lead you to love reading starting from now. Book is the window to open the new world. The world that you want is in the better stage and level. World will always guide you to even the prestige stage of the life. You know, this is some of how reading will give you the kindness. In this case, more books you read more knowledge you know, but it can mean also the bore is full.
European Psychiatry, 2008
European Psychiatry, 2010
Selective serotonin reuptake inhibitors (SSRI) are the most commonly prescribed antidepressants. ... more Selective serotonin reuptake inhibitors (SSRI) are the most commonly prescribed antidepressants. It has been suggested however that SSRI administration may affect response inhibition and contextual processing but the available evidence is minimal. Therefore, the purpose of this study was to identify the effect size of acute (within 24 hours) and chronic (28 days) administration of the highly selective SSRI, Citalopram, compared to placebo on response inhibition (measured by the Degraded Symbol Continuous Performance Task [DS-CPT]) and contextual processing (assessed using a Delayed Non-Matching to Sample Task [DNMS]) in healthy males (n = 20) using a randomised double-blind design. We found no effect of Citalopram on participants’ performance on the DS-CPT which suggests either that SSRIs do not affect response inhibition or that this measure is insensitive to any potential disinhibition effects of SSRI. Acute, but not chronic, Citalopram administration was associated with a measura...
European Neuropsychopharmacology, 2006
Generalized anxiety disorder (GAD) frequently occurs comorbidly with other conditions, including ... more Generalized anxiety disorder (GAD) frequently occurs comorbidly with other conditions, including depression and somatic complaints. Comorbid GAD sufferers have increased psychologic and social impairment, request additional treatment, and have an extended course and poorer outcome than those with GAD alone; therapy should alleviate both the psychic and somatic symptoms of GAD without negatively affecting the comorbid condition. The ideal treatment would provide relief from both GAD and the comorbid condition, reducing the need for polypharmacy. Physicians need suitable tools to assist them in the detection and monitoring of GAD patients-the GADI, a new, self-rating scale, may meet this requirement. Clinical data have shown that various neurobiologic irregularities (e.g., in the GABA and serotonin systems) are associated with the development of anxiety. Prescribing physicians must take into account these abnormalities when choosing a drug. Effective diagnosis and treatment should improve patients' quality of life and their prognosis for recovery.
Serotonergic Neurocircuitry in Mood and Anxiety Disorders, 2003
Pediatric Clinical Advisor, 2007
Drugs, 2005
Most antidepressants change sleep; in particular, they alter the physiological patterns of sleep ... more Most antidepressants change sleep; in particular, they alter the physiological patterns of sleep stages recorded overnight with EEG and other physiological measures. These effects are greatest and most consistent on rapid eye movement (REM) sleep, and tend to be in the opposite direction to the sleep abnormalities found in major depression, but are usually of greater degree. Reductions in the amount of REM sleep and increases in REM sleep onset latency are seen after taking antidepressants, both in healthy volunteers and in depressed patients. Antidepressants that increase serotonin function by blocking reuptake or by inhibiting metabolism have the greatest effect on REM sleep. The decrease in amount of REM sleep appears to be greatest early in treatment, and gradually diminishes during long-term treatment, except after monoamine oxidase inhibitors when REM sleep is often absent for many months. Sleep initiation and maintenance are also affected by antidepressants, but the effects a...
Journal of Creativity in Mental Health
ABSTRACT Investigation of the relationship between creativity and psychopathology has yielded mix... more ABSTRACT Investigation of the relationship between creativity and psychopathology has yielded mixed results with few studies investigating the impact of psychopathology on creativity among professional artists. To address this gap, the present study compared 115 living Greek artists, with and without major psychiatric disorder, using self-report questionnaires measuring defense styles (DSQ-40), ego boundaries (BQ-18), and early trauma inventory (ETI-SR-SF). An open-ended exploratory questionnaire inquired about the effects of their psychological issues, upon their creative work. Results showed that artists with psychiatric disorder had thinner ego boundaries, employed more immature defense mechanisms, and reported higher rates of childhood trauma as well as expressing their creative endeavor as a “need” rather than “desire” and relied on their creative work as the sole means of livelihood.
Advances in Management and Treatment of Depression, 2003
Journal of Psychopharmacology, 2002
Uploads
Papers by Spilios Argyropoulos