Objective: We evaluated the safety and ef®cacy of high dose rate (HDR) brachytherapy using and 3D... more Objective: We evaluated the safety and ef®cacy of high dose rate (HDR) brachytherapy using and 3D conformal external beam radiotherapy in patients with localized prostate cancer. Methods: A total of 444 patients with localized prostate cancer underwent combined radiotherapy with interstitial Ir 192 and 3D conformal external beam radiotherapy between December 1992 and March 2001. The 230 patients, treated between December 1992 and December 1997 were analyzed. All patients underwent laparoscopic pelvic lymph node dissection to exclude patients with lymphatic involvement. Ir 192 was delivered twice with a 1-week interval in HDR remote control technique. The interstitial dose from December 1992 to December 1993 was 10 Gy, after December 1993 the dose was reduced to 9 Gy per treatment session. The interstitial application was followed by external beam radiation of 45 Gy for cT1±cT2 and 50.4 Gy for cT3 tumor (40 Gy from December 1992 to December 1993). Progression was de®ned as biochemical failure according to ASTRO criteria, e.g. three consecutive PSA rises following the PSA nadir. Results: The median PSA value decreased from 12.8 to 0.93 ng/ml 12 months after treatment. Median PSA value was 0.47 after 24 months, 0.30 ng/ml after 36 months and 0.18 ng/ml after 60 months. 68% of the biopsies were negative 24 months after therapy. Progression-free rate was 100% for cT1 tumors, 75% for cT2 and 60% for stage-cT3 on 5-year follow-up. Five-year overall survival was 93%, 5-year disease-speci®c survival was 98%. Initial PSA value <10 ng/ml, low stage and low grade were signi®cantly related to 5-year progression-free survival. Conclusions: Combined HDR brachytherapy with Ir 192 is an alternative treatment option especially for patients with cT3 prostate cancer. Initial PSA value, stage and grade, are important prognostic factors. #
Zusammenfassung Sind ausreichend Erfahrungen mit der laparoskopischen Prostatektomie vorhanden,... more Zusammenfassung Sind ausreichend Erfahrungen mit der laparoskopischen Prostatektomie vorhanden, ist der Schritt zur laparoskopischen Zystektomie nicht mehr sehr groß. Die eigentliche Herausforderung besteht in der laparoskopischen Konstruktion der Harnableitung. Wir berichten in diesem Artikel über Erfahrungen mit 11 laparoskopischen Zystektomien und der intrakorporalen Anlage eines Mainz Pouch II als kontinente Harnableitung bei Patienten mit einem muskelinvasiven Harnblasenkarzinom. Alle 11 Eingriffe
Turkiye Parazitolojii Dergisi Turkiye Parazitoloji Dernegi Acta Parasitologica Turcica Turkish Society For Parasitology, 2008
The aim of this study was to assess the effects of natural distomatosis infections on sheep liver... more The aim of this study was to assess the effects of natural distomatosis infections on sheep liver malondialdehyde (MDA) concentration, activities of enzymatic antioxidants (glutathione peroxidase (GPx), superoxide dismutase (Cu, Zn-SOD), catalase (CAT)) and concentrations of non-enzymatic antioxidants (reduced glutathione (GSH), vitamin C, and beta-carotene). Eighteen Akkaraman sheep naturally infected with Fasciola sp and Dicrocoelium dentriticum (D. dentriticum) and ten healthy Akkaraman sheep were included in the study Liver samples for the analysis of MDA, GPx, Cu, Zn-SOD, CAT, GSH, vitamin C, and beta-carotene and blood samples for the measurement of alanine aminotransferase and aspartate aminotransferase were collected immediately after sheep in the two groups were slaughtered. The concentration of MDA and activity of GPx in the group with distomatosis were higher than in the control group (P &amp;amp;amp;amp;amp;amp;lt; 0.001). However, the Cu, Zn-SOD, CAT activities and the GSH, vitamin C concentrations in the infected group were significantly lower than in the control group (P &amp;amp;amp;amp;amp;amp;lt; 0.001). The serum beta-carotene was not found to be statistically different in the two groups (P &amp;amp;amp;amp;amp;amp;gt; 0.05). ALT and AST serum activities of the group with distomatosis were significantly higher in comparison to the control group (P &amp;amp;amp;amp;amp;amp;lt; 0.001). In this study it was demonstrated that lipid peroxidation increased and activities or/and concentrations of antioxidant compounds were significantly changed in the liver of sheep with distomatosis.
Turkiye Parazitolojii Dergisi Turkiye Parazitoloji Dernegi Acta Parasitologica Turcica Turkish Society For Parasitology, Feb 1, 2008
Endoparasites cause significant economic losses and health problems in domestic animals. In this ... more Endoparasites cause significant economic losses and health problems in domestic animals. In this study, lipid peroxidation and the antioxidant status were investigated in the lung tissue taken from twenty cattle infected with Dictyocaulus viviparus and ten healthy cattle. Malondialdehyde superoxide dismutase, catalase, glutathione, vitamin C and beta-carotene were measured. In comparison to the control group, the concentration of MDA was high (p &amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), but the activities of Cu-Zn-SOD and CAT, and the concentration of GSH, vitamin C and beta-carotene were low (Cu-Zn-SOD, CAT, GSH, vitamin C, p &amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001 and beta-carotene p &amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) in the parasite infected group. These results suggested that endoparasitic infection is among the major causes of oxidative stress. Lipid peroxidation was observed and the activities and concentrations of antioxidants systems were decreased in the lungs of cattle infected with Dictyocaulus viviparus.
... Der initialer Median-PSA-Wert fiel von 12,3 ng/ml nach 3 Monaten auf 2,65 ng/ml, nach 6 Monat... more ... Der initialer Median-PSA-Wert fiel von 12,3 ng/ml nach 3 Monaten auf 2,65 ng/ml, nach 6 Monaten auf Der Urologe [A] 32001 | 197 ... Ryu S, Brown SL, Khil MS, Kim SH, Kim JH (1996) Preferential radiosensitization of human pro-static carcinoma cells by mild hyperthermia. ...
The aim of this study was to investigate the changes in the blood serum concentration of some bio... more The aim of this study was to investigate the changes in the blood serum concentration of some biochemical parameters and lipid-soluble vitamin levels in the goats naturally infested with lice and Trichostrongylidae before and after treatment with moxidectin and effects of ...
LLDN), which was first performed 7 years ago, 1 is now the routine procedure for kidney procureme... more LLDN), which was first performed 7 years ago, 1 is now the routine procedure for kidney procurement in more than 100 transplantation centers worldwide. Multiple retrospective and prospective studies demonstrated that LLDN combines the advantages for the donor of less postoperative pain, shorter hospital stay, and better cosmesis at no increased operative risk with an excellent organ quality, equivalent to open donor nephrectomy. 2-5 Following the increasing distribution of laparoscopic techniques in urologic departments, many European centers are now starting to offer LLDN. 6 -8 We will present the data of our LLDN program, which was initiated in February 1999, and compare donor and recipient outcomes with the open approach performed in our department. Actual matters concerning the technique of graft retrieval, safety for donor and recipient, economic aspects, and impact of LLDN on the local organ kidney transplant program will be discussed. LLDN were performed at our department, harvesting 54 left and nine right kidneys from donors aging 25 to 68 years (mean donor age 47.8 years). Eighteen donor kidneys had multiple vessels for blood supply (arterial and/or venous). Of the donors, 27 were genetically related to the recipient. Median HLA-A/-B and -DR mismatches for all LLDNs was 3 (0 -6).
Turkiye Parazitolojii Dergisi Turkiye Parazitoloji Dernegi Acta Parasitologica Turcica Turkish Society For Parasitology, Feb 1, 2009
This research was carried out in order to detect the prevalence of Linguatula serrata nymphs in l... more This research was carried out in order to detect the prevalence of Linguatula serrata nymphs in lung and mesenteric lymph nodes of sheep in Van province. For this purpose, mesenteric lymph nodes of 347 sheep and lung lymph nodes of 224 sheep were examined. L. serrata nymphs were found in 18 (5.19%) out of 347 sheep. L. serrata nymphs were not found in the lung lymph nodes of 224 sheep. In infected sheep, a total of 19 L. serrata nymphs were collected and two nymphs of L. serrata were seen in one mesenteric lymph node.
Zusammenfassung Die Brachytherapie des Prostatakarzinoms hat in den letzten Jahren auch in Deut... more Zusammenfassung Die Brachytherapie des Prostatakarzinoms hat in den letzten Jahren auch in Deutschland mehr Anwendung gefunden. Dabei kommen verschiedene Strahlenquellen in Frage. Diese unterscheiden sich teilweise aufgrund ihrer physikalischen Eigenschaften. Es werden permanente oder temporäre Strahlenquellen angewendet. Permanente Quellen sind 125Jod, 103Palladium und 198Gold. Als temporäre Quelle ist 192Iridium vorhanden. Der Erfolg der Brachytherapie ist von der Patienten- und der
ABSTRACT Due to the increasing waiting time for transplantation of a cadaveric kidney, living don... more ABSTRACT Due to the increasing waiting time for transplantation of a cadaveric kidney, living donor kidney transplantation is an increasingly oncoming issue. Laparoscopic donor nephrectomies (LDN) have been performed since 1995 and presently more than 100 transplant centers offer this minimally invasive surgical approach. The advantages for the donor of less pain, shorter hospital stay, earlier return to work, better cosmetic results in combination with an organ function equal to open donor nephrectomy are the reasons for an enormous increase in LDN. Since up to 30% of the donor kidneys have multiple vessels for blood supply, an increase of these organs for LDN can be expected. We performed a retrospective study of LDN at our center and compared donors with multiple vs single vessel supply. From February 1999 to September 2002, 63 LDN were performed at the department of Urology, Charité University Hospital, Berlin. A comparison between 18 donor kidneys with multiple vessel supply and 45 donor organs with single vessels showed no difference for the time of laparoscopic explantation (207 vs 201 min, p=0.4) or the warm (166 vs 148 s, p=0.2) and cold ischemic times (117 vs 103 min, p=0.66). As could be expected, the mixed ischemic time, i.e., the time for anastomosis of the kidney with the recipient&#39;s vessels, showed a significant difference (53 vs 46 min, p=0.02). Intra- and postoperative complication rates for donors and recipients were not different in both groups. Laparoscopic donor nephrectomy for kidneys with multiple vessels is feasible and safe for donor and recipient.
... Der initialer Median-PSA-Wert fiel von 12,3 ng/ml nach 3 Monaten auf 2,65 ng/ml, nach 6 Monat... more ... Der initialer Median-PSA-Wert fiel von 12,3 ng/ml nach 3 Monaten auf 2,65 ng/ml, nach 6 Monaten auf Der Urologe [A] 32001 | 197 ... Ryu S, Brown SL, Khil MS, Kim SH, Kim JH (1996) Preferential radiosensitization of human pro-static carcinoma cells by mild hyperthermia. ...
Objective: We evaluated the safety and ef®cacy of high dose rate (HDR) brachytherapy using and 3D... more Objective: We evaluated the safety and ef®cacy of high dose rate (HDR) brachytherapy using and 3D conformal external beam radiotherapy in patients with localized prostate cancer. Methods: A total of 444 patients with localized prostate cancer underwent combined radiotherapy with interstitial Ir 192 and 3D conformal external beam radiotherapy between December 1992 and March 2001. The 230 patients, treated between December 1992 and December 1997 were analyzed. All patients underwent laparoscopic pelvic lymph node dissection to exclude patients with lymphatic involvement. Ir 192 was delivered twice with a 1-week interval in HDR remote control technique. The interstitial dose from December 1992 to December 1993 was 10 Gy, after December 1993 the dose was reduced to 9 Gy per treatment session. The interstitial application was followed by external beam radiation of 45 Gy for cT1±cT2 and 50.4 Gy for cT3 tumor (40 Gy from December 1992 to December 1993). Progression was de®ned as biochemical failure according to ASTRO criteria, e.g. three consecutive PSA rises following the PSA nadir. Results: The median PSA value decreased from 12.8 to 0.93 ng/ml 12 months after treatment. Median PSA value was 0.47 after 24 months, 0.30 ng/ml after 36 months and 0.18 ng/ml after 60 months. 68% of the biopsies were negative 24 months after therapy. Progression-free rate was 100% for cT1 tumors, 75% for cT2 and 60% for stage-cT3 on 5-year follow-up. Five-year overall survival was 93%, 5-year disease-speci®c survival was 98%. Initial PSA value <10 ng/ml, low stage and low grade were signi®cantly related to 5-year progression-free survival. Conclusions: Combined HDR brachytherapy with Ir 192 is an alternative treatment option especially for patients with cT3 prostate cancer. Initial PSA value, stage and grade, are important prognostic factors. #
Zusammenfassung Sind ausreichend Erfahrungen mit der laparoskopischen Prostatektomie vorhanden,... more Zusammenfassung Sind ausreichend Erfahrungen mit der laparoskopischen Prostatektomie vorhanden, ist der Schritt zur laparoskopischen Zystektomie nicht mehr sehr groß. Die eigentliche Herausforderung besteht in der laparoskopischen Konstruktion der Harnableitung. Wir berichten in diesem Artikel über Erfahrungen mit 11 laparoskopischen Zystektomien und der intrakorporalen Anlage eines Mainz Pouch II als kontinente Harnableitung bei Patienten mit einem muskelinvasiven Harnblasenkarzinom. Alle 11 Eingriffe
Turkiye Parazitolojii Dergisi Turkiye Parazitoloji Dernegi Acta Parasitologica Turcica Turkish Society For Parasitology, 2008
The aim of this study was to assess the effects of natural distomatosis infections on sheep liver... more The aim of this study was to assess the effects of natural distomatosis infections on sheep liver malondialdehyde (MDA) concentration, activities of enzymatic antioxidants (glutathione peroxidase (GPx), superoxide dismutase (Cu, Zn-SOD), catalase (CAT)) and concentrations of non-enzymatic antioxidants (reduced glutathione (GSH), vitamin C, and beta-carotene). Eighteen Akkaraman sheep naturally infected with Fasciola sp and Dicrocoelium dentriticum (D. dentriticum) and ten healthy Akkaraman sheep were included in the study Liver samples for the analysis of MDA, GPx, Cu, Zn-SOD, CAT, GSH, vitamin C, and beta-carotene and blood samples for the measurement of alanine aminotransferase and aspartate aminotransferase were collected immediately after sheep in the two groups were slaughtered. The concentration of MDA and activity of GPx in the group with distomatosis were higher than in the control group (P &amp;amp;amp;amp;amp;amp;lt; 0.001). However, the Cu, Zn-SOD, CAT activities and the GSH, vitamin C concentrations in the infected group were significantly lower than in the control group (P &amp;amp;amp;amp;amp;amp;lt; 0.001). The serum beta-carotene was not found to be statistically different in the two groups (P &amp;amp;amp;amp;amp;amp;gt; 0.05). ALT and AST serum activities of the group with distomatosis were significantly higher in comparison to the control group (P &amp;amp;amp;amp;amp;amp;lt; 0.001). In this study it was demonstrated that lipid peroxidation increased and activities or/and concentrations of antioxidant compounds were significantly changed in the liver of sheep with distomatosis.
Turkiye Parazitolojii Dergisi Turkiye Parazitoloji Dernegi Acta Parasitologica Turcica Turkish Society For Parasitology, Feb 1, 2008
Endoparasites cause significant economic losses and health problems in domestic animals. In this ... more Endoparasites cause significant economic losses and health problems in domestic animals. In this study, lipid peroxidation and the antioxidant status were investigated in the lung tissue taken from twenty cattle infected with Dictyocaulus viviparus and ten healthy cattle. Malondialdehyde superoxide dismutase, catalase, glutathione, vitamin C and beta-carotene were measured. In comparison to the control group, the concentration of MDA was high (p &amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), but the activities of Cu-Zn-SOD and CAT, and the concentration of GSH, vitamin C and beta-carotene were low (Cu-Zn-SOD, CAT, GSH, vitamin C, p &amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001 and beta-carotene p &amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) in the parasite infected group. These results suggested that endoparasitic infection is among the major causes of oxidative stress. Lipid peroxidation was observed and the activities and concentrations of antioxidants systems were decreased in the lungs of cattle infected with Dictyocaulus viviparus.
... Der initialer Median-PSA-Wert fiel von 12,3 ng/ml nach 3 Monaten auf 2,65 ng/ml, nach 6 Monat... more ... Der initialer Median-PSA-Wert fiel von 12,3 ng/ml nach 3 Monaten auf 2,65 ng/ml, nach 6 Monaten auf Der Urologe [A] 32001 | 197 ... Ryu S, Brown SL, Khil MS, Kim SH, Kim JH (1996) Preferential radiosensitization of human pro-static carcinoma cells by mild hyperthermia. ...
The aim of this study was to investigate the changes in the blood serum concentration of some bio... more The aim of this study was to investigate the changes in the blood serum concentration of some biochemical parameters and lipid-soluble vitamin levels in the goats naturally infested with lice and Trichostrongylidae before and after treatment with moxidectin and effects of ...
LLDN), which was first performed 7 years ago, 1 is now the routine procedure for kidney procureme... more LLDN), which was first performed 7 years ago, 1 is now the routine procedure for kidney procurement in more than 100 transplantation centers worldwide. Multiple retrospective and prospective studies demonstrated that LLDN combines the advantages for the donor of less postoperative pain, shorter hospital stay, and better cosmesis at no increased operative risk with an excellent organ quality, equivalent to open donor nephrectomy. 2-5 Following the increasing distribution of laparoscopic techniques in urologic departments, many European centers are now starting to offer LLDN. 6 -8 We will present the data of our LLDN program, which was initiated in February 1999, and compare donor and recipient outcomes with the open approach performed in our department. Actual matters concerning the technique of graft retrieval, safety for donor and recipient, economic aspects, and impact of LLDN on the local organ kidney transplant program will be discussed. LLDN were performed at our department, harvesting 54 left and nine right kidneys from donors aging 25 to 68 years (mean donor age 47.8 years). Eighteen donor kidneys had multiple vessels for blood supply (arterial and/or venous). Of the donors, 27 were genetically related to the recipient. Median HLA-A/-B and -DR mismatches for all LLDNs was 3 (0 -6).
Turkiye Parazitolojii Dergisi Turkiye Parazitoloji Dernegi Acta Parasitologica Turcica Turkish Society For Parasitology, Feb 1, 2009
This research was carried out in order to detect the prevalence of Linguatula serrata nymphs in l... more This research was carried out in order to detect the prevalence of Linguatula serrata nymphs in lung and mesenteric lymph nodes of sheep in Van province. For this purpose, mesenteric lymph nodes of 347 sheep and lung lymph nodes of 224 sheep were examined. L. serrata nymphs were found in 18 (5.19%) out of 347 sheep. L. serrata nymphs were not found in the lung lymph nodes of 224 sheep. In infected sheep, a total of 19 L. serrata nymphs were collected and two nymphs of L. serrata were seen in one mesenteric lymph node.
Zusammenfassung Die Brachytherapie des Prostatakarzinoms hat in den letzten Jahren auch in Deut... more Zusammenfassung Die Brachytherapie des Prostatakarzinoms hat in den letzten Jahren auch in Deutschland mehr Anwendung gefunden. Dabei kommen verschiedene Strahlenquellen in Frage. Diese unterscheiden sich teilweise aufgrund ihrer physikalischen Eigenschaften. Es werden permanente oder temporäre Strahlenquellen angewendet. Permanente Quellen sind 125Jod, 103Palladium und 198Gold. Als temporäre Quelle ist 192Iridium vorhanden. Der Erfolg der Brachytherapie ist von der Patienten- und der
ABSTRACT Due to the increasing waiting time for transplantation of a cadaveric kidney, living don... more ABSTRACT Due to the increasing waiting time for transplantation of a cadaveric kidney, living donor kidney transplantation is an increasingly oncoming issue. Laparoscopic donor nephrectomies (LDN) have been performed since 1995 and presently more than 100 transplant centers offer this minimally invasive surgical approach. The advantages for the donor of less pain, shorter hospital stay, earlier return to work, better cosmetic results in combination with an organ function equal to open donor nephrectomy are the reasons for an enormous increase in LDN. Since up to 30% of the donor kidneys have multiple vessels for blood supply, an increase of these organs for LDN can be expected. We performed a retrospective study of LDN at our center and compared donors with multiple vs single vessel supply. From February 1999 to September 2002, 63 LDN were performed at the department of Urology, Charité University Hospital, Berlin. A comparison between 18 donor kidneys with multiple vessel supply and 45 donor organs with single vessels showed no difference for the time of laparoscopic explantation (207 vs 201 min, p=0.4) or the warm (166 vs 148 s, p=0.2) and cold ischemic times (117 vs 103 min, p=0.66). As could be expected, the mixed ischemic time, i.e., the time for anastomosis of the kidney with the recipient&#39;s vessels, showed a significant difference (53 vs 46 min, p=0.02). Intra- and postoperative complication rates for donors and recipients were not different in both groups. Laparoscopic donor nephrectomy for kidneys with multiple vessels is feasible and safe for donor and recipient.
... Der initialer Median-PSA-Wert fiel von 12,3 ng/ml nach 3 Monaten auf 2,65 ng/ml, nach 6 Monat... more ... Der initialer Median-PSA-Wert fiel von 12,3 ng/ml nach 3 Monaten auf 2,65 ng/ml, nach 6 Monaten auf Der Urologe [A] 32001 | 197 ... Ryu S, Brown SL, Khil MS, Kim SH, Kim JH (1996) Preferential radiosensitization of human pro-static carcinoma cells by mild hyperthermia. ...
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