The performance of a sub-100-nm gate-length p-channel TFET-based biosensor (pTFET-BS) covering a ... more The performance of a sub-100-nm gate-length p-channel TFET-based biosensor (pTFET-BS) covering a wide range of protein-molecules is presented, and for the first time the optimized length-range of the nanogap cavity of the biosensor through the modeling of the presence of discrete number of biomolecules, followed by shift-saturation in corresponding transfer characteristics, is reported in this paper. Furthermore, considering a real time process related over-etching effect, a variability study on the random position of the conjugated protein-molecules within the cavity, followed by a corresponding statistical analysis, are carried out. Results show that 85% to 95% (65-85%) of total combinations produce beyond 50% of maximum V th-(I DS-) sensitivity values, ensuring stability and hence reliability of the proposed sensor device.
In this paper, for the first time, a unique pTFET-based biosensor device having channel epilayer ... more In this paper, for the first time, a unique pTFET-based biosensor device having channel epilayer has been introduced and its performance in the sensing domain has been studied in terms of five different sensitivity parameters. A rigorous analysis of the effect of the existent corner point (corner-effect) in the proposed device architecture on the sensitivity metrics has been performed for five different channel epilayer thicknesses, covering five different types of protein-molecules, viz., Apomyoglobin, Myoglobin, Protein-G, Ferricytochrome-C, and Ferrocytochrome-C. This is followed by determining detectability and optimum length-window of nanogap cavity of the proposed sensor device for the successful detection. Interestingly, it has been found that the undesired corner-effect, generally known for its unfavorable impact on the electrical behaviors of the MOS-based structures, actually comes to the aid by enhancing the detectability of the proposed device compared to its equivalent conventional SOI pTFET sensor device by almost 67% (for Protein-G, Ferricytochrome-C, and Ferrocytochrome-C) and 50% (for Apomyoglobin and Myoglobin) yet maintaining significantly good values for the sensitivity metrics throughout. Furthermore, smaller epilayer thicknesses ensure smaller optimum length-window of the nanogap cavity, resulting in more scaled-down device, compared to larger epilayer thickness values. A position-dependent variability study for the detectability also follows, and it has been found that for small epilayer thicknesses this dependency becomes large leading to less stable device, although, at the same time producing higher sensitivity metrics compared to the devices having large epilayer thicknesses. This makes the choice of channel epilayer thickness as application-specific.
The performance of a sub-100-nm gate-length p-channel TFET-based biosensor (pTFET-BS) covering a ... more The performance of a sub-100-nm gate-length p-channel TFET-based biosensor (pTFET-BS) covering a wide range of protein-molecules is presented, and for the first time the optimized length-range of the nanogap cavity of the biosensor through the modeling of the presence of discrete number of biomolecules, followed by shift-saturation in corresponding transfer characteristics, is reported in this paper. Furthermore, considering a real time process related over-etching effect, a variability study on the random position of the conjugated protein-molecules within the cavity, followed by a corresponding statistical analysis, are carried out. Results show that 85% to 95% (65-85%) of total combinations produce beyond 50% of maximum V th-(I DS-) sensitivity values, ensuring stability and hence reliability of the proposed sensor device.
In this paper, for the first time, a rigorous analysis of determining minimum number of biomolecu... more In this paper, for the first time, a rigorous analysis of determining minimum number of biomolecules and maximum length of the nanogap cavity, used to entrap biomolecules for the detection purpose, has been done. A pTFET-based biosensor (pTB-sensor) device is being proposed, and the corresponding detection sensitivity in terms of threshold voltage (Vth)—sensitivity, threshold voltage (Vth)—shift, subthreshold swing (SS) sensitivity, subthreshold swing (SS) shift, ON current/OFF current (ION/IOFF)—shift, leakage power (Pleak)—sensitivity is determined. It is found that the minimum number of biomolecules or minimum detection limit is 2 for Myoglobin and Apomyoglobin, while the same is 3 for Protein-G, Ferricytochrome-C, and Ferrocytochrome-C, respectively. The maximum biomolecules required for successful detection are found to be 5 for Myoglobin and Apomyoglobin, while the same is 7 for Protein-G, Ferricytochrome-C, and Ferrocytochrome-C, respectively, with 78%, 67%, 41%, 55%, and 50%...
The performance of a sub-100-nm gate-length p-channel TFET-based biosensor (pTFET-BS) covering a ... more The performance of a sub-100-nm gate-length p-channel TFET-based biosensor (pTFET-BS) covering a wide range of protein-molecules is presented, and for the first time the optimized length-range of the nanogap cavity of the biosensor through the modeling of the presence of discrete number of biomolecules, followed by shift-saturation in corresponding transfer characteristics, is reported in this paper. Furthermore, considering a real time process related over-etching effect, a variability study on the random position of the conjugated protein-molecules within the cavity, followed by a corresponding statistical analysis, are carried out. Results show that 85% to 95% (65-85%) of total combinations produce beyond 50% of maximum V th-(I DS-) sensitivity values, ensuring stability and hence reliability of the proposed sensor device.
In this paper, for the first time, a unique pTFET-based biosensor device having channel epilayer ... more In this paper, for the first time, a unique pTFET-based biosensor device having channel epilayer has been introduced and its performance in the sensing domain has been studied in terms of five different sensitivity parameters. A rigorous analysis of the effect of the existent corner point (corner-effect) in the proposed device architecture on the sensitivity metrics has been performed for five different channel epilayer thicknesses, covering five different types of protein-molecules, viz., Apomyoglobin, Myoglobin, Protein-G, Ferricytochrome-C, and Ferrocytochrome-C. This is followed by determining detectability and optimum length-window of nanogap cavity of the proposed sensor device for the successful detection. Interestingly, it has been found that the undesired corner-effect, generally known for its unfavorable impact on the electrical behaviors of the MOS-based structures, actually comes to the aid by enhancing the detectability of the proposed device compared to its equivalent conventional SOI pTFET sensor device by almost 67% (for Protein-G, Ferricytochrome-C, and Ferrocytochrome-C) and 50% (for Apomyoglobin and Myoglobin) yet maintaining significantly good values for the sensitivity metrics throughout. Furthermore, smaller epilayer thicknesses ensure smaller optimum length-window of the nanogap cavity, resulting in more scaled-down device, compared to larger epilayer thickness values. A position-dependent variability study for the detectability also follows, and it has been found that for small epilayer thicknesses this dependency becomes large leading to less stable device, although, at the same time producing higher sensitivity metrics compared to the devices having large epilayer thicknesses. This makes the choice of channel epilayer thickness as application-specific.
The performance of a sub-100-nm gate-length p-channel TFET-based biosensor (pTFET-BS) covering a ... more The performance of a sub-100-nm gate-length p-channel TFET-based biosensor (pTFET-BS) covering a wide range of protein-molecules is presented, and for the first time the optimized length-range of the nanogap cavity of the biosensor through the modeling of the presence of discrete number of biomolecules, followed by shift-saturation in corresponding transfer characteristics, is reported in this paper. Furthermore, considering a real time process related over-etching effect, a variability study on the random position of the conjugated protein-molecules within the cavity, followed by a corresponding statistical analysis, are carried out. Results show that 85% to 95% (65-85%) of total combinations produce beyond 50% of maximum V th-(I DS-) sensitivity values, ensuring stability and hence reliability of the proposed sensor device.
In this paper, for the first time, a rigorous analysis of determining minimum number of biomolecu... more In this paper, for the first time, a rigorous analysis of determining minimum number of biomolecules and maximum length of the nanogap cavity, used to entrap biomolecules for the detection purpose, has been done. A pTFET-based biosensor (pTB-sensor) device is being proposed, and the corresponding detection sensitivity in terms of threshold voltage (Vth)—sensitivity, threshold voltage (Vth)—shift, subthreshold swing (SS) sensitivity, subthreshold swing (SS) shift, ON current/OFF current (ION/IOFF)—shift, leakage power (Pleak)—sensitivity is determined. It is found that the minimum number of biomolecules or minimum detection limit is 2 for Myoglobin and Apomyoglobin, while the same is 3 for Protein-G, Ferricytochrome-C, and Ferrocytochrome-C, respectively. The maximum biomolecules required for successful detection are found to be 5 for Myoglobin and Apomyoglobin, while the same is 7 for Protein-G, Ferricytochrome-C, and Ferrocytochrome-C, respectively, with 78%, 67%, 41%, 55%, and 50%...
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Papers by Sanu Gayen