Papers by Sabyasachi Sengupta
Indian Journal of Ophthalmology
Indian Journal of Ophthalmology
Indian Journal of Ophthalmology
Journal of Cataract & Refractive Surgery
Indian Journal of Ophthalmology
Indian Journal of Ophthalmology
Indian Journal of Ophthalmology
The purpose of this study was to review the incidence and microbiology of acute postcataract surg... more The purpose of this study was to review the incidence and microbiology of acute postcataract surgery endophthalmitis in India. Methods: Systematic review of English-language PubMed referenced articles on endophthalmitis in India published in the past 21 years (January 1992-December 2012), and retrospective chart review of 2 major eye care facilities in India in the past 5 years (January 2010-December 2014) were done. The incidence data were collected from articles that described "in-house" endophthalmitis and the microbiology data were collected from all articles. Both incidence and microbiological data of endophthalmitis were collected from two large eye care facilities. Case reports were excluded, except for the articles on cluster infection. Results: Six of 99 published articles reported the incidence of "in-house" acute postcataract surgery endophthalmitis, 8 articles reported the microbiology spectrum, and 11 articles described cluster infection. The clinical endophthalmitis incidence was between 0.04% and 0.15%. In two large eye care facilities, the clinical endophthalmitis incidence was 0.08% and 0.16%; the culture proven endophthalmitis was 0.02% and 0.08%. Gram-positive cocci (44%-64.8%; commonly, Staphylococcus species), and Gram-negative bacilli (26.2%-43%; commonly Pseudomonas species) were common bacteria in south India. Fungi (16.7%-70%; commonly Aspergillus flavus) were the common organisms in north India. Pseudomonas aeruginosa (73.3%) was the major organism in cluster infections. Conclusions: The incidence of postcataract surgery clinical endophthalmitis in India is nearly similar to the world literature. There is a regional difference in microbiological spectrum. A registry with regular and uniform national reporting will help formulate region specific management guidelines.
Indian journal of ophthalmology, 2017
Indian journal of ophthalmology, 2017
To identify social factors associated with delayed follow-up in South Indian patients with diabet... more To identify social factors associated with delayed follow-up in South Indian patients with diabetic retinopathy (DR) and to study DR progression during the delayed follow-up period. In this cross-sectional study, 500 consecutive patients with DR returning after greater than twice the advised follow-up period were identified from a tertiary referral center in South India. A previously validated 19-item questionnaire was administered to study patients to assess causes for the follow-up delay. Patient demographics, DR status, and treatment plan were recorded at the study visit and the visit immediately before the delay. The eye with the most severe disease was included in the analysis. Complete data were available for 491 (98.2%) patients. Among these, 248 (50.5%) cited "my eyes were okay at the time," 201 (41.0%) cited "no attender to accompany me," and 190 (38.6%) cited "financial cost" as causes of the follow-up delay. Those with vision-threatening DR (...
Indian journal of ophthalmology, 2016
To determine the publication rates of free papers and posters presented at the All India Ophthalm... more To determine the publication rates of free papers and posters presented at the All India Ophthalmic Conference (AIOC) 2010 in peer-reviewed journals up to December 2015 and compare this with publication rates from AIOC2000 published previously. A thorough literature search was conducted using PubMed, Google Scholar, and the general Google search engine by two independent investigators. The title of the paper, keywords and author names were used to "match" the AIOC free-paper with the published paper. In addition, the "purpose," "methods," and "outcome measures" between the two were studied to determine the "match." A total of 58 out of 394 free-papers (14.7%) from AIOC2010 were published till December 2015 compared to 16.5% from AIOC2000. Out of these, 52 (90%) were published in PubMed indexed journals. Maximum publications were seen in pediatric ophthalmology (50%) followed by glaucoma (24.4%) and cornea (23.8%). Fifteen out of 272 ...
Indian Journal of Ophthalmology, 2017
Combined vascular occlusions involving the parts of the retinal arterial and venous systems have ... more Combined vascular occlusions involving the parts of the retinal arterial and venous systems have been reported in the past. Among these, simultaneous occlusion of the central retinal artery (CRAO) and vein (CRVO) is well characterized. [1-3] Coexistent cilioretinal artery occlusion along with CRVO is most frequently reported and is equally well described. [4,5] Rarely, branch retinal arterial occlusion has been reported to coexist with CRVO. [6,7] Many of these combined vascular occlusions have been described in association with comorbidities such as diabetes, dyslipidemia, systemic lupus, and hyperhomocysteinemia. [8] Combined branch retinal vein (BRVO) and artery (BRAO) occlusion affecting the same retinal quadrant or hemisphere has been rarely reported in the past. Lee et al., in a study of 308 eyes of BRVO, reported 56 eyes with simultaneous arterial insufficiency but not frank obstruction. [9] Most other reports have been anecdotal and describe single cases. [10-15] We present a series of six cases of combined BRAO and BRVO and describe the clinical, angiographic, and optical coherence tomographic (OCT) features along with comorbid systemic associations and visual outcomes in these eyes. Methods All individuals attending the vitreoretina services of our institution between November 2013 and November 2015 and diagnosed with combined BRAO and BRVO were enrolled in this prospective study. The study was approved by the Institutional Ethics Committee, and Informed consent was obtained. All participants underwent comprehensive ophthalmic assessment by a single fellowship-trained vitreoretina specialist (SS). A thorough review of the patient's medical history was done with special attention to the presence and duration of diabetes mellitus, hypertension, cardiac disease, renal disease, and dyslipidemia. At baseline and every follow-up visit, best-corrected visual acuity was recorded, undilated slit lamp evaluation was done with ×45 magnification to detect iris neovascularization (NVI), gonioscopy was performed to detect the neovascularization of the anterior chamber angle, and dilated fundus examination was done to document findings associated with BRAO and BRVO such as quadrantic involvement, macular status, and retinal neovascularization at disc (NVD) or elsewhere (NVE). Fundus fluorescein angiography (FFA) was done once at baseline, and OCT was done at every visit (Cirrus spectral domain-OCT, Carl Zeiss Meditec, Dublin, USA). All patients underwent a thorough systemic evaluation including measurement of blood pressure (BP), fasting and Cite this article as: Sengupta S, Pan U. Combined branch retinal vein and branch retinal artery occlusion-clinical features, systemic associations, and outcomes.
Indian Journal of Ophthalmology, 2016
is the most common primary malignant intraocular tumor of childhood presenting usually before 5 y... more is the most common primary malignant intraocular tumor of childhood presenting usually before 5 years of age. RB in adults older than 20 years is extremely rare. A literature search using PubMed/PubMed Central, Scopus, Google Scholar, EMBASE, and Cochrane databases revealed only 45 cases till date. Over the past decade, there has been a significant increase in the number of such reports, indicating heightened level of suspicion among ophthalmologists. Compared to its pediatric counterpart, adult onset RB poses unique challenges in diagnosis and treatment. This article summarizes available literature on adult onset RB and its clinical and pathologic profile, genetics, association with retinocytoma, diagnostics, treatment, and outcomes.
Indian journal of ophthalmology, 2017
We report an unusual case of retained metallic intraocular foreign body (IOFB) presenting with ac... more We report an unusual case of retained metallic intraocular foreign body (IOFB) presenting with acute retinal necrosis (ARN). A healthy young man presented with signs of ARN including hypopyon, dense vitritis, and peripheral retinal necrosis following alleged history of trauma with a high-velocity projectile. After initial management of ARN with systemic antivirals, a retained metallic IOFB was identified and subsequently removed surgically. The patient was followed up for 12 months postoperatively and retained excellent vision without recurrence of the ARN. The diagnosis of an IOFB in a case with associated inflammation can be challenging. A strong clinical suspicion with proper investigations can achieve optimum results.
Journal of cataract and refractive surgery, 2016
To compare the intermediate-term anatomic and visual results of scleral-fixated intraocular lens ... more To compare the intermediate-term anatomic and visual results of scleral-fixated intraocular lens (IOL) implantation using 4-point suture fixation or transscleral sutureless fixation. Tertiary referral eye care center in South India. Retrospective case series. Medical records of consecutive patients who had scleral-fixated IOL surgery from January 1, 2010, to March 31, 2014, with more than 1 year of follow-up were retrospectively analyzed. Indication for scleral-fixated IOL implantation was aphakia after cataract extraction or trauma. The surgical technique was based on individual surgeon preference. The uncorrected distance visual acuity (UDVA), previous surgery, type of trauma, surgical technique, and complications were analyzed. One hundred nine cases were analyzed. The mean follow-up was 18.9 months ± 8.7 (SD). The majority of eyes experienced an improvement in UDVA after surgery; 93 eyes (86%) had a Snellen equivalent corrected distance visual acuity of 6/12 or better. The basel...
Journal of Cataract and Refractive Surgery, 2009
In this retrospective observational series at a single eye hospital, records of patients who had ... more In this retrospective observational series at a single eye hospital, records of patients who had cataract surgery using a modified sterilization protocol from January 2007 through August 2008 and developed postoperative endophthalmitis within the first 3 postoperative months were drawn from a computerized database. The patient's socioeconomic status, the surgeon's experience, and the type of cataract procedure performed were analyzed as possible risk factors using the chi-square test/Fischer exact test.
Ophthalmology, 2016
To compare reduction in intraocular pressure (IOP) and change in anterior chamber angle configura... more To compare reduction in intraocular pressure (IOP) and change in anterior chamber angle configuration between eyes undergoing phacoemulsification versus those undergoing manual small-incision cataract surgery (MSICS). Prospective, randomized, double-masked, parallel assignment clinical trial. Five hundred eyes of 500 participants 40 to 70 years of age with normal IOP, gonioscopically open angles, and age-related cataract. Eyes underwent phacoemulsification or MSICS after a 1:1 randomization and allocation code. Best-corrected vision, IOP, comprehensive slit-lamp evaluation, and anterior segment (AS) optical coherence tomography (OCT) were performed at baseline and at 1, 3, and 6 months follow-up. Change in IOP (ΔIOP) and AS OCT parameters between baseline and 6 months after surgery. Six months, similar IOP reduction was observed in eyes undergoing phacoemulsification (ΔIOP = 2.7±2.9 mmHg) and MSICS (ΔIOP = 2.6±2.6 mmHg; P = 0.70). Widening of the angle opening distance (AOD) 500 μm from the scleral spur (median ΔAOD500 = 103 μm; interquartile range = 39-179 μm) was also similar in both groups (P = 0.28). Multivariate linear regression analysis showed that eyes with higher baseline IOP experienced significantly greater reduction in IOP at 6 months (ΔIOP = 0.46-mmHg reduction for every 1-mmHg increment in baseline IOP; 95% confidence interval [CI], 0.4-0.5 mmHg; P < 0.001). After adjusting for covariates, the magnitude of widening of AOD500 was not associated significantly with reduction in IOP (1.33-mmHg reduction for every 1-mm increment in AOD500; P = 0.07). Baseline AOD500 (β = -0.60-mm change/1-mm increment of baseline AOD; 95% CI, -0.67 to -0.53 mm) and anterior chamber depth (β = 0.07-mm change/1-mm increment of baseline anterior chamber depth; 95% CI, 0.04-0.1 mm) were significant predictors of AOD500 widening at 6 months. Both phacoemulsification and MSICS led to significant and similar IOP reductions 6 months after surgery, and both surgeries produced similar changes in anterior chamber and angle parameters. Higher baseline IOP was associated with greater IOP reduction; IOP reduction also can be attributed partly to changes in angle and anterior chamber configuration, although these parameters were unable to predict significantly predict IOP drop at 6 months.
2013 Indian Conference on Medical Informatics and Telemedicine (ICMIT), 2013
ABSTRACT
Journal of Cataract and Refractive Surgery, Nov 1, 2010
To compare the safety and efficacy of phacoemulsification and manual small-incision cataract surg... more To compare the safety and efficacy of phacoemulsification and manual small-incision cataract surgery (SICS) to treat white cataracts in southern India. Aravind Eye Hospital, Pondicherry, India. Randomized prospective study. Consecutive patients with white cataract were randomly assigned to have phacoemulsification or manual SICS by 1 of 3 surgeons experienced in both techniques. Surgical complications, operative time, uncorrected (UDVA) and corrected (CDVA) distance visual acuities, and surgically induced astigmatism were compared. On the first postoperative day, the UDVA was comparable in the 2 groups (P = .805) and the manual SICS group had less corneal edema (10.2%) than the phacoemulsification group (18.7%) (P = .047). At 6 weeks, the UDVA was 20/60 or better in 99 patients (87.6%) in the phacoemulsification group and 96 patients (82.0%) in the manual SICS group (P = .10) and the CDVA was 20/60 or better in 112 (99.0%) and 115 (98.2%), respectively (P = .59). The mean time was statistically significantly shorter in the manual SICS group (8.8 minutes ± 3.4 [SD]) than in the phacoemulsification group (12.2 ± 4.6 minutes) (P<.001). Posterior capsule rupture occurred in 3 eyes (2.2%) in the phacoemulsification group and 2 eyes (1.4%) in the manual SICS group (P = .681). Both techniques achieved excellent visual outcomes with low complication rates. Because manual SICS is significantly faster, less expensive, and less technology-dependent than phacoemulsification, it may be a more appropriate technique in eyes with mature cataract in the developing world.
Uploads
Papers by Sabyasachi Sengupta