World Journal of Pharmacy and Pharmaceutical Sciences, 2024
Standardization and product acceptability is used to describe all measures under taken during the... more Standardization and product acceptability is used to describe all measures under taken during the manufacturing process and quality control and quality assurance of drug leading to its reproducible quality. Therefore we need to develop standard validation techniques to standardize and validate of the herbal products and formulations using QC. QA Screening Studies. The drug Woodfordia fruticosa (Linn.) Kurz) is therapeutically useful in the treatment of Anti-pyretic, Anti-pills, Anti-inflammatory, Anti-ulcer, Anti-diarrheal, Anti-Sinus, Anti-Diabetes, Anti-Leukorrhea, Anti-Leprosy, Anti-hyperglycemic activity, Anti-depressant activity, Anti-cancer activity, Antioxidant activity. The single drug WF was Standardization, Quality Control Screening studied in three different batches as per the guidelines of WHO/ AYUSH Protocols basis. Present research study is aimed to evaluate the Standardization and product quality acceptability using physico-chemical parameters; HPTLC fingerprinting as per WHO guidelines of analyzed parameters. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain Foreign matter, w/w- (0.08 %,0.07%,0.08%), LOD/ Moisture, w/w- (6.054%,6.010% 6.320%), Total ash, w/w-(5.79%,5.82%,6.93%), Acid in-soluble ash, w/w-(0.776%,0.770%,0.778%), Alcohol and water soluble extractive matter, w/v- (12.80%,12.46%, 12.38%) & (24.40%, 4.46%,24.50%), pH(10% solution) (4.8,4.9,4.8), the HPTLC finger prints showed various spots at 254nm, 366nm Iodine vapours and visible light (M-S reagent). The tested drug samples showed significant Antibacterial potential and Toxicology studies against certain pathogens organisms and microbial load analysis. The QC. findings revealed that the test drug was free from adulterations. The evaluated validated quality standards will be very useful for referential support, validation of the standards of WF, pharmaco-vigilance and providing the quality raw medicine to deprived human being.
KEYWORDS: (Woodfordia fruticosa (Linn) Kurz), Physico-chemical quality QC and QA HPTLC fingerprinting and Unani Compound drug.
Abstract / अमूर्त : मानकीकरण और उत्पाद स्वीकार्यता का उपयोग विनिर्माण प्रक्रिया और गुणवत्ता नियंत... more Abstract / अमूर्त : मानकीकरण और उत्पाद स्वीकार्यता का उपयोग विनिर्माण प्रक्रिया और गुणवत्ता नियंत्रण और दवा की गुणवत्ता आश्वासन के दौरान किए गए, सभी उपायों का वर्णन करने के लिए किया जाता है, जिससे इसकी प्रतिलिपि प्रस्तुत करने योग्य गुणवत्ता प्राप्त होती है। इसलिए हमें गुणवत्ता नियंत्रण का उपयोग करके हर्बल फॉर्मूलेशन के मानकीकरण और सत्यापन के लिए मानक सत्यापन तकनीक विकसित करने की आवश्यकता है। गुणवत्ता आश्वासन स्क्रीनिंग अध्ययन। दवा धातकी / धाई फूल / गुल-ए-धावा वुडफोर्डिया फ्रुटिकोसा (लिनन.) कुर्ज़) एंटी-पायरेटिक, एंटी-पिल्स, एंटी-इंफ्लेमेटरी, एंटी-अल्सर, एंटी-डायरिया, एंटी-साइनस, एंटीएंटरोवायरल, एंटी-हाइपरग्लाइसेमिक के उपचार में चिकित्सीय रूप से उपयोगी है। , मधुमेह रोधी, ल्यूकोरिया रोधी, कुष्ठ रोग रोधी, स्त्री रोग, अधिक रक्तस्राव, प्लीहा, दांत निकलने संबंधी आदि विभिन्न समस्याओं को नियंत्रित और सुरक्षित रखता है। एकल दवा डब्ल्यूएफ का मानकीकरण, गुणवत्ता नियंत्रण स्क्रीनिंग का डब्ल्यूएचओ/आयुष प्रोटोकॉल के आधार पर दिशानिर्देशों के अनुसार तीन अलग-अलग बैचों में अध्ययन किया गया। वर्तमान शोध अध्ययन का उद्देश्य भौतिक-रासायनिक मापदंडों का उपयोग करके मानकीकरण और उत्पाद गुणवत्ता स्वीकार्यता का मूल्यांकन करना है; विश्लेषण किए गए मापदंडों के डब्ल्यूएचओ दिशानिर्देशों के अनुसार एचपीटीएलसी फिंगरप्रिंटिंग। परीक्षण नमूनों के प्रत्येक III बैच के भौतिक-रासायनिक औसत रीडिंग डेटा से पता चला कि दवा में विदेशी पदार्थ, w/w-(0.08%, 0.07%, 0.08%), LOD / नमी, w/w- (5.79%,5.82,6.93 % शामिल हैं ), कुल राख, w/w- (5.79%,5.82%, एवं 6.93, %), एसिड में घुलनशील राख, w/w-(0.776%,0.770%, एवं 0.778,%), अल्कोहल और पानी में घुलनशील अर्क पदार्थ, w/v- (12.80%, 12.46%, 12.38%) और (24.40%, 24.46%, 24.50%), पीएच (10% समाधान) (4.8 ,4.9, 4.8), एचपीटीएलसी फिंगर प्रिंट्स ने 254 एनएम, 366 एनएम आयोडीन वाष्प और दृश्य प्रकाश (एम-एस अभिकर्मक) पर विभिन्न धब्बे दिखाए। गुणवत्ता नियंत्रण अध्ययनों के सत्यापन से माइक्रोबियल लोड, एफ्लाटॉक्सिन, भारी धातु और कीटनाशक अवशेषों की अनुपस्थिति का पता चला, मूल्यांकन किया गया मान्य गुणवत्ता मानक संदर्भात्मक समर्थन, डब्ल्यूएफ के मानकों के सत्यापन, फार्माको-सतर्कता और वंचित मानव को गुणवत्तापूर्ण कच्ची दवा प्रदान करने के लिए बहुत उपयोगी होंगे।
Keywords / मूलशब्द : धातकी / धाई फूल / गुल-ए-धावा वुडफोर्डिया फ्रुटिकोसा (लिनन) कुर्ज़), भौतिक-रासायनिक गुणवत्ता, गुणवत्ता नियंत्रण और आश्वासन पैरामीटर, टीएलसी / एचपीटीएलसी फिंगरप्रिंटिंग और यूनानी यौगिक दवा।
International Journal of Pharmacy and Pharmaceutical Science ; https://www.pharmacyjournal.org/, 2024
Traditionally utilization of ASU herbal drugs as medicine used is the since ancient time for heal... more Traditionally utilization of ASU herbal drugs as medicine used is the since ancient time for health, wellness and cures to mankind and it is used in all cultures all over history The primeval and tribal's, hillers persons learned by trial and error basis to identified valuable potent medicinal plants. In modern scenario more demand increasing towards herbal medicinal ASU products because ASU and TAM herbal products having low hazardness and toxicity as compare to other medicine and there is increasing awareness and general acceptability of herbal drugs in today's medical practice on global demand basis. In present, It is however a known fact that over 80% of the world population used herbal medicines and product for healthy living. As well as globally demand of herbal products increases the need of herbal quality assurance for customer satisfaction also increases. For the prevention of drug substitution, adulteration and developed abuse herbal products, WHO have been released guidelines on global requirement and public domain to all herbal industries. The identification of this highly active moiety is an important requirement for Quality assurance, quality control and dose determination of plant related dugs. Standardization research of ASU. Herbal drugs means confirmation or validation of its identity, purity, quality and efficacy. It is mandatory for every ASU herbal industry. It must need for collection, handling, processing and production of ASU herbal medicine as well as employ such parameters in ensuring the quality, safety, efficacy and compulsory need for the global ASU. TAM. Herbal market. In this overview all guidelines which are required for development of ASU and TAM herbal products at global scale.
International Journal of Pharmacy and Pharmaceutical Science, 2024
Traditionally utilization of ASU herbal drugs as medicine used is the since ancient time for heal... more Traditionally utilization of ASU herbal drugs as medicine used is the since ancient time for health, wellness and cures to mankind and it is used in all cultures all over history The primeval and tribal's, hillers persons learned by trial and error basis to identified valuable potent medicinal plants. In modern scenario more demand increasing towards herbal medicinal ASU products because ASU and TAM herbal products having low hazardness and toxicity as compare to other medicine and there is increasing awareness and general acceptability of herbal drugs in today's medical practice on global demand basis. In present, It is however a known fact that over 80% of the world population used herbal medicines and product for healthy living. As well as globally demand of herbal products increases the need of herbal quality assurance for customer satisfaction also increases. For the prevention of drug substitution, adulteration and developed abuse herbal products, WHO have been released guidelines on global requirement and public domain to all herbal industries. The identification of this highly active moiety is an important requirement for Quality assurance, quality control and dose determination of plant related dugs. Standardization research of ASU. Herbal drugs means confirmation or validation of its identity, purity, quality and efficacy. It is mandatory for every ASU herbal industry. It must need for collection, handling, processing and production of ASU herbal medicine as well as employ such parameters in ensuring the quality, safety, efficacy and compulsory need for the global ASU. TAM. Herbal market. In this overview all guidelines which are required for development of ASU and TAM herbal products at global scale.
International Journal of Pharmacy and Pharmaceutical Science; www.pharmacyjournal.org , 2022
Introduction: Quality control of herbal products remains a big challenging task. There needs to b... more Introduction: Quality control of herbal products remains a big challenging task. There needs to be more than the Pharmacognosy, physicochemical and screening parameters to validation, authenticate and differentiate adulterants in medicinal plants. Genda phool / Gul-e-Sad Barg (Marigold), Tagetes erecta L. is one of the herbs used to treat various health wellness and therapeutic illness of public mankind. This study aims to evaluate the QC, Botanical identification, Pharmacognosy, physicochemical studies of the flower part of plant of Marigold. Methods: The Botanical identification, Pharmacognosy physicochemical and quality control research analysis of the flower part of plant of T E. coarse powder were carried out using standard methods. The Quality, safety and toxicity effects of the tested drug samples were also investigated. Results: The Botanical identification, Pharmacognosy, physicochemical and QC. Properties of T E. have shown that all the parameters were within the permissible limits. The tested drug samples showed significant Quality, safety and toxicity studies against certain pathogens organisms and promising antipathogenic activity. Conclusions: The Botanical identification, Pharmacognosy, quality control research findings revealed that the test drug was free from adulterations. This investigated herb's research data confirmed to drug standardization and therapeutically may treat that the drug is safe for internal use and cures in Scabies, Fever, Skin diseases and eyes diseases.
International Journal of Scientific Research in Chemistry , 2023
Medicated Brain booster oil drug Raughan-e-Muqawwi-e-Dimagh a classical formulation used in the t... more Medicated Brain booster oil drug Raughan-e-Muqawwi-e-Dimagh a classical formulation used in the treatment of Brain Weakness, Insomnia, Amnesia and other Neurological disorders from since ancient time. Three drugs samples of REMED taken into these studies which 3 Batches were prepared B1,B2 and B3. and developed from applied SOP. on the basis of authenticated classical texts and literature of standard methods. The quality control & quality assurance studies were conducted in accordance to the WHO., AOAC., IPC. and UPC., approved guidelines. The physicochemical data showed Extractive, %, w/v. (100), that the drug samples contained Petroleum ether(60-80°C), Acid value (69.12), Iodine value (23.99), Peroxide value(14.86), Saponification Value (248.29), Unsaponifiable matter,% (2.36),Refractive index (1.4657),Weight per ml.(gm.) (0.9006),Test for presence of Arachis oil, Cotton seed oil and Mineral oil both are found negatives and various bioactive phytochemical screening examined were assessed in REMED. HPTLC. studies of alcohol extracts of different Batches B1.B2 and B3 of REMED. Classical formulation showed various spots at 366nm (UV. region), under exposed to Vinyl - Sulfuric acid reagent. derivatized obtained with equate, best separation using selected suitable solvent system of mobile phase. The quality control studies results revealed the absence of hazardous and toxic contamination from the drug samples. Moreover the obtained research studies data and comparative screening will provide the referential supportive information in the development of pharmacopeial standard monographs, identification of classical formulation, reinvestigation, quality assurance and pharmacovigilance and validation of the Quality standard of REMED classical drug providing the quality medicine to needful public mass of the World.
KEYWORDS: Raughan-e-Muqawwi-e-Dimagh (REMED), Anti-amnesic,Medicated Brain booster oil, development of pharmacopeial standards, physicochemical, comparative screening, quality control and assurance.
International Journal of Scientific Research in Chemistry , 2023
The polyherbal drug Majoon-e-Maddat-ul-Hayat Jadwari has been used as a traditional and alternati... more The polyherbal drug Majoon-e-Maddat-ul-Hayat Jadwari has been used as a traditional and alternative medicine to treat and cure therapeutically in the treatment of Nisyan (Amnesia), Salasul Baul (Urinary Incontinence), Waja-ul-Kulya (Renal pain /Nephralgia), Waj-ul-Qutn (Lumbago), Waj-ul-Mafasil (Rheumatoid / Poly Arthritis) and has also been used Action wise Muqawwi-e-Asab, (Nervine Tonic), Muwallid-i-Mani (Spermatogenic), Hazim (Digestive), Daf-e-waja (Analgesic), Muqawwi-i-Bah (Aphrodisiac). In the present research study is aimed to evaluate the product drug standardization and quality validation using physico-chemical parameters; HPTLC fingerprinting, essential WHO and AYUSH Pharmacopeial parameters as per WHO and AYUSH guidelines protocols of analyzed parameters. Drug Standardization and product validation is very essential tools for validation and measured the batch to batch variation or uniformity of ASU herbal product. Therefore we need to develop standard validation techniques to standardize and validate of the poly herbal formulation. The drug MEMUHJ was prepared in three different batches as per the guidelines of Classical text / literatures of NFUM Vol, IVth Edition Ist and IInd. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain LOD/ Moisture ,w/w-(6.42%,6.69%,6.56%), Total ash, w/w- (1.66%,1.78%,1.66%), Acid in-soluble ash, w/w-(0.266%,0.323%,0.318%), Alcohol (ASEM) and Water (WSEM) soluble extractive matter, w/v- (53.66%,54.66%,55.04%) & (73.48%,74.01%,74.41%) and Alcohol soluble successive extractive value (ASSEV). w/v-54.92%,54.96%,54.90% , Chloroform soluble successive extractive value (CSSEV). w/v- 6.85%,16.72%,16.82%, pH (1% solution) (4.58,4.55,4.51), pH(10% solution) (5.45,5.57, 5.75), Bulk density ,gm/ml - (1.525,1.515,1.518),Reducing Sugar (54.31, 55.40, 54.80) and Non-Reducing Sugar(23.43,23.52,23.50) the HPTLC finger prints showed various spots at 254nm, 366nm and visible light (V-S reagent). The validation of quality control study revealed the absence of Microbial load, Aflatoxins, Heavy metal and Pesticide residues, The evaluated validated quality standards will be very useful for referential support, pharmaco-vigilance and validation of the standards of MEMUHJ providing the quality medicine to needful human being. Keywords: Majoon-e-Maddat-ul-Hayat Jadwari, Physico-chemical quality, Quality Control and Assurance parameters, TLC/ HPTLC fingerprinting and Unani Compound drug.
International Journal of Scientific Research in Chemistry , 2023
Standardization and product validation is used to describe all measures under taken during the ma... more Standardization and product validation is used to describe all measures under taken during the manufacturing process and quality control and quality assurance of drug leading to its reproducible quality. Therefore we need to develop standard validation techniques to standardize and validate of the herbal formulations. The drug Jawarish-e-Usquf is therapeutically useful in the treatment of Laqwa (Facial / Bell’s palsy), Qulanj (intestinal pain, coli), Nafkh-i-Shikam (flatulence), Bawasir (piles / haemorrhoids), Waja’ al-Khasira (low backache) Waja’ al-Zahr (bachache), Qay(vomiting) Action wise Munaqqi-e-Asab, (Nervine Cleansers). The drug JEU was prepared in three different batches as per the guidelines of National Formulary of Unani Medicine(Part-IVth) and UPI.(Part-IInd, Edition-IInd). Present research study is aimed to evaluate the product quality validation using physico-chemical parameters; HPTLC fingerprinting as per WHO guidelines of analyzed parameters. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain LOD/ Moisture ,w/w- (15.14%,14.44%, 14.63%), Total ash, w/w- (1.34%,1.37%,1.42%), Acid in-soluble ash, w/w-(0.015%,0.014%,0.016%), Alcohol and water soluble extractive matter,(ASEM and WSEM) w/v- (60.21%, 60.54%,61.29%) & (70.78%,71.24%, 70.58%),and (ASSEV.), (CSSEV.) extractive values w/v.- (16.81%,16.80,15.80), (7.85%, 7.87%,7.86%), pH(1% solution) (5.77,5.83,5.69), pH(10% solution) (4.66,4.81, 4.74), Bulk density ,gm/ml -(1.615,1.606,1.603),Reducing Sugar (53.78, 53.36, 52.97) and Non-Reducing Sugar (6.32,6.79,6.27) the HPTLC finger prints showed various spots at 254nm, 366nm and visible light (V-S reagent).The validation of quality control studies revealed the absence of Microbial load, Aflatoxins, Heavy metal and Pesticide residues, The evaluated validated quality standards will be very useful for referential support, validation of the standards of JEU formulated drug, pharmaco-vigilance and providing the quality medicine to needful human being.
Keywords: Jawarish-Usquf, Physico-chemical quality, Quality Control and Assurance parameters, TLC/ HPTLC fingerprinting and Unani Compound drug.
International Journal of Scientific Research in Chemistry , 2022
Adiantum capillus-veneris L. is commonly known as herbaceous plant belong to the family Adiantace... more Adiantum capillus-veneris L. is commonly known as herbaceous plant belong to the family Adiantaceae. It is an important medicinal plant native to the United States America, Eurasia, the Levant in Western Asia, Australasia and Asian region, North east India region and west Bengal etc. The aerial parts of the plant were
Lack of standardized herbal medicines as OTC products is a major setback in the popular acceptanc... more Lack of standardized herbal medicines as OTC products is a major setback in the popular acceptance of these products. Standardization and quality control of indigenous medicines will not only increase the benefits of the drugs but also translate into higher profits for industry. Present study has been carried out to ascertain the quality of the ingredients used in the formulation through pharmacognostic, physicochemical and TLC studies which may serve as tool for standardization of herbal products.
afran, a Unani drug of repute is known as Saffron in English and Kesar in Hindi, consists of dry ... more afran, a Unani drug of repute is known as Saffron in English and Kesar in Hindi, consists of dry stigmas and top of style of Crocus sativus L. (Fig. 1), belongs to family Iridaceae. The drug is used for the treatment of amenorrhea, colic, leucorrhoea and headache, besides exhibiting antioxidant and anti-cancerous properties. It is produced mainly in Spain (70% of world supply), and other producers are Iran and India, mainly Pampur (Kashmir). It contains Crocin as a main constituent, which is responsible for its colouring property and offers the distinctive aroma, taste and aromatic oil. Present studies deal with the standardization of Zafran, and include macroscopy, microscopy and powder analysis, TLC with marker compound, extractive values and ash values. All these standards may be fruitful for correct identification and quality assurance of the drug and help manufacturing quality medicines of Indian Systems of Medicine.
Heracleum candicans Wall. (Fam., Umbellifereae), commonly known as cowparanship, is frequently us... more Heracleum candicans Wall. (Fam., Umbellifereae), commonly known as cowparanship, is frequently used in the treatment of spasmodic, mutagenic, dermal photosensitizing, skin diseases, anti-tuberculosive and anticonvulsive activity and antimicrobial activities. This review summarizes the chemical constituents (furanocoumarin, coumarin and other chemical compounds) present in Heracleum candicans Wall. This plant species is a rich source of furanocoumarin, coumarin, fatty acids and their derivatives
Stamens of Mesua ferrea Linn. is the source of "Nagkesara," a drug considered to be astringent, s... more Stamens of Mesua ferrea Linn. is the source of "Nagkesara," a drug considered to be astringent, stomachic and expectorant, but Ochrocarpus longifolius B & H is also available as Nagkesara in the commerce. The present communication deals with the comparative morphological and chromatographic (HPTLC) studies of both the species which may help to differentiate the drug Nagkesara resourced from both the botanical and available in commerce.
II o li c The drugs used in Unani Medicine consist of materials from plant, animal and mineral or... more II o li c The drugs used in Unani Medicine consist of materials from plant, animal and mineral origin that are either used si ngle or in combination with other drugs as poly-pharmaceuticals. .F.. flabb-e-Mudir is a poly-ingredient formulation compri sing Sibr (Aloe species), Zafran (Crocus sativus) and Hira Kasees Bufo (Ferrous Sulphate), in the ratio of 2: I : I (NFUM I) indicated for the treatment of ameno rrhoea. Present study is aimed to 95-standardize the fonnnulation for quality control purpose. Standard sample of the formulation was prepared in laboratory following the NFlJM methodology (National Formulary of Unani Medicine). Separate studies were undertaken for each ingredi ent in respect yl/um of pharmacognostical characters, physico-chemical constituents and HPTLC profile. Standard formulation was subjected to chemical anal ys is viz. extractive values, ash values, etc. including chromatographic profil e in li ne with standard pharmacopoe ial pctic protocols. The results may ensure the quality of f!abb-e-Mudir through determining the genuineness and quality of ingredients as well as the manufacturing process. pt iv e ~c ri a. cens.
A rare triterpenoid queretoric acid from Swertia purpurascens Wall. (Gentianaceae) has been isola... more A rare triterpenoid queretoric acid from Swertia purpurascens Wall. (Gentianaceae) has been isolated along with β-sitosterol-D-glycoside, oleanolic acid. Except oleanolic acid these two compounds for the first time have been reported from this plant source and identified by means of chemical as well as spectroscopic methods
International Journal for Multidisciplinary Research, 2024
Ustukhuddus (Lavandula stoechas L.) is one of the most important aromatic plants of Lamiaceae fam... more Ustukhuddus (Lavandula stoechas L.) is one of the most important aromatic plants of Lamiaceae family. It is named as Jarub-i Dimagh (broom of brain) in Unani System of Medicine due to its scavenging property of evacuating morbid matters from the brain; those matters may cause neurological disorders like insomnia, amnesia, melancholia etc. The drug is used since time immemorial and was mentioned by Dioscorides in 1st Century AD for its various pharmacological properties. Various studies on its effect on nervous system have been explored by researchers which may attribute to its bioactive compounds present in it, like, glycosides, phenols, steroids, terpenes etc. Present research paper deals with the comparative macroscopy, microscopic powder study and physicochemical studies of three different samples of Ustukhuddus. This study will be helpful for correct identification and genuineness of the drug sample.
The impending world is reliant on traditional medicine, and its recognition escalating at present... more The impending world is reliant on traditional medicine, and its recognition escalating at present as essential. In regulating the therapeutic efficacy of herbal drugs, standardization and quality control are the key factors. Organoleptic characters are not much consistent in establishing the standards of herbal drugs, for which the instrumental analysis of the drugs provide more accurate picture regarding the qualitative and quantitative aspects of bioactive molecules, which are held liable for therapeutic action and is widely accepted in quality assessment of herbal drugs. The present study was taken to scientifically evaluate the sample by various parameters such as macroscopy, microscopy, powder study and physico-chemical analysis such as loss on drying, extractive values i.e., water-soluble matter, ethanol soluble matter, Hexane soluble matter, percentage of ash values i.e., Total ash and acid insoluble ash, pH of 1% & 10% aqueous solution and HPTLC Fingerprinting analysis. This will be helpful for botanical identification and standardization of Kasondi leaves in crude form.
World Journal of Pharmacy and Pharmaceutical Sciences, 2024
Standardization and product acceptability is used to describe all measures under taken during the... more Standardization and product acceptability is used to describe all measures under taken during the manufacturing process and quality control and quality assurance of drug leading to its reproducible quality. Therefore we need to develop standard validation techniques to standardize and validate of the herbal products and formulations using QC. QA Screening Studies. The drug Woodfordia fruticosa (Linn.) Kurz) is therapeutically useful in the treatment of Anti-pyretic, Anti-pills, Anti-inflammatory, Anti-ulcer, Anti-diarrheal, Anti-Sinus, Anti-Diabetes, Anti-Leukorrhea, Anti-Leprosy, Anti-hyperglycemic activity, Anti-depressant activity, Anti-cancer activity, Antioxidant activity. The single drug WF was Standardization, Quality Control Screening studied in three different batches as per the guidelines of WHO/ AYUSH Protocols basis. Present research study is aimed to evaluate the Standardization and product quality acceptability using physico-chemical parameters; HPTLC fingerprinting as per WHO guidelines of analyzed parameters. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain Foreign matter, w/w- (0.08 %,0.07%,0.08%), LOD/ Moisture, w/w- (6.054%,6.010% 6.320%), Total ash, w/w-(5.79%,5.82%,6.93%), Acid in-soluble ash, w/w-(0.776%,0.770%,0.778%), Alcohol and water soluble extractive matter, w/v- (12.80%,12.46%, 12.38%) & (24.40%, 4.46%,24.50%), pH(10% solution) (4.8,4.9,4.8), the HPTLC finger prints showed various spots at 254nm, 366nm Iodine vapours and visible light (M-S reagent). The tested drug samples showed significant Antibacterial potential and Toxicology studies against certain pathogens organisms and microbial load analysis. The QC. findings revealed that the test drug was free from adulterations. The evaluated validated quality standards will be very useful for referential support, validation of the standards of WF, pharmaco-vigilance and providing the quality raw medicine to deprived human being.
KEYWORDS: (Woodfordia fruticosa (Linn) Kurz), Physico-chemical quality QC and QA HPTLC fingerprinting and Unani Compound drug.
Abstract / अमूर्त : मानकीकरण और उत्पाद स्वीकार्यता का उपयोग विनिर्माण प्रक्रिया और गुणवत्ता नियंत... more Abstract / अमूर्त : मानकीकरण और उत्पाद स्वीकार्यता का उपयोग विनिर्माण प्रक्रिया और गुणवत्ता नियंत्रण और दवा की गुणवत्ता आश्वासन के दौरान किए गए, सभी उपायों का वर्णन करने के लिए किया जाता है, जिससे इसकी प्रतिलिपि प्रस्तुत करने योग्य गुणवत्ता प्राप्त होती है। इसलिए हमें गुणवत्ता नियंत्रण का उपयोग करके हर्बल फॉर्मूलेशन के मानकीकरण और सत्यापन के लिए मानक सत्यापन तकनीक विकसित करने की आवश्यकता है। गुणवत्ता आश्वासन स्क्रीनिंग अध्ययन। दवा धातकी / धाई फूल / गुल-ए-धावा वुडफोर्डिया फ्रुटिकोसा (लिनन.) कुर्ज़) एंटी-पायरेटिक, एंटी-पिल्स, एंटी-इंफ्लेमेटरी, एंटी-अल्सर, एंटी-डायरिया, एंटी-साइनस, एंटीएंटरोवायरल, एंटी-हाइपरग्लाइसेमिक के उपचार में चिकित्सीय रूप से उपयोगी है। , मधुमेह रोधी, ल्यूकोरिया रोधी, कुष्ठ रोग रोधी, स्त्री रोग, अधिक रक्तस्राव, प्लीहा, दांत निकलने संबंधी आदि विभिन्न समस्याओं को नियंत्रित और सुरक्षित रखता है। एकल दवा डब्ल्यूएफ का मानकीकरण, गुणवत्ता नियंत्रण स्क्रीनिंग का डब्ल्यूएचओ/आयुष प्रोटोकॉल के आधार पर दिशानिर्देशों के अनुसार तीन अलग-अलग बैचों में अध्ययन किया गया। वर्तमान शोध अध्ययन का उद्देश्य भौतिक-रासायनिक मापदंडों का उपयोग करके मानकीकरण और उत्पाद गुणवत्ता स्वीकार्यता का मूल्यांकन करना है; विश्लेषण किए गए मापदंडों के डब्ल्यूएचओ दिशानिर्देशों के अनुसार एचपीटीएलसी फिंगरप्रिंटिंग। परीक्षण नमूनों के प्रत्येक III बैच के भौतिक-रासायनिक औसत रीडिंग डेटा से पता चला कि दवा में विदेशी पदार्थ, w/w-(0.08%, 0.07%, 0.08%), LOD / नमी, w/w- (5.79%,5.82,6.93 % शामिल हैं ), कुल राख, w/w- (5.79%,5.82%, एवं 6.93, %), एसिड में घुलनशील राख, w/w-(0.776%,0.770%, एवं 0.778,%), अल्कोहल और पानी में घुलनशील अर्क पदार्थ, w/v- (12.80%, 12.46%, 12.38%) और (24.40%, 24.46%, 24.50%), पीएच (10% समाधान) (4.8 ,4.9, 4.8), एचपीटीएलसी फिंगर प्रिंट्स ने 254 एनएम, 366 एनएम आयोडीन वाष्प और दृश्य प्रकाश (एम-एस अभिकर्मक) पर विभिन्न धब्बे दिखाए। गुणवत्ता नियंत्रण अध्ययनों के सत्यापन से माइक्रोबियल लोड, एफ्लाटॉक्सिन, भारी धातु और कीटनाशक अवशेषों की अनुपस्थिति का पता चला, मूल्यांकन किया गया मान्य गुणवत्ता मानक संदर्भात्मक समर्थन, डब्ल्यूएफ के मानकों के सत्यापन, फार्माको-सतर्कता और वंचित मानव को गुणवत्तापूर्ण कच्ची दवा प्रदान करने के लिए बहुत उपयोगी होंगे।
Keywords / मूलशब्द : धातकी / धाई फूल / गुल-ए-धावा वुडफोर्डिया फ्रुटिकोसा (लिनन) कुर्ज़), भौतिक-रासायनिक गुणवत्ता, गुणवत्ता नियंत्रण और आश्वासन पैरामीटर, टीएलसी / एचपीटीएलसी फिंगरप्रिंटिंग और यूनानी यौगिक दवा।
International Journal of Pharmacy and Pharmaceutical Science ; https://www.pharmacyjournal.org/, 2024
Traditionally utilization of ASU herbal drugs as medicine used is the since ancient time for heal... more Traditionally utilization of ASU herbal drugs as medicine used is the since ancient time for health, wellness and cures to mankind and it is used in all cultures all over history The primeval and tribal's, hillers persons learned by trial and error basis to identified valuable potent medicinal plants. In modern scenario more demand increasing towards herbal medicinal ASU products because ASU and TAM herbal products having low hazardness and toxicity as compare to other medicine and there is increasing awareness and general acceptability of herbal drugs in today's medical practice on global demand basis. In present, It is however a known fact that over 80% of the world population used herbal medicines and product for healthy living. As well as globally demand of herbal products increases the need of herbal quality assurance for customer satisfaction also increases. For the prevention of drug substitution, adulteration and developed abuse herbal products, WHO have been released guidelines on global requirement and public domain to all herbal industries. The identification of this highly active moiety is an important requirement for Quality assurance, quality control and dose determination of plant related dugs. Standardization research of ASU. Herbal drugs means confirmation or validation of its identity, purity, quality and efficacy. It is mandatory for every ASU herbal industry. It must need for collection, handling, processing and production of ASU herbal medicine as well as employ such parameters in ensuring the quality, safety, efficacy and compulsory need for the global ASU. TAM. Herbal market. In this overview all guidelines which are required for development of ASU and TAM herbal products at global scale.
International Journal of Pharmacy and Pharmaceutical Science, 2024
Traditionally utilization of ASU herbal drugs as medicine used is the since ancient time for heal... more Traditionally utilization of ASU herbal drugs as medicine used is the since ancient time for health, wellness and cures to mankind and it is used in all cultures all over history The primeval and tribal's, hillers persons learned by trial and error basis to identified valuable potent medicinal plants. In modern scenario more demand increasing towards herbal medicinal ASU products because ASU and TAM herbal products having low hazardness and toxicity as compare to other medicine and there is increasing awareness and general acceptability of herbal drugs in today's medical practice on global demand basis. In present, It is however a known fact that over 80% of the world population used herbal medicines and product for healthy living. As well as globally demand of herbal products increases the need of herbal quality assurance for customer satisfaction also increases. For the prevention of drug substitution, adulteration and developed abuse herbal products, WHO have been released guidelines on global requirement and public domain to all herbal industries. The identification of this highly active moiety is an important requirement for Quality assurance, quality control and dose determination of plant related dugs. Standardization research of ASU. Herbal drugs means confirmation or validation of its identity, purity, quality and efficacy. It is mandatory for every ASU herbal industry. It must need for collection, handling, processing and production of ASU herbal medicine as well as employ such parameters in ensuring the quality, safety, efficacy and compulsory need for the global ASU. TAM. Herbal market. In this overview all guidelines which are required for development of ASU and TAM herbal products at global scale.
International Journal of Pharmacy and Pharmaceutical Science; www.pharmacyjournal.org , 2022
Introduction: Quality control of herbal products remains a big challenging task. There needs to b... more Introduction: Quality control of herbal products remains a big challenging task. There needs to be more than the Pharmacognosy, physicochemical and screening parameters to validation, authenticate and differentiate adulterants in medicinal plants. Genda phool / Gul-e-Sad Barg (Marigold), Tagetes erecta L. is one of the herbs used to treat various health wellness and therapeutic illness of public mankind. This study aims to evaluate the QC, Botanical identification, Pharmacognosy, physicochemical studies of the flower part of plant of Marigold. Methods: The Botanical identification, Pharmacognosy physicochemical and quality control research analysis of the flower part of plant of T E. coarse powder were carried out using standard methods. The Quality, safety and toxicity effects of the tested drug samples were also investigated. Results: The Botanical identification, Pharmacognosy, physicochemical and QC. Properties of T E. have shown that all the parameters were within the permissible limits. The tested drug samples showed significant Quality, safety and toxicity studies against certain pathogens organisms and promising antipathogenic activity. Conclusions: The Botanical identification, Pharmacognosy, quality control research findings revealed that the test drug was free from adulterations. This investigated herb's research data confirmed to drug standardization and therapeutically may treat that the drug is safe for internal use and cures in Scabies, Fever, Skin diseases and eyes diseases.
International Journal of Scientific Research in Chemistry , 2023
Medicated Brain booster oil drug Raughan-e-Muqawwi-e-Dimagh a classical formulation used in the t... more Medicated Brain booster oil drug Raughan-e-Muqawwi-e-Dimagh a classical formulation used in the treatment of Brain Weakness, Insomnia, Amnesia and other Neurological disorders from since ancient time. Three drugs samples of REMED taken into these studies which 3 Batches were prepared B1,B2 and B3. and developed from applied SOP. on the basis of authenticated classical texts and literature of standard methods. The quality control & quality assurance studies were conducted in accordance to the WHO., AOAC., IPC. and UPC., approved guidelines. The physicochemical data showed Extractive, %, w/v. (100), that the drug samples contained Petroleum ether(60-80°C), Acid value (69.12), Iodine value (23.99), Peroxide value(14.86), Saponification Value (248.29), Unsaponifiable matter,% (2.36),Refractive index (1.4657),Weight per ml.(gm.) (0.9006),Test for presence of Arachis oil, Cotton seed oil and Mineral oil both are found negatives and various bioactive phytochemical screening examined were assessed in REMED. HPTLC. studies of alcohol extracts of different Batches B1.B2 and B3 of REMED. Classical formulation showed various spots at 366nm (UV. region), under exposed to Vinyl - Sulfuric acid reagent. derivatized obtained with equate, best separation using selected suitable solvent system of mobile phase. The quality control studies results revealed the absence of hazardous and toxic contamination from the drug samples. Moreover the obtained research studies data and comparative screening will provide the referential supportive information in the development of pharmacopeial standard monographs, identification of classical formulation, reinvestigation, quality assurance and pharmacovigilance and validation of the Quality standard of REMED classical drug providing the quality medicine to needful public mass of the World.
KEYWORDS: Raughan-e-Muqawwi-e-Dimagh (REMED), Anti-amnesic,Medicated Brain booster oil, development of pharmacopeial standards, physicochemical, comparative screening, quality control and assurance.
International Journal of Scientific Research in Chemistry , 2023
The polyherbal drug Majoon-e-Maddat-ul-Hayat Jadwari has been used as a traditional and alternati... more The polyherbal drug Majoon-e-Maddat-ul-Hayat Jadwari has been used as a traditional and alternative medicine to treat and cure therapeutically in the treatment of Nisyan (Amnesia), Salasul Baul (Urinary Incontinence), Waja-ul-Kulya (Renal pain /Nephralgia), Waj-ul-Qutn (Lumbago), Waj-ul-Mafasil (Rheumatoid / Poly Arthritis) and has also been used Action wise Muqawwi-e-Asab, (Nervine Tonic), Muwallid-i-Mani (Spermatogenic), Hazim (Digestive), Daf-e-waja (Analgesic), Muqawwi-i-Bah (Aphrodisiac). In the present research study is aimed to evaluate the product drug standardization and quality validation using physico-chemical parameters; HPTLC fingerprinting, essential WHO and AYUSH Pharmacopeial parameters as per WHO and AYUSH guidelines protocols of analyzed parameters. Drug Standardization and product validation is very essential tools for validation and measured the batch to batch variation or uniformity of ASU herbal product. Therefore we need to develop standard validation techniques to standardize and validate of the poly herbal formulation. The drug MEMUHJ was prepared in three different batches as per the guidelines of Classical text / literatures of NFUM Vol, IVth Edition Ist and IInd. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain LOD/ Moisture ,w/w-(6.42%,6.69%,6.56%), Total ash, w/w- (1.66%,1.78%,1.66%), Acid in-soluble ash, w/w-(0.266%,0.323%,0.318%), Alcohol (ASEM) and Water (WSEM) soluble extractive matter, w/v- (53.66%,54.66%,55.04%) & (73.48%,74.01%,74.41%) and Alcohol soluble successive extractive value (ASSEV). w/v-54.92%,54.96%,54.90% , Chloroform soluble successive extractive value (CSSEV). w/v- 6.85%,16.72%,16.82%, pH (1% solution) (4.58,4.55,4.51), pH(10% solution) (5.45,5.57, 5.75), Bulk density ,gm/ml - (1.525,1.515,1.518),Reducing Sugar (54.31, 55.40, 54.80) and Non-Reducing Sugar(23.43,23.52,23.50) the HPTLC finger prints showed various spots at 254nm, 366nm and visible light (V-S reagent). The validation of quality control study revealed the absence of Microbial load, Aflatoxins, Heavy metal and Pesticide residues, The evaluated validated quality standards will be very useful for referential support, pharmaco-vigilance and validation of the standards of MEMUHJ providing the quality medicine to needful human being. Keywords: Majoon-e-Maddat-ul-Hayat Jadwari, Physico-chemical quality, Quality Control and Assurance parameters, TLC/ HPTLC fingerprinting and Unani Compound drug.
International Journal of Scientific Research in Chemistry , 2023
Standardization and product validation is used to describe all measures under taken during the ma... more Standardization and product validation is used to describe all measures under taken during the manufacturing process and quality control and quality assurance of drug leading to its reproducible quality. Therefore we need to develop standard validation techniques to standardize and validate of the herbal formulations. The drug Jawarish-e-Usquf is therapeutically useful in the treatment of Laqwa (Facial / Bell’s palsy), Qulanj (intestinal pain, coli), Nafkh-i-Shikam (flatulence), Bawasir (piles / haemorrhoids), Waja’ al-Khasira (low backache) Waja’ al-Zahr (bachache), Qay(vomiting) Action wise Munaqqi-e-Asab, (Nervine Cleansers). The drug JEU was prepared in three different batches as per the guidelines of National Formulary of Unani Medicine(Part-IVth) and UPI.(Part-IInd, Edition-IInd). Present research study is aimed to evaluate the product quality validation using physico-chemical parameters; HPTLC fingerprinting as per WHO guidelines of analyzed parameters. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain LOD/ Moisture ,w/w- (15.14%,14.44%, 14.63%), Total ash, w/w- (1.34%,1.37%,1.42%), Acid in-soluble ash, w/w-(0.015%,0.014%,0.016%), Alcohol and water soluble extractive matter,(ASEM and WSEM) w/v- (60.21%, 60.54%,61.29%) & (70.78%,71.24%, 70.58%),and (ASSEV.), (CSSEV.) extractive values w/v.- (16.81%,16.80,15.80), (7.85%, 7.87%,7.86%), pH(1% solution) (5.77,5.83,5.69), pH(10% solution) (4.66,4.81, 4.74), Bulk density ,gm/ml -(1.615,1.606,1.603),Reducing Sugar (53.78, 53.36, 52.97) and Non-Reducing Sugar (6.32,6.79,6.27) the HPTLC finger prints showed various spots at 254nm, 366nm and visible light (V-S reagent).The validation of quality control studies revealed the absence of Microbial load, Aflatoxins, Heavy metal and Pesticide residues, The evaluated validated quality standards will be very useful for referential support, validation of the standards of JEU formulated drug, pharmaco-vigilance and providing the quality medicine to needful human being.
Keywords: Jawarish-Usquf, Physico-chemical quality, Quality Control and Assurance parameters, TLC/ HPTLC fingerprinting and Unani Compound drug.
International Journal of Scientific Research in Chemistry , 2022
Adiantum capillus-veneris L. is commonly known as herbaceous plant belong to the family Adiantace... more Adiantum capillus-veneris L. is commonly known as herbaceous plant belong to the family Adiantaceae. It is an important medicinal plant native to the United States America, Eurasia, the Levant in Western Asia, Australasia and Asian region, North east India region and west Bengal etc. The aerial parts of the plant were
Lack of standardized herbal medicines as OTC products is a major setback in the popular acceptanc... more Lack of standardized herbal medicines as OTC products is a major setback in the popular acceptance of these products. Standardization and quality control of indigenous medicines will not only increase the benefits of the drugs but also translate into higher profits for industry. Present study has been carried out to ascertain the quality of the ingredients used in the formulation through pharmacognostic, physicochemical and TLC studies which may serve as tool for standardization of herbal products.
afran, a Unani drug of repute is known as Saffron in English and Kesar in Hindi, consists of dry ... more afran, a Unani drug of repute is known as Saffron in English and Kesar in Hindi, consists of dry stigmas and top of style of Crocus sativus L. (Fig. 1), belongs to family Iridaceae. The drug is used for the treatment of amenorrhea, colic, leucorrhoea and headache, besides exhibiting antioxidant and anti-cancerous properties. It is produced mainly in Spain (70% of world supply), and other producers are Iran and India, mainly Pampur (Kashmir). It contains Crocin as a main constituent, which is responsible for its colouring property and offers the distinctive aroma, taste and aromatic oil. Present studies deal with the standardization of Zafran, and include macroscopy, microscopy and powder analysis, TLC with marker compound, extractive values and ash values. All these standards may be fruitful for correct identification and quality assurance of the drug and help manufacturing quality medicines of Indian Systems of Medicine.
Heracleum candicans Wall. (Fam., Umbellifereae), commonly known as cowparanship, is frequently us... more Heracleum candicans Wall. (Fam., Umbellifereae), commonly known as cowparanship, is frequently used in the treatment of spasmodic, mutagenic, dermal photosensitizing, skin diseases, anti-tuberculosive and anticonvulsive activity and antimicrobial activities. This review summarizes the chemical constituents (furanocoumarin, coumarin and other chemical compounds) present in Heracleum candicans Wall. This plant species is a rich source of furanocoumarin, coumarin, fatty acids and their derivatives
Stamens of Mesua ferrea Linn. is the source of "Nagkesara," a drug considered to be astringent, s... more Stamens of Mesua ferrea Linn. is the source of "Nagkesara," a drug considered to be astringent, stomachic and expectorant, but Ochrocarpus longifolius B & H is also available as Nagkesara in the commerce. The present communication deals with the comparative morphological and chromatographic (HPTLC) studies of both the species which may help to differentiate the drug Nagkesara resourced from both the botanical and available in commerce.
II o li c The drugs used in Unani Medicine consist of materials from plant, animal and mineral or... more II o li c The drugs used in Unani Medicine consist of materials from plant, animal and mineral origin that are either used si ngle or in combination with other drugs as poly-pharmaceuticals. .F.. flabb-e-Mudir is a poly-ingredient formulation compri sing Sibr (Aloe species), Zafran (Crocus sativus) and Hira Kasees Bufo (Ferrous Sulphate), in the ratio of 2: I : I (NFUM I) indicated for the treatment of ameno rrhoea. Present study is aimed to 95-standardize the fonnnulation for quality control purpose. Standard sample of the formulation was prepared in laboratory following the NFlJM methodology (National Formulary of Unani Medicine). Separate studies were undertaken for each ingredi ent in respect yl/um of pharmacognostical characters, physico-chemical constituents and HPTLC profile. Standard formulation was subjected to chemical anal ys is viz. extractive values, ash values, etc. including chromatographic profil e in li ne with standard pharmacopoe ial pctic protocols. The results may ensure the quality of f!abb-e-Mudir through determining the genuineness and quality of ingredients as well as the manufacturing process. pt iv e ~c ri a. cens.
A rare triterpenoid queretoric acid from Swertia purpurascens Wall. (Gentianaceae) has been isola... more A rare triterpenoid queretoric acid from Swertia purpurascens Wall. (Gentianaceae) has been isolated along with β-sitosterol-D-glycoside, oleanolic acid. Except oleanolic acid these two compounds for the first time have been reported from this plant source and identified by means of chemical as well as spectroscopic methods
International Journal for Multidisciplinary Research, 2024
Ustukhuddus (Lavandula stoechas L.) is one of the most important aromatic plants of Lamiaceae fam... more Ustukhuddus (Lavandula stoechas L.) is one of the most important aromatic plants of Lamiaceae family. It is named as Jarub-i Dimagh (broom of brain) in Unani System of Medicine due to its scavenging property of evacuating morbid matters from the brain; those matters may cause neurological disorders like insomnia, amnesia, melancholia etc. The drug is used since time immemorial and was mentioned by Dioscorides in 1st Century AD for its various pharmacological properties. Various studies on its effect on nervous system have been explored by researchers which may attribute to its bioactive compounds present in it, like, glycosides, phenols, steroids, terpenes etc. Present research paper deals with the comparative macroscopy, microscopic powder study and physicochemical studies of three different samples of Ustukhuddus. This study will be helpful for correct identification and genuineness of the drug sample.
The impending world is reliant on traditional medicine, and its recognition escalating at present... more The impending world is reliant on traditional medicine, and its recognition escalating at present as essential. In regulating the therapeutic efficacy of herbal drugs, standardization and quality control are the key factors. Organoleptic characters are not much consistent in establishing the standards of herbal drugs, for which the instrumental analysis of the drugs provide more accurate picture regarding the qualitative and quantitative aspects of bioactive molecules, which are held liable for therapeutic action and is widely accepted in quality assessment of herbal drugs. The present study was taken to scientifically evaluate the sample by various parameters such as macroscopy, microscopy, powder study and physico-chemical analysis such as loss on drying, extractive values i.e., water-soluble matter, ethanol soluble matter, Hexane soluble matter, percentage of ash values i.e., Total ash and acid insoluble ash, pH of 1% & 10% aqueous solution and HPTLC Fingerprinting analysis. This will be helpful for botanical identification and standardization of Kasondi leaves in crude form.
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control and quality assurance of drug leading to its reproducible
quality. Therefore we need to develop standard validation techniques
to standardize and validate of the herbal products and formulations
using QC. QA Screening Studies. The drug Woodfordia fruticosa
(Linn.) Kurz) is therapeutically useful in the treatment of Anti-pyretic,
Anti-pills, Anti-inflammatory, Anti-ulcer, Anti-diarrheal, Anti-Sinus,
Anti-Diabetes, Anti-Leukorrhea, Anti-Leprosy, Anti-hyperglycemic
activity, Anti-depressant activity, Anti-cancer activity, Antioxidant
activity. The single drug WF was Standardization, Quality Control
Screening studied in three different batches as per the guidelines of
WHO/ AYUSH Protocols basis. Present research study is aimed to
evaluate the Standardization and product quality acceptability using
physico-chemical parameters; HPTLC fingerprinting as per WHO
guidelines of analyzed parameters. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain Foreign matter, w/w- (0.08 %,0.07%,0.08%), LOD/ Moisture, w/w- (6.054%,6.010% 6.320%), Total ash, w/w-(5.79%,5.82%,6.93%), Acid in-soluble ash, w/w-(0.776%,0.770%,0.778%), Alcohol and water soluble extractive matter, w/v- (12.80%,12.46%, 12.38%) & (24.40%, 4.46%,24.50%), pH(10% solution) (4.8,4.9,4.8), the HPTLC finger prints showed various spots at 254nm, 366nm Iodine vapours and visible light (M-S reagent). The tested drug samples showed significant Antibacterial potential and Toxicology studies against certain pathogens organisms and microbial load analysis. The QC. findings revealed that the test drug was free
from adulterations. The evaluated validated quality standards will be very useful for referential support, validation of the standards of WF, pharmaco-vigilance and providing the quality raw medicine to deprived human being.
KEYWORDS: (Woodfordia fruticosa (Linn) Kurz), Physico-chemical quality QC and QA HPTLC fingerprinting and Unani Compound drug.
Keywords / मूलशब्द : धातकी / धाई फूल / गुल-ए-धावा वुडफोर्डिया फ्रुटिकोसा (लिनन) कुर्ज़), भौतिक-रासायनिक गुणवत्ता, गुणवत्ता नियंत्रण और आश्वासन पैरामीटर, टीएलसी / एचपीटीएलसी फिंगरप्रिंटिंग और यूनानी यौगिक दवा।
KEYWORDS: Raughan-e-Muqawwi-e-Dimagh (REMED), Anti-amnesic,Medicated Brain booster oil, development of pharmacopeial standards, physicochemical, comparative screening, quality control and assurance.
Keywords: Jawarish-Usquf, Physico-chemical quality, Quality Control and Assurance parameters, TLC/ HPTLC fingerprinting and Unani Compound drug.
in the treatment of spasmodic, mutagenic, dermal photosensitizing, skin diseases, anti-tuberculosive and
anticonvulsive activity and antimicrobial activities. This review summarizes the chemical constituents
(furanocoumarin, coumarin and other chemical compounds) present in Heracleum candicans Wall. This
plant species is a rich source of furanocoumarin, coumarin, fatty acids and their derivatives
along with β-sitosterol-D-glycoside, oleanolic acid. Except oleanolic acid these two compounds for the first
time have been reported from this plant source and identified by means of chemical as well as
spectroscopic methods
control and quality assurance of drug leading to its reproducible
quality. Therefore we need to develop standard validation techniques
to standardize and validate of the herbal products and formulations
using QC. QA Screening Studies. The drug Woodfordia fruticosa
(Linn.) Kurz) is therapeutically useful in the treatment of Anti-pyretic,
Anti-pills, Anti-inflammatory, Anti-ulcer, Anti-diarrheal, Anti-Sinus,
Anti-Diabetes, Anti-Leukorrhea, Anti-Leprosy, Anti-hyperglycemic
activity, Anti-depressant activity, Anti-cancer activity, Antioxidant
activity. The single drug WF was Standardization, Quality Control
Screening studied in three different batches as per the guidelines of
WHO/ AYUSH Protocols basis. Present research study is aimed to
evaluate the Standardization and product quality acceptability using
physico-chemical parameters; HPTLC fingerprinting as per WHO
guidelines of analyzed parameters. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain Foreign matter, w/w- (0.08 %,0.07%,0.08%), LOD/ Moisture, w/w- (6.054%,6.010% 6.320%), Total ash, w/w-(5.79%,5.82%,6.93%), Acid in-soluble ash, w/w-(0.776%,0.770%,0.778%), Alcohol and water soluble extractive matter, w/v- (12.80%,12.46%, 12.38%) & (24.40%, 4.46%,24.50%), pH(10% solution) (4.8,4.9,4.8), the HPTLC finger prints showed various spots at 254nm, 366nm Iodine vapours and visible light (M-S reagent). The tested drug samples showed significant Antibacterial potential and Toxicology studies against certain pathogens organisms and microbial load analysis. The QC. findings revealed that the test drug was free
from adulterations. The evaluated validated quality standards will be very useful for referential support, validation of the standards of WF, pharmaco-vigilance and providing the quality raw medicine to deprived human being.
KEYWORDS: (Woodfordia fruticosa (Linn) Kurz), Physico-chemical quality QC and QA HPTLC fingerprinting and Unani Compound drug.
Keywords / मूलशब्द : धातकी / धाई फूल / गुल-ए-धावा वुडफोर्डिया फ्रुटिकोसा (लिनन) कुर्ज़), भौतिक-रासायनिक गुणवत्ता, गुणवत्ता नियंत्रण और आश्वासन पैरामीटर, टीएलसी / एचपीटीएलसी फिंगरप्रिंटिंग और यूनानी यौगिक दवा।
KEYWORDS: Raughan-e-Muqawwi-e-Dimagh (REMED), Anti-amnesic,Medicated Brain booster oil, development of pharmacopeial standards, physicochemical, comparative screening, quality control and assurance.
Keywords: Jawarish-Usquf, Physico-chemical quality, Quality Control and Assurance parameters, TLC/ HPTLC fingerprinting and Unani Compound drug.
in the treatment of spasmodic, mutagenic, dermal photosensitizing, skin diseases, anti-tuberculosive and
anticonvulsive activity and antimicrobial activities. This review summarizes the chemical constituents
(furanocoumarin, coumarin and other chemical compounds) present in Heracleum candicans Wall. This
plant species is a rich source of furanocoumarin, coumarin, fatty acids and their derivatives
along with β-sitosterol-D-glycoside, oleanolic acid. Except oleanolic acid these two compounds for the first
time have been reported from this plant source and identified by means of chemical as well as
spectroscopic methods