Back to index Results: Proportions of C homozygote, heterozygote, and T homozygote for TGF-B1 gen... more Back to index Results: Proportions of C homozygote, heterozygote, and T homozygote for TGF-B1 gene polymorphisms were 21.4/77.1/1.5% in the control and 14/64/22% in the patient group. Statistical analysis indicates that homozygote gene type T/T is obviously more frequent in the patients group (χ2 = 13,92, p = 0,0009), and that there is corelation of the genotype T/T with the kidney scars forming risk (TT vs.CT + CC: OR = 19.4615; CI 2.420-156.477; p = 0.0003).There wasn't statistical significance between genotypes with T alleles and the genotype C/C (T-vs. CC: OR = 1.675; CI 0. 63-4.47; p>0,20). Conclusion: The presence of the genotype T/T on the position -509 in the promoter region TGF-B1 gene is risk factor for the kidney scars development in patients with VUR in children.
ABSTRACT The interest in parental aging and reproductive outcomes has increased significantly with... more ABSTRACT The interest in parental aging and reproductive outcomes has increased significantly with the change in societal structure and age at family planning. Although the effect of advanced maternal age on obstetric and neonatal morbidities is well established, the effect of advanced paternal age needs additional exploration in association with adverse reproductive outcomes. Some studies suggest that the sperm of fathers with advanced age harbor germline mutations that influence reproductive, neonatal, and adult health outcomes of the progeny. Data on the contribution of advanced paternal age to spontaneous abortion, postconceptual age, birth weight, and neonatal mortality depends on the population and the design of the study. There is stronger evidence that advanced paternal age contributes significantly to congenital malformations and the health of the offspring in adolescence and adulthood with an increased risk of cancer, neurologic disorders, and cardiac diseases. In this review, we summarize the results of different studies that address the effect of advanced paternal age on reproductive outcomes and the origin of illnesses in adulthood. We also discuss possible mechanisms and theories behind these potential associations.
Maternal behavior before and after conception affects maternal and child health. Limited awarenes... more Maternal behavior before and after conception affects maternal and child health. Limited awareness of adolescents in preconception health may be addressed through school education. The aim of this intervention is to assess preconception health awareness among adolescents in Lebanese high schools and to test the effectiveness of a one-time educational session in improving preconception knowledge. The intervention consisted of a 30-minute educational session about good practices in preconception health, developed by the National Collaborative Perinatal Neonatal Network's (NCPNN) research team. A convenience sample of high school Lebanese students in grades 10 to 12, aged 14 to 26 years old, from 70 private and public schools in all six Lebanese provinces, participated in the intervention in 2011 and 2012. A multiple-choice questionnaire administered prior to and 2 months after the session was used to assess knowledge improvement among the students. A total of 7,290 students were e...
To test the utility of a preconception checklist tool in identifying preconception health needs o... more To test the utility of a preconception checklist tool in identifying preconception health needs of women in three countries; China, Lebanon and the Philippines. An academic medical center within each country participated in the development and testing of a preconception checklist tool, which was administered over a 6 month period to selected target groups in each country. The checklist provided valuable data on the preconception health of 6,530 women. Aggregated data identified common preconception health needs across all countries, including provision of modern contraceptives and adequate immunization coverage; HIV and STI screening; treatment for anemia; and counseling for maintenance of a healthy weight. A preconception checklist tool was found to be useful in distinct cultural settings. The study was a pilot. Future steps include validation and standardization of the checklist, data from which could be used to help shape preconception care policies and implementation strategies.
Background: Pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) are reported to... more Background: Pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) are reported to impact the preterm birth (PTB) rate and newborn size. Most studies have been conducted in developed countries, although PTB and adverse pregnancy outcomes are more frequent in the developing world. The aim of this study is to elucidate the association of pre-pregnancy BMI and GWG on the occurrence of PTB and sub-optimal fetal size in Lebanon.
Back to index Results: Proportions of C homozygote, heterozygote, and T homozygote for TGF-B1 gen... more Back to index Results: Proportions of C homozygote, heterozygote, and T homozygote for TGF-B1 gene polymorphisms were 21.4/77.1/1.5% in the control and 14/64/22% in the patient group. Statistical analysis indicates that homozygote gene type T/T is obviously more frequent in the patients group (χ2 = 13,92, p = 0,0009), and that there is corelation of the genotype T/T with the kidney scars forming risk (TT vs.CT + CC: OR = 19.4615; CI 2.420-156.477; p = 0.0003).There wasn't statistical significance between genotypes with T alleles and the genotype C/C (T-vs. CC: OR = 1.675; CI 0. 63-4.47; p>0,20). Conclusion: The presence of the genotype T/T on the position -509 in the promoter region TGF-B1 gene is risk factor for the kidney scars development in patients with VUR in children.
ABSTRACT The interest in parental aging and reproductive outcomes has increased significantly with... more ABSTRACT The interest in parental aging and reproductive outcomes has increased significantly with the change in societal structure and age at family planning. Although the effect of advanced maternal age on obstetric and neonatal morbidities is well established, the effect of advanced paternal age needs additional exploration in association with adverse reproductive outcomes. Some studies suggest that the sperm of fathers with advanced age harbor germline mutations that influence reproductive, neonatal, and adult health outcomes of the progeny. Data on the contribution of advanced paternal age to spontaneous abortion, postconceptual age, birth weight, and neonatal mortality depends on the population and the design of the study. There is stronger evidence that advanced paternal age contributes significantly to congenital malformations and the health of the offspring in adolescence and adulthood with an increased risk of cancer, neurologic disorders, and cardiac diseases. In this review, we summarize the results of different studies that address the effect of advanced paternal age on reproductive outcomes and the origin of illnesses in adulthood. We also discuss possible mechanisms and theories behind these potential associations.
Maternal behavior before and after conception affects maternal and child health. Limited awarenes... more Maternal behavior before and after conception affects maternal and child health. Limited awareness of adolescents in preconception health may be addressed through school education. The aim of this intervention is to assess preconception health awareness among adolescents in Lebanese high schools and to test the effectiveness of a one-time educational session in improving preconception knowledge. The intervention consisted of a 30-minute educational session about good practices in preconception health, developed by the National Collaborative Perinatal Neonatal Network's (NCPNN) research team. A convenience sample of high school Lebanese students in grades 10 to 12, aged 14 to 26 years old, from 70 private and public schools in all six Lebanese provinces, participated in the intervention in 2011 and 2012. A multiple-choice questionnaire administered prior to and 2 months after the session was used to assess knowledge improvement among the students. A total of 7,290 students were e...
To test the utility of a preconception checklist tool in identifying preconception health needs o... more To test the utility of a preconception checklist tool in identifying preconception health needs of women in three countries; China, Lebanon and the Philippines. An academic medical center within each country participated in the development and testing of a preconception checklist tool, which was administered over a 6 month period to selected target groups in each country. The checklist provided valuable data on the preconception health of 6,530 women. Aggregated data identified common preconception health needs across all countries, including provision of modern contraceptives and adequate immunization coverage; HIV and STI screening; treatment for anemia; and counseling for maintenance of a healthy weight. A preconception checklist tool was found to be useful in distinct cultural settings. The study was a pilot. Future steps include validation and standardization of the checklist, data from which could be used to help shape preconception care policies and implementation strategies.
Background: Pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) are reported to... more Background: Pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) are reported to impact the preterm birth (PTB) rate and newborn size. Most studies have been conducted in developed countries, although PTB and adverse pregnancy outcomes are more frequent in the developing world. The aim of this study is to elucidate the association of pre-pregnancy BMI and GWG on the occurrence of PTB and sub-optimal fetal size in Lebanon.
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