Papers by R. Blancas-Espinosa
Contact …, 2005
ABSTRACT Healthcare workers (or relatives) crushing drug tablets for patients with difficulties i... more ABSTRACT Healthcare workers (or relatives) crushing drug tablets for patients with difficulties in swallowing are at risk of developing sensitization via airborne exposure. Tetrazepam, in particular, is increasingly being described as an important occupational allergen in this regard, although other drugs are also involved. To identify the allergenic culprits in 4 patients, namely 2 nurses, 1 pharmacy assistant, and 1 spouse, who all regularly crushed tablets of systemic drugs and presented with severe airborne dermatitis. The patients were patch tested with all of the drugs that they handled, as well as with potential cross-sensitizing molecules. All 4 patients reacted to tetrazepam and other benzodiazepines, some of which they had not previously come into contact with, which favours cross-reactivity rather than concomitant sensitization. These patients also had positive reactions to several other non-structurally related drugs for which, in some cases, there was no history of exposure. Subjects having to crush drugs, in either an occupational or a non-occupational context, and who present with dermatitis suspected of being airborne-induced, should be patch tested with all contacted medicaments, as well as with possible cross-reacting molecules. Prevention by the use of crushing devices and protective measures (gloves and masks) when medications are handled should be advised.
Ginecología y obstetricia de México, 1994
Herpes gestationis (HG) is a rare autoimmune blistering complication of pregnancy. It is of unkno... more Herpes gestationis (HG) is a rare autoimmune blistering complication of pregnancy. It is of unknown etiology and it occurs once in every 3,000 to 50,000 pregnancies. The diagnosis can strongly be suggested by the clinical picture, but it must be confirmed using immunopathological methods. The treatment of choice is local measures and systemic corticosteroids. Although the maternal prognosis is excellent, there are controversies on the perinatal outcome. A typical case of HG is presented and the literature is reviewed.
American Journal of Contact Dermatitis, 2000
A 56-YEAR-OLD WOMAN presented with a 5-year history of a relapsing dermatitis confined to the ank... more A 56-YEAR-OLD WOMAN presented with a 5-year history of a relapsing dermatitis confined to the ankles. Physical examination showed a bilateral, sharply demarcated eruption with erythema, edema, vesicles, and bullae limited to the area covered by her socks . The biopsy results were consistent with spongiotic dermatitis. Immunofluorescence study results were negative. Patch test studies included the standard, corticosteroid, and rubber additive trays. Patch tests were applied to the back using IQ chambers. Only the nickel sulfate patch test elicited a positive result that had a past relevance. Results of patch tests to 2 samples of the patient's socks were + + + positive .
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Papers by R. Blancas-Espinosa