Papers by Panayotis Spyridis
Tubercle and Lung Disease, 1995
This study was undertaken to determine the effects of INH monotherapy and TBC-I itself on chromat... more This study was undertaken to determine the effects of INH monotherapy and TBC-I itself on chromatid/ chromosomal breakage and sister chromatid exchange frequency (SCE) in lymphocytes of children with TBC-I. 28 boys and 32 girls, 2-13 yrs old were evaluated at the time of diagnosis (internal controls) and after completion of INH prophylaxis; 30/60 received daily INH (10 mg/kg) for 6 mos (group I), while in the rest, 30/60, the drug was administered at the same dosage only for the first 2 mos and then twice weekly (20 mg/kg/d) for 4 mos (group II). The general control group included 30 healthy children (15 d and 15 ~?, 1-13 yrs old).
Tubercle and Lung Disease, 1995
in San Diego County increased by 400% from 15 to 75 cases. The largest increase was seen in child... more in San Diego County increased by 400% from 15 to 75 cases. The largest increase was seen in children 0.4 years of age. Health department, hospital, and clinic records of cases of TB in children 0-4 years reported in 1989, 1991, and 1993 in San Diego County were reviewed. Data collected included demographic information; country of birth; immigration status of the child and parents; and source case. Records of 85/89 (96%) TB cases were reviewed. HIV serology was negative for the 7 (8%) with known results. Of the 85 cases, 17 (20%) were foreign-born, 14 of whom were born in Mexico. Of the 68 US-born cases, 59 (87%) were Hispanic; 22/68 (32%) had immigrant parents (20 from Mexico), 17 (25%) others were reported to visit family in Mexico. Of the 17 immigrant parents of the 22 USborn children for whom date of entry into the US was known, 11 (65%) arrived less than 2 years prior to diagnosis in the child. A presumed source case was identified for 35 (51%) US-born cases; of these, 15 (43%) were parents, 10 (67%) of whom immigrated from Mexico, 9 (26%) a relative, 6 (17%) a neighbor or family friend, 4 (11%) a housemate, and 1 a sibling. At least 56/85 (66%) cases were in children who immigrated from a country where TB is highly endemic, or the child was US-born and the parents were immigrants, or there was extended family in Mexico.
Pediatric Neurology, 1995
A boy, 4 years, 9 months of age, presented with acute hemiplegia, lethargy, ataxia, and dysarthri... more A boy, 4 years, 9 months of age, presented with acute hemiplegia, lethargy, ataxia, and dysarthria 24 hours prior to the eruption of typical varicella exanthem. Magnetic resonance imaging findings were typical of multiple cerebral ischemic infarcts. It is suggested that during the period of secondary viremia varicella zoster virus invaded the cerebral blood vessels causing vasculopathy and cerebrovascular infarcts. Tsolia M, Skardoutsou A, Tsolas G, Karayanni C, Spyridis P, Sinaniotis C. Pre-eruptive neurologic manifestations associated with multiple cerebral infarcts in varicelia. Pediatr Neurol 1995; 12:165-168.
Tubercle and Lung Disease, 1995
The Pediatric Infectious Disease Journal, 1999
To describe the clinical and epidemiologic features, management and outcome associated with the d... more To describe the clinical and epidemiologic features, management and outcome associated with the development of nontuberculous mycobacterial (NTM) superficial lymphadenitis in children. The medical records of all children 0 to 14 years of age with NTM superficial lymphadenitis who were diagnosed at P. and A. Kyriakou Children's Hospital between January, 1982, and December, 1997, were reviewed. Forty-seven children were identified, 76.5% during the second half of the study period. Mycobacterium avium complex was the predominant isolate. Children with NTM lymphadenitis noted satisfactory aesthetic results when total excision was performed within 1 month after its onset. NTM superficial lymphadenitis in children has been increasingly recognized during the last decade. Prompt total excision of the involved lymph node is required in such patients.
Clinical Infectious Diseases, 2007
Archives of Disease in Childhood, 1979
The incidence of INH-associated liver injury was evaluated in 239 children aged between 9 and 14 ... more The incidence of INH-associated liver injury was evaluated in 239 children aged between 9 and 14 years, who were receiving 300 mg INH/day for tuberculosis prophylaxis. Serum SGOT and SGPT levels were determined before INH administration and at 4-weekly intervals thereafter. Levels of both enzymes were raised during the first 3 months of treatment in 18 (7.5%) children, while in 23 (9.6%) children either SGOT or SGPT exceeded normal levels (SGOT greater than 40 units, SGPT greater than 30 units). Only 2 (0.8%) children showed SGOT and SGPT values above 100 units and in them treatment with INH had to be discontinued. In all other children transaminases returned to normal during uninterrupted INH administration. It was noted also that transaminase values in children who did not exhibit a rise above normal, still had significantly higher levels during treatment compared with before. The findings of this study suggest that liver injury in children receiving INH for prophylaxis occurs more often than it had hitherto been believed but that it is usually mild and transient.
European Journal of Pediatrics, Apr 7, 2006
Eur J Pediatr (2006) 165: 458461 DOI 10.1007/s00431-006-0110-7 ... Maria N. Tsolia . Ariane Chap... more Eur J Pediatr (2006) 165: 458461 DOI 10.1007/s00431-006-0110-7 ... Maria N. Tsolia . Ariane Chapgier . Polyxeni Taprantzi . Marina Servitzoglou . Ioannis Tassios . Nikolaos Spyridis . Fotini Papageorgiou . Orchidée Filipe Santos . Jean-Laurent Casanova . Panayotis Spyridis
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Papers by Panayotis Spyridis