Papers by Mustafa Erdogan
Background: Pulmonary hypertension (PH) is an important cause of morbidity and mortality in patie... more Background: Pulmonary hypertension (PH) is an important cause of morbidity and mortality in patients with systemic sclerosis (SSc). Different screening algorithms have been proposed for identifying patients who have a high probability of PH and require right heart catheterization (RHC), which is the gold standard for diagnosing PH. Objectives: To compare the performance of PH screening algorithms in our patients with SSc. Methods: Sixty-nine consecutive pts fulfilling ACR/EULAR 2013 SSc criteria have been screened for PH until now, using the 2015 ESC/ERS, DETECT and ASIG algorithms. Pulmonary function tests (PFT), diffusing capacity of the lung for carbon monoxide (DLCO), trans-thoracic echocardiography, serum NT-proBNP and uric acid assay and high-resolution computed tomography (HRCT) were performed as needed. Patients with known PH, severe interstitial lung disease and severe left ventricular dysfunction (LVD) were not included. RHC was performed in all patients with positive scre...
Current Opinion in Rheumatology
Scleroderma, myositis and related syndromes
presence of anti-cN-1A. Anti-cN-1A positivity had a sensitivity of 43.6% and a specificity of 91.... more presence of anti-cN-1A. Anti-cN-1A positivity had a sensitivity of 43.6% and a specificity of 91.8% for sIBM. The positive and negative predictive values were 36.4% and 93.8%, respectively. There was no significant difference in gender, age at study entry, age at symptom onset, duration of symptoms or max creatine kinase (CK) levels during disease course between the anti-cN-1A positive and negative sIBM patients. Dysphagia was present in 19 (79%) of the anti-cN-1A positive and in 17 (55%) of the anti-cN-1A negative sIBM patients (P = 0.06). Conclusion: Antibodies against cN-1A are the first and so far the only serological marker for sIBM. Our data showed that cN-1A autoantibodies are specific for sIBM and further corroborate the potential diagnostic role of cN-1A autoantibodies in this distinct subgroup of myositis.
Abstracts Accepted for Publication
AB1209 Table 2. Group differences of physical and mental health parameters * Significant at p £ 0... more AB1209 Table 2. Group differences of physical and mental health parameters * Significant at p £ 0.05. Average age for all three groups falls in the 50-59 year range. Differences were found between PHQ-9, WHO-5 and FFbH-R, whereas none were found for HPA. Conclusion: As expected, a difference in mental health parameters was found for the "known diagnosis" and "no diagnosis+CRP negative" groups. The results also show differences for daily functional tasks between all three groups. However, the lowest scores were found for the group "no diagnosis+CRP pos", i.e. people with strong indications for an early rheumatic disease. This further supports evidence of reduced functionality for early stage patients and the need for early diagnosis and therapy. The lack of significant differences for HPA patterns could be caused by generally very low physical activity for all three groups.
Saturday, 15 June 2019
events in 2 (testicular abscess and worsening renal failure) and refractory disease in 2. Conclus... more events in 2 (testicular abscess and worsening renal failure) and refractory disease in 2. Conclusion: The results of this study suggest that TNF-alpha blockers and TCZ may achieve higher rates of remission and GC-sparing in relapsing and/or refractory PAN than other biologics. Our data warrant further study to confirm or not these findings.
Rheumatology
methotrexate and plasma-exchange. At the end of follow up 2 patients were renal transplant recipi... more methotrexate and plasma-exchange. At the end of follow up 2 patients were renal transplant recipients, 5 had chronic kidney disease (CKD) and 4 maintained normal kidney function. Conclusion: Although renal involvement in EGPA is less frequent than in other AAV, it must be taken into account especially in ANCA positive patients who can present with NCGN leading to CKD. However, it also presents in ANCA negative patients, who can have other manifestations such as TIN with eosinophil infiltrates or obstructive uropathy.
Journal of Academic Emergency Medicine Case Reports, 2015
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Papers by Mustafa Erdogan