Papers by Muhammad Moniruzzaman
Jurnal Rekayasa Kimia & Lingkungan
The technological utility of enzymes for delignification can be increased by using ionic liquid t... more The technological utility of enzymes for delignification can be increased by using ionic liquid to open more accessible surface area for biomass transformation into bio-based products. The present paper demonstrates application of ionic liquid (IL) [emim][DEP] 1-ethyl-3 methyllimidazolium-diethyl phospate for empty fruit bunch (EFB) pretreatment process followed by enzymatic delignification by using Laccase. It was found that [emim][DEP] increased the performance of the enzyme laccase and henced higher cellulose rich materials, whereas also reduced the lignin content in the EFB. The lowest lignin content obtained from IL-laccase treated EFB was approximately 17.92%, lower than the lignin content in the untreated EFB. Both treated and untreated EFB were characterized in chemical and physical properties by using scanning electron microscope (SEM), fourier transform infrared (FTIR), and thermogravimetric analysis (TGA/DTG) to observe the changes resulted from the pretreatment.
Molecules
In the current study, we have synthesized an imidazolium based cross-linked polymer, namely, 1-vi... more In the current study, we have synthesized an imidazolium based cross-linked polymer, namely, 1-vinyl-3-ethylimidazolium bis(trifluoromethylsulfonyl)imide (poly[veim][Tf2N]-TRIM) using trimethylolpropane trimethacrylate as cross linker, and demonstrated its efficiency for the removal of two extensively used ionic dyes—methylene blue and orange-II—from aqueous systems. The detailed characterization of the synthesized poly[veim][Tf2N]-TRIM was performed with the help of 1H NMR, TGA, FT-IR and FE-SEM analysis. The concentration of dyes in aqueous samples before and after the adsorption process was measured using an UV-vis spectrophotometer. The process parameters were optimised, and highest adsorption was obtained at a solution pH of 7.0, adsorbent dosage of 0.75 g/L, contact time of 7 h and dye concentrations of 100 mg/L and 5.0 mg/L for methylene blue and orange-II, respectively. The adsorption kinetics for orange-II and methylene blue were well described by pseudo-first-order and pse...
Ionic Liquid Devices
In the pharmaceutical industry, there are challenges in topical and transdermal administration of... more In the pharmaceutical industry, there are challenges in topical and transdermal administration of drugs, which are sparingly soluble in water and most organic solvents. Ionic liquids (ILs) have been found to be very effective for dissolution of sparingly soluble drugs. However, hydrophilic IL-borne drugs cannot penetrate into or across the skin because of the highly hydrophobic barrier function of the outer skin. In this chapter we report a novel IL-in-oil (IL/o) microemulsion (ME) that is able to dissolve a significant amount of sparingly soluble drug, acyclovir, in the IL core while the continuous oil phase can provide the desired features for topical/transdermal transport through the skin. The ME is composed of a blend of the nonionic surfactants polyoxyethylene sorbitan monooleate (Tween 80) and sorbitan laurate (Span 20), isopropyl myristate (IPM) as an oil phase, and the IL [C1mim][(MeO)2PO2] (dimethylimidazolium dimethylphosphate) as a dispersed phase. The size and size distribution of the aggregates in the MEs were characterized by dynamic light scattering, showing formation of the nanocarrier in the size range 8–34 nm. In vitro drug permeation studies into and across the skin showed that the IL/o ME increased drug administration compared with other formulations. The safety profile of the new carrier was evaluated using a cytotoxicity assay on the human epidermal model LabCyte. We believe that these IL-assisted nonaqueous MEs can serve as a versatile and efficient nanodelivery system for sparingly soluble drug molecules.
Weber, T., McPhee, M.J. and Anderssen, R.S. (eds) MODSIM2015, 21st International Congress on Modelling and Simulation, 2015
Environmental Technology & Innovation, 2021
Abstract The quality of tyre pyrolysis oil (TPO) and the pollution generated through tyre pyrolys... more Abstract The quality of tyre pyrolysis oil (TPO) and the pollution generated through tyre pyrolysis units were investigated. Two oil types are generally produced, known as light TPO and heavy TPO, exhibiting a pungent smell. Gross calorific value of TPO varies from 18275.5 Btu/lb to 18641.8 Btu/lb. Gross calorific value (GCV) shows TPO can be used as fuel oil in industries for energy recovery purposes. The density of heavy oil was lower as compared to light oil. Values of density for both oils were higher than the furnace oil and petroleum, which are 0.96 g/cm 3 for local furnace oil and 0.98 g/cm3 for imported furnace oil and 0.88 for petroleum. Results showed that tyre pyrolysis units are badly affecting the surrounding environment. The emission level of CO was 2608 ± 1442.3 mg/Nm3 at site 1, NOx was 826.16 ± 645.52 mg/Nm3 at site 2, SO2 was 997 ± 1164 at site 2 and emission of PM was 1629 ± 311.6 mg/Nm3 at site 2. The emission level of all these pollutants was above permissible limits. The effluents results show that the concentration of sulfate, TSS, TDS, copper (Cu 2 + ), and manganese was above the allowable limit. COD was very high; it varied from 31809 mg/L to 42144 mg/L.
Journal of Physics: Conference Series, 2021
Nanocellulose (NC) has generated interest from the scientific community because of their biodegra... more Nanocellulose (NC) has generated interest from the scientific community because of their biodegradability, and unique physiochemical characteristics. In this study, ionic liquid 1-butyl-3-methylimidazolium hydrogen sulfate [Bmim][HSO4] combined with high ultrasonication is used to prepare NC from microcrystalline cellulose (MCC). The investigation by atomic force microscopy (AFM) revealed that the obtained NC had a rod-like shape with average particle diameter and length of 0.77±0.28μm, 2.11±0.65mμ respectively. Fourier transform infrared spectroscopy (FTIR) characterization exhibited that the prepared NC maintained the cellulose type I structure and the recovered IL (97%) composition remained intact as the pure IL. Therefore, it is expected to develop a green approach to produce nanocellulose with high quality using ILs.
Environmental Pollution, 2021
The well-known toxicity of conventional chemical oil spill dispersants demands the development of... more The well-known toxicity of conventional chemical oil spill dispersants demands the development of alternative and environmentally friendly dispersant formulations. Therefore, in the present study we have developed a pair of less toxic and green dispersants by combining lactonic sophorolipid (LS) biosurfactant individually with choline myristate and choline oleate ionic liquid surfactants. The aggregation behavior of resulted surfactant blends and their dispersion effectiveness was investigated using the baffled flask test. The introduction of long hydrophobic alkyl chain with unsaturation (attached to choline cation) provided synergistic interactions between the binary surfactant mixtures. The maximum dispersion effectiveness was found to be 78.23% for 80:20 (w/w) lactonic sophorolipid-choline myristate blends, and 81.15% for 70:30 (w/w) lactonic sophorolipid-choline oleate blends at the dispersant-to-oil ratio of 1:25 (v/v). The high dispersion effectiveness of lactonic sophorolipid-choline oleate between two developed blends is attributed to the stronger synergistic interactions between surfactants and slower desorption rate of blend from oil-water interface. The distribution of dispersed oil droplets at several DOR were evaluated and it was observed that oil droplets become smaller with increasing DOR. In addition, the acute toxicity analysis of developed formulations against zebra fish (Danio rerio) confirmed their non-toxic behavior with LC50 values higher than 400 ppm after 96 h. Overall, the proposed new blends/formulations could effectively substitute the toxic and unsafe chemical dispersants.
Molecular Pharmaceutics, 2021
Coronavirus disease 2019 (COVID-19) has spread across the world, and no specific antiviral drugs ... more Coronavirus disease 2019 (COVID-19) has spread across the world, and no specific antiviral drugs have yet been approved to combat this disease. Favipiravir (FAV) is an antiviral drug that is currently in clinical trials for use against COVID-19. However, the delivery of FAV is challenging because of its limited solubility, and its formulation is difficult with common organic solvents and water. To address these issues, four FAV ionic liquids (FAV-ILs) were synthesized as potent antiviral prodrugs and were fully characterized by nuclear magnetic resonance (NMR) spectroscopy, Fourier-transform infrared (FT-IR) spectrometry, powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), derivative thermogravimetry (DTG), and differential scanning calorimetry (DSC). The aqueous solubility and in vivo pharmacokinetic properties of the FAV-ILs were also evaluated. The FAV-ILs exhibited improved aqueous solubility by 78 to 125 orders of magnitude when compared with that of free FAV. Upon oral dosing in mice, the absolute bioavailability of the β-alanine ethyl ester FAV formulation was increased 1.9-fold compared with that of the control FAV formulation. The peak blood concentration, elimination half-life, and mean absorption time of FAV were also increased by 1.5-, 2.0-, and 1.5-fold, respectively, compared with the control. Furthermore, the FAV in the FAV-ILs exhibited significantly different biodistribution compared with the control FAV formulation. Interestingly, drug accumulation in the lungs and liver was improved 1.5-fold and 1.3-fold, respectively, compared with the control FAV formulation. These results indicate that the use of ILs exhibits potential as a simple, scalable strategy to improve the solubility and oral absorption of hydrophobic drugs, such as FAV.
Journal of Physics: Conference Series, 2021
Polyetheretherketone (PEEK) is a stable semi-crystalline thermoplastic polymer with excellent the... more Polyetheretherketone (PEEK) is a stable semi-crystalline thermoplastic polymer with excellent thermal and chemical properties and is used in many applications, especially as a biomaterial. However, poor mechanical properties: mismatching of elastic modulus to human bone retards the use of PEEK as a biomaterial for bone implant material. In the present study, ionic liquid (IL) modified multiwalled carbon nanotubes were used to prepare PEEK nanocomposites via internal mixer and compression molding processes. The morphologies, thermal and mechanical properties of the prepared nanocomposites were evaluated. Uniform and excellent distribution of MWCNTs into PEEK was achieved by optical microscopy. The thermogravimetric study showed that the decomposition temperature of the composites was boosted 7 % ± 0.9 as compared to those of PEEK composites prepared without IL. Moreover, the elastic modulus of the PEEK nanocomposites was improved by ionic liquid modified MWCNTs into the PEEK. Thus, t...
The enzymatic hydrolysis of lignocellulosic biomass is one of the obstacles in the process of sug... more The enzymatic hydrolysis of lignocellulosic biomass is one of the obstacles in the process of sugar production, due to the presence of lignin that protects the cellulose molecules against cellulases. Although the pretreatment of lignocellulose in ionic liquid (IL) system has been receiving a lot of interest; however, it requires IL removal with an anti-solvent in order to proceed with the enzymatic hydrolysis. At this point, introducing a compatible cellulase enzyme seems more efficient in this process. A cellulase enzyme that was produced by Trichoderma reesei on palm kernel cake (PKC) exhibited a promising stability in several ILs. The enzyme called PKC-Cel was tested for its optimum pH and temperature as well as its molecular weight. One among evaluated ILs, 1,3-diethylimidazolium dimethyl phosphate [DEMIM] DMP was applied in this study. Evaluation of six factors was executed in Stat-Ease Design Expert V.9, definitive screening design, which are IL/ buffer ratio, temperature, hyd...
Journal of Materials Chemistry A, 2020
Micelles are formed using a CO2-philic surfactant (N-ethyl perfluorooctyl sulfonamide) and embedd... more Micelles are formed using a CO2-philic surfactant (N-ethyl perfluorooctyl sulfonamide) and embedded in in situ formed polymeric materials (SMI-ILPs) to enhance CO2 sorption.
Ionic Liquid-Based Technologies for Environmental Sustainability, 2022
journal of engineering science and technology, 2015
Enzyme immobilization methods are continuously being developed for a wide range of applications i... more Enzyme immobilization methods are continuously being developed for a wide range of applications including biocatalysis and biotransformation. Compared to other immobilization methods, physical entrapment into a matrix is relatively simple and inexpensive, and causes a relatively small perturbation to the native enzyme structure and function. However, significant enzyme leaching from such biocatalytic polymers is the main constraint in using them for industrial levels. This study reports an ionic liquid (IL) polymer materials incorporating enzymes that can be used as active, stable and reusable biocatalysts to overcome the limitations. Lipase was microencapsulated in surfactant aggregates formed in an IL monomer or the solution of an IL monomer/IL and then incorporated into polymer frameworks through the free radical polymerization of an IL (1-vinyl-3-ethylimidazolium bis(trifluoromethylsulfonyl) amide ([veim][Tf2N]). The activity, stability and reusability of IL polymer materials co...
One conventional way to address the poor solubility of drugs in order to increase their performan... more One conventional way to address the poor solubility of drugs in order to increase their performance is to use excipients polar organic solvents. However, the use of such organic solvents has many drawbacks. They are often volatile, flammable and toxic. Pharmaceutical ingredients must be free from all such traces. So in this work, we have showed that we can use ionic liquids (ILs) as a replacement for conventional solvent in pharmaceutical industries. The solubility of Acyclovir in ILs was studied within two cations groups of ILs (Ammonium, Pyridinium) and sixteen anions using COSMOtherm-X software at room temperature and atomosphere pressure. The results showed that the solubility of Acyclovir in ammonium-based ILs is relatively higher than other studied ILs. Considering ammonium salts examined in this work, tetramethylammonium-acetate [N 1111 ][OAc], trimethylethylammonium-acetate [N 1112 ][OAc] and dimethylethylpropylammonium-acetate [N 1123 ][OAc] are excellent solvents. Due to ...
Inorganic and Nano-Metal Chemistry, 2021
Abstract The meticulous modulations of size and morphology are challenging to produce scale of pl... more Abstract The meticulous modulations of size and morphology are challenging to produce scale of plants mediated gold nanoparticles (AuNPs). In addition, the specific role of phytochemicals to precede the bio-reduction reaction and capping of the nanoparticles is also a mystery and need to be addressed. In the same line of action, we reported a green, eco-friendly, efficient and one-step method for synthesis of tailored size and shaped AuNPs and were controlled by various process parameters including pH, volume of extract and concentration of gold precursor. Bio-reduction process and formation of AuNPs were identified through various characterization techniques including UV-vis, TEM, DLS, FTIR, XRD and XPS. Shapes of AuNPs were observed predominantly spherical with average projected and hydrodynamic diameters of 9.49 and 168 nm respectively. The role of phytochemicals acting as active reducing and capping agents has been recognized and explained by the establishment of the reaction mechanism.
E3S Web of Conferences, 2021
Chemical dispersants is one of the globally accepted remediation technique used for marine oil sp... more Chemical dispersants is one of the globally accepted remediation technique used for marine oil spill. However, the toxicity related with these dispersants confined its application in marine environment. Therefore, to overcome this problem, the employment of environmentally benign dispersants is one of the effective conceivable approach. In this study, the formulation comprised of choline based ionic liquid, choline laurate ([Cho][Lau]) and a biosurfactant, lactonic sophorolipids (LS) were used as a crude oil emulsifier. The toxicity of the newly developed formulation was evaluated to confirm their safe employment in sea water. The developed formulation worked effectively as a crude oil emulsifier and formed a stable crude oil emulsion. The toxicity study against Gram-positive and -negative bacteria depicts the “practically harmless” nature of the developed formulation. Thus, the results presented in this study showed that the new formulation can potentially replace the conventional ...
E3S Web of Conferences, 2021
The conversion of palm oil into a sulfur-based polymer by copolymerization with sulfur powder at ... more The conversion of palm oil into a sulfur-based polymer by copolymerization with sulfur powder at its molten state is herein reported. The obtained sulfur-containing polymer was characterized using Fourier transform infrared (FTIR), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) to demonstrate the successful conversion. The disappearance of the peaks related to vinylic groups of oil together with the appearance of a peak representing C-H rocking vibrations in the vicinity of C-S bonds confirmed the copolymerization of sulfur with oil. TGA revealed that the polymers have thermal stability up to 230°C under nitrogen and the polymers leave 10% sulfur-rich ash. DSC proved that a small amount of elemental sulfur remained unreacted in the polymer, which showed amorphous and heavily crosslinked structure resembling thermosets. These copolymers are an environmental-friendly polymeric material promoting the utilization of the abundant sulfur while also adding va...
Environmental Technology & Innovation, 2021
Abstract Chemical oil spill dispersants are toxic to the marine environment, spurring a search fo... more Abstract Chemical oil spill dispersants are toxic to the marine environment, spurring a search for environmentally friendly dispersant formulations. We have formulated an oil spill dispersant composed of two biocompatible surfactants, Tween 80 (T) and surface-active ionic liquid (SAIL), [BMIM] [Lausar] (1- butyl -3-methylimidazolium lauroyl sarcosinate). Various micellar, interfacial, and thermodynamic properties of Tween 80 and ionic liquid (T/IL) blends were studied. The T/IL blends were solubilized in simulated seawater, and their oil (light Arab crude oil) dispersion effectiveness was determined by the baffled flask test. A synergistic interaction was observed between T and IL, such that a blend is effective as an oil dispersant, but neither is effective on its own. The stability of crude oil droplets was maximized at a 40/60 (w/w) of T/IL. The dispersion effectiveness at this specific ratio was found to be 81.19%, with a dispersant to oil ratio (DOR) of 1:25 (volume). The size and size distribution of dispersed oil droplets at function of DOR were investigated using optical microscopy and particle size analyzer. The results showed that the sizes of oil droplets decreased with DOR. We conclude that T/IL blends have unique properties which make them viable alternatives for oil spill remediation.
Uploads
Papers by Muhammad Moniruzzaman