Abstract: The present study was carried out to investigate the effect of some nutrients on Nutrit... more Abstract: The present study was carried out to investigate the effect of some nutrients on Nutritional and Health status in copper and lead intoxicated male albino rats. Fifty male albino rats weighing (125±7 g) were used. The rats were divided into 5 groups (10 rats each). The first group ...
The effect of dietary carbohydrates and vanadium toxicity on haematalogical profile, blood chemis... more The effect of dietary carbohydrates and vanadium toxicity on haematalogical profile, blood chemistry and hormonal level was studied in fry Clarias Lazera. Fry fish were divided into 3 groups (n=10) and exposed to different doses of vanadium sulfated and carbohydrate. Group1 was served as control, group 2 was fed with carbohydrate and vanadium sulfate (10 mg/ Kg diet ration), group 3 was fed with carbohydrate and vanadium sulfate (15 mg/Kg diet ration). There is a significant decrease in hemoglobin and P.C.V in group (3). There is a significant increase in serum cortisol, cholestrol, AST, ALT, urea, creatinine and alkaline phosphatase in group (3), also there is a significant decrease in serum phosphorous, sodium and potasium in treated fish. There is a significant high level of vanadium content in kidney muscles, heart and spleen in group (3) suggesting toxic effects of vanadium on cat fry fish Clarious Lazara. The total viable count of bacteria identified higher in fry fish fed on ...
Chloroquine phosphate and its analogue hydroxychloroquine are used on long term basis as anti-inf... more Chloroquine phosphate and its analogue hydroxychloroquine are used on long term basis as anti-inflammatory drugs in the treatment of a multitude of chronic diseases. In the present work the dose of the drug was calculated and given to albino rats in the usual low therapeutic regimen used in man. This work has shown that chloroquine depresses testosterone secretion in a progressive manner which increased the longer the duration of treatment, sperm count was also decreased, the percent of abnormal forms increased and the weight of the testes and accessory sex organ (epididymis, vas deference, seminal vesicle and prostate) was also reduced, these abnormalities did not return to the normal control figures, even after one month of discontinuation of the drug. This work emphasizes the need for testosterone administration concomitantly with chloroquine treatment to maintain the integrity of the sexual organs of the patients. At the same time this work emphasizes the need of further study o...
The present study included 40 female subjects. They were classified into two groups: group I incl... more The present study included 40 female subjects. They were classified into two groups: group I included 20 females diagnosed as primary hypothyroidism with age ranged between 45 -65 years and group II included 20 ages matched normal female volunteers and served as control group. Insulin like growth factor -1, (IGF-1) cholesterol, triglycerides, Thyroid stimulating hormone, thyroxine-3 (T 3 ) and thyroxine-4 (T 4 ) hormones were measured in both groups. The obtained results revealed that, there was a significant decrease in IGF-1 level in group I, when compared to control group (P ≤ 0.01). Correlation studies showed that IGF-1 is strongly positively correlated with T 3 (R=0.81, P ≤ 0.01) and moderately positively correlated with T 4 (R= 0.58, P ≤ 0.05). Meanwhile, it was moderately negatively correlated with cholesterol (R= 0.6, P ≤ 0.05). The results indicate that IGF-1 deficiency in elder women suffering from ٍ◌hypothyroidism may have a direct relation in the pathogenesis of hypercholesterolemia.
International Journal of Nutrition and Food Sciences, 2013
The effect of high fat diet on lipid and carbohydrate metabolic changes was studied in mature mal... more The effect of high fat diet on lipid and carbohydrate metabolic changes was studied in mature male albino rats.
National guidelines for coronary artery disease (CAD) risk reduction have focused on high-risk fa... more National guidelines for coronary artery disease (CAD) risk reduction have focused on high-risk families, yet little is known about prevalence of risk factors in general population. To determine the magnitude of the problem relative to the general population, a community-based pilot study of the widely accepted CAD risk factors was carried out over the period of 12 months on a random sample of apparently healthy adults (n =880), aged 18 -60 years, living in Jeddah Governorate. Three hundred eighty eight (388) subjects (156 males and 232 females) residing in Jeddah town (urban group) and four hundred ninety two (492) subjects (264 males and 228 females) adjoining different rural centers in Jeddah Governorate (rural group) participated. The study was based on complete history taking, prevalence of family history of CAD, obesity, hypertension, diabetes mellitus, and history of current cigarettes smoking. Body Mass Index (BMI) was significantly high in urban than rural men and in urban than rural women. Systolic hypertension was recorded in 30.8 % of urban men, 25.8 % of rural men, 24.6 % of rural women and 13.8 % of urban women. Total caloric intake per day was much increased in urban than rural women and in urban than rural men. Serum total cholesterol was significantly higher in urban men and women than in rural men and women respectively. Total cholesterol / HDL ratio showed insignificant difference in the studied groups. Serum Cu +2 and Mg +2 were significantly higher in urban than rural women. Serum Zn +2 and Zn +2 / Cu +2 ratios showed insignificant difference between the studied groups. Meanwhile, rural smokers showed significant increase in serum level of total cholesterol and Cu +2 with low Zn +2 levels. BMI correlated significantly with serum Mg +2 in urban women and serum Cu +2 in urban men. The prevalence risk factors for CAD were markedly raised in rural women and urban men, while rural men showed high prevalence of absence of risk factors. Prevalence of major risk factors increases in rural areas and may be due to dietary and life style changes. Serum trace elements like Cu +2 , Zn +2 and Mg +2 may predict coronary ischemia as they correlated significantly with BMI and total caloric daily intake which might be affected by current smoking. Further studies of CAD risk factors, their predictive capacity, heritability estimates, and the degree of which they are amenable to treatment are actually needed.
ABSTRACT: The current study was conducted to investigate the hypocholesterolemic effect of a mixt... more ABSTRACT: The current study was conducted to investigate the hypocholesterolemic effect of a mixture of three plant by-products (orange albedo, potato peel and carrot pomace), as a source of natural fibers on hypercholesterolemia and hyperglycemia in hypercholesterolemic rats. Furthermore, production of bread hazing high natural fiber contents, formed from these by-products. The diet was supplemented with 10% and 20% of this mixture. The obtained results revealed that the hypercholesterolemic rats which fed on the diet supplemented with 20% mixture showed the highest significant improve in lipid profile, liver function, kidney function, blood picture and plasma glucose compared to positive and negative control. Also the results showed a high significant decrease in body weight gain compared to positive control. In addition, the sensory evaluation of the bread which formed from these by-products showed that the addition of the mixture to the bread significantly decreased the bread qu...
Abstract: The present study was carried out to investigate the effect of some nutrients on Nutrit... more Abstract: The present study was carried out to investigate the effect of some nutrients on Nutritional and Health status in copper and lead intoxicated male albino rats. Fifty male albino rats weighing (125±7 g) were used. The rats were divided into 5 groups (10 rats each). The first group ...
The effect of dietary carbohydrates and vanadium toxicity on haematalogical profile, blood chemis... more The effect of dietary carbohydrates and vanadium toxicity on haematalogical profile, blood chemistry and hormonal level was studied in fry Clarias Lazera. Fry fish were divided into 3 groups (n=10) and exposed to different doses of vanadium sulfated and carbohydrate. Group1 was served as control, group 2 was fed with carbohydrate and vanadium sulfate (10 mg/ Kg diet ration), group 3 was fed with carbohydrate and vanadium sulfate (15 mg/Kg diet ration). There is a significant decrease in hemoglobin and P.C.V in group (3). There is a significant increase in serum cortisol, cholestrol, AST, ALT, urea, creatinine and alkaline phosphatase in group (3), also there is a significant decrease in serum phosphorous, sodium and potasium in treated fish. There is a significant high level of vanadium content in kidney muscles, heart and spleen in group (3) suggesting toxic effects of vanadium on cat fry fish Clarious Lazara. The total viable count of bacteria identified higher in fry fish fed on ...
Chloroquine phosphate and its analogue hydroxychloroquine are used on long term basis as anti-inf... more Chloroquine phosphate and its analogue hydroxychloroquine are used on long term basis as anti-inflammatory drugs in the treatment of a multitude of chronic diseases. In the present work the dose of the drug was calculated and given to albino rats in the usual low therapeutic regimen used in man. This work has shown that chloroquine depresses testosterone secretion in a progressive manner which increased the longer the duration of treatment, sperm count was also decreased, the percent of abnormal forms increased and the weight of the testes and accessory sex organ (epididymis, vas deference, seminal vesicle and prostate) was also reduced, these abnormalities did not return to the normal control figures, even after one month of discontinuation of the drug. This work emphasizes the need for testosterone administration concomitantly with chloroquine treatment to maintain the integrity of the sexual organs of the patients. At the same time this work emphasizes the need of further study o...
The present study included 40 female subjects. They were classified into two groups: group I incl... more The present study included 40 female subjects. They were classified into two groups: group I included 20 females diagnosed as primary hypothyroidism with age ranged between 45 -65 years and group II included 20 ages matched normal female volunteers and served as control group. Insulin like growth factor -1, (IGF-1) cholesterol, triglycerides, Thyroid stimulating hormone, thyroxine-3 (T 3 ) and thyroxine-4 (T 4 ) hormones were measured in both groups. The obtained results revealed that, there was a significant decrease in IGF-1 level in group I, when compared to control group (P ≤ 0.01). Correlation studies showed that IGF-1 is strongly positively correlated with T 3 (R=0.81, P ≤ 0.01) and moderately positively correlated with T 4 (R= 0.58, P ≤ 0.05). Meanwhile, it was moderately negatively correlated with cholesterol (R= 0.6, P ≤ 0.05). The results indicate that IGF-1 deficiency in elder women suffering from ٍ◌hypothyroidism may have a direct relation in the pathogenesis of hypercholesterolemia.
International Journal of Nutrition and Food Sciences, 2013
The effect of high fat diet on lipid and carbohydrate metabolic changes was studied in mature mal... more The effect of high fat diet on lipid and carbohydrate metabolic changes was studied in mature male albino rats.
National guidelines for coronary artery disease (CAD) risk reduction have focused on high-risk fa... more National guidelines for coronary artery disease (CAD) risk reduction have focused on high-risk families, yet little is known about prevalence of risk factors in general population. To determine the magnitude of the problem relative to the general population, a community-based pilot study of the widely accepted CAD risk factors was carried out over the period of 12 months on a random sample of apparently healthy adults (n =880), aged 18 -60 years, living in Jeddah Governorate. Three hundred eighty eight (388) subjects (156 males and 232 females) residing in Jeddah town (urban group) and four hundred ninety two (492) subjects (264 males and 228 females) adjoining different rural centers in Jeddah Governorate (rural group) participated. The study was based on complete history taking, prevalence of family history of CAD, obesity, hypertension, diabetes mellitus, and history of current cigarettes smoking. Body Mass Index (BMI) was significantly high in urban than rural men and in urban than rural women. Systolic hypertension was recorded in 30.8 % of urban men, 25.8 % of rural men, 24.6 % of rural women and 13.8 % of urban women. Total caloric intake per day was much increased in urban than rural women and in urban than rural men. Serum total cholesterol was significantly higher in urban men and women than in rural men and women respectively. Total cholesterol / HDL ratio showed insignificant difference in the studied groups. Serum Cu +2 and Mg +2 were significantly higher in urban than rural women. Serum Zn +2 and Zn +2 / Cu +2 ratios showed insignificant difference between the studied groups. Meanwhile, rural smokers showed significant increase in serum level of total cholesterol and Cu +2 with low Zn +2 levels. BMI correlated significantly with serum Mg +2 in urban women and serum Cu +2 in urban men. The prevalence risk factors for CAD were markedly raised in rural women and urban men, while rural men showed high prevalence of absence of risk factors. Prevalence of major risk factors increases in rural areas and may be due to dietary and life style changes. Serum trace elements like Cu +2 , Zn +2 and Mg +2 may predict coronary ischemia as they correlated significantly with BMI and total caloric daily intake which might be affected by current smoking. Further studies of CAD risk factors, their predictive capacity, heritability estimates, and the degree of which they are amenable to treatment are actually needed.
ABSTRACT: The current study was conducted to investigate the hypocholesterolemic effect of a mixt... more ABSTRACT: The current study was conducted to investigate the hypocholesterolemic effect of a mixture of three plant by-products (orange albedo, potato peel and carrot pomace), as a source of natural fibers on hypercholesterolemia and hyperglycemia in hypercholesterolemic rats. Furthermore, production of bread hazing high natural fiber contents, formed from these by-products. The diet was supplemented with 10% and 20% of this mixture. The obtained results revealed that the hypercholesterolemic rats which fed on the diet supplemented with 20% mixture showed the highest significant improve in lipid profile, liver function, kidney function, blood picture and plasma glucose compared to positive and negative control. Also the results showed a high significant decrease in body weight gain compared to positive control. In addition, the sensory evaluation of the bread which formed from these by-products showed that the addition of the mixture to the bread significantly decreased the bread qu...
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