Papers by Mohammad Hassanzadeh-Khayyat
Pizhūhish va Nuāvarī dar ̒Ulūm va Sanāyi̒-i Ghaz̠āyī, 2013
Fructan is widely used throughout the world for its health-promoting and functional properties. &... more Fructan is widely used throughout the world for its health-promoting and functional properties. <em>Eremurus spectabilis </em>which has traditionally been used in different industries as well as in folk medicine is considered one of the valuable resources of fructan. However, there is little information about fructan extraction from this plant. Ultrasound-assisted extraction is considered one of the most important methods for extraction of the most valuable compounds from plant sources and is applicable in both laboratory and industrial scales. In this study, box-behnken design was used in order to investigate the effect of time (5-40 min), temperature (30-70º C) and ultrasound amplitude (20–100 %) on the yield of fructan extraction from <em>Eremurus spectabilis </em>and optimization the extraction process using ultrasound waves. To describe the extraction yield, a first-order model was developed and verified its performance. The model was subsequently used t...
Planta Medica, 2011
To study the effect of different levels of water stress on essential oil content and composition ... more To study the effect of different levels of water stress on essential oil content and composition of Agastache foeniculum Kuntze at second harvest, a field experiment in randomized complete block design with three replications was conducted. Water stress treatments were: 100% of field capacity (FC), 85% of FC, 70% of FC, 55% of FC, 100–85% of FC (100% at vegetative and 85% at reproductive phases), 100–70% of FC (100% at vegetative and 70% at reproductive phases), 85–100% of FC (85% at vegetative and 100% at reproductive phases). The highest of essential oil content was observed at 70% of FC (1.69) and 100–85% of FC (1.67). Also the treatment 85% of FC (1.33) caused the lowest of essential oil content. There was not significant different between other treatments. The main essential oil constituent was methyl chavicol which showed a increasing with progress water stress till 70% of FC and then decreased at 55% of FC treatment. Limonene, another main component was decreased with increasing water stress levels from 100 of FC to 70% of FC. The highest amount of methyl chavicol (98.3%) and limonene (2.4%) were found at 70% of FC and 85–100% of FC, respectively.
Planta Medica, 2011
Drying is one of the important pre-processing methods of medicinal plants after harvest that has ... more Drying is one of the important pre-processing methods of medicinal plants after harvest that has a major role in quantity and quality of their active substances. To determine the effect of different drying methods on drying time, essential oil content and composition of Savory (Satureja hortensis L.), the experiment was carried out during 2008. The experimental design was randomized complete block design with three replications and treatments were: two temperatures: 50°C and 70°C, six microwave powers: 100, 180, 300, 450, 600 and 900 w and drying in shade and under sun light. The drying process was continued until the mass of the sample reduced to a moisture content of about 0.10 on a dry weight basis or 10% on a wet weight basis. Results indicated that different treatments of drying method had significant effects on drying time and essential oil content. The maximum essential oil content (3%) obtained from drying at 70°C and drying in shade while minimum content (0.9%) obtained from drying under sun light. One hundred and 300 w microwave powers had an average content of essential oil (2.3%). Carvacrol content percentage in treatments of microwave drying was more than other methods as maximum percentage (63.9 %) was obtained from 300 w microwave drying with a little difference with 180 w microwave drying treatment. Drying by low microwave powers is recommended for Satureja hortensis L. due to the reduction of drying time and considerable maintenance of essential oil content and composition. Maximum γ-terpinene content (28.2%) obtained from drying at 70°C with a low difference with 50°C, 100 and 300 w microwave.
Oriental journal of chemistry, 2017
Indian Journal of Pharmaceutical Sciences, 1999
Relative bioavailability of four brands of amoxycillin capsules were examined. The absorption of ... more Relative bioavailability of four brands of amoxycillin capsules were examined. The absorption of each dosage form was compared in a crossover study of thirteen healthy subjects (6 males and 7 females). Plasma concentrations and urinary excretion rates were employed to evaluate the absorption process. Statistical analysis of the results were carried out to evaluate the significance of differences between dosage forms and subjects. The statistical analysis indicated no significant differences between different tested brands of amoxycillin (except for brand A) while the differences between subject were significant. Although the differences between brand A and other brands are significant, the differences, are within the % ± 20 range and is not clinically important. Comparison between the two different genders indicated no significant differences between the male and female subjects.
The genus Juniperus L. (Cupressaceae), an aromatic evergreen plant, consists of up to 68 species ... more The genus Juniperus L. (Cupressaceae), an aromatic evergreen plant, consists of up to 68 species around the world. We classified five species of Juniperus found in Iran using molecular markers to provide a means for molecular identification of Iranian species. Plants were collected (three samples of each species) from two different provinces of Iran (Golestan and East Azarbayejan). The DNA was extracted from the leaves using a Qiagen Dneasy Plant Mini Kit. Amplification was performed using 18 ten-mer RAPD primers. Genetic distances were estimated based on 187 RAPD bands to construct a dendrogram by means of unweighted pair group method of arithmetic means. It was found that J. communis and J. oblonga were differentiated from the other species. Genetic distance values ranged from 0.19 (J. communis and J. oblonga) to 0.68 (J. communis and J. excelsa). Juniperus foetidissima was found to be most similar to J. sabina. Juniperus excelsa subspecies excelsa and J. excelsa subspecies polycarpos formed a distinct group.
Oriental warmwood (Artemisia scoparia Waldst. et. Kit) is a sweet smelling and perennial medicina... more Oriental warmwood (Artemisia scoparia Waldst. et. Kit) is a sweet smelling and perennial medicinal plant from Asteraceae family where is widespread in Iran. The aerial parts especially fresh or dried leaves used for many purposes such as antibacterial, anticholesterolemic, antiseptic by local peoples in Khorasan province where located in north east of Iran. The objective of this study was to determine essential oils compositions of A. scoparia at flowering stage in north east of Iran. The leaves samples were collected from around the city of Mashhad (Seyyedi region) at the autumn (Nov.). The essential oils were recovered using steam distillation method. The analysis of the essential oils was also performed by GC and GC/MS method. The oil yield of A. scoparia was 0.7% based on leaf fresh weight. The volatile components of the essential oil of the leaves of A. scoparias were identified based on comparison of the resultant mass spectra with available standard on well as comparison of s...
Ultrasonics, 2013
The particles in a liquid decrease the ultrasonic intensity threshold required for cavitation ons... more The particles in a liquid decrease the ultrasonic intensity threshold required for cavitation onset. In this study, a new nanoconjugate composed of Protoporphyrin IX and gold nanoparticles (Au-PpIX) was used as a nucleation site for cavitation. The nonradiative relaxation time of Protoporphyrin IX in the presence of gold nanoparticles is longer than the similar time without gold nanoparticles. The acoustic cavitation activity was investigated via recording of the integrated sonoluminescence signal in the wavelength range of 220-700 nm in a gel phantom by a cooled charge coupled device (CCD) at different intensities of 1 MHz ultrasound. In order to confirm these results, a chemical dosimetric method was utilized, too. The recorded sonoluminescence signal in the gel phantom containing Au-PpIX was higher than the other phantoms. These records have been confirmed by the chemical dosimetric data. Therefore, we anticipate that a new nanoconjugate composed of Protoporphyrin IX and gold nanoparticles can act as an efficient sonoluminescence agent and could be introduced as a novel sonosensitizer for sonodynamic therapy.
Acta Veterinaria Hungarica, 2010
In order to investigate the relationship between carbon dioxide tensions in the venous blood of y... more In order to investigate the relationship between carbon dioxide tensions in the venous blood of young chickens and ascites susceptibility, one hundred dayold chickens from two pure broiler breeder lines differing in susceptibility to ascites syndrome were obtained and reared at low environmental temperature. Weekly, blood samples were taken for the determination of blood gas parameters and plasma thyroid hormone levels. Dead birds were examined for lesions of ascites daily and all survived birds were autopsied at the end of the trials. In cold conditioning, the cumulative incidence of right ventricular hypertrophy (RVH) and ascites was 78% (39/50) in fast-growing (line A) and 50% (25/50) in slow-growing (line B) chickens, confirming that line A chickens had higher susceptibility to ascites than line B chickens. At 12 days of age, the mean pCO 2 tension was significantly (P < 0.01) higher in the venous blood of line A than line B chickens. During the experiment, the majority of li...
Environmental Technology, 2017
Imidaclopride is an insecticide widely used for pest control in agriculture around the world. It ... more Imidaclopride is an insecticide widely used for pest control in agriculture around the world. It acts on the central nervous system of insects, while posing lower toxicity to mammals. This is an organic material made of Pyridinium, Dihydroimidazol and Nitramide. This structure poses a threat to the environment and humans. Until now, different types of methods have been used for elimination of this organic pollution. Recently, advanced oxidation processes (AOPs) are presented as a proposed method to remove this organic pollution. Photocatalytic degradation is also used as an efficient method for destruction of organic structures. In this study, the effect of titanium dioxide (TiO2) nanoparticle as a photocatalyst activated by UV irradiation is investigated. The new design of the reactor was prepared with coaxial cylinders in which the inner cylinder is rotated at a constant speed. The reactor worked in two batch and continuous modes. The results show that the UV irradiation is more effective than activated TiO2 nanoparticle, as the designed reactor with UV irradiation eliminated Imidaclopride in less than 2 hours.
Research on Chemical Intermediates, 2016
Journal of Biological & Scientific Opinion, 2016
In this work, we studied antibacterial activity of oils extract of leaves Rosmarinus officinalis.... more In this work, we studied antibacterial activity of oils extract of leaves Rosmarinus officinalis. Rosemary is well known as a spice and widely used plant in ethno medicine worldwide. This study showed that essential oil extract of Rosmarinus officinalis from leaves (grow in Al-Jabal Al Akhdar and house) at 10% ,20% and 30% concentration were effective against both Gram-positive and Gram-negative bacteria., while the essential oil commercial was no effective against both Gram-positive and Gram-negative bacteria at all concentration. We suggest the oils of Rosmarinus officinalis (grow in Al-Jabal Al Akhdar and house) rich in phenolic constituent such as α-pinene and 1.8-cineole has the highest anti-oxidant activity against bacterial.
Current Pharmaceutical Design
: Cupressus sempervirens, Platycladus orientalis, Juniperus communis, J. excelsa, J. foetidissima... more : Cupressus sempervirens, Platycladus orientalis, Juniperus communis, J. excelsa, J. foetidissima, J. polycarpos var. turcomanica, J. sabina, and Taxus baccata are conifers in Iran. These plants have a long reputation in different systems of traditional medicines for a variety of diseases. This review aims to provide comprehensive and up-to-date information about the ethnopharmacological uses, chemical constituents, and pharmacology of these conifers. Furthermore this study comprises a bibliographical survey of major Islamic Traditional Medicine (ITM) books regarding different medical aspects of these species. A literature search was conducted on the applications of these conifers both in traditional and modern medicines by referencing traditional textbooks and scientific databases. Ethnobotanical literature review indicates that various parts of the plants including cones, berries, leaves, bark, wood, and resin have been used for a broad spectrum of applications. In Iran, C. sempervirens, J. sabina, J. communis, and T. baccata have been used traditionally for the treatment of urinary, digestive, nervous, respiratory, and integumentary systems-related problems. The phytochemical constituents of these plants can be divided into two main categories: volatile and non-volatile components, all dominated by terpenes. Considering the pharmacological and clinical evidence, while some of the traditional applications of these plants are supported by modern medicine, implying the value of the traditional and folklore knowledge for finding new lead compounds in drug discovery, some have remained unexamined showing the need for much more studies in this regard.
Journal of Molecular Liquids
Journal of Chromatography A
Journal of Pharmaceutical Investigation
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Papers by Mohammad Hassanzadeh-Khayyat