Papers by Mohaddeseh Behjati
Clinical and Experimental Hypertension, 2021
Background Using manometer sphygmomanometers as standard measurement tool, there are controversia... more Background Using manometer sphygmomanometers as standard measurement tool, there are controversial data regarding accuracy and validity of digital manometers for measurement of systolic (SBP) and diastolic blood pressure (DBP). Thus, we aimed to compare the accuracy of readings of digital sphygmomanometer in reference to mercury sphygmomanometer in a large population of healthy adults. Methods and Materials This cross-sectional study was performed on 1119 healthy adults. We measured participant’s blood pressure once with mercury sphygmomanometer, as gold standard and again with digital mercury sphygmomanometer. Blood pressure was measured in sitting position after 5 min of rest and preferentially from right arm unless deformed. Results The mean ± standard deviation of age of participants was 37.25 ± 10.45 years. Majority of participants were male 588 (52.5%). The right/left SBP measured by digital sphygmomanometer were significantly higher compared with those measured by mercury sph...
Sleep medicine, 2017
Heart rate variability (HRV) analysis is used for the evaluation of autonomic function in the car... more Heart rate variability (HRV) analysis is used for the evaluation of autonomic function in the cardiovascular system. Decreased HRV is associated with disorders affecting the autonomous system such as diabetes mellitus (DM) and obstructive sleep apnea (OSA). Previous studies have shown an association between OSA and DM. However, the interrelationships of HRV with OSA and DM are not well known. The aim of this study was to assess nocturnal HRV in patients who suffered from OSA with and without DM. Sixty patients with OSA (27 with DM and 33 non-DM) underwent polysomnography for eight hours starting at midnight. From electrocardiogram (ECG) recordings taken as a part of polysomnography, time-domain and frequency-domain HRV parameters were evaluated to compare patients with regard to nocturnal HRV components such as low frequency (LF) and high frequency (HF), apnea-hypopnea index (AHI) and sleep parameters. In the non-DM group, a direct relationship was observed between AHI and HRV rathe...
Journal of Renal Injury Prevention
Introduction: Pulmonary hypertension is a progressive and severe disease associated with left or ... more Introduction: Pulmonary hypertension is a progressive and severe disease associated with left or right ventricular dysfunction and is common in patients under hemodialysis. One of the factors in its development is parathormone but this relationship is unclear. Objectives: In this study, the difference between serum levels of parathyroid hormone (PTH) in hemodialysis patients with and without pulmonary artery hypertension (PAH) was investigated. Patients and Methods: We conducted a cross-sectional study among hemodialysis patients referred to a tertiary hospital in Iran. Characteristics of coronary artery and pulmonary arteries were recorded by echocardiography. The laboratory data were measured and recorded. Statistical analysis was performed at 95% confidence level and with a significance level of less than 5%. Results: Of 65 enrolled patients, 41 had normal pulmonary artery pressure, and 24 had pulmonary hypertension. The mean age in patients with and without pulmonary hypertensio...
Background Although cardiac magnetic resonance (CMR) is the most reliable tool for assessment of ... more Background Although cardiac magnetic resonance (CMR) is the most reliable tool for assessment of CIO in patients with thalassemia, it is not always readily available. Recent studies have explored the potential of GLS as an alternative for diagnosis of CIO. We aimed to investigate the efficacy of global longitudinal strain (GLS) for detection of cardiac iron level (CIO). Methods We searched SCOPUS, MEDLINE, and Embase to identify the studies which used GLS for assessment of CIO. We searched for individual participant data (IPD) in eligible studies to perform ROC curve analysis. CMR with a T2* cut-off value of 20ms was considered as the gold standard. A meta-analysis was performed and the risk of bias was assessed using the JBI Checklist. Results A total of 14 studies with 789 thalassemia patients (310 and 430 with and without CIO respectively and 49 with undetermined condition) were considered eligible for meta-analysis. IPDs of 405 participants were available. GLS was significantly ...
SSRN Electronic Journal, 2021
Introduction: To reduce mortality in hospitalized patients with COVID-19 and cardiovascular disea... more Introduction: To reduce mortality in hospitalized patients with COVID-19 and cardiovascular disease (CVD), it is necessary to understand the relationship between patient's symptoms, risk factors, and comorbidities with their mortality rate. To the best of our knowledge, this paper is the first which take into account the determinants like risk factors, symptoms, and comorbidities leading to mortality in CVD patients who are hospitalized with COVID-19. Methods: This study was conducted on 660 hospitalized patients with CVD
ISRN Microbiology, 2012
Widespread use of various antimicrobial agents resulted in the emergence of bacterial resistance.... more Widespread use of various antimicrobial agents resulted in the emergence of bacterial resistance. Mechanisms like direct efflux, formation, and sequestration of metals and drugs in complexes and antiporter pumps are some examples. This investigation aims to investigate the resistance pattern of penicillin-resistant bacterial strains to some physicochemical agents. Sensitivity/resistance pattern of common bacterial strains to antimicrobial agents were evaluated by disk diffusion assay. Broth and agar dilution method were used for determination of minimum inhibitory concentration and minimal bactericidal concentration. The impact of UV ray on the bacterial growth under laminar flow hood was measured using photonmeter. Our data demonstrates that the most prevalent metal resistance was against arsenate (95.92%), followed by cadmium (52.04%) and mercury (36.73%). There was significant difference between cetrimide resistances among studied microbial strains especially for P. aeruginosa ()...
International Journal of Cardiology, 2013
Background: Enhanced attraction of selective vascular reparative cells is of great importance in ... more Background: Enhanced attraction of selective vascular reparative cells is of great importance in order to increase vascular patency after endovascular treatments. We aimed to evaluate efficient attachment of endothelial cells and their progenitors on surfaces coated with mixture of specific antibodies, L-selectin and VE-cadherin, with prohibited platelet attachment. Methods: The most efficient conditions for coating of L-selectin-Fc chimera and VE-cadherin-Fc chimera proteins were first determined by protein coating on ELISA plates. The whole processes were repeated on titanium substrates, which are commonly used to coat stents. Endothelial progenitor cells (EPCs) and human umbilical vein endothelial cells (HUVECs) were isolated and characterized by flow cytometry. Cell attachment, growth, proliferation, viability and surface cytotoxicity were evaluated using nuclear staining and MTT assay. Platelet and cell attachment were evaluated using scanning electron microscopy. Results: Optimal concentration of each protein for surface coating was 50 ng/ml. The efficacy of protein coating was both heat and pH independent. Calcium ions had significant impact on simultaneous dual-protein coating (Pb 0.05). Coating stability data revealed more than one year stability for these coated proteins at 4°C. Lselectin and VE-cadherin (ratio of 50:50) coated surface showed highest EPC and HUVEC attachment, viability and proliferation compared to single protein coated and non-coated titanium surfaces (Pb 0.05). This double coated surface did not show any cytotoxic effect. Conclusions: Surfaces coated with L-selectin and VE-cadherin are friendly surface for EPC and endothelial cell attachment with less platelet attachment. These desirable factors make the L-selectin and VE-cadherin coated surfaces perfect candidate endovascular device.
Heart Failure Reviews, 2020
Maternally mitochondrial dysfunction includes a heterogeneous group of genetic disorders which le... more Maternally mitochondrial dysfunction includes a heterogeneous group of genetic disorders which leads to the impairment of the final common pathway of energy metabolism. Coronary heart disease and coronary venous disease are two important clinical manifestations of mitochondrial dysfunction due to abnormality in the setting of underlying pathways. Mitochondrial dysfunction can lead to cardiomyopathy, which is involved in the onset of acute cardiac and pulmonary failure. Mitochondrial diseases present other cardiac manifestations such as left ventricular noncompaction and cardiac conduction disease. Different clinical findings from mitochondrial dysfunction originate from different mtDNA mutations, and this variety of clinical symptoms poses a diagnostic challenge for cardiologists. Heart transplantation may be a good treatment, but it is not always possible, and other complications of the disease, such as mitochondrial encephalopathy, lactic acidosis, and stroke-like syndrome, should be considered. To diagnose and treat most mitochondrial disorders, careful cardiac, neurological, and molecular studies are needed. In this study, we looked at molecular genetics of MIDs and cardiac manifestations in patients with mitochondrial dysfunction. Keywords Mitochondrial dysfunction. mtDNA. Cardiac. Atrioventricular Abbreviations ANT Adenine nucleotide translocator BSCL2 Berardinelli-Seip congenital lipodystrophy CMP Cardiomyopathy COX Cytochrome c oxidase ECMP Encephalocardiomyopathy MELAS Mitochondrial encephalopathy lactic acidosis and stroke-like episodes MERRF Myoclonus epilepsy red ragged fibers MID Mitochondrial dysfunction MRP Mitochondrial ribosomal protein MTO Mitochondrial tRNA translation optimization ND1 NADH-ubiquinone oxidoreductase chain 1 NDUFAF1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1 OXPHOS Oxidation-phosphorylation ROS Reactive oxygen species
Irish Journal of Medical Science (1971 -), 2017
Background The p22phox gene encodes the main subunit of NADH/NADPH-oxidase. This enzyme is expres... more Background The p22phox gene encodes the main subunit of NADH/NADPH-oxidase. This enzyme is expressed in smooth muscle cells of arteries, and it produces the reactive oxygen species. On the other hand, oxidative stress plays a main role in the pathogenesis of coronary artery disease (CAD). Aim The aim of this study is to evaluate the association between rs4673 and rs1049255 polymorphisms of p22phox gene with CAD in an Iranian population which was followed with a computational analysis approach. Methods In a cross-sectional study, we collected blood samples of 302 Iranian Caucasian including 143 patients and 159 healthy controls. Genotype of the polymorphisms was detected through PCR-RFLP method. A computational analysis was also performed using SNAP, Polyphen-2, Chou-Fasman, RNAsnp, and miRNA SNP databases. Results Data of case control study demonstrated that CT genotype (R = 1.84, 95% CI = 1.13-3.00, p = 0.014) and T allele (OR = 1.53, 95% CI = 1.09-2.15, p = 0.013) of rs4673 polymorphism, have a significant association with enhanced risk of CAD. But rs1049255 analysis demonstrated the absence of such an association with CAD. Indeed, in silico data analysis demonstrated that rs4673 transition could impact on function of p22phox protein (SNAP score 56, expected accuracy 75%; Polyphen-2 score 0.99, sensitivity 0.09, specificity 0.99). Data derived from miRNA SNP database demonstrated that rs1049255 polymorphism increases the affinity of attachment between has-miR-3689a-3b with 3′-UTR of p22phox gene. Conclusion Our data demonstrated that rs4673 transition may be involved in susceptibility to CAD and could be applied as a potential biomarker for this disease.
European Heart Journal, 2021
Background Complex aortic atherosclerotic plaques (AAPs) carry a significant risk of embolism. Cu... more Background Complex aortic atherosclerotic plaques (AAPs) carry a significant risk of embolism. Currently, two-dimensional (2D) transesophageal echocardiography (TEE) is the principal diagnostic tool of AAPs. However, we hypothesized that the data obtained from three-dimensional (3D) imaging may improve AAPs' spatial assessment. Purpose This study was aimed to evaluate the efficacy of 3DTEE in assessment of AAPs. Methods This study includes 96 patients who underwent routine TEE in our center within 2018–2019. The entire aorta including aortic root, ascending aorta, aortic arch, and descending thoracic aorta was investigated using both 2D and 3D TEE. The size and grade of aortic atherosclerotic plaques were compared using both 2D and 3D TEE. In addition, we examined to see if there is any correlation between the grade and size of the plaque, and patient's cardiac risk factors including their history of atherosclerotic diseases. Results Patients with atherosclerotic plaque in t...
Neurochemistry International
Air pollution exposure is among the most prevalent reasons for environmentally-induced oxidative ... more Air pollution exposure is among the most prevalent reasons for environmentally-induced oxidative stress and inflammation, both of which are involved in the development and progression of central nervous system (CNS) diseases. Ultrafine particles (UFPs) plays an important role in global air pollution and the diesel exhaust particles (DEPs) are the most important component in this regard. There are more than 40 toxic air pollutants in diesel exhaust (DE), which is one of the main constituents of an environmental pollutant and including particulate matter (PM) especially UFPs. Thus, in this study, adult female and male NMRI mice were exposed to DEPs (350–400 µg/m3) for 14 weeks (6 h per day and 5 days per week). After 14 weeks of exposure, expression of pro-inflammatory cytokines (IL-1α, IL-1β, IL-6, TNF-α), nNOS, HO1, NR2A, and NR2B and malondialdehyde (MDA) level were analyzed in various brain regions such as the hippocampus (HI) and olfactory bulb (OB). Exposure to DEPs caused neuroinflammation and oxidative stress in female and male mice. That these effects observed in females were less pronounced than in male mice. The male mice emerged to be more susceptible significantly than the female mice to induced neuroinflammation following DEPs exposure. Also, our findings indicate that long term exposure to DEPs results in altered expression of hippocampal NMDA receptor subunits, and suggests that gender can play important role in the modulating susceptibility to neurotoxicity induced by DEPs exposure.
Dermatologic Therapy, 2020
Background: Rapid diagnosis of pemphigus vulgaris (PV) is an important task in patient's prognosi... more Background: Rapid diagnosis of pemphigus vulgaris (PV) is an important task in patient's prognosis and treatment. Although PV is routinely diagnosed through investigation of pathology specimens and direct immunofluorescence assays, Tzanck smear can be used as rapid, inexpensive and easily used test to confirm its clinical diagnosis. Objectives: This study aimed to determine the diagnostic value of Tzanck smear in erosive oral lesions of PV and determination of its sensitivity and specificity for diagnostic purposes. Materials and Methods: A total of 68 patients with erosive/ulcerated oral lesions were included in this study and divided into PV (case group) vs. other causes of erosive oral lesions (control group). From all participants, two Tzanck smears were prepared for both Giemsa and hematoxylin-eosin (H&E) staining. For definite diagnosis, histopathology and direct immunofluorescence evaluations were performed based on clinical findings. Results: The sensitivity of acantholytic cells in Tzanck smear of erosive oral lesions of PV cases was 80.5% (for both Giemsa and H&E staining); whereas specificity values of Giemsa and H&E staining were 84.6% and 96.3%, respectively. Conclusion: Based on our findings, the Tzanck smear of erosive oral lesions is a simple, quick and inexpensive test for screening and primary diagnosis of PV.
Iranian Journal of Clinical …, 2009
Iranian Journal of Clinical Infectious Disease 2009;4(1):13-18 ... Iranian Journal of Clinical In... more Iranian Journal of Clinical Infectious Disease 2009;4(1):13-18 ... Iranian Journal of Clinical Infectious Diseases 2009;4(1):13-18 ©2009 IDTMRC, Infectious Diseases and Tropical Medicine Research Center ... Farzin Khorvash1*, Kamyar Mostafavizadeh1, Sina Mobasherizadeh1, ...
مجله دانشکده پزشکی اصفهان, 2020
Background: One of the most common cardiovascular diseases (CVDs) in the world is myocardial infa... more Background: One of the most common cardiovascular diseases (CVDs) in the world is myocardial infarction (MI). By analyzing electrocardiogram and vectorcardiography (VCG) signals, it is possible to identify and characterize heart diseases such as MI. One of the new methods of detection is the use of spatio-temporal parameters of VCG signals. This study aimed to correctly distinguish healthy signals from patients, achieve acceptable accuracy, and show the benefits of VCG and its application as a method to cover the shortcoming of electrocardiography. Methods: In this study, in addition to applying electrocardiogram signals in the time domain, spatio-temporal patterns of VCG signals were used to identify 80 patients with MI, and differentiate them from 80 healthy individuals. Findings: When combining the 12-lead electrocardiography (ECG) and the 3-lead VCG features applied to the Feedforward Neural Network classifier input, an accuracy of 91.2%, specificity of 92.6%, and specificity of...
Tanaffos, 2020
Background: A significant association has been found between the pulmonary artery (PA) diameter a... more Background: A significant association has been found between the pulmonary artery (PA) diameter and obstructive sleep apnea (OSA) in patients with pulmonary artery hypertension (PAH). We aimed to evaluate the relationship between the diameters of the PA trunk and aortic artery with their ratio as PAH markers in high risk cases for OSA based on the Berlin questionnaire without PAH. Materials and Methods: This case-control study included 161 non-PAH patients admitted to a multi-slice CT scan ward. Filling out the Berlin questionnaire, the patients were divided into high and low risk cases for OSA. The diameters of the PA trunk and aortic ascending aorta and their ratio were assessed using the multi-slice CT scan. Results: The PA to aortic ratios in the case and control groups were 0.89±0.17 and 0.88±0.17, respectively, which all were non-significant. With regard to gender, the PA diameter was significantly lower among males in the control group than in the case group (P=0.034). The me...
international cardiovascular research journal, 2018
Background: Vitamin D serves several cancer protective roles within the human body.Vitamin D func... more Background: Vitamin D serves several cancer protective roles within the human body.Vitamin D functions through binding with the VDR encoded by VDR gene. It has been demonstrated that polymorphism in VDR gene would influence expression and/or function of the VDR protein. The researchers found that the most important VDR gene polymorphisms that are associated with tumorigenesis include Fok1 (rs2228570), Bsm1 (rs1544410), Taq1 (rs771236), and Apa1 (rs7975232). The purpose of this study was to assess the association between Fok1, Bsm1, and Taq1 polymorphisms and breast cancer development. Methods: In this study, 50 patients suffering from breast cancer with less than 6 months after the diagnosis of breast cancer and 50 healthy control individuals were included. Restriction fragment length polymorphism PCR (RFLP-PCR) was used to determine the genotype of polymorphisms.Results: Statistical results showed that among the studied polymorphisms, Tt genotypes of Taq1 polymorphism have correlat...
International Journal of Organ Transplantation Medicine, 2018
Concomitant replacement of the ascending aorta and heart transplantation are an infrequent proced... more Concomitant replacement of the ascending aorta and heart transplantation are an infrequent procedure. This procedure was most often performed in patients with Marfan syndrome, however, it has its own technical difficulties. Hereby, we report on combined heart transplantation and aortic root replacement using donor’s ascending aorta in a 25-year-old man diagnosed with dilated cardiomyopathy and ascending aorta aneurysm. This procedure was successful and beneficial to patients with aortopathy who are candidates for heart transplantation.
Journal of Cardiovascular and Thoracic Research, 2021
Fontan operation is a reliable palliative surgery for patients with single ventricle physiology. ... more Fontan operation is a reliable palliative surgery for patients with single ventricle physiology. Still, the development of complication is common; one of these complications that need to interventional approach is veno-venous collaterals between systemic and pulmonary veins. A 16-yearoldgirl with a history of modified Fontan operation at 9 years ago was referred with progressive cyanosis and dyspnea on exertion. In contrast trans-thoracic echocardiography (TTE), no fenestration was seen in Fontan circulation. Cardiac magnetic resonance revealed partial anomalous pulmonary vein connection (PAPVC) from left upper pulmonary vein to vertical vein and then into the in nominate vein and SVC with the reverse flow from superior vena cava (SVC) to left upper pulmonary vein(LUPV). This anomalous vein became severe engorged and tortuous. Possibly, LUPV and the verticalvein was dilated gradually as a result of increased pressure in the Fontan circuit. Finally, she underwent successful coil embo...
Pulse, 2020
Background: Iron accumulation leads to increased susceptibility to cardiovascular diseases in tha... more Background: Iron accumulation leads to increased susceptibility to cardiovascular diseases in thalassemia major (TM) patients. Depressed heart rate variability (HRV) and development of arrhythmia are among the manifestations of subclinical cardiac involvement in TM cases. Determination of subclinical cardiac involvement is essential for preventive measures. Thus, we aimed to evaluate the best method for identification of subclinical cardiac dysfunction in TM cases. Materials and Methods: In this prospective study, 45 TM and 45 non-TM cases, who were referred for cardiac evaluation, were enrolled. Exclusion criteria included non-sinus rhythm and overt cardiac disease. TM cases underwent cardiac MRI, electrocardiography (ECG), and Holter monitoring. TM cases were divided into two groups of normal versus iron overload with a cardiac T2* of more or less than 20 ms, respectively. The non-TM cases underwent only ECG and Holter monitoring. Results: We observed no significant difference reg...
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Papers by Mohaddeseh Behjati