Papers by Martha Sierra-vargas
Journal of Energy Research and Reviews
Aims: In the present work, health risk from inhalation of PM2.5 pollutants in both areas was asse... more Aims: In the present work, health risk from inhalation of PM2.5 pollutants in both areas was assessed spatially Place and Duration of Study: The metropolitan areas of the Toluca (MATV) and Mexico Valleys (MAMV), between September and November 2009. Methodology: A simultaneous sampling campaign was conducted in the Toluca and Mexico Valleys on alternate days from September-22 to November-29, 2009. From the samples collected, their gravimetric concentration was obtained, and S, Cl, K, Ca Ti, V, Mn, Fe, Ni, Cu, Zn, and Pb were determined using the particle-induced X-ray emission technique (PIXE). Results: The health risk by inhalation of PM2.5 with a higher result for the metropolitan area of the Toluca Valley (2.09 for adults, 6.25 for children from 6-12 years old, and 6.58 for children from 2-6 years old) in contrast with that of the metropolitan area of the Mexico Valley (1.67 for adults, 5.20 for children from 6-12 years old, and 5.28 for children from 2-6 years old). Conclusion: T...
Respirology, 2012
Air pollution is becoming a major health problem that affects millions of people worldwide. In su... more Air pollution is becoming a major health problem that affects millions of people worldwide. In support of this observation, the World Health Organization estimates that every year, 2.4 million people die because of the effects of air pollution on health. Mitigation strategies such as changes in diesel engine technology could result in fewer premature mortalities, as suggested by the US Environmental Protection Agency. This review: (i) discusses the impact of air pollution on respiratory disease; (ii) provides evidence that reducing air pollution may have a positive impact on the prevention of disease; and (iii) demonstrates the impact concerted polices may have on population health when governments take actions to reduce air pollution.
Health and Environmental Impacts, 2010
Experimental and Molecular Pathology, 2014
Background: The obesity has been shown to increase the severity of A/H1N1 infection and the devel... more Background: The obesity has been shown to increase the severity of A/H1N1 infection and the development of acute respiratory distress syndrome (ARDS) and organ involvement. Methods: Circulating levels of C-peptide, insulin, glucagon, leptin, acute phase reactants (procalcitonin, C-reactive protein, tissue plasminogen activator, and serum amyloids A and P), were measured in samples from 32 critically ill patients with A/H1N1 virus infection, 17 of whom had ARDS complicated by acute kidney injury (AKI) and 15 of whom had ARDS but did not develop AKI. Results: Patients with ARDS and AKI (ARDS/AKI) had higher BMI and higher levels of C-peptide, insulin, leptin, procalcitonin and serum amyloid A compared to those ARDS patient who did not develop AKI. Adjusting for confounding variables using logistic regression analysis, higher levels of C-peptide (N 0.75 ng/mL) (OR = 64.8, 95% CI = 2.1-1980, p = 0.0006) and BMI N 30Kg/m 2 (OR = 42.0, 95% CI = 1.2-1478, p = 0.04) were significantly associated with the development of AKI in ARDS patients. Conclusion: High levels of C-peptide and BMI N 30 kg/m 2 were associated with the development of AKI in ARDS patients due to A/H1N1 infection. These metabolic/obesity indicators, together with the profiles of pro-inflammatory acute phase proteins, may be important links between obesity and poor outcomes in A/H1N1 09 infection.
Revista del Instituto …, 2007
Introducción: El incremento en la actividad de mieloperoxidasa (MPO) (EC l . 11.1.7) plasmática h... more Introducción: El incremento en la actividad de mieloperoxidasa (MPO) (EC l . 11.1.7) plasmática ha sido relacionada con la evolución de diferentes patologías destacando las enfermedades crónico-degenerativas que tienen en común el cursar con un estado de estrés oxidativo (EO) concomitante a un proceso in flamatorio persistente. Este es Palabras clave: el caso del asma. La enzima paraoxona- MPO, PON-,, sa (PON-?) (EC 3.1.1.2), es una arilesteoxidativo, asma, rasa que forma parte de la APO A-1 de función respiratoria, las HDL. Su función catalítica le permi-
Revista del Instituto …, 2005
Rev. Inst. Nal. Enf. Resp. Mex
Rev. Inst. Nal. Enf. …, 2006
Obesity Facts, 2012
Studies show that diet and exercise are important in the treatment of obesity. The aim of this st... more Studies show that diet and exercise are important in the treatment of obesity. The aim of this study was to determine whether additional regular moderate aerobic exercise during a treatment with hypocaloric diet has a beneficial effect on oxidative stress and molecular damage in the obese patient. Oxidative stress of 16 normal-weight (NW) and 32 obese 1 (O1) subjects (BMI 30-34.9 kg/m(2)) were established by biomarkers of oxidative stress in plasma. Recombinant human insulin was incubated with blood from NW or O1 subjects, and the molecular damage to the hormone was analyzed. Two groups of treatment, hypocaloric diet (HD) and hypocaloric diet plus regular moderate aerobic exercise (HDMAE), were formed, and their effects in obese subjects were analyzed. The data showed the presence of oxidative stress in O1 subjects. Molecular damage and polymerization of insulin was observed more frequently in the blood from O1 subjects. The treatment of O1 subjects with HD decreased the anthropometric parameters as well as oxidative stress and molecular damage, which was more effectively prevented by the treatment with HDMAE. HD and HDMAE treatments decreased anthropometric parameters, oxidative stress, and molecular damage in O1 subjects.
Clinical and Translational Science, 2012
In a subanalysis on the me tformin, arterial f unction, i ntima-media thicknes s , and nitroxidat... more In a subanalysis on the me tformin, arterial f unction, i ntima-media thicknes s , and nitroxidation in the me t abolic syndr o me (MEFISTO) (an open-label fashion, with 1 year of 850 mg daily of metformin) subjects' samples, we measured the paraoxonase 1 (PON1) activity in 39 patients that fi nished the study and relate values with high density lipoprotein (HDL). The comparative PON1 activities at the beginning and at the end of the study were 5.528 ± 0.588 and 4.743 ± 0.619 nmol/mg protein/min (NS) for control group and 3.229 ± 0.403 and 5.135 ± 0.585 nmol/mg protein/min ( p < 0.02) for the metformin group. Our data showed an enhance of PON1 activity in patients with metabolic syndrome treated with metformin, although in them, the raise of HDL concentration was less than control patients, suggesting that the increase in quality (measured here as PON1 activity) could be at least as important as an increase in its concentration. Our results point out that there is a relationship among PON1 activity and the reduction of carotideal intima-media thickness. Clin Trans Sci 2012; Volume 5: 265-268
Journal of Occupational Medicine and Toxicology, 2009
The Mexico City Metropolitan Area is densely populated, and toxic air pollutants are generated an... more The Mexico City Metropolitan Area is densely populated, and toxic air pollutants are generated and concentrated at a higher rate because of its geographic characteristics. It is well known that exposure to particulate matter, especially to fine and ultra-fine particles, enhances the risk of cardio-respiratory diseases, especially in populations susceptible to oxidative stress. The aim of this study was to evaluate the effect of fine particles on the respiratory burst of circulating neutrophils from asthmatic patients living in Mexico City.
Uploads
Papers by Martha Sierra-vargas