Papers by Franklin Marino
Clinical Investigation, 2013
Although rhinosinusitis is not a life-threatening condition, it impairs daily functioning and qua... more Although rhinosinusitis is not a life-threatening condition, it impairs daily functioning and quality of life (QoL). The evaluation of rhinosinusitis patients must include a complete sinonasal history and nasal exploration, and in addition may include CT scan and the quantification of QoL. The burden of rhinosinusitis can be assessed and compared with controls using the available generic questionnaires. Specific questionnaires offer more sensitivity than generics in terms of details on distinct diseases such as rhinosinusitis when studying a selected population. This article is intended to provide a review of the available measurement instruments on QoL that have been used in clinical trials related to rhinosinusitis, both acute and chronic. The indexed English literature up to 2012 from PUBMED and EMBASE was reviewd. The studies suggest that the available instruments to quantify the impact of acute and chronic rhinosinusitis demonstrate impairment on QoL and the available treatments lead to a similar improvement.
Rhinology, 2010
of wine tasters with Spanish healthy population using the Methods: Wine tasters were tested for s... more of wine tasters with Spanish healthy population using the Methods: Wine tasters were tested for smell and compared with a control group of healthy volunteers, by tasting 20 odours and scoring smell detection, identification, intensity, irritability, freshness, pleasure and forced choice. Results: Wine tasters performed significantly better on identification and forced choice than healthy controls. In addition, wine tasters perceived more odours as intense, but fewer as irritating than controls. Conclusions: Probably linked to smell education, wine tasters show better cognitive but not sensorial smell skills than a non-trained healthy population.
Respiratory Medicine, 2011
Background: The aim of the study was to evaluate the sense of smell in patients with bronchiectas... more Background: The aim of the study was to evaluate the sense of smell in patients with bronchiectasis. Methods: Prospective controlled study was performed on 91 patients with bronchiectasis. Bronchiectasis patients were sub-classified depending on: the presence of chronic rhinosinusitis, with or without nasal polyps, and the bronchiectasis ethiology. Olfactory function was evaluated by means of the Barcelona Smell Test (BAST-24) olfactometry for detection, identification, and forced choice for the first and fifth cranial nerve dependent odours in comparison to a group of 120 healthy volunteers. Results: Most patients with bronchiectasis (80.2%) satisfied EP 3 OS criteria of chronic rhinosinusitis (CRS), and 26.4% presented nasal polyps (NP). Smell detection, identification, and forced choice tests were significantly (p < 0.001) worse in bronchiectasis patients than healthy controls for both the 1st and 5th CN. Among subgroups, patients with CRS presented a significant (p < 0.05) reduction in smell detection compared to both healthy controls and patients without CRS. Patients with both CRS and NP presented a significant (p < 0.01) reduction in both smell detection and forced choice compared to patients with CRS and without NP. Patients with bronchiectasis and primary humoral immunodeficiency had a poorer smell detection (p < 0.001) and forced choice (p < 0.001) compared with post-infective and idiopathic bronchiectasis patients. (J.M. Guilemany). a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : w w w . e l s e v i e r . c o m / l o c a t e / r m e d Respiratory Medicine (2011) 105, 44e49 0954-6111/$ -see front matter ª
International Archives of Allergy and Immunology, 2012
served after 7 days of levocetirizine treatment (7.2 8 4.3; p ! 0.05) compared to placebo (-9.4 8... more served after 7 days of levocetirizine treatment (7.2 8 4.3; p ! 0.05) compared to placebo (-9.4 8 6.2). Improvement in smell identification by BAST-24 was strongly correlated (r = 0.72; p ! 0.05) with smell improvement by VAS after 30 days. After 7 days of treatment with levocetirizine, the nNO values decreased (-494 8 188) compared to placebo (155 8 284 ppb; p ! 0.05). Conclusions: The CIRANO study suggests that levocetirizine is effective on PER symptoms, including a transient improvement in loss of smell, and that this improvement concurs more with reduction of nasal inflammation than of nasal patency.
Acta Otorrinolaringológica Española, 2011
Resumen Presentamos el caso de una mujer de 28 años diagnosticada inicialmente de absceso periami... more Resumen Presentamos el caso de una mujer de 28 años diagnosticada inicialmente de absceso periamigdalino izquierdo, obteniendo mejoría tras drenaje. Doce días después presentó abombamiento de pared posterior faríngea. La TC y RMN mostraron una tumoración que destruía la masa lateral del atlas con componente de partes blandas en espacios prevertebral, retrofaríngeo, paraespinal y carotídeo izquierdos. La biopsia y el estudio microbiológico confirmaron la presencia de Mycobacterium tuberculosis. Se inició tratamiento con isoniazida, pirazinamida, rifampicina y etambutol, así como fijación-artrodesis occipitocervical C1-C2, y la paciente evolucionó satisfactoriamente.
American Journal of Rhinology and Allergy, 2013
Endoscopic transsphenoidal surgery is currently the optimal treatment for skull base tumors. This... more Endoscopic transsphenoidal surgery is currently the optimal treatment for skull base tumors. This study was designed to assess patient&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s sinonasal symptoms and quality of life (QoL) after resection of pituitary adenoma or skull base tumors using vascularized septal flap (VSF) reconstruction. Patients with pituitary adenoma underwent the transnasal transsphenoidal endoscopic approach (TTEA; n = 38), and patients with other benign parasellar tumors underwent the expanded endonasal approach (EEA; n = 17) with VSF. Assessment of sinonasal symptoms and QoL by the 36-item Short-Form (SF-36) and the 31-item Rhinosinusitis Outcome Measure (RSOM-31) were performed before and 3 months after surgery. At baseline, the total seven-sinonasal symptom score (T7SSS) was similar between both groups. After surgery, T7SSS significantly increased in EEA but not in TTEA patients. EEA patients reported more smell loss (40.1 ± 26.2; p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) and posterior nasal discharge (49.3 ± 30.1; p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) than TTEA patients (21.6 ± 30.9 and 22.5 ± 27.5, respectively). At baseline, both groups had poorer SF-36 compared with the general population. TTEA patients had poorer QoL (on general health, vitality, and mental health) than EEA patients. After surgery, TTEA patients showed impaired physical role and bodily pain compared with baseline, and EEA patients showed impaired physical role and mental health. At baseline, RSOM scores were similar in TTEA and EEA groups. After surgery, EEA but not TTEA patients reported poorer nasal and general symptoms. The EEA with VSF produces more sinonasal symptoms than pituitary surgery, surgery for skull base and pituitary tumors has negative impact on QoL, and functioning tumors have no further negative effect on sinonasal symptoms and QoL.
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Papers by Franklin Marino