Lee Yan

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Alessandro Silvestri

Università degli Studi di Salerno

Antonio Salvatore Romano

Pontificia Facoltà Teologica dell'Italia Meridionale

Antonio Alvarez-Ossorio Alvariño

Universidad Autónoma de Madrid

Prof. Dr. Hesham N Mustafa 🩺

King AbdulAziz University (KAU) Jeddah, Saudi Arabia

Handika Tri Tawangsasi

Universitas Airlangga

Pierre Dorny

Institute of Tropical Medicine, Antwerp

Joel A Swanson

University of Michigan

Cumhur Gunduz

Ege University

Ruth Ottman

Columbia University

Roberta Zappasodi

Memorial Sloan-Kettering Cancer Center

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Papers by Lee Yan

The Malaysian Acute Vascular Events Risk (MAVERIK) study protocol: studying genetic and other determinants of first-ever myocardial infarction in Malaysia (Preprint)

JMIR Research Protocols, 2021

Background: Although the burden of premature myocardial infarction (MI) is high in Malaysia, dire... more Background: Although the burden of premature myocardial infarction (MI) is high in Malaysia, direct evidence on the determinants of MI in this multi-ethnic population remains sparse. Objective: The Malaysian Acute Vascular Events Risk (MAVERIK) study is a retrospective case-control study established to investigate the genomic, lipid-related, and other determinants of acute MI in Malaysia. In this paper, we report the study protocol and early results. Methods: By June 2019, we had enrolled approximately 2500 patients with their first MI and 2500 controls without cardiovascular disease, who were frequency-matched by age, sex, and ethnicity, from 17 hospitals in Malaysia. For each participant, serum and whole blood have been collected and stored. Clinical, demographic, and behavioral information has been obtained using a 200-item questionnaire. Results: Tobacco consumption, a history of diabetes, hypertension, markers of visceral adiposity, indicators of lower socioeconomic status, and a family history of coronary disease were more prevalent in cases than in controls. Adjusted (age and sex) logistic regression models for traditional risk factors indicated that current smoking (odds ratio [

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The immediate effect of smoking on left ventricular systolic and diastolic function among healthy volunteers

Highlights of the first Malaysian National Cardiovascular Disease Database (NCVD): Percutaneous Coronary Intervention (PCI) Registry

Global Heart, 2011

The Malaysian NCVD-PCI registry attempts to determine the number and to monitor the outcomes of P... more The Malaysian NCVD-PCI registry attempts to determine the number and to monitor the outcomes of Percutaneous Coronary Intervention (PCI), based on selected performance indicators. It provides a comprehensive view to determine the level of adherence to existing guidelines, to evaluate the cost-effectiveness of treatment and prevention programs and to facilitate quality improvement activities of the participants. It also aims to stimulate research and to act as a reference for future studies. Methods: It was a voluntary, multi-centered, observational, cohort study and included patients of 18 years or above, with coronary artery disease who underwent PCI at eight participating centers in the year 2007. Results: A total of 3677 patients underwent 3920 PCI procedures with 6299 stents for 5512 lesions. The mean age of patients was 56.7 ± 10.11 years. The mean BMI was 26.38 ± 4.21 kg/ m 2 , while 80% of all subjects had a BMI above 23 kg/m 2. Males constituted 81.2% of the total population and 98.4% of the total population had at least one cardiovascular risk factor. Regarding PCI status, 90.1% were elective cases and 94% of cases had a low TIMI risk index at the beginning of PCI. Femoral approach accounted for 59%, radial approach for 34% and brachial

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Highlights of the first Malaysian National Cardiovascular Disease Database (NCVD): Percutaneous Coronary Intervention (PCI) Registry

by Lee Yan, Omar Ismail, and Robaayah Zambahari

CVD Prevention and Control, 2011

Objective: The Malaysian NCVD-PCI registry attempts to determine the number and to monitor the ou... more Objective: The Malaysian NCVD-PCI registry attempts to determine the number and to monitor the outcomes of Percutaneous Coronary Intervention (PCI), based on selected performance indicators. It provides a comprehensive view to determine the level of adherence to existing guidelines, to evaluate the cost-effectiveness of treatment and prevention programs and to facilitate quality improvement activities of the participants. It also aims to stimulate research and to act as a reference for future studies. Methods: It was a voluntary, multi-centered, observational, cohort study and included patients of 18 years or above, with coronary artery disease who underwent PCI at eight participating centers in the year 2007. Results: A total of 3677 patients underwent 3920 PCI procedures with 6299 stents for 5512 lesions. The mean age of patients was 56.7 ± 10.11 years. The mean BMI was 26.38 ± 4.21 kg/ m 2 , while 80% of all subjects had a BMI above 23 kg/m 2 . Males constituted 81.2% of the total population and 98.4% of the total population had at least one cardiovascular risk factor. Regarding PCI status, 90.1% were elective cases and 94% of cases had a low TIMI risk index at the beginning of PCI. Femoral approach accounted for 59%, radial approach for 34% and brachial 1875-4570/$ -see front matter ª a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : ww w . e l s e v i e r h e a l t h . c o m / j o u r n a l s / p r e c o n approach for 1% of all cases. The median fluoroscopy time was 15.7 min and the median doorto-balloon time for primary infarct PCI was 93.5 min. The commonest site of lesion was the left anterior descending artery, accounting for 48% of all lesions and 92.8% of all lesions were de novo. The mean lesion length was 24.4 ± 15.18 mm and about 28% of all lesions had high risk characteristics. Drug-eluting stents and bare metal stents were used in 53.6% and 42.5% of cases, respectively. After PCI, 91% of all lesions achieved TIMI grade 3 flow. Regarding pharmacotherapy, 99.5% of all patients received unfractionated heparin, 5% received LMWH prior to intervention, 96% received aspirin and 98% received clopidogrel. Over-all in-hospital mortality and 30 day mortality for the entire cohort was 1.1% and 1.8%, respectively. Conclusion: A summary of the first nationwide PCI registry has been presented. The subjects were much younger with a high prevalence of cardiovascular risk factors. The majority of cases (90%) were elective procedures with a low TIMI risk index. Mean door-to-balloon time for primary PCI was higher than the recommended guidelines. There was good prescribing of antiplatelets and heparin. Over-all in-hospital and 30 day mortality were comparable to other registries.

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The Malaysian Acute Vascular Events Risk (MAVERIK) study protocol: studying genetic and other determinants of first-ever myocardial infarction in Malaysia (Preprint)

JMIR Research Protocols, 2021

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The immediate effect of smoking on left ventricular systolic and diastolic function among healthy volunteers

Highlights of the first Malaysian National Cardiovascular Disease Database (NCVD): Percutaneous Coronary Intervention (PCI) Registry

Global Heart, 2011

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Highlights of the first Malaysian National Cardiovascular Disease Database (NCVD): Percutaneous Coronary Intervention (PCI) Registry

by Lee Yan, Omar Ismail, and Robaayah Zambahari

CVD Prevention and Control, 2011

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