Papers by Kristine Hansen
Chemosphere, 2018
Persistent organic pollutants (POPs) are found in the food chain of both humans and animals and e... more Persistent organic pollutants (POPs) are found in the food chain of both humans and animals and exert a wide spectrum of potentially adverse effects. The present experiment aimed to investigate whether a defined mixture of 29 POPs, based on the dietary intake of Scandinavians, could affect the stress response in female mice exposed through ingestion, and in their offspring. Female mice 129:C57BL/6F0 hybrids were exposed from weaning, throughout pregnancy, and up until necropsy, to either 5000 × or 100 000 × the estimated daily intake for Scandinavians. The offspring were fed a reference diet containing no POPs. Both the mothers and their offspring were tested for basal and stress responsive corticosterone levels, and in an open field test to measure locomotor activity and anxiety-like behaviours. We found mothers to have elevated basal corticosterone levels, as well as a prolonged stress response following POP exposure. In the offspring, there was no effect of POPs on the stress res...
Data Revues 00029610 V200i2 S000296100900779x, Aug 19, 2011
AIM: To determine the effect of a single dose of bevacizumab on adhesion formation in the rat cec... more AIM: To determine the effect of a single dose of bevacizumab on adhesion formation in the rat cecum abrasion model.
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, 2014
Pain and adhesions represent the challenge in hernia surgery. To investigate mesh fixation and ad... more Pain and adhesions represent the challenge in hernia surgery. To investigate mesh fixation and adhesion prevention with a collagen-fibrin sealant. Twenty-seven male Sprague-Dawley rats were operated twice, to create and repair 2 ventral hernias. Mesh fixation was with collagen-fibrin sealant on 1 side (group I), whereas an additional peritoneal suture was added in group II. On day 60 animals were killed and mesh migration, integration and number, grade and location of adhesions noted. Migration occurred in 12 (44.4%) in group 1 and 3 (11.1%) in group 2, P=0.023. Adhesions developed to 18 (33.3%) meshes. There was no difference in adhesion grade or area for mesh center or edge between the groups (P=0.735 and P=0.829, respectively). Median adhesion grade for mesh center was 1 and edge 3 (range, 0 to 4), P=0.005 and P=0.001, respectively. Granuloma formation was noted in 8 (18.6%) animals; only with suture-fixed mesh. Mesh fixation with fibrin sealant is not satisfactory, however, adhesion prevention seems to be; adhesions to the edge of the mesh are most severe.
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Papers by Kristine Hansen