Papers by Katarina Jeremic
Jugoslovenska …, 2005
Antiphospholipid antibodies (lupus anticoagulans and anticardiolipine antibodies) are freqent cau... more Antiphospholipid antibodies (lupus anticoagulans and anticardiolipine antibodies) are freqent cause of recurrent spontaneous abortion in patients with secondary sterility. Our aim was to evaluate the freqency of lupus anticoagulans antibodies in patients with recurrent abortions and to analyze their coagulation status relative to health (control) patients. We got the statistical significances (p < 0.05) in number of lupus anticoagulans positive women between the groups. Activated partial tromboplastin time and protrombin time are statistical significans (p < 0.05) higher in analyzed patients with recurrent abortion, which is in agreement of existing lupus anticoagulans activity. Detecting by the time, antiphospholipid antibodies and giving the anticoagulant therapy to the patients, the risk for abortion will be decreased.
Vojnosanitetski pregled, 2006
Klinički centar Srbije, Institut za ginekologiju i akušerstvo, Beograd Apstrakt Uvod/Cilj. Tibolo... more Klinički centar Srbije, Institut za ginekologiju i akušerstvo, Beograd Apstrakt Uvod/Cilj. Tibolon je preparat koji pripada grupi steroidnih supstancija. Efekti primene tibolona su posledica aktivnosti njegovih metabolita pri čemu njihova hormonska aktivnost zavisi od vrste tkiva u kome se stvaraju. Cilj rada je bio ispitivanje efekta primene tibolona na faktore rizika za nastanak kardiovaskularnih oboljenja kod žena u postmenopauzi. Metode. U prospektivnu studiju je uključeno 94 ispitanica koje su imale koncentraciju 17ß-estradiola < od 50 pg/ml i koje su bile u menopauzi bar jednu godinu. Od ukupnog broja, 63 ispitanice koje su prihvatile da primaju tibolon u dozi od 2,5mg na dan, činile su ispitivanu tibolon (T) grupu, dok je 31 ispitanica odbila da koristi supstitucionu terapiju i one su činile kontrolnu (K) grupu. Merene su koncentracije lipida (ukupni holesterol, LDL holesterol, HDL holesterol, trigliceridi), antitrombina III, fibrinogena i C-reaktivnog proteina (CRP) pre i posle terapije tibolonom koja je trajala šest meseci, a zatim je ispitivana statistička značajnost razlike u vrednostima posmatranih koncentracija. Ispitivane su i promene u vrednostima ispitivanih koncentracija u kontrolnoj grupi žena. Rezultati. Kod 31 ispitanice u postmenopauzi koje su činile kontrolnu grupu, nije došlo do značajnije promene vrednosti definisanih parametara u odnosu na njihove početne vrednosti, tokom posmatranog perioda. Kod ispitanica kod kojih je primenjen tibolon došlo je do značajnih promena u vrednostima posmatranih parametara (p < 0,001) tokom perioda od šest meseci, kao što je smanjenje vrednosti ukupnog holesterola za 17,8%, smanjenje vrednosti HDL holesterola za 27%, smanjenje vrednosti LDL holesterola za 4% (bez statističke značajnosti p > 0,05) uz smanjenje vrednosti triglicerida za 35%. Nije uočena statistička značajnost u promeni koncentracije antitrombina III, fibrinogena i CRP nakon primene tibolona. Zaključak. Primena tibolona dovodi do smanjenja vrednosti ukupnog holesterola, triglicerida, HDL holesterola, ne smanjujući značajno vrednost LDL holesterola. Takođe primena tibolona ne utiče značajno na promene koncentracije fibrinogena, antitrombina III i CRP. Broj serumskih parametara merenih u ovoj studiji je ograničen, zbog čega se može diskutovati samo o metabolizmu lipida, dok definitivni zaključak o riziku za nastanak kardiovaskularnih oboljenja tokom primene tibolona zahteva dalja klinička istraživanja.
American journal of obstetrics and gynecology, 2008
Injuries of the ureter or bladder or development of vesicovaginal and ureterovaginal fistulas are... more Injuries of the ureter or bladder or development of vesicovaginal and ureterovaginal fistulas are the most serious complications in gynecological surgery. This study included 536 women who underwent radical hysterectomy because of invasive cancer of the cervix uteri. During the surgery the ureter was injured in 1.32% of cases, whereas the percentage of bladder injuries was 1.49. In the early postoperative period vesicovaginal or ureterovaginal fistulas appeared in 2.61% and 2.43% of cases, respectively. The stage of the disease, obesity, diabetes, and postoperative surgical infection acted as predisposing factors of the urinary tract complications.
European journal of gynaecological oncology
A uterine tumor resembling an ovarian sex cord tumor (UTROSCT) shows a poly phenotypic immunophen... more A uterine tumor resembling an ovarian sex cord tumor (UTROSCT) shows a poly phenotypic immunophenotype with coexpression of epithelial, myoid, and sex cord markers, as well as hormone receptors. The authors present a case of a 59-year-old multiparous woman admitted to the Institute of Gynecology and Obstetrics Clinical Centre of Serbia in January 2010 due to prolonged vaginal bleeding and abdominal discomfort. The vaginal ultrasound showed an enlarged uterus size of 100 x 74 x 81 mm, with extended cavity with an unhomogenic content and myomas sized 54 x 69 mm located in fundus with secondary changes. She underwent abdominal hysterectomy with adnexectomy. Microscopic examination revealed submucosal uterine tumor with variabile histological organization that had anastomotic trabeculae with solid cellular grupations. Rare mitotic figures (2/10 HPF) were found. Additional imunohistochemistry showed immunophenotype: the sex cord areas were positive for vimentin(++), aSMA(++), AE1/AE3(+),...
Case Reports in Oncology, 2013
Etoposide is commonly used in the treatment of a variety of neoplasms. Hypersensitivity reactions... more Etoposide is commonly used in the treatment of a variety of neoplasms. Hypersensitivity reactions to etoposide are infrequently reported and include hypotension, hypertension, flushing, diaphoresis, chest discomfort, dyspnea, bronchospasm and loss of consciousness. We report the case of a 39-year-old woman who experienced acute bronchospasm, tachycardia, hypoxia and hypotension. The symptoms resolved within an hour after administration of intravenous fluids, methylprednisolone, diphenhydramine and oxygen. Subsequently, the patient was given etoposide phosphate without incident.
Srpski arhiv za celokupno lekarstvo, 2013
Uterus didelphys with obstructed hemivagina and ipsilateral renal agenesis represents a complex c... more Uterus didelphys with obstructed hemivagina and ipsilateral renal agenesis represents a complex congenital anomaly, also known in the literature as Herlyn-Werner-Wunderlich (HWW) syndrome. A 16-year-old patient presented with secondary amenorrhoea and abdominal pain. Her history revealed anorexia nervosa; she had menarche at the age of 14; her menstrual cycles were regular, with progressive dysmenorrhoea. Nine months after the explorative laparotomy performed at the regional healthcare center there was no a definitive diagnosis. Pelvic examination showed a paravaginal pelvic mass located on the right side. Magnetic resonance imaging of the abdomen and pelvis confirmed the diagnosis of HWW syndrome. Transvaginal excision and marsupialisation of the vaginal septum were performed. Regular menstrual cycles were resumed after four years following the treatment of anorexia nervosa. Twelve years after the operation, the patient conceived spontaneously; pregnancy developed in the left non-obstructed uterus. She underwent Cesarean section at the 37th gestational week and gave birth to a healthy female infant. HWW syndrome is an uncommon cause of abdominal pain and progressive menstrual discomfort shortly after menarche. It is therefore essential to maintain a high index of suspicion of the existence of this syndrome in such cases, since prompt and adequate treatment prevents the development of complications and allows for preservation of the reproductive potential of both hemi-uteri.
Vojnosanitetski pregled, 2006
Klinički centar Srbije, Institut za ginekologiju i akušerstvo, Beograd Apstrakt Uvod/Cilj. Primen... more Klinički centar Srbije, Institut za ginekologiju i akušerstvo, Beograd Apstrakt Uvod/Cilj. Primena medikamentnog prekida trudnoće odobrena je u našoj zemlji od septembra 2001. godine. Cilj našeg istraživanja je procena efikasnosti primene ove metode, učestalosti pojave neželjenih efekata, kao i prihvatljivosti primene ove metode kao načina prekida rane trudnoće, primenom mifepristona oralno (600 mg) i 48 sati kasnije misoprostola, oralno ili vaginalno u različitim dozama (400, 600 ili 800 μg), u našoj populaciji. Metode. Ispitivanjem je obuhvaćeno 235 žena sa trudnoćom do 49. dana amenoreje koje su na osnovu načina primene i primenjene doze misoprostola podeljene u četiri grupe (I grupa 400 μg, II 600 μg, III 800 μg oralno i IV grupa 800 μg podeljenih oralno i vaginalno). Metoda je označena kao uspešna u slučaju kompletnog abortusa. Pored uspešnosti metode, praćena je i učestalost pojave neželjenih efekata i komplikacija. Rezultati. Efikasnost metoda izražena kao kompletna ekspulzija produkata začeća bez potrebe za instrumentalnom intervencijom bila je u I grupi 50%, 89,48% u II, 75% u III i 92,11% u IV grupi, što četvrti protokol čini najuspešnijim (t 1:4 = 7,005; t 2:4 = 0,3872, t 3:4 = 2,9784, p < 0,01). Učestalost pojave neželjenih efekata (abdominalni bol, povraćanje, vaginalno krvarenje, groznica) bila je niska i javljale su se kod viših oralnih doza misoprostola (600 i 800 μg). U samo jednom slučaju je bila zbog profuzne hemoragije neophodna hitna hemostatska kiretaža i primena dve transfuzije krvi. Nisu zabeleženi slučajevi neprekinutih trudnoća. Zaključak. Naša studija je pokazala da najefikasniji protokol za medikamentni prekid trudnoće, istovremeno sa najmanje neželjenih efekata, obuhvata oralnu primenu 600 mg mifepristona i kombinovanu oralnu i vaginalnu primenu 800 μg misoprostola. Nadalje, ona sugeriše da bi ovaj način prekida trudnoće mogao postići veći udeo u ukupnom broju prekida rane trudnoće.
Uploads
Papers by Katarina Jeremic