jected after the onset of neural development, to assess the role Sip1 during cranial neural crest... more jected after the onset of neural development, to assess the role Sip1 during cranial neural crest development. With this approach we can determine whether Sip1 functions similarly in cancer cells and neural crest EMT and if it has any additional functions during embryonic development. Our results show that loss of Sip1 has no effect on cranial crest specification, but it prevents or delays migration of the crest out of the dorsal neural tube. Future studies will identify the mechanism by which Sip1 regulates the onset of migration in these cells.
jected after the onset of neural development, to assess the role Sip1 during cranial neural crest... more jected after the onset of neural development, to assess the role Sip1 during cranial neural crest development. With this approach we can determine whether Sip1 functions similarly in cancer cells and neural crest EMT and if it has any additional functions during embryonic development. Our results show that loss of Sip1 has no effect on cranial crest specification, but it prevents or delays migration of the crest out of the dorsal neural tube. Future studies will identify the mechanism by which Sip1 regulates the onset of migration in these cells.
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Papers by Kamal Sharma