Papers by Jessica Büetiger
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Jan 27, 2015
Cocaine users consistently develop working memory (WM) impairments but the mediating molecular me... more Cocaine users consistently develop working memory (WM) impairments but the mediating molecular mechanisms are unknown so far. Recent evidence suggests that the serotonin (5-HT) system is altered by chronic cocaine use, while also being involved in WM processing. Thus, we investigated the effects of genetic variations impacting 5-HT activity and of peripheral 5-HT transporter (5-HTT) mRNA expression on WM performance in cocaine users and stimulant-naïve controls. Two-hundred-twenty participants (126 cocaine users, 94 controls) were assessed with visuospatial, spatial and verbal WM tasks, genotyped for the length polymorphism in the promoter region of the 5-HTT (5-HTTLPR), the variable number of tandem repeats in the second intron of the 5-HTT (VNTR In2), two single nucleotide polymorphisms (rs4570625, rs1386497) in the tryptophan hydroxylase-2 (TPH2) gene and quantified for peripheral 5-HTT mRNA expression in whole blood samples. Several significant gene*environment interactions betw...
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Papers by Jessica Büetiger