Major civilization diseases that are related to cardiovascular system are accompanied with inflam... more Major civilization diseases that are related to cardiovascular system are accompanied with inflammation. Inflammatory process is known to change function of vascular endothelium which plays a crucial role in atherosclerotic plaque development and related disturbances in heart function. In addition to pharmacotherapy the natural substances have been recommended to reduce incidence and severity of atherosclerotic heart diseases. Therefore, the aim of our study was to examine if acetylcholine (Ach)- modulated heart function may be affected by endotoxin and carotenoids produced by yeast strain Rhodontorula characterized with antioxidative properties. Ach is an important neurotransmitter of the parasympathicus nerve system, opposite to the sympathicus nerve system, slowing the heart functions. The experiment was performed on male Wistar rats. The inflammation was induced with a single dose of endotoxin (LPS E. coli, 1 mg/kg). Rats were treated with yeast biomass (10 mg/kg/day) for 10 day...
Major civilization diseases that are related to cardiovascular system are accompanied with inflam... more Major civilization diseases that are related to cardiovascular system are accompanied with inflammation. Inflammatory process is known to change function of vascular endothelium which plays a crucial role in atherosclerotic plaque development and related disturbances in heart function. In addition to pharmacotherapy the natural substances have been recommended to reduce incidence and severity of atherosclerotic heart diseases. Therefore, the aim of our study was to examine if acetylcholine (Ach)- modulated heart function may be affected by endotoxin and carotenoids produced by yeast strain Rhodontorula characterized with antioxidative properties. Ach is an important neurotransmitter of the parasympathicus nerve system, opposite to the sympathicus nerve system, slowing the heart functions. The experiment was performed on male Wistar rats. The inflammation was induced with a single dose of endotoxin (LPS E. coli, 1 mg/kg). Rats were treated with yeast biomass (10 mg/kg/day) for 10 day...
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Papers by Jakub Križák