Many studies have indicated that the E-cadherin (E-CAD) expression loss is associated with the lo... more Many studies have indicated that the E-cadherin (E-CAD) expression loss is associated with the loss of cellular differentiation and increased cellular invasiveness and can be correlated with poor prognosis in urothelial carcinoma (UC) of the urinary bladder. The aim of this study was to define the role of E-CAD mRNA expression on recurrence, progression and survival in UC of the urinary bladder over a long follow-up period. From 30 patients with bladder UC, enrolled in our previous study, 27 were selected for this study. All patients were re-analyzed in terms of clinical and tumor characteristics, tumor pathological analysis and tumor E-CAD mRNA expression. The data were correlated to 12-year follow-up results. Significant correlations between stage (p=0.002), grade (p=0.008) and E-CAD mRNA expression were reported. E-CAD did not show any correlation in predicting recurrence or progression in bladder UC. The survival analysis demonstrated a significant relationship (p=0.019) between patients with expressed E-CAD mRNA levels and cancer-specific survival. Multivariate analysis demonstrated that expression of E-CAD mRNA levels is an independent prognostic factor in terms of cancerspecific survival in UC of the urinary bladder (p=0.002). Our study is the first to demonstrate that mRNA extraction and Northen blot analysis is to be considered a reliable method to evaluate E-CAD mRNA levels for predicting survival rate in patients affected by urothelial bladder cancers. We stress that a long follow-up period is needed to evaluate the role of molecular factors in predicting prognosis in patients affected by bladder UC.
Orang Rimba merupakan masyarakat adat dengan salah satu karakteristiknya yang menonjol yaitu bahw... more Orang Rimba merupakan masyarakat adat dengan salah satu karakteristiknya yang menonjol yaitu bahwa mereka masih menjaga tradisi peninggalan nenek moyangnya. Berdasarkan tradisi dan kebudayaan Orang Rimba, nenek moyang mereka melakukan kegiatan berburu dan meramu bahan makanan hasil hutan guna memenuhi kebutuhan hidup. Realita di lapangan ada kelompok Orang Rimba yang melakukan usaha dalam memenuhi kebutuhan hidupnya yaitu dengan bercocok tanam. Penelitian ini dilakukan untuk mengetahui peralihan dan faktor-faktor yang mempengaruhi peralihan sistem mata pencaharian hidup Orang Rimba. Penelitian ini dilakukan di Desa Bukit Suban Kecamatan Air Hitam Kabupaten Sarolangun. Lokasi penelitian dipilih secara sengaja dengan pertimbangan bahwa di Desa ini terdapat Orang Rimba yang telah tinggal menetap dan melakukan cocok tanam menetap. Informan pada penelitian ini adalah Orang Rimba dan pemerintah desa. Data penelitian ini dianalisis dengan menggunakan model interaktif yang terdiri dari tig...
... Intracranial mesenchymal chondrosarcoma: Report of two pediatric cases. Iacopo Sardi MD, PhD ... more ... Intracranial mesenchymal chondrosarcoma: Report of two pediatric cases. Iacopo Sardi MD, PhD 1,3,* ,; Maura Massimino MD 2 ,; Lorenzo Genitori MD 3 ,; Anna Maria Buccoliero MD 4 ,; Felice Giangaspero MD 5 ,; Andrea Ferrari MD 2. Article first published online: 1 DEC 2010 ...
Many studies have indicated that the E-cadherin (E-CAD) expression loss is associated with the lo... more Many studies have indicated that the E-cadherin (E-CAD) expression loss is associated with the loss of cellular differentiation and increased cellular invasiveness and can be correlated with poor prognosis in urothelial carcinoma (UC) of the urinary bladder. The aim of this study was to define the role of E-CAD mRNA expression on recurrence, progression and survival in UC of the urinary bladder over a long follow-up period. From 30 patients with bladder UC, enrolled in our previous study, 27 were selected for this study. All patients were re-analyzed in terms of clinical and tumor characteristics, tumor pathological analysis and tumor E-CAD mRNA expression. The data were correlated to 12-year follow-up results. Significant correlations between stage (p=0.002), grade (p=0.008) and E-CAD mRNA expression were reported. E-CAD did not show any correlation in predicting recurrence or progression in bladder UC. The survival analysis demonstrated a significant relationship (p=0.019) between patients with expressed E-CAD mRNA levels and cancer-specific survival. Multivariate analysis demonstrated that expression of E-CAD mRNA levels is an independent prognostic factor in terms of cancerspecific survival in UC of the urinary bladder (p=0.002). Our study is the first to demonstrate that mRNA extraction and Northen blot analysis is to be considered a reliable method to evaluate E-CAD mRNA levels for predicting survival rate in patients affected by urothelial bladder cancers. We stress that a long follow-up period is needed to evaluate the role of molecular factors in predicting prognosis in patients affected by bladder UC.
Orang Rimba merupakan masyarakat adat dengan salah satu karakteristiknya yang menonjol yaitu bahw... more Orang Rimba merupakan masyarakat adat dengan salah satu karakteristiknya yang menonjol yaitu bahwa mereka masih menjaga tradisi peninggalan nenek moyangnya. Berdasarkan tradisi dan kebudayaan Orang Rimba, nenek moyang mereka melakukan kegiatan berburu dan meramu bahan makanan hasil hutan guna memenuhi kebutuhan hidup. Realita di lapangan ada kelompok Orang Rimba yang melakukan usaha dalam memenuhi kebutuhan hidupnya yaitu dengan bercocok tanam. Penelitian ini dilakukan untuk mengetahui peralihan dan faktor-faktor yang mempengaruhi peralihan sistem mata pencaharian hidup Orang Rimba. Penelitian ini dilakukan di Desa Bukit Suban Kecamatan Air Hitam Kabupaten Sarolangun. Lokasi penelitian dipilih secara sengaja dengan pertimbangan bahwa di Desa ini terdapat Orang Rimba yang telah tinggal menetap dan melakukan cocok tanam menetap. Informan pada penelitian ini adalah Orang Rimba dan pemerintah desa. Data penelitian ini dianalisis dengan menggunakan model interaktif yang terdiri dari tig...
... Intracranial mesenchymal chondrosarcoma: Report of two pediatric cases. Iacopo Sardi MD, PhD ... more ... Intracranial mesenchymal chondrosarcoma: Report of two pediatric cases. Iacopo Sardi MD, PhD 1,3,* ,; Maura Massimino MD 2 ,; Lorenzo Genitori MD 3 ,; Anna Maria Buccoliero MD 4 ,; Felice Giangaspero MD 5 ,; Andrea Ferrari MD 2. Article first published online: 1 DEC 2010 ...
Uploads
Papers by I. Sardi