BACKGROUND AND OBJECTIVES: There are conflicting views as to whether testing for biotinidase defi... more BACKGROUND AND OBJECTIVES: There are conflicting views as to whether testing for biotinidase deficiency (BD) ought to be incorporated into universal newborn screening (NBS) programs. The aim of this study was to evaluate the cost-effectiveness of adding BD to the panel of conditions currently screened under the national NBS program in Spain.
En este trabajo se presenta un nuevo esquema de control robusto aplicado a un sistema robótico. E... more En este trabajo se presenta un nuevo esquema de control robusto aplicado a un sistema robótico. Este esquema introduce un término autoadaptativo para un parámetro de diseño del controlador robusto. Dicho término corrige el comportamiento ineficiente del controlador robusto clásico en presencia de incertidumbres en el modelo, ya sea en sus parámetros dinámicos o bien en el caso de una masa de transporte desconocida. En las distintas simulaciones que se presentan se comparan ambos comportamientos y se corrobora la eficiencia de la nuevo algoritmo presentado.
Electroconvulsive therapy (ECT) is widely applied to treat severe depression resistant to standar... more Electroconvulsive therapy (ECT) is widely applied to treat severe depression resistant to standard treatment. Results from previous studies comparing the cost-effectiveness of this technique with treatment alternatives such as repetitive transcranial magnetic stimulation (rTMS) are conflicting. We conducted a cost-effectiveness analysis comparing ECT alone, rTMS alone and rTMS followed by ECT when rTMS fails under the perspective of the Spanish National Health Service. The analysis is based on a Markov model which simulates the costs and health outcomes of individuals treated under these alternatives over a 12-month period. Data to populate this model were extracted and synthesized from a series of randomized controlled trials and other studies that have compared these techniques on the patient group of interest. We measure effectiveness using quality-adjusted life years (QALYs) and characterize the uncertainty using probabilistic sensitivity analyses. ECT alone was found to be less costly and more effective than rTMS alone, while the strategy of providing rTMS followed by ECT when rTMS fails is the most expensive and effective option. The incremental cost per QALY gained of this latter strategy was found to be above the reference willingness-to-pay threshold used in these types of studies in Spain and other countries. The probability that ECT alone is the most cost-effective alternative was estimated to be around 70%. ECT is likely to be the most cost-effective option in the treatment of resistant severe depression for a willingness to pay of €30 000 per QALY.
Palabras Clave: simulación, sistema de eventos discretos, programación orientada a objetos (Java)... more Palabras Clave: simulación, sistema de eventos discretos, programación orientada a objetos (Java), modelado orientado al proceso.
Technological improvements in the use of computers through the better management of multithreadin... more Technological improvements in the use of computers through the better management of multithreading, such as with multi-core computers (core duo, core 2 duo, core 2 quad), have resulted in a reassessment of systems for simulating discrete events which can exploit these new capabilities. We consider the design and implementation of a process-oriented discrete event simulation library which makes exhaustive use
International Journal of Simulation and Process Modelling, 2011
ABSTRACT Since the early 1990s, when it was first released, Java has become one of the most wides... more ABSTRACT Since the early 1990s, when it was first released, Java has become one of the most widespread programming languages. Discrete Event Simulation (DES) and also Parallel Discrete Event Simulation (PDES) have attracted more and more projects which are Java-based. This paper presents a brief survey on the tools and facilities that make Java such an attractive option for parallel simulation developers. Nevertheless, several drawbacks and lacks of the language are also exposed.
2007). Use of Constructivism and Collaborative Teaching in an ILP Processors Course. IEEE Trans. ... more 2007). Use of Constructivism and Collaborative Teaching in an ILP Processors Course. IEEE Trans. Education 50(2):101-111.
Computer Applications in Engineering Education, 2007
This article presents SIMDE, a cycle-by-cycle simulator to support teaching of Instruction-Level ... more This article presents SIMDE, a cycle-by-cycle simulator to support teaching of Instruction-Level Parallelism (ILP) architectures. The simulator covers dynamic and static instruction scheduling by using a shared structure for both approaches. Dynamic scheduling is illustrated by means of a simple superscalar processor based on Tomasulo's algorithm. A basic Very Long Instruction Word (VLIW) processor has been designed for static scheduling. The simulator is intended as an aid-tool for teaching theoretical contents in Computer Architecture and Organization courses. The students are provided with an easy-to-use common environment to perform different simulations and comparisons between superscalar and VLIW processors. Furthermore, the simulator has been tested by students in a Computer Architecture course in order to assess its real usefulness. ß ADDI Rd, Rs, #Imm Rd ¼ Rs þ #Imm ADD Rd, Rs1, Rs2
ABSTRACT Peaks and valleys affecting the efficiency of the power system can be detected by analyz... more ABSTRACT Peaks and valleys affecting the efficiency of the power system can be detected by analyzing the load curve. These oscillations are caused by changes in consumer behavior, mainly consumers in the residential sector. This paper presents the use of fuzzy logic systems to model human behavior related to activation of appliances and lighting at home. Based on this model, the hourly activation profile for each appliance can be obtained and, subsequently, the load curve of the residential sector can be calculated. This model aims at contributing to the simulation of strategies for demand-side management.
Using a cytofluorimetric approach, we studied intramitochondrial cardiolipin (CL) distribution in... more Using a cytofluorimetric approach, we studied intramitochondrial cardiolipin (CL) distribution in HCW-2 cells, an apoptosis-resistant clone of human HL-60 cells. In HL-60, about 50% of total CL is distributed in the outer leaflet of mitochondrial inner membrane, while in HCW-2 a significantly higher amount of CL (about 65%) is in that site. In basal conditions, HSW-2 cells also show a reduced mitochondrial membrane potential even if they are able to proliferate as the parental line. Taking into account the complex functions that CL plays in the regulation of mitochondrial activity, it is likely that HCW-2 could produce ATP utilizing more glycolytic pathways rather than mitochondrial respiratory chain. ß 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
BACKGROUND AND OBJECTIVES: There are conflicting views as to whether testing for biotinidase defi... more BACKGROUND AND OBJECTIVES: There are conflicting views as to whether testing for biotinidase deficiency (BD) ought to be incorporated into universal newborn screening (NBS) programs. The aim of this study was to evaluate the cost-effectiveness of adding BD to the panel of conditions currently screened under the national NBS program in Spain.
En este trabajo se presenta un nuevo esquema de control robusto aplicado a un sistema robótico. E... more En este trabajo se presenta un nuevo esquema de control robusto aplicado a un sistema robótico. Este esquema introduce un término autoadaptativo para un parámetro de diseño del controlador robusto. Dicho término corrige el comportamiento ineficiente del controlador robusto clásico en presencia de incertidumbres en el modelo, ya sea en sus parámetros dinámicos o bien en el caso de una masa de transporte desconocida. En las distintas simulaciones que se presentan se comparan ambos comportamientos y se corrobora la eficiencia de la nuevo algoritmo presentado.
Electroconvulsive therapy (ECT) is widely applied to treat severe depression resistant to standar... more Electroconvulsive therapy (ECT) is widely applied to treat severe depression resistant to standard treatment. Results from previous studies comparing the cost-effectiveness of this technique with treatment alternatives such as repetitive transcranial magnetic stimulation (rTMS) are conflicting. We conducted a cost-effectiveness analysis comparing ECT alone, rTMS alone and rTMS followed by ECT when rTMS fails under the perspective of the Spanish National Health Service. The analysis is based on a Markov model which simulates the costs and health outcomes of individuals treated under these alternatives over a 12-month period. Data to populate this model were extracted and synthesized from a series of randomized controlled trials and other studies that have compared these techniques on the patient group of interest. We measure effectiveness using quality-adjusted life years (QALYs) and characterize the uncertainty using probabilistic sensitivity analyses. ECT alone was found to be less costly and more effective than rTMS alone, while the strategy of providing rTMS followed by ECT when rTMS fails is the most expensive and effective option. The incremental cost per QALY gained of this latter strategy was found to be above the reference willingness-to-pay threshold used in these types of studies in Spain and other countries. The probability that ECT alone is the most cost-effective alternative was estimated to be around 70%. ECT is likely to be the most cost-effective option in the treatment of resistant severe depression for a willingness to pay of €30 000 per QALY.
Palabras Clave: simulación, sistema de eventos discretos, programación orientada a objetos (Java)... more Palabras Clave: simulación, sistema de eventos discretos, programación orientada a objetos (Java), modelado orientado al proceso.
Technological improvements in the use of computers through the better management of multithreadin... more Technological improvements in the use of computers through the better management of multithreading, such as with multi-core computers (core duo, core 2 duo, core 2 quad), have resulted in a reassessment of systems for simulating discrete events which can exploit these new capabilities. We consider the design and implementation of a process-oriented discrete event simulation library which makes exhaustive use
International Journal of Simulation and Process Modelling, 2011
ABSTRACT Since the early 1990s, when it was first released, Java has become one of the most wides... more ABSTRACT Since the early 1990s, when it was first released, Java has become one of the most widespread programming languages. Discrete Event Simulation (DES) and also Parallel Discrete Event Simulation (PDES) have attracted more and more projects which are Java-based. This paper presents a brief survey on the tools and facilities that make Java such an attractive option for parallel simulation developers. Nevertheless, several drawbacks and lacks of the language are also exposed.
2007). Use of Constructivism and Collaborative Teaching in an ILP Processors Course. IEEE Trans. ... more 2007). Use of Constructivism and Collaborative Teaching in an ILP Processors Course. IEEE Trans. Education 50(2):101-111.
Computer Applications in Engineering Education, 2007
This article presents SIMDE, a cycle-by-cycle simulator to support teaching of Instruction-Level ... more This article presents SIMDE, a cycle-by-cycle simulator to support teaching of Instruction-Level Parallelism (ILP) architectures. The simulator covers dynamic and static instruction scheduling by using a shared structure for both approaches. Dynamic scheduling is illustrated by means of a simple superscalar processor based on Tomasulo's algorithm. A basic Very Long Instruction Word (VLIW) processor has been designed for static scheduling. The simulator is intended as an aid-tool for teaching theoretical contents in Computer Architecture and Organization courses. The students are provided with an easy-to-use common environment to perform different simulations and comparisons between superscalar and VLIW processors. Furthermore, the simulator has been tested by students in a Computer Architecture course in order to assess its real usefulness. ß ADDI Rd, Rs, #Imm Rd ¼ Rs þ #Imm ADD Rd, Rs1, Rs2
ABSTRACT Peaks and valleys affecting the efficiency of the power system can be detected by analyz... more ABSTRACT Peaks and valleys affecting the efficiency of the power system can be detected by analyzing the load curve. These oscillations are caused by changes in consumer behavior, mainly consumers in the residential sector. This paper presents the use of fuzzy logic systems to model human behavior related to activation of appliances and lighting at home. Based on this model, the hourly activation profile for each appliance can be obtained and, subsequently, the load curve of the residential sector can be calculated. This model aims at contributing to the simulation of strategies for demand-side management.
Using a cytofluorimetric approach, we studied intramitochondrial cardiolipin (CL) distribution in... more Using a cytofluorimetric approach, we studied intramitochondrial cardiolipin (CL) distribution in HCW-2 cells, an apoptosis-resistant clone of human HL-60 cells. In HL-60, about 50% of total CL is distributed in the outer leaflet of mitochondrial inner membrane, while in HCW-2 a significantly higher amount of CL (about 65%) is in that site. In basal conditions, HSW-2 cells also show a reduced mitochondrial membrane potential even if they are able to proliferate as the parental line. Taking into account the complex functions that CL plays in the regulation of mitochondrial activity, it is likely that HCW-2 could produce ATP utilizing more glycolytic pathways rather than mitochondrial respiratory chain. ß 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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Papers by I. Castilla