Diabetes/metabolism research and reviews, May 22, 2017
Metformin, a widely used anti-hyperglycemic, has a good safety profile, reasonably manageable sid... more Metformin, a widely used anti-hyperglycemic, has a good safety profile, reasonably manageable side-effects, is inexpensive and causes a desirable amount of weight loss. In four studies of patients with tuberculosis (one prospective and three retrospective), metformin administration resulted in better outcomes. In mice with several models of endotoxemia, metformin diminished levels of pro-inflammatory cytokines and improved survival. Laboratory studies showed effectiveness of the drug on multiple pathogens, including Trichinella spiralis, Staphylococcus aureus, Pseudomonas aeruginosa, Hepatitis B virus, Hepatitis C virus and human immunodeficiency virus. Metformin administration in humans and mice produced major changes in the composition of the gut microbiota. These recently discovered microbe-modulating properties of the drug have led investigators to predict wide therapeutic utility for metformin. The recent easing in FDA guidelines regarding administration of metformin to patient...
Background: Institutional childhood morbidity, mortality analysis and their trends reflect the lo... more Background: Institutional childhood morbidity, mortality analysis and their trends reflect the local disease occurrence, changes in treatment modalities and quality of treatment available. This study was aimed to evaluate the magnitude of post neonatal mortality and its seasonal pattern at Hemawati Nandan Bahuguna Teaching Base Hospital, Srikot over a period of 10 years.Methods: A retrospective cross-sectional descriptive analysis was done on post neonatal mortality data by Pediatric Department of the Hemawati Nandan Bahuguna Teaching Base Hospital, Srikot from April 2008 to March 2018. Neonates admitted to PICU, referral and LAMA patients were excluded from the study. Data was analyzed using SPSS 16.0.Results: Overall post neonatal mortality of 1.83% was found in the study. Mortality amongst the boys was 119 (54.34 %) and the girls were 100 (45.66 %). Three most common causes of mortality were septicemia (27.40 %) followed by encephalitis (11.41 %) and protein energy malnutrition/u...
To determine the prevalence of ABO and Rh blood groups based on the antigenic presence on the sur... more To determine the prevalence of ABO and Rh blood groups based on the antigenic presence on the surface of red blood cells with respect to gender and calculate allele frequency of the blood groups. Globally, approximately 700 type red cell antigens have been identified till now. ABO and Rh blood groups play an important role in the process of blood transfusion, resolving certain medicolegal issues, parental testing, and various genetic studies. This study was conducted in H.N.B. Base Hospital, Srinagar, Uttarakhand, from January 2012 to December 2016. Relevant data of blood donors were collected from blood bank department of the hospital. Blood grouping was conducted using commercially available standard monoclonal antisera applying test tube and column agglutination techniques. Out of 9883 individuals, 9333 (92.4%) were males and 750 (7.6%) were female individuals. The most common blood group found was B (31.68%) and least common being AB (11.70%). The prevalence of Rhesus positive a...
Background: Iodine deficiency is the world's single greatest cause of preventable mental retardat... more Background: Iodine deficiency is the world's single greatest cause of preventable mental retardation. In developing countries, only 69% of households are consuming iodized salt. Objective: To assess knowledge and practices with respect to the current use of iodized salt, and to estimate its uptake at the household level. Materials and Methods: This cross-sectional survey was conducted in six villages under Rural Health Training Center. A total number of households surveyed were 253. The data collectors obtained verbal consent from the Family, and Pretested Standardized Questionnaire was administered in every selected household. The respondents were asked questions regarding salt purchasing and consumption habits, salt storage, awareness of iodized salt, and iodine deficiency diseases. Rapid iodized salt test kit (MBI kit) was used in the survey to assess iodine content in salt used in households. Results: In this study, 93.7% households were using packet salt. The most common source of information was a television (31.1%). More than half (53.8%) of the households were unaware of the benefits of iodine. About 62.5% of households were consuming adequately iodized salt. Significant association was found between the practice of storing salt in closed containers and use of packaged iodized salt (Chi-square value −37.6, P < 0.001), awareness about the benefits of iodine and type of salt used (P = 0.02) while no association was observed between the socioeconomic status and type of salt used in the household. Conclusions: Though the use of packet salt was more than 90%, adequately iodized salt was consumed only in 62.5%, and more than half of the subjects lacked the knowledge about iodine deficiency diseases.
International Journal of Public Health Science (IJPHS)
The current study was designed to identify the morbidity pattern of outpatients attending Urban H... more The current study was designed to identify the morbidity pattern of outpatients attending Urban Health Training Centre in an urban area of a medical college in Srinagar, Pauri Garhwal district, Uttarakhand, North India. The present study record-based retrospective study was conducted among the outpatients attending the regular clinic at the Urban Health Training Centre, of a medical college in Srinagar city of Uttarakhand State of North India during the study period of one year in 2014. Data was retrieved from the OPD registers maintained at the clinic. Data was collected pertaining to socio-demographic profile, morbidity details and treatment pattern. Diseases were identified using the International Classification of Diseases (ICD-10) code. Descriptive analysis was done. During the study period, a total of 9343 subjects attended the OPD. Among them, majority of them (60%) were females. More than half (56 %) belonged to the age group of 35-65 year age-group. The association of disease classification was found to be statistically significant with respect to gender. The leading morbidity of communicable disease was found to be certain infectious and parasitic diseases especially Typhoid whereas musculoskeletal system and connective tissue disorders were the most common cause among morbidity due to NCDs. Out of all, typhoid was found to cause maximum of morbidity among the subjects. The present study highlights the morbidity pattern of communicable and NCDs among the population of hilly areas of Garhwal, Uttarakhand India. Priority should be preferred for the regular tracking of diseases in terms of preventive and promotive aspects. Morbidity in the outdoor clinics reflects the emerging trend of mixed disease spectrum burden comprising communicable and non-communicable diseases.
Diabetes/metabolism research and reviews, May 22, 2017
Metformin, a widely used anti-hyperglycemic, has a good safety profile, reasonably manageable sid... more Metformin, a widely used anti-hyperglycemic, has a good safety profile, reasonably manageable side-effects, is inexpensive and causes a desirable amount of weight loss. In four studies of patients with tuberculosis (one prospective and three retrospective), metformin administration resulted in better outcomes. In mice with several models of endotoxemia, metformin diminished levels of pro-inflammatory cytokines and improved survival. Laboratory studies showed effectiveness of the drug on multiple pathogens, including Trichinella spiralis, Staphylococcus aureus, Pseudomonas aeruginosa, Hepatitis B virus, Hepatitis C virus and human immunodeficiency virus. Metformin administration in humans and mice produced major changes in the composition of the gut microbiota. These recently discovered microbe-modulating properties of the drug have led investigators to predict wide therapeutic utility for metformin. The recent easing in FDA guidelines regarding administration of metformin to patient...
Background: Institutional childhood morbidity, mortality analysis and their trends reflect the lo... more Background: Institutional childhood morbidity, mortality analysis and their trends reflect the local disease occurrence, changes in treatment modalities and quality of treatment available. This study was aimed to evaluate the magnitude of post neonatal mortality and its seasonal pattern at Hemawati Nandan Bahuguna Teaching Base Hospital, Srikot over a period of 10 years.Methods: A retrospective cross-sectional descriptive analysis was done on post neonatal mortality data by Pediatric Department of the Hemawati Nandan Bahuguna Teaching Base Hospital, Srikot from April 2008 to March 2018. Neonates admitted to PICU, referral and LAMA patients were excluded from the study. Data was analyzed using SPSS 16.0.Results: Overall post neonatal mortality of 1.83% was found in the study. Mortality amongst the boys was 119 (54.34 %) and the girls were 100 (45.66 %). Three most common causes of mortality were septicemia (27.40 %) followed by encephalitis (11.41 %) and protein energy malnutrition/u...
To determine the prevalence of ABO and Rh blood groups based on the antigenic presence on the sur... more To determine the prevalence of ABO and Rh blood groups based on the antigenic presence on the surface of red blood cells with respect to gender and calculate allele frequency of the blood groups. Globally, approximately 700 type red cell antigens have been identified till now. ABO and Rh blood groups play an important role in the process of blood transfusion, resolving certain medicolegal issues, parental testing, and various genetic studies. This study was conducted in H.N.B. Base Hospital, Srinagar, Uttarakhand, from January 2012 to December 2016. Relevant data of blood donors were collected from blood bank department of the hospital. Blood grouping was conducted using commercially available standard monoclonal antisera applying test tube and column agglutination techniques. Out of 9883 individuals, 9333 (92.4%) were males and 750 (7.6%) were female individuals. The most common blood group found was B (31.68%) and least common being AB (11.70%). The prevalence of Rhesus positive a...
Background: Iodine deficiency is the world's single greatest cause of preventable mental retardat... more Background: Iodine deficiency is the world's single greatest cause of preventable mental retardation. In developing countries, only 69% of households are consuming iodized salt. Objective: To assess knowledge and practices with respect to the current use of iodized salt, and to estimate its uptake at the household level. Materials and Methods: This cross-sectional survey was conducted in six villages under Rural Health Training Center. A total number of households surveyed were 253. The data collectors obtained verbal consent from the Family, and Pretested Standardized Questionnaire was administered in every selected household. The respondents were asked questions regarding salt purchasing and consumption habits, salt storage, awareness of iodized salt, and iodine deficiency diseases. Rapid iodized salt test kit (MBI kit) was used in the survey to assess iodine content in salt used in households. Results: In this study, 93.7% households were using packet salt. The most common source of information was a television (31.1%). More than half (53.8%) of the households were unaware of the benefits of iodine. About 62.5% of households were consuming adequately iodized salt. Significant association was found between the practice of storing salt in closed containers and use of packaged iodized salt (Chi-square value −37.6, P < 0.001), awareness about the benefits of iodine and type of salt used (P = 0.02) while no association was observed between the socioeconomic status and type of salt used in the household. Conclusions: Though the use of packet salt was more than 90%, adequately iodized salt was consumed only in 62.5%, and more than half of the subjects lacked the knowledge about iodine deficiency diseases.
International Journal of Public Health Science (IJPHS)
The current study was designed to identify the morbidity pattern of outpatients attending Urban H... more The current study was designed to identify the morbidity pattern of outpatients attending Urban Health Training Centre in an urban area of a medical college in Srinagar, Pauri Garhwal district, Uttarakhand, North India. The present study record-based retrospective study was conducted among the outpatients attending the regular clinic at the Urban Health Training Centre, of a medical college in Srinagar city of Uttarakhand State of North India during the study period of one year in 2014. Data was retrieved from the OPD registers maintained at the clinic. Data was collected pertaining to socio-demographic profile, morbidity details and treatment pattern. Diseases were identified using the International Classification of Diseases (ICD-10) code. Descriptive analysis was done. During the study period, a total of 9343 subjects attended the OPD. Among them, majority of them (60%) were females. More than half (56 %) belonged to the age group of 35-65 year age-group. The association of disease classification was found to be statistically significant with respect to gender. The leading morbidity of communicable disease was found to be certain infectious and parasitic diseases especially Typhoid whereas musculoskeletal system and connective tissue disorders were the most common cause among morbidity due to NCDs. Out of all, typhoid was found to cause maximum of morbidity among the subjects. The present study highlights the morbidity pattern of communicable and NCDs among the population of hilly areas of Garhwal, Uttarakhand India. Priority should be preferred for the regular tracking of diseases in terms of preventive and promotive aspects. Morbidity in the outdoor clinics reflects the emerging trend of mixed disease spectrum burden comprising communicable and non-communicable diseases.
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Papers by Haroon Ali