Papers by Gustavo Henrique de Mattos Pereira
ARQUIVOS EM ODONTOLOGIA. - v. 52 Suplemento 1 Dezembro 2016 Belo Horizonte: Faculdade de Odontolo... more ARQUIVOS EM ODONTOLOGIA. - v. 52 Suplemento 1 Dezembro 2016 Belo Horizonte: Faculdade de Odontologia da UFMG, 1974. Trimestral Continuacao de: Arquivos dos Centros de Estudos na Faculdade de Odontologia da UFMG Odontologia - Periodicos. I. Faculdade de Odontologia da UFMG.
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Journal of Oral and Maxillofacial Anesthesia
Journal of Clinical Periodontology, 2021
AimTo determine the impact of the degree of furcation involvement (FI) on the longevity of molar ... more AimTo determine the impact of the degree of furcation involvement (FI) on the longevity of molar teeth and assess the risk variables (tooth‐ and patient‐related factors) associated with the loss of molars (LM) in individuals treated for periodontitis and monitored in a private programme of supportive periodontal care (SPC).Materials and MethodsThe present retrospective cohort study included 222 individuals with 1329 molars under a 10‐year monitoring period in SPC. Periodontal clinical parameters, FI, the type of molar, pulp vitality, and other variables of interest were collected at approximately 50 days after active periodontal therapy and after 10 years. The association of tooth‐ and patient‐related factors with LM was assessed using a multilevel Cox regression analysis.ResultsTwo‐hundred and thirty‐five molars were extracted during the SPC period of 12.4 ± 1.9 years. Age >50 years, male gender, diabetes, smoking, and non‐compliance were identified as relevant patient‐related f...
Clinical Oral Investigations, 2021
OBJECTIVE The objective of this study was to evaluate the potential association between liver cir... more OBJECTIVE The objective of this study was to evaluate the potential association between liver cirrhosis and peri-implant diseases, as well as the influence of different risk indicators on this association. METHODS This case-control study included 64 cases with liver cirrhosis and 128 controls without liver diseases that presented the same socio-demographic and economic profile. The specific inclusion criteria were the following: aged group of 35-55 years and presenting at least one osseointegrated implant functioning for >5 years. A full-mouth peri-implant and periodontal examination was performed and risk variables were recorded. The association between risk variables and the occurrence of peri-implant diseases was tested through univariate analysis and multivariate logistic regression, stratified by alcohol status. Additionally, a mediation analysis was performed to examine the mediating effect of age with peri-implantitis. RESULTS A high prevalence of peri-implantitis (29.7%) was observed among cases when compared to controls (18.0%). Individuals with cirrhosis presented ~2.5 higher chance of having peri-implantitis than controls (p<0.001). Significant variables associated with the occurrence of peri-implantitis in the final logistic model were the following: cirrhosis, alcohol use, age (>55 years), male sex, smoking, periodontitis, and number of ≤14. CONCLUSIONS An important risk association between liver cirrhosis and peri-implantitis was reported. Future studies with a larger sample size controlling for the patient- and implant-related confounders are needed to better understand the link between peri-implantitis and liver cirrhosis. CLINICAL RELEVANCE Cirrhosis individuals, age, and periodontitis, as well as alcohol use and smoking interaction, should be considered as potential risk indicators for peri-implantitis.
Clinical Oral Implants Research
BackgroundThere is insufficient evidence for pain control in preemptive analgesia (PA) after dent... more BackgroundThere is insufficient evidence for pain control in preemptive analgesia (PA) after dental implant surgery, signaling the need for further studies. The objective of this study was to evaluate the efficacy of PA in single dental implant surgeries (SDIS), seeking to identify among the etoricoxib (ETOR), ibuprofen (IBU), nimesulide (NIME), and acetaminophen (ACETA)], which one has the higher efficacy effectiveness in relieving postoperative pain and reducing the use of rescue medication compared to placebo.MethodsIn this triple‐blind, parallel, randomized controlled clinical trial, 135 individuals with a mean age of 57.6 years (±11.7), both genders, were randomly divided into five groups according to the test drug: I—PLACEBO; II—IBU (600 mg); III—NIME (100 mg); IV—ACETA (750 mg); and V—ETOR (90 mg). The occurrence, duration, and intensity of pain were analyzed using the Chi‐square, Fisher's exact and ANOVA tests, and the generalized estimating equation models, when appropr...
Journal of Periodontology
Clinical Implant Dentistry and Related Research
Journal of Periodontology
Clinical Oral Investigations, 2022
OBJECTIVES To investigate the association of cumulative smoking exposure and span since smoking c... more OBJECTIVES To investigate the association of cumulative smoking exposure and span since smoking cessation with the occurrence of peri-implantitis. METHODS A sample of 350 individuals aged ≥ 35 years, with the presence of at least one osseointegrated implant functioning for > 5 years, were enrolled in the study. According to smoking habits, participants were categorized into 3 groups: non-smokers (NS; n = 212), former smokers (FC; n = 66), and current smokers (CS; n = 72). Complete peri-implant and periodontal examinations were evaluated. Associations between the occurrence of peri-implantitis and smoking habits, as well as potential confounders, were evaluated through univariate and multivariate analyses. RESULTS The occurrence of peri-implantitis in the NS, FS, and CS groups was 18.2%, 19.7%, and 30.5%, respectively. A high prevalence of the overall number of cases with periodontitis (54.2%) was observed in the CS group when compared to the FS and NS groups. After adjusting for confounders, the odds ratio (OR) for the occurrence of peri-implantitis was 2.63 (1.39-6.77; p < 0.001) for CS compared to NS. There was a significant dose-response relationship between pack/year of smoking and the occurrence of peri-implantitis, as well as a significant decrease in the risk as the years of smoking cessation increased. CONCLUSIONS The occurrence of peri-implantitis among CS was high. The cumulative smoking exposure in an incremental manner and the shorter smoking cessation span was directly associated with a higher risk for peri-implantitis. CLINICAL RELEVANCE Educational and preventive strategies in general health services must attempt to reduce the adverse effects of cumulative smoking exposure and to explore the beneficial effects of smoking cessation on peri-implant status.
Journal of Oral and Maxillofacial Anesthesia, 2022
Medicina Oral Patología Oral y Cirugia Bucal, 2021
Background: To assess the effectiveness of preemptive analgesia in dental implant surgery in rand... more Background: To assess the effectiveness of preemptive analgesia in dental implant surgery in randomized controlled trials (RCTs). Material and Methods: The present study was conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and registered in PROSPERO database CRD42020168757. A search without restrictions regarding language or date of publication was conducted in six databases and gray literature. A random effect meta-analysis compared the efficacy of preemptive analgesia compared to placebo through pooled OR and 95%CI. The interpretation of results followed the certainty of evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach together with the magnitude of the effect according to GRADE guidelines. Results: Four studies were included in the review and three were incorporated into the meta-analysis. All studies demonstrated that preemptive analgesia contributed to a significant improvement in the postoperative pain control. However, the overall pooled standard mean difference (SMD) showed that preemptive analgesia had small effects compared to placebo in reducing pain (
Journal of Clinical and Experimental Dentistry, 2020
Background: Preemptive analgesia has as its basic principle the administration of analgesics befo... more Background: Preemptive analgesia has as its basic principle the administration of analgesics before the onset of painful stimuli, in order to reduce or prevent postoperative pain, but this question is little explored in implantology. Thus, this study was conducted in order to evaluate the clinical efficacy of ibuprofen in pain prevention after unit implant surgery. Material and Methods: For this triple-blind, parallel, placebo-controlled and randomized clinical trial, 54 insertion surgeries of unitary implants were performed. Two groups have received two different protocols 1 hour before surgery: Ibuprofen group (IBU) 600 mg of ibuprofen; and (2) placebo group (maize starch). The intensity of the pain was evaluated through the visual analogue scale (VAS) in 6 times (1, 6, 12, 24, 48 and 72 hours after the surgery). Patients were instructed to take 750 mg of paracetamol as rescue medication, if necessary. The occurrence and the intensity of pain were analyzed by means of an analysis of variance ANOVA with repeated measurements using the general linear model procedure. Results: The IBU group had significantly lower VAS scores overall (IBU = 0.30, ± 0.57; placebo = 1.14, ± 1.07; p<0.001) and at all times in the intra, intergroup comparisons and time/group interaction than the placebo group (p< 0.001). The use of rescue medication was significantly lower and the postoperative time was longer in the IBU group compared to placebo (p = 0.002). Conclusions: The single use of ibuprofen was found to be significantly superior in reducing pain after unit implant surgery compared to placebo.
Este estudo foi realizado para avaliar a eficacia clinica do ibuprofeno na prevencao de dor apos ... more Este estudo foi realizado para avaliar a eficacia clinica do ibuprofeno na prevencao de dor apos cirurgias unitarias de implantes e desenvolver um aplicativo de monitoramento operatorio. Para o ensaio clinico triplo-cego, paralelo, placebocontrolado e randomizado, 54 cirurgias de insercao de implantes unitarios foram realizadas. Dois grupos receberam dois protocolos diferentes 1 hora antes da cirurgia: grupo I Ibuprofeno (IBU) 600 mg de ibuprofeno; e (2) grupo placebo (amido de milho). A intensidade da dor foi avaliada por meio da escala analogica visual (EVA) impressa em papel, em 6 tempos (1,6,12,24,48 e 72 horas apos a cirurgia). Os pacientes foram instruidos a tomar 750 mg de paracetamol como medicacao de resgate, se necessario. A ocorrencia e intensidade da dor foi analisada por meio de uma analise de variância ANOVA com medidas repetidas atraves do procedimento de modelo linear geral. O grupo IBU apresentou menores escores EVA no global (IBU=0.30; ±0.57; placebo=1.14; ±1.07) e...
Journal of Oral Research, 2020
Journal of Oral and Maxillofacial Surgery, 2021
PURPOSE Peri-implantitis is an inflammatory disease, characterized by the progressive loss of the... more PURPOSE Peri-implantitis is an inflammatory disease, characterized by the progressive loss of the peri-implant support bone tissue. The objective of this study was to assess whether implantoplasty is efficacious in promoting peri-implant health. METHODS In this systematic review and meta-analysis, a search without restrictions regarding language or date of publication was conducted across different databases. Grey literature search, Google Scholar search and manual searches were also carried out. Studies evaluating periimplant clinical parameters of individuals with peri-implantitis who had been submitted to implantoplasty were included. Study selection, data extraction, and risk of bias assessment were conducted. The outcome variables were implant probing depth, the percentage of implants with bleeding on probing or suppuration on probing, and the success rate of implants after implantoplasty. The predictor variable was implantoplasty and the follow-up time after implantoplasty. Data on sample size, implant location, implant diameter, and diagnostic criteria for peri-implantitis were also collected during data extraction. Meta-analysis, sensitivity analysis, and analysis of the probability of implant success after implantoplasty with the Kalan-Meier method were performed. RESULTS Ninety-four studies were assessed. Eight articles were included and 7 were incorporated into quantitative analyses. Subjects' mean age ranged between 50 to 70.7 years. The studies demonstrated that implantoplasty contributed to a significant improvement in the peri-implant condition, reducing the probing depth, bleeding and suppuration on probing. Overall, the included studies exhibited low risk of bias. Meta-analysis demonstrated that probing depth before implantoplasty was significantly higher than after implantoplasty (mean difference = -3.37 mm, confidence interval = -4.74; -2.00). This result was confirmed in the sensitivity analysis. The probability of success of implants at 6 months of follow-up after implantoplasty was 97.5% and at 24 months of follow-up was 94.7%. CONCLUSIONS There is some evidence in the literature to recommend implantoplasty as a potential treatment for periimplantitis.
Head and Neck Pathology, 2016
Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease that often affects the anog... more Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease that often affects the anogenital area and causes significant discomfort and morbidity. Oral mucosal lesions in LS are extremely rare and might be associated with genital and/or skin manifestations. As a unique manifestation of LS, oral lesions are even more rare, with only 20 cases reported in English-language literature. In reviewing that literature in this paper, we present the case of a 44-year-old white man who sought dental assistance with a complaint of a white spot on his upper lip. Extraoral clinical examination revealed a slight white macule on the left upper lip vermilion next to the labial commissure. Intraoral examination revealed that the macule was approximately 3.5 9 2.0 cm, extended to the upper left labial mucosa, and presented an ivory-white color. Following an incisional biopsy and microscopy, the lesion was shown to be covered by a stratified squamous epithelium showing hyperkeratosis and atrophy. The superficial lamina propria revealed a well-marked band of subepithelial hyalinization and, below it, a band-like mononuclear inflammatory infiltrate. Sections stained by Verhoeff's technique revealed a scantiness of elastic fibers in the superficial lamina propria. The diagnosis of LS was then established. The patient was referred for dermatologic evaluation, which identified no skin or genital lesions, and no treatment was employed. After 6 years, no significant changes in clinical features were observed. Altogether, this rare case makes an important contribution to knowledge on this uncommon condition.
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Papers by Gustavo Henrique de Mattos Pereira