Papers by Godfrey William
Hepatitis is among the world's most prevalent and life threatening diseases. High risk population... more Hepatitis is among the world's most prevalent and life threatening diseases. High risk populations like sanitary workers dealing with all sorts of infective materials are easy targets for transmission of this killer disease. The primary objective of our study is to determine the burden of hepatitis B and C among people belonging to this occupation. The secondary objective is to compare the efficacy of ELISA with ICT for screening of both the maladies. 107 subjects who gave informed consent were included in this study. Blood samples were drawn and screening performed with both ELISA and ICT. 26 subjects were found to be sero positive with ICT while 39 were positive with ELISA. 20 subjects were found sero positive with ICT and 36 with ELISA. Our study found that there is a high burden of HBV and HCV among sanitary workers and therefore, there is a great need to devise preventive regimens for protection of this high risk group against viral hepatitis. Objectives: To evaluate the burden of Hepatitis B & C among Sanitary Workers in Pakistan, To compare the sensitivity of ICT and ELISA for screening of HBV and HCV I.
Pakistan Postgraduate Medical Journal
Objective/Background: Ever rising trend of consuming soft drinks and energy drinks has raised con... more Objective/Background: Ever rising trend of consuming soft drinks and energy drinks has raised concerns about their safety. Hence, this study was designed to observe the potential adverse effects of most commonly consumed soft drink, Coca Cola (containing caffeine) and energy drink, Red Bull(caffeine and taurine) on the morphology and histology of hepatocyte of rats. Material and Methods: 45 albino rats were divided into three equal groups, control group A and experimental groups B and C. 11ml/kg body weight of distilled water, Coca Cola and Red Bull were given to groups A, B and C respectively for 8 weeks. Later the rats were sacrificed and livers were dissected and preserved in formaline for histological examination. Results: Hepatocytes of both experimental groups B and C were rounded and enlarged in comparison to control group with p value of <0.01. Both group B and C had swelling and ballooning of hepatocyte due to hydropic degeneration and appeared vacuolated in comparison t...
Background: The generous use of MSG in commercial and domestic areas in Pakistan forms the basis ... more Background: The generous use of MSG in commercial and domestic areas in Pakistan forms the basis of this study. The hypothesis resides on the fact that kidneys are excretory route of nitrogenous waste products; therefore endure most of the harmful effect s of MSG. Methods: The study was done on 45 adult Wister rats randomly divided in three groups. The experimental groups A was given 6 mg/kg body weight of MSG and group B was given 18mg/kg body weight of MSG once daily for 12 weeks duration whereas group C was kept as control. After 12 weeks, kidneys were removed and processed for routine histological examination, integrity of basement membrane was observed by PAS staining technique. The variables recorded include changes in organ weight, relative tissue weight index and changes in structure of uriniferous tubules. Results: The microscopic examination of experimental groups A and B showed changes in renal corpuscles, vacuolization in cells of tubules, sloughing off tubular cells as ...
IOSR Journal of Dental and Medical Sciences, 2014
Hepatitis is among the world's most prevalent and life threatening diseases. High risk population... more Hepatitis is among the world's most prevalent and life threatening diseases. High risk populations like sanitary workers dealing with all sorts of infective materials are easy targets for transmission of this killer disease. The primary objective of our study is to determine the burden of hepatitis B and C among people belonging to this occupation. The secondary objective is to compare the efficacy of ELISA with ICT for screening of both the maladies. 107 subjects who gave informed consent were included in this study. Blood samples were drawn and screening performed with both ELISA and ICT. For HCV, 26 subjects were found to be sero-positive with ICT while 39 were positive with ELISA. For HBV, 20 subjects were found sero-positive with ICT and 36 with ELISA. Our study found that there is a high burden of HBV and HCV among sanitary workers and therefore, there is a great need to devise preventive regimens for protection of this high risk group against viral hepatitis.
IOSR Journal of Dental and Medical Sciences, 2014
Infertility is a growing challenge worldwide that cause many affiliated socio-psychological probl... more Infertility is a growing challenge worldwide that cause many affiliated socio-psychological problems in many cultures that carry a negative impact on many families. As a last resort, many physicians engage certain drugs to over stimulate the gonadotropins to hope for the production of healthy Sperms and Ovum to materialize the fertility. Also, Fertilization in Vitro is a growing solution for the rich but many patients are not able to afford. Over stimulation of the sperms or ovum does not constitute the chromosomal DNA/RNA to amicably contribute to the successful fertility, Normal fetal development, uneventful pregnancy and/ or normal delivery. Many countries have established the prominent link to the Cytomegaloviral and Herpes Simplex Virus to the infertility. We studied the prevalence and the role of herpes simplex virus (HSV), cytomegalovirus (CMV) in the semen of infertile men. Data was collected from sixty nine infertile men. Serum Anti-HSV IgG & IgM, CMV IgG & IgM from the blood and the Real Time Polymerase chain reaction RT/ PCR test were performed on the semen to detect the presence of the HSV & CMV RNA's in these infertile subjects. Anti-CMV IgG was found in 44 (62.9%), CMV IgM in 4 (5.9%), HSV IgG in 22 (31.4%), HSV IgM in (0%) and PCR of CMV in 26 (37.1%), HSV PCR in 13 (18.8%). Overall, results revealed that the RT/ PCR of CMV were relatively more prevalent in the semen of infertile men as compared to the HSV IgG & IgM, CMV IgG & CMV IgM in the blood of infertile men.
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Papers by Godfrey William