Papers by Giovani Gadonski
Nephron. Clinical practice, 2010
... Giovani Gadonski a, Ajay K. Singh b, Domingos O. d'Avila c, Ivan CF Antonello c, Fernand... more ... Giovani Gadonski a, Ajay K. Singh b, Domingos O. d'Avila c, Ivan CF Antonello c, Fernando Fervenza d aNephrology Division, Instituto ... 12 Al-Shamari A, Yeung K, Levin A, Taylor P, Magil A: Collapsing glomerulopathy coex-isting with membranous glomerulonephritis in native ...
Platelets, 2015
Imbalance in hemostatic mechanisms can occur during pregnancy with a tendency for hypercoagulabil... more Imbalance in hemostatic mechanisms can occur during pregnancy with a tendency for hypercoagulability and increased thrombosis risk. Pregnant women with hypertensive disorder, especially preeclampsia, show alterations in platelet indexes. Immature platelet fraction (IPF) has been suggested as a sensitive index for monitoring changes in platelet production and destruction. To evaluate the IPF in patients diagnosed with a gestational hypertensive disorder (GHD). A cross-sectional study was conducted at an University Hospital to estimate maternal blood IPF index in 99 pregnant women, divided into three groups: normotensive pregnancy (NP), preeclampsia syndrome (PES), and non-proteinuric hypertensive pregnancy (nPHP). Following ethical approval and written informed consent, samples were collected from 33 NP, 34 PES, and 32 nPHP women. Platelet indexes were measured by fluorescent flow cytometry. IPF and mean platelet volume (MPV) counts in GHD were significantly higher than in NP (IPF: 3.8, 2.4-5.1%; 8.6, 5.8-10.6%; 7.3, 4.2-10.2%; p < 0.001 and MPV: 10.6 ± 0.9 fL; 12.1 ± 1.0 fL; 11.6 ± 1.0 fL; p < 0.001 for NP, PES, and nPHP, respectively). No difference was detected between PES and nPHP groups. The distribution of patients with an IPF above 6.1%for NP, PES, and nPHP was 9%, 65%, and 43.8%, respectively (p < 0.001). IPF as a test to differentiate GHD from the controls achieved an area under the curve of 0.83 on a receiver operating characteristics curve. A distinct profile in platelet indexes was detected in hypertensive pregnancies. It suggests that these markers could be used in daily routine as an additional tool in the management of pregnant women.
Scientia Medica, 2014
Objetivos: Descrever um caso de Arterite de Takayasu diagnosticada durante o puerpério precoce, d... more Objetivos: Descrever um caso de Arterite de Takayasu diagnosticada durante o puerpério precoce, demonstrando a importância da aferição adequada da pressão arterial para o diagnóstico da doença hipertensiva gestacional. Descrição do caso: Uma mulher de 40 anos, em sua quarta gestação, com idade gestacional de 36 semanas e três dias, foi hospitalizada por gestação de alto risco devido a hipertensão arterial sistêmica crônica. Durante a internação observou-se diferença nos níveis tensionais e assimetria de pulsos entre os membros superiores. No pós-parto a paciente foi submetida à ecografia de carótidas com Doppler, que demonstrou oclusão de artéria carótida comum esquerda e de artéria subclávia esquerda, levando ao diagnóstico de Arterite de Takayasu. Conclusões: O diagnóstico precoce da Arterite de Takayasu é difícil, pois as manifestações iniciais são inespecíficas e os sintomas discretos. Entretanto, um exame físico cuidadoso pode evidenciar sinais que suscitem suspeitas e justifiquem investigação adicional, podendo prevenir um desfecho negativo, especialmente no período gestacional.
Clinical advances in hematology & oncology : H&O, 2012
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2015
A hypoxic placenta may release factors that result in maternal endothelial dysfunction, among whi... more A hypoxic placenta may release factors that result in maternal endothelial dysfunction, among which, leptin seems to participate. The aim of this study was evaluate the association of leptin levels in placenta, maternal and umbilical cord plasma between normotensive controls and pre-eclamptic women. Placental biopsies, maternal and umbilical cord plasma were taken from 67 normotensive and 50 pre-eclamptic women. Leptin levels were quantified using MagPlexTH-C - microspheres system. The leptin concentration was analyzed by ANCOVA adjusted by BMI, gestational age and maternal age. To estimate the difference between groups, mean ratio (MR) and confidence interval (CI) of 95% was calculated. Analysis between leptin levels and maternal/fetal variables were made by Pearson correlation. The null hypothesis was rejected when p<0.05. Higher levels of leptin were found in maternal plasma (MR=1.40; 95%CI: 1.00-1.97, p=0.049) and placenta (MR=1.82; 95%CI: 1.11-2.98, p=0.019) in patients with pre-eclampsia. A positive correlation between gestational age, birth weight vs. fetal leptin levels in pre-eclamptic group was found (r=0.416, r=0.618; p<0.001, for both), respectively. Also, a positive correlation was found between placental leptin and maternal plasma levels in entire group (r=0.36, p<0.001) and in the normotensive group (r=0.344, p=0.021). No correlation was found between placenta vs. fetal plasma or fetal plasma vs. maternal plasma. Leptin values in patients with pre-eclampsia were significantly increased in maternal plasma and placental tissue. Besides that, the positive correlation not observed between placentae and maternal leptin levels in pre-eclamptic group may be due to a loose of this regulation in pre-eclampsia, and should be considered for future work. Finally, a strong positive correlation in relation to clinical data and fetal leptin concentration, in pre-eclamptic group, intensify the possibility of leptin being also involved in preterm birth and birth weight, when pre-eclampsia is presented. M.R. Hentschke: None. A.B. Comparsi: None. L.S. Lucas: None. F. Sontag: None. G. Gadonski: None. L.G. Paula: None. C.E. Poli-de-Figueiredo: None. B.E. Pinheiro da Costa: None.
Case Reports in Oncological Medicine, 2013
Journal of Stroke and Cerebrovascular Diseases, 2014
Background: Posterior reversible encephalopathy syndrome (PRES) is a clinical entity characterize... more Background: Posterior reversible encephalopathy syndrome (PRES) is a clinical entity characterized by headaches, altered mental status, seizures, and visual disturbances and is associated with white matter vasogenic edema. There are no experimental models to study PRES brain changes. Methods: Twenty-eight pregnant Wistar rats were divided into 4 groups of 7: (1) pregnant-control; (2) reduced uterine perfusion pressure (RUPP); (3) invasive blood pressure (IBP); and (4) reduced uterine perfusion pressure plus invasive blood pressure (RUPP-IBP). The RUPP and RUPP-IBP groups were submitted to a reduction of uterine perfusion pressure at pregnancy days 13 to 15. The invasive mean arterial pressure of the IBP and RUPP-IBP groups was measured on day 20. The blood-brain barriers (BBBs) of all groups were analyzed using 2% Evans Blue dye on day 21. Results: RUPP rats had higher blood pressures and increased BBB permeability to Evans Blue dye compared with the control animals. Brain staining occurred in 11 of 14 RUPP rats and in none of the control groups (P , .0001). Conclusions: The physiopathology From the
Revista brasileira de reumatologia, 2012
The posterior reversible encephalopathy syndrome (PRES) is a novel entity clinically manifested b... more The posterior reversible encephalopathy syndrome (PRES) is a novel entity clinically manifested by headache, changes of sensorium, seizures, and visual loss. PRES pathogenesis has not been fully clarified. The entity can be associated to a variety of clinical conditions, mainly hypertension, renal insufficiency and immunosuppressive therapy. A possible link of autoimmune disorders with PRES has been recently hypothesized. We herein describe two cases of systemic lupus erythematosus whereby PRES was triggered by different factors.
Revista Brasileira de Reumatologia, 2012
Neurology International, 2014
Case Reports in Oncology, 2011
Posterior reversible encephalopathy syndrome is a clinicoradiologic entity that may present with ... more Posterior reversible encephalopathy syndrome is a clinicoradiologic entity that may present with headaches, altered mental status, seizures and visual loss as well as specific neuroimaging findings. We report a case of a 74-year-old woman receiving adjuvant gemcitabine chemotherapy as monotherapy for a stage IIa pancreatic adenocarcinoma, who developed posterior reversible encephalopathy syndrome.
Nephron Clinical Practice, 2010
... Giovani Gadonski a, Ajay K. Singh b, Domingos O. d'Avila c, Ivan CF Antonello c, Fernand... more ... Giovani Gadonski a, Ajay K. Singh b, Domingos O. d'Avila c, Ivan CF Antonello c, Fernando Fervenza d aNephrology Division, Instituto ... 12 Al-Shamari A, Yeung K, Levin A, Taylor P, Magil A: Collapsing glomerulopathy coex-isting with membranous glomerulonephritis in native ...
Journal of Neuroimaging, 2013
Arquivos Brasileiros de Cardiologia, 2010
Background: The preeclampsia syndrome is associated with endothelial dysfunction and the differen... more Background: The preeclampsia syndrome is associated with endothelial dysfunction and the differential diagnosis between pure preeclampsia (PE) and superimposed preeclampsia (SPE) can be only be attained 12 weeks after delivery.
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2014
Objectives: The purpose of the present study was to evaluate the association between preeclampsia... more Objectives: The purpose of the present study was to evaluate the association between preeclampsia and blood groups in a group of pregnant women hospitalized in a University Hospital in Porto Alegre, Brazil -Hospital São Lucas (HSL)/PUCRS. Study design: Our sample consisted of 10,040 pregnant women admitted to the maternity department of HSL between 2005 and 2010. The patients were reviewed retrospectively for inclusion. Medical records of 414 women were diagnosed as preeclampsia/eclampsia and 9611 women were identified to the control group. The patients were divided into two groups: the group with preeclampsia/eclampsia and the control group, and their blood groups were considered. Data were analyzed using SPSS for Windows version 17.0. Categorical data were summarized by counts and percentages, with the statistical significance evaluated by the Chi-square test. The null hypothesis was rejected when p < 0.05. Main outcome measures: Maternal parameters were compared between control group and pre-eclampsia, respectively, Systolic Blood Pressure (117 ± 19.98 vs. 165 ± 19.99); Diastolic Blood Pressure (73 ± 14.23 vs. 106 ± 14.24) and maternal weight at booking (73 ± 33 vs. 83 ± 33). For all data: mean + SD; p < 0.05. In relation to blood groups, firstly they were stratified by Rh and ABO phenotypes, separately. After that the groups were put together. Results: No differences in blood group distribution were observed between controls and pre-eclampsia for any analysis. (p > 0.05). Conclusions: When we adopted stricter criteria for pre-eclampsia and a large sample from the same region we noted that the results did not show any association between blood groups and the development of pre-eclampsia. Ó
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Papers by Giovani Gadonski