Papers by Frederic Bastides
EMC - Tratado de Medicina
Médecine et Maladies Infectieuses, 2008
Journal of Ocular Pharmacology and Therapeutics, 2008
European Respiratory Journal, 2020
EMC - AKOS - Trattato di Medicina
mBio
The epidemiology of invasive fungal diseases (IFDs) is hard to delineate given the difficulties i... more The epidemiology of invasive fungal diseases (IFDs) is hard to delineate given the difficulties in ascertaining the diagnosis that is often based on the confrontation of clinical and microbiological criteria. The present report underlines the interest of active surveillance involving mycologists and clinicians to describe the global incidence and that of the main IFDs.
TOURS-BU Médecine (372612103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Science, 2022
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine i... more We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log 10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virul...
Journal De Mycologie Medicale, 2008
Un homme de 84 ans, traite par prednisone pour une maladie de Horton et une broncho-pneumopathie ... more Un homme de 84 ans, traite par prednisone pour une maladie de Horton et une broncho-pneumopathie chronique obstructive, a presente une dermo-hypodermite de la cheville et de la jambe gauche. Paecilomyces lilacinus a ete isole a plusieurs reprises des lesions, et des spores et filaments fongiques ont ete mis en evidence dans les biopsies. affirmant ainsi l'origine fongique des lesinons. La realisation d'un E-test a montre que la souche etait totalement resistante in vitro a l'amphotericine B et a l'itraconazole, mais pas au voriconazole. La baisse de la dose quotidienne de corticoides, deux interventions chirurgicales et 103 jours de traitement par voriconazole ont permis la guerison des lesions cutanees. Compte tenu de la grande variabilite de sensibilite des Paecilomyces aux antifongiques, la realisation d'un E-test facilite la prise en charge de ces mycoses, souvent delicates sur ce type de terrain.
Virus Evolution, 2018
from the outbreak. The present study highlighted the integral role that real-time phylogenetic an... more from the outbreak. The present study highlighted the integral role that real-time phylogenetic analyses can play alongside extensive epidemiological investigations, assisting the clarification of epidemiological case definitions in temporal transmission network in a HIV outbreak investigation.
Seminars in Arthritis and Rheumatism, 2018
To describe the clinical and microbiological characteristics and outcomes after antibiotic treatm... more To describe the clinical and microbiological characteristics and outcomes after antibiotic treatment of a national cohort of patients with Lyme arthritis confirmed by PCR testing on synovial fluid and by serology, when available. Methods: Using the French National Reference Center for Borrelia database, patients with a positive PCR on synovial fluid for Borrelia were identified. Patient clinical and biological characteristics were reviewed from patient records. Long-term outcomes after treatment were studied through a questionnaire and with follow-up data. Results: Among 357 synovial fluid testing by PCR between 2010 and 2016, 37 (10.4%) were positive for Borrelia. Patients' median age was 36 years (range 6À78) with 61% of men and 28% patients under 18. The presentation was monoarticular in 92% and the knee was involved in 97%. Contrary to the Borrelia species repartition in European ticks, B. burgdorferi sensu stricto was the most prevalent species found in synovial fluid (54%) followed by B. azfelii (29%) and B. garinii (17%). Antibiotic treatments were mainly composed of doxycycline (n = 24), ceftriaxone (n = 10) and amoxicillin (n = 6), for a median duration of 4 weeks (range 3À12). Despite
Journal of Korean Medical Science, 2017
International journal of antimicrobial agents, 2015
Linezolid-related adverse events predictive score (LAPS): Usefulness in clinical practice ଝ Sir, ... more Linezolid-related adverse events predictive score (LAPS): Usefulness in clinical practice ଝ Sir, Due to its good bioavailability, linezolid may be used to reduce Q2 the duration of therapy and in-hospital length of stay (LOS), however it is associated with a high rate of adverse events (AEs) [1,2]. Here we develop the first tool to predict linezolid-related AEs, called the linezolid-related AEs predictive score (LAPS). This monocentric retrospective study recorded the characteristics of adult patients who received linezolid for ≥4 days between 2004 and 2012. The pre-therapeutic age-adjusted Charlson comorbidity index (AACCI), categorising co-morbidities based on diagnostic codes from the International Classification of Diseases (ICD), was calculated for each patient (Table 1) [3]. AEs were defined as related to linezolid if: (i) they occurred during therapy; (ii) the same AE had been previously reported for linezolid; (iii) no other potential cause was identified; or (iv) a clinician identified linezolid as the cause and the patient's condition improved following its discontinuation. In all other cases, no drug-related AEs were considered to have occurred. Cytopenias were assessed with criteria previously defined by Legout et al. as follows: thrombocytopenia, platelet count of <150 × 10 9 /L, or 75% lower than baseline; anaemia, a ≥2 g/dL reduction in haemoglobin, or a haemoglobin concentration of <10 g/dL; and leukopenia, a leukocyte count of <4 × 10 9 /L [4]. Statistical analyses were performed to develop the LAPS based on variables independently associated with the occurrence of AEs. Variables with a P-value of <0.1 in the univariate analysis (Fisher's exact test, Mann-Whitney U-test or Spearman correlation test, as necessary) were included in the multivariate analysis, performed by logistic regression using R software v.3.1 (R Core Team). The final model was developed by a selection of step-down approach, using the Akaike criterion to compare models [5]. During the study period, 146 prescriptions (131 patients) met the inclusion criteria [mean ± standard deviation (S.D.) duration of therapy, 27.2 ± 42.3 days]. In 45.9% of prescriptions (n = 67), linezolid was selected to reduce the in-hospital LOS, leading to a reduction of 9.6 days per patient, resulting in savings of ca. D 600 000 in hospital costs. Among the 131 patients, the mean ± S.D. age was 57.9 ± 17.2 years; 27.5% of patients (n = 36) had impaired kidney function defined by the Modification of Diet in Renal Disease (MDRD) equation (<60 mL/min) and 13.7% (n = 18) had a haematological disease. The mean ± S.D. AACCI was 3.6 ± 2.8.
Annales de biologie clinique
Tuberculosis is the most common disease inaugural of AIDS in France and HIV serology should be of... more Tuberculosis is the most common disease inaugural of AIDS in France and HIV serology should be offered routinely when a tuberculosis case is diagnosed. Similarly, tuberculosis should also be sought before starting antiretroviral treatment. The case of pleural tuberculosis revealing AIDS presented here illustrates the difficulties of management of this co-infection due to polychemotherapy used to treat each of these pathologies causing drug interactions requiring dose adjustments and changes in treatment protocol and an increase in side effects. This is especially true when combining rifampicin and protease inhibitors and non-nucleoside reverse transcriptase inhibitors. On the other hand, resistance of Mycobacterium tuberculosis is possible in these patients coinfected by HIV particularly among migrants and in the case history of tuberculosis treatment.
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Papers by Frederic Bastides