E. Yaris

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Petros Bouras-Vallianatos

National & Kapodistrian University of Athens

Agostino Paravicini Bagliani

University of Lausanne

Jakob Tanner

University of Zurich, Switzerland

Maria Pia Donato

Centre National de la Recherche Scientifique / French National Centre for Scientific Research

Irene Caiazzo

Centre National de la Recherche Scientifique / French National Centre for Scientific Research

Maria Antónia Lopes

Universidade de Coimbra

Eliane Miotto

Universidade de São Paulo

Dr.Vykunta Raju K.N

Rajiv Gandhi University of Health Sciences

Pavel Rozsíval

Charles University, Prague

Devi Dayal

PGIMER,CHD,India

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Papers by E. Yaris

Heterogeneity of 5-HT responsiveness in different segments of rabbit arteries

Archives Internationales de Physiologie, de Biochimie et de Biophysique, 1992

The variation in sensitivity to serotonin (5-HT) as assessed by pD2 was investigated in isolated ... more The variation in sensitivity to serotonin (5-HT) as assessed by pD2 was investigated in isolated 25 arterial segments of different vascular regions obtained from rabbits. The responses of the vascular rings which were opened by a transverse cut to form rectangular strips were recorded isometrically. pD2 values for 5-HT of thoracic and abdominal aortic segments were significantly greater than those of visceral arterial branches. Maximal contractions produced by 5-HT in visceral segments were higher than those of thoracic and abdominal aortic segments. There was a positive correlation between the pD2 values for 5-HT and the radii and the thickness of the tunica media layer (r = 0.62 and r = 0.54, respectively, P less than 0.05). The results indicate that the activity of 5-HT varies regionally in different segments of the rabbit arteries and the sensitivity to 5-HT of the segments decreases as the radii of the vessels diminish.

The Outcomes of Tianeptine in Pregnancy

Reproductive Toxicology, 2020

The Outcomes of Statin Exposure in Pregnancy

Reproductive Toxicology, 2020

The Outcomes of Mesalamine Exposure in Pregnancy

Reproductive Toxicology, 2020

Low Dose Penicillamine Exposure in a Pregnant Woman with Wilson Disease

Reproductive Toxicology, 2020

The Outcomes of Butamirate Exposure in Pregnancy

Reproductive Toxicology, 2020

Evaluation of teratogenic effects of ciprofloxacin in pregnant women exposed due to urinary tract infections

Reproductive Toxicology, 2016

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Actions of cyclosporin A preparation and Cremophor-EL in rabbit mesenteric artery and thoracic aorta in vitro

Clinical Science, 1992

1. We studied the in vitro and direct effects of intravenous cyclosporin A preparation (Sandimmun... more 1. We studied the in vitro and direct effects of intravenous cyclosporin A preparation (Sandimmun) and its solvent (Cremophor-EL) on acetylcholine-induced endothelium-dependent relaxation, phenylephrine-induced contraction and drug-induced contraction of rabbit thoracic aorta and superior mesenteric artery segments. 2. At the lower concentration (5 μg/ml), cyclosporin A preparation inhibited endothelium-dependent relaxation of the superior mesenteric artery but not of the thoracic aorta. At this concentration cyclosporin A preparation augmented phenylephrine-induced contraction in both segments but by more in the superior mesenteric artery, and induced a slow increase in the tone of isolated superior mesenteric artery and thoracic aortic rings, which was greater in magnitude in the superior mesenteric artery than in the thoracic aorta. 3. Acetylcholine-induced endothelium-dependent relaxation was inhibited by cyclosporin A preparation (50 μg/ml) in both arteries but to a greater ext...

Hydroxyzine use in pregnant women in the first trimester

Reproductive Toxicology, 2015

Betahistine use in pregnant women with vertigo

Reproductive Toxicology, 2015

Diosmin-hesperidin use in pregnant women with varicose veins

Reproductive Toxicology, 2015

The Effect of Indomethacin on Cyclosporin A- and Its Solvent-Induced Inhibition of Endothelium-Dependent Relaxation and the Drug-Induced Contraction of Rabbit Isolated Arteries

Vascular Endothelium, 1993

1. In the isolated rabbit arteries, the effects of intravenous cyclosporin A preparation (Sandimm... more 1. In the isolated rabbit arteries, the effects of intravenous cyclosporin A preparation (Sandimmun) and its solvent (Cremophor-EL) on acetylcholine-induced endothelium-dependent relaxation were investigated in the absence and presence of indomethacin (10(-5) M), a cyclooxygenase inhibitor. 2. The effect of indomethacin on the drug- and solvent-induced contraction of superior mesenteric artery was also evaluated. 3. The inhibitory effects of cyclosporin and the solvent on endothelium-dependent relaxations were decreased by indomethacin. The direct contractions produced by the drug and the solvent in rabbit mesenteric artery were inhibited by indomethacin.

The effect of simvastatin on picrotoxin-induced seizure in mice

JPMA. The Journal of the Pakistan Medical Association, 2012

To study the effect of simvastatin on picrotoxin-induce seizures in mice in order to understand t... more To study the effect of simvastatin on picrotoxin-induce seizures in mice in order to understand the impact of gabaergic system on neuronal cell death. The study was held between July and September 2011, at the Karadeniz Technical University in Trabzon, Turkey. Balb/c mice weighting 20-40g were randomly selected and divided into five groups of six each. The first group was designated as control group; and the second as the picrotoxin (10mg/kg; intraperitoneal) alone group. The rest of the groups were administered simvastatin in dozes of 10, 20 and 40mg/kg respectively. Onset, number and duration of seizures, and death time were measured in mice for one hour. At the end of the study, the brain was removed from mice and normal and degenerative pyramidal neurons were counted in hippocampal CA1, CA2, CA3 region by light microscope. Using SPSS 17, Mann=Whitney U and Chi square and student-T tests were performed for statistical analysis. Simvastatin (10mg/kg) significantly decreased the nu...

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The evaluation of analgesic effects of simvastatin, pravastatin and atorvastatin in hot plate test

European review for medical and pharmacological sciences, 2012

Simvastatin, pravastatin and atorvastatin have been evaluated whether to have analgesic effects i... more Simvastatin, pravastatin and atorvastatin have been evaluated whether to have analgesic effects in mice in hot plate test. Simvastatin (5, 10, 30 mg/kg), pravastatin (5, 10, 30 mg/kg) and atorvastatin (5, 10, 30 mg/kg) were administered acute and chronically by oral gavage in mice. Control (pretreatment value) and posttreatment (after drugs application) values in 60th and 120th minutes were measured in hot-plate test. All three drugs at 10, 30 mg/kg doses produced analgesic effects compared with their control values in 60th and 120th minutes on acute and chronic application in mice. The analgesic effects of drugs were evaluated after the application of L-nitro arginine methyl ester (L-NAME) (10 mg/kg) or naloxone (0.5 mg/kg). L-NAME (10 mg/kg) has no effect compared to the control value on both minutes. The analgesic effects of both atorvastatin (30 mg/kg) and simvastatin (30 mg/kg) in the presence of L-NAME (10 mg/kg) were not inhibited. However, the analgesic effect of pravastatin...

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Antinociceptive effects of fluoxetine and paroxetine with their related actions on glycemia in mice

Neuro endocrinology letters

Clinical and experimental trials have demonstrated that some of selective serotonin reuptake inhi... more Clinical and experimental trials have demonstrated that some of selective serotonin reuptake inhibitors (SSRIs) have some suspicious effects on blood glucose levels in different directions. Especially fluoxetine and sertraline are studied in this point of view. These drugs are also used in treatment of depression and peripheral neuropathy in diabetic patients. Paroxetine and fluoxetine, members of this drug group, besides having antidepressant effects were shown to have antinociceptive effects in animals and humans. They can be used in the treatment of chronic pain as an adjuvant drug or alone. But less is known about their actions on pain in case of diabetes. The aim of this study is to investigate the antinociceptive effects of fluoxetine and paroxetine in diabetic and non-diabetic mice while monitoring their effects on blood glucose levels. Mice of either sex were randomly used in experiments. The antinociceptive effects of paroxetine and fluoxetine were evaluated using hot plate...

Pregnancy outcome following exposure to orlistat, ramipril, glimepiride in a woman with metabolic syndrome

Saudi medical journal, 2005

The evaluation of analgesic effects of milnacipran and sertraline in tail-flick test

by D. Pepeoglu and E. Yaris

Bratislava Medical Journal, 2014

Psychotropic drugs in pregnancy: a case-control study

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2005

Psychotropic drug exposure during pregnancy is a common problem. Among the 601 cases exposed to d... more Psychotropic drug exposure during pregnancy is a common problem. Among the 601 cases exposed to drugs during pregnancy, who were followed by our Toxicology Information and Follow-up Service, 124 cases had used psychotropic drugs for depression, anxiety, or psychotic disorders. As the control group, 248 women, who did not use any drugs were selected. Of the 124 cases, 80 (64.5%) had healthy babies, and 17 (13.7%) decided to terminate the pregnancy. Spontaneous abortions, intrauterine death (in the 38th week) and premature deliveries were observed in the 9 (7.3%), 1 (0.8%) and 3 (2.4%) cases, respectively, in the drug exposure group. Pregnancies of the 14 (11.3%) cases were continuing during the preparation of this manuscript. Of the 248 controls, 151 (60.9%) had healthy babies, 9 (3.6%) experienced spontaneous abortion and 3 (1.2%) decided to terminate their pregnancies, 3 (1.2%) had premature deliveries, and we observed one (0.4%) congenital abnormality, 81 (32.7%) cases were still pregnant. Odds Ratio (95% confidence interval) for spontaneous abortion was found to be 1.35 (1.27-11.82) in the cases exposed to psychotropic drugs (P=0.02). No developmental problems were observed in the babies followed for 12 months. These data may give information about the early-but not the late-term effects of psychotropic drugs used in pregnant women.

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flow of internal thoracic artery Effects of papaverine and carbon dioxide alone or in combination on the blood

Should every pregnancy with preconceptional isotretinoin exposure be considered as high risk?

Reproductive Toxicology, 2013

Heterogeneity of 5-HT responsiveness in different segments of rabbit arteries

Archives Internationales de Physiologie, de Biochimie et de Biophysique, 1992