Journal of Cancer Research and Clinical Oncology, 2020
Purpose The formation of new blood vessels from previous ones, angiogenesis, is critical in tissu... more Purpose The formation of new blood vessels from previous ones, angiogenesis, is critical in tissue repair, expansion or remodeling in physiological processes and in various pathologies including cancer. Despite that, the development of antiangiogenic drugs has great potential as the treatment of cancer faces many problems such as development of the resistance to treatment or an improperly selected therapy approach. An evaluation of predictive markers in personalized medicine could significantly improve treatment outcomes in many patients. Methods This comprehensive review emphasizes the anticancer potential of flavonoids mediated by their anti-angiogenic efficacy evaluated in current preclinical and clinical cancer research. Results and conclusion Flavonoids are important groups of phytochemicals present in common diet. Flavonoids show significant anticancer effects. The anti-angiogenic effects of flavonoids are currently a widely discussed topic of preclinical cancer research. Flavonoids are able to regulate the process of tumor angiogenesis through modulation of signaling molecules such as VEGF, MMPs, ILs, HIF or others. However, the evaluation of the anti-angiogenic potential of flavonoids within the clinical studies is not frequently discussed and is still of significant scientific interest.
Journal of Cancer Research and Clinical Oncology, 2019
Purpose Cancer is a serious health issue and a leading cause of death worldwide. Most of the canc... more Purpose Cancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation. Results Current research has brought many promising results from anti-metastatic experimental studies, and has shown that chemoprevention by natural or semisynthetic phytochemicals with plethora of biological activities could be one of the potentially effective options in the fight against this problem. However, there is a lack of clinical trials to confirm these findings. In this review, we focused on summarization and discussion of the general features of metastatic cancer, and recent preclinical and clinical studies dealing with anti-metastatic potential of various plant-derived compounds. Conclusions Based on our findings, we can conclude and confirm our hypothesis that phytochemicals with pleiotropic anticancer effects can be very useful in retarding and/or reversing the metastasis process, and can also be used to prevent tissue invasion and metastases. But, further studies in this area are certainly necessary and desirable.
Breast cancer is the most common malignancy in women worldwide. Over 90% of all breast cancer cas... more Breast cancer is the most common malignancy in women worldwide. Over 90% of all breast cancer cases are of different 'sporadic' cell types, thus placing emphasis on the need for breast cancer prevention and new effective treatment strategies. In recent years, pre-clinical research provides growing evidence regarding the beneficial action of bioactive plant-derived substances - phytochemicals, on multiple cancer-related biological pathways. The important natural source of various phytochemicals with anti-oncogenic properties are plant-based functional foods. It is hypothesized that a significant anti-tumour activity of plant-based functional foods are the result of a combination of various phytochemicals rather than an isolated agent. The mixture of phytochemicals with various biological activities present in whole foods could have additive or synergistic effects against carcinogenesis. Clinically, it is very important to compare the effect of the isolated phytochemicals agai...
New Trends and Issues Proceedings on Humanities and Social Sciences, 2019
Biological invasions are recognised as a potentially major threat to biodiversity and may have co... more Biological invasions are recognised as a potentially major threat to biodiversity and may have considerable economic and social effects. Public, including pupils, attitudes may have large implications for invasive species management in terms of prevention, early warning and eradication success, but significant is the relations between the lay public’s visions of nature, their knowledge about non-native species and their perceptions of invasive species management. The more direct experience people have with the impact of invasive species, the more likely they will be able to understand the potential benefits of management programmes. The aim of our work was to prepare educational materials about invasive organisms for elementary schools. Some of them were subsequently applied directly in practice as part of an excursion in a schoolyard in west Slovakia, where up to six species of invasive plants were identified in the close proximity to the school. Keywords: Biological invasions, p...
Present relationship between a man and a biosphere results from the level of progress of human ci... more Present relationship between a man and a biosphere results from the level of progress of human civilization. The idea of permanently sustainable development is based on condition of positive qualitative attitudes, behavior and actions of people in the various spheres of society. Education and training is the main tool of creating positive attitudes towards the environment and permanently sustainable development. At present, developing contextual thinking in pupils seems to be in the forefront of the educational process. The need for direct contact with the environment and direct participation in the monitoring and problem solving activities prevails over the need of obtaining individual knowledge. We can “brand“ this understanding of education as an environmental education. According to the progressive changes in the lifestyle of population, it is necessary to implement environmental education in all the social and educational levels of education. It cannot be understood as an isola...
The authors of this article applied the determination of phenolic and flavonoid content in small ... more The authors of this article applied the determination of phenolic and flavonoid content in small berries to create a didactic cycle based on student-centered active learning (SCAL) in which students actively participated in the topic while studying and profile-forming as future biology and chemistry teachers. The fundamental part of the proposed didactic cycle is that students solve the following task: Determine the phenolic and flavonoid content in berries (Vaccinium myrtillus L., Vaccinium vitis-idaea L., and Vaccinium corymbosum L.) in your region. The submitted interdisciplinary topic is relevant to everyday life, and it aroused interest and enthusiasm among students. The students had the opportunity to test their theoretical knowledge in practical experimental research, and they attempted to work as researchers.
Water is not a commercial product, but the legacy that we must honor and protect. The global wate... more Water is not a commercial product, but the legacy that we must honor and protect. The global water problems led the European Parliament to adopt a coordinated water policy in the EU Member States. On December 22nd 2000 entry into force of the European Parliament and Council n.2000/60/EC establishing a framework in the field of water policy, called the Water Framework Directive. The Directive provides a legislative framework for the introduction of a single water policy in the EU. According to the requirements of the Directive member states must make the identification of anthropogenic impacts on the status of surface waters and introduce monitoring programs for surface water. Teachers and students at the Catholic University are actively involved in monitoring streams. As part of ongoing learning project where students learn the methodology used for monitoring rivers. Sažetak Voda nije komercijalni proizvod, već naslijeđe koje moramo poštivati i zaštititi. Globalni problem vode doveo...
Present relationship between a man and a biosphere results from the level of progress of human ci... more Present relationship between a man and a biosphere results from the level of progress of human civilization. The idea of permanently sustainable development is based on condition of positive qualitative attitudes, behavior and actions of people in the various spheres of society. Education and training is the main tool of creating positive attitudes towards the environment and permanently sustainable development. At present, developing contextual thinking in pupils seems to be in the forefront of the educational process. The need for direct contact with the environment and direct participation in the monitoring and problem solving activities prevails over the need of obtaining individual knowledge. We can “brand“ this understanding of education as an environmental education. According to the progressive changes in the lifestyle of population, it is necessary to implement environmental education in all the social and educational levels of education. It cannot be understood as an isola...
Several att empts to establish the new teaching methods using school experiment as a tool develop... more Several att empts to establish the new teaching methods using school experiment as a tool developing pupil's personality are known from history of science education. The goal of the reform of education system in Slovakia is to transform the traditional encyclopedic teaching for the creative and value education, which emphasis is on activity and personal freedom, the power to create its progressive, creative way of being to live in the new millennium. This could be reached by gradually introducing of the innovative elements of project teaching to the science education what should fi nally lead to the pupil's visions of the nature as a whole. It is important that the student is able to orient himself in the topic, to gather information, process it and sort and be well on its own original solutions and design. Our article refers to the possibility of using the project teaching in topic “the cycle of substances in nature”. Sažetak Iz povijesti znanosti obrazovanja poznato je nek...
Several att empts to establish the new teaching methods using school experiment as a tool develop... more Several att empts to establish the new teaching methods using school experiment as a tool developing pupil's personality are known from history of science education. The goal of the reform of education system in Slovakia is to transform the traditional encyclopedic teaching for the creative and value education, which emphasis is on activity and personal freedom, the power to create its progressive, creative way of being to live in the new millennium. This could be reached by gradually introducing of the innovative elements of project teaching to the science education what should fi nally lead to the pupil's visions of the nature as a whole. It is important that the student is able to orient himself in the topic, to gather information, process it and sort and be well on its own original solutions and design. Our article refers to the possibility of using the project teaching in topic "the cycle of substances in nature". Sažetak Iz povijesti znanosti obrazovanja poznato je nekoliko pokušaja izrade novih nastavnih metoda pomoću školskih eksperimenata kao alata u razvoju učenikove osobnosti. Cilj reforme obrazovnog sustava u Slovačkoj je transformirati tradicionalnu enciklopedijsku nastavu u smjeru kreativnog i vrijednog obrazovanja, koje naglasak stavlja na aktivnost i osobne slobode. To bi se moglo postići postupnim uvođenjem inovativnih elemenata projektne nastave za znanost obrazovanja, što bi konačno trebalo dovesti do toga da učenika doživljava prirodu kao cjelinu. Važno je da se učenik može orijentirati na temu, prikupiti podatke, obraditi ih i sortirati i dati vlastita originalna rješenja i dizajn. Naš rad se odnosi na mogućnost korištenja projektne nastave na temu "ciklus tvari u prirodi".
Sažetak Multimedijalni obrazovni sustavi stvaraju nove mogućnosti za pristup određenim informacij... more Sažetak Multimedijalni obrazovni sustavi stvaraju nove mogućnosti za pristup određenim informacijama. Za komunikaciju s korisnicima ti sustavi koriste tekst, video za projekcije pravih eksperimenata, animacije za prikaz nekih procesa ili zvuk. Osim toga, ovi atributi su povezani interaktivnima linijama, što znači da je ovaj tip multimedijskog obrazovnog sustava prilagođen individualnim zahtjevima. Računalo može biti prisutno u svim predmetima obrazovnog procesa, kao i u svim fazama nastavnog procesa (npr. motivacija, objašnjavanje, ponavljanje pronalazaka i zaključci). Rad s računalom će tijekom školskih lekcija učenicima biti zanimljiv, privlačan i atraktivan, a osobito će se istaknuti oni koji u klasičnom obrazovanju nikada ne bi pokazali svoj talent. Abstract Multimedia educational systems create new possibilities in the access to some information. They communicate with users using text, video for real experiments projection, animations for viewing some processes or sound. Moreov...
Journal of Cancer Research and Clinical Oncology, 2020
Purpose The formation of new blood vessels from previous ones, angiogenesis, is critical in tissu... more Purpose The formation of new blood vessels from previous ones, angiogenesis, is critical in tissue repair, expansion or remodeling in physiological processes and in various pathologies including cancer. Despite that, the development of antiangiogenic drugs has great potential as the treatment of cancer faces many problems such as development of the resistance to treatment or an improperly selected therapy approach. An evaluation of predictive markers in personalized medicine could significantly improve treatment outcomes in many patients. Methods This comprehensive review emphasizes the anticancer potential of flavonoids mediated by their anti-angiogenic efficacy evaluated in current preclinical and clinical cancer research. Results and conclusion Flavonoids are important groups of phytochemicals present in common diet. Flavonoids show significant anticancer effects. The anti-angiogenic effects of flavonoids are currently a widely discussed topic of preclinical cancer research. Flavonoids are able to regulate the process of tumor angiogenesis through modulation of signaling molecules such as VEGF, MMPs, ILs, HIF or others. However, the evaluation of the anti-angiogenic potential of flavonoids within the clinical studies is not frequently discussed and is still of significant scientific interest.
Journal of Cancer Research and Clinical Oncology, 2019
Purpose Cancer is a serious health issue and a leading cause of death worldwide. Most of the canc... more Purpose Cancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation. Results Current research has brought many promising results from anti-metastatic experimental studies, and has shown that chemoprevention by natural or semisynthetic phytochemicals with plethora of biological activities could be one of the potentially effective options in the fight against this problem. However, there is a lack of clinical trials to confirm these findings. In this review, we focused on summarization and discussion of the general features of metastatic cancer, and recent preclinical and clinical studies dealing with anti-metastatic potential of various plant-derived compounds. Conclusions Based on our findings, we can conclude and confirm our hypothesis that phytochemicals with pleiotropic anticancer effects can be very useful in retarding and/or reversing the metastasis process, and can also be used to prevent tissue invasion and metastases. But, further studies in this area are certainly necessary and desirable.
Breast cancer is the most common malignancy in women worldwide. Over 90% of all breast cancer cas... more Breast cancer is the most common malignancy in women worldwide. Over 90% of all breast cancer cases are of different 'sporadic' cell types, thus placing emphasis on the need for breast cancer prevention and new effective treatment strategies. In recent years, pre-clinical research provides growing evidence regarding the beneficial action of bioactive plant-derived substances - phytochemicals, on multiple cancer-related biological pathways. The important natural source of various phytochemicals with anti-oncogenic properties are plant-based functional foods. It is hypothesized that a significant anti-tumour activity of plant-based functional foods are the result of a combination of various phytochemicals rather than an isolated agent. The mixture of phytochemicals with various biological activities present in whole foods could have additive or synergistic effects against carcinogenesis. Clinically, it is very important to compare the effect of the isolated phytochemicals agai...
New Trends and Issues Proceedings on Humanities and Social Sciences, 2019
Biological invasions are recognised as a potentially major threat to biodiversity and may have co... more Biological invasions are recognised as a potentially major threat to biodiversity and may have considerable economic and social effects. Public, including pupils, attitudes may have large implications for invasive species management in terms of prevention, early warning and eradication success, but significant is the relations between the lay public’s visions of nature, their knowledge about non-native species and their perceptions of invasive species management. The more direct experience people have with the impact of invasive species, the more likely they will be able to understand the potential benefits of management programmes. The aim of our work was to prepare educational materials about invasive organisms for elementary schools. Some of them were subsequently applied directly in practice as part of an excursion in a schoolyard in west Slovakia, where up to six species of invasive plants were identified in the close proximity to the school. Keywords: Biological invasions, p...
Present relationship between a man and a biosphere results from the level of progress of human ci... more Present relationship between a man and a biosphere results from the level of progress of human civilization. The idea of permanently sustainable development is based on condition of positive qualitative attitudes, behavior and actions of people in the various spheres of society. Education and training is the main tool of creating positive attitudes towards the environment and permanently sustainable development. At present, developing contextual thinking in pupils seems to be in the forefront of the educational process. The need for direct contact with the environment and direct participation in the monitoring and problem solving activities prevails over the need of obtaining individual knowledge. We can “brand“ this understanding of education as an environmental education. According to the progressive changes in the lifestyle of population, it is necessary to implement environmental education in all the social and educational levels of education. It cannot be understood as an isola...
The authors of this article applied the determination of phenolic and flavonoid content in small ... more The authors of this article applied the determination of phenolic and flavonoid content in small berries to create a didactic cycle based on student-centered active learning (SCAL) in which students actively participated in the topic while studying and profile-forming as future biology and chemistry teachers. The fundamental part of the proposed didactic cycle is that students solve the following task: Determine the phenolic and flavonoid content in berries (Vaccinium myrtillus L., Vaccinium vitis-idaea L., and Vaccinium corymbosum L.) in your region. The submitted interdisciplinary topic is relevant to everyday life, and it aroused interest and enthusiasm among students. The students had the opportunity to test their theoretical knowledge in practical experimental research, and they attempted to work as researchers.
Water is not a commercial product, but the legacy that we must honor and protect. The global wate... more Water is not a commercial product, but the legacy that we must honor and protect. The global water problems led the European Parliament to adopt a coordinated water policy in the EU Member States. On December 22nd 2000 entry into force of the European Parliament and Council n.2000/60/EC establishing a framework in the field of water policy, called the Water Framework Directive. The Directive provides a legislative framework for the introduction of a single water policy in the EU. According to the requirements of the Directive member states must make the identification of anthropogenic impacts on the status of surface waters and introduce monitoring programs for surface water. Teachers and students at the Catholic University are actively involved in monitoring streams. As part of ongoing learning project where students learn the methodology used for monitoring rivers. Sažetak Voda nije komercijalni proizvod, već naslijeđe koje moramo poštivati i zaštititi. Globalni problem vode doveo...
Present relationship between a man and a biosphere results from the level of progress of human ci... more Present relationship between a man and a biosphere results from the level of progress of human civilization. The idea of permanently sustainable development is based on condition of positive qualitative attitudes, behavior and actions of people in the various spheres of society. Education and training is the main tool of creating positive attitudes towards the environment and permanently sustainable development. At present, developing contextual thinking in pupils seems to be in the forefront of the educational process. The need for direct contact with the environment and direct participation in the monitoring and problem solving activities prevails over the need of obtaining individual knowledge. We can “brand“ this understanding of education as an environmental education. According to the progressive changes in the lifestyle of population, it is necessary to implement environmental education in all the social and educational levels of education. It cannot be understood as an isola...
Several att empts to establish the new teaching methods using school experiment as a tool develop... more Several att empts to establish the new teaching methods using school experiment as a tool developing pupil's personality are known from history of science education. The goal of the reform of education system in Slovakia is to transform the traditional encyclopedic teaching for the creative and value education, which emphasis is on activity and personal freedom, the power to create its progressive, creative way of being to live in the new millennium. This could be reached by gradually introducing of the innovative elements of project teaching to the science education what should fi nally lead to the pupil's visions of the nature as a whole. It is important that the student is able to orient himself in the topic, to gather information, process it and sort and be well on its own original solutions and design. Our article refers to the possibility of using the project teaching in topic “the cycle of substances in nature”. Sažetak Iz povijesti znanosti obrazovanja poznato je nek...
Several att empts to establish the new teaching methods using school experiment as a tool develop... more Several att empts to establish the new teaching methods using school experiment as a tool developing pupil's personality are known from history of science education. The goal of the reform of education system in Slovakia is to transform the traditional encyclopedic teaching for the creative and value education, which emphasis is on activity and personal freedom, the power to create its progressive, creative way of being to live in the new millennium. This could be reached by gradually introducing of the innovative elements of project teaching to the science education what should fi nally lead to the pupil's visions of the nature as a whole. It is important that the student is able to orient himself in the topic, to gather information, process it and sort and be well on its own original solutions and design. Our article refers to the possibility of using the project teaching in topic "the cycle of substances in nature". Sažetak Iz povijesti znanosti obrazovanja poznato je nekoliko pokušaja izrade novih nastavnih metoda pomoću školskih eksperimenata kao alata u razvoju učenikove osobnosti. Cilj reforme obrazovnog sustava u Slovačkoj je transformirati tradicionalnu enciklopedijsku nastavu u smjeru kreativnog i vrijednog obrazovanja, koje naglasak stavlja na aktivnost i osobne slobode. To bi se moglo postići postupnim uvođenjem inovativnih elemenata projektne nastave za znanost obrazovanja, što bi konačno trebalo dovesti do toga da učenika doživljava prirodu kao cjelinu. Važno je da se učenik može orijentirati na temu, prikupiti podatke, obraditi ih i sortirati i dati vlastita originalna rješenja i dizajn. Naš rad se odnosi na mogućnost korištenja projektne nastave na temu "ciklus tvari u prirodi".
Sažetak Multimedijalni obrazovni sustavi stvaraju nove mogućnosti za pristup određenim informacij... more Sažetak Multimedijalni obrazovni sustavi stvaraju nove mogućnosti za pristup određenim informacijama. Za komunikaciju s korisnicima ti sustavi koriste tekst, video za projekcije pravih eksperimenata, animacije za prikaz nekih procesa ili zvuk. Osim toga, ovi atributi su povezani interaktivnima linijama, što znači da je ovaj tip multimedijskog obrazovnog sustava prilagođen individualnim zahtjevima. Računalo može biti prisutno u svim predmetima obrazovnog procesa, kao i u svim fazama nastavnog procesa (npr. motivacija, objašnjavanje, ponavljanje pronalazaka i zaključci). Rad s računalom će tijekom školskih lekcija učenicima biti zanimljiv, privlačan i atraktivan, a osobito će se istaknuti oni koji u klasičnom obrazovanju nikada ne bi pokazali svoj talent. Abstract Multimedia educational systems create new possibilities in the access to some information. They communicate with users using text, video for real experiments projection, animations for viewing some processes or sound. Moreov...
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Papers by Dana Blahútová