1 , Gülsel Yalç›n ABSTRACT: Behçet's disease and late onset rapidly cycling bipolar affective... more 1 , Gülsel Yalç›n ABSTRACT: Behçet's disease and late onset rapidly cycling bipolar affective disorder: a case report A 48-year old woman who is suffering from Behcet's disease (BD) for 16 years was diagnosed as having bipolar affective disorder (BAD) at the age of 41. Correlative effects of her both illness have been examined when she has been treated in
We compared standard and patient-targeted in-patient education in terms of their effect on patien... more We compared standard and patient-targeted in-patient education in terms of their effect on patients' anxiety. One hundred and ninety-eight patients who were hospitalised for coronary artery bypass surgery were given standard education (group 1) or individualised education (group 2) on the management of their healthcare after discharge. Patients in group 2 were assessed on the patient learning needs scale and were given education according to their individual needs. The level of anxiety was measured by the state-trait anxiety inventory. Anxiety scores were significantly lower in group 2 than group 1 after education (p < 0.001). While state anxiety did not change after education in group 1 (p = 0272), it decreased significantly in group 2 (p < 0.001). For cardiovascular surgery patients, patient-targeted in-patient education was more effective than standard education in decreasing anxiety levels, therefore the content of the education should be individualised according to the patient's particular needs.
OBJECTIVE: The aim of this study is to examine depression and anxiety related arrhytmia risk in f... more OBJECTIVE: The aim of this study is to examine depression and anxiety related arrhytmia risk in fibromyalgia syndrome (FMS). METHODS: Fifty-nine patients with the diagnosis of FMS and 20 control participants were included in the study. Fibromyalgia Impact Questionnaire (FIQ), Visual Pain Scale (VPS) surveys were applied to determine the severity of the disease. Beck Anxiety (BAS) and Beck Depression scales (BDS) were applied to all participants. Electrocardiograms were obtained from all participants. P-wave dispersions (Pd) were estimated to determine the risk of the atrial arrhythmia, and QT wave dispersion (QTd) and corrected QT(QTdd) values were used to predict the risk of ventricular arrhythmia. RESULTS: BAS and BDS results were significantly higher in the patient group compared to the control group (p˂0001). In the patient group, Pd was significantly longer (p=0.034). Other clinical, and demographic data did not differ significantly between groups. CONCLUSION: In this study, the risk of arrhythmia in FMS was evaluated and increased Pd in patients with FMS compared to the control group was detected. This finding shows increased risk of atrial fibrilation (AF) in patients with FMS. If we consider that patients with fibromyalgia consist relatively of young patients together with the increased risk of AF with age, it is important to follow-up these patients in later ages for AF risk.
The aim of this study was to investigate the relationship between plasma glutamate, glutamine and... more The aim of this study was to investigate the relationship between plasma glutamate, glutamine and gamma-aminobutyric acid (GABA) levels in female patients with major depression treated with S-citalopram or fluoxetine. The patients were assigned into S-citalopram (10 mg/day) or fluoxetine (20 mg/day) groups (n = 15 per group). The Hamilton and Beck Depression Inventory Scales were performed on all study participants, and blood samples were collected. The same procedures were repeated 10 days following the onset of therapy. Fifteen female healthy volunteers were also included in the study for the evaluation of normal plasma levels. The plasma GABA levels of the healthy volunteers were higher whereas those for glutamate and glutamine were lower than the day zero samples of the patients. An increase in plasma GABA levels and a decrease in glutamate and glutamine levels were observed on the 10th day of treatment. No difference was detected between the drug treatments. Our findings may suggest that GABA, glutamate and glutamine play a role in depression and that plasma GABA may be used as a biomarker for treatment control.
International Journal of Basic and Clinical Medicine, Oct 9, 2015
Obsessive-compulsive disorder (OCD) is common and frequently disabling psychiatric disorder. The ... more Obsessive-compulsive disorder (OCD) is common and frequently disabling psychiatric disorder. The onset of OCD is usually in adolesence and early adulthood. In literature there are limited case reports which were investigating the association between frontal brain tumors and OCD. In this paper, we report a case who developed late onset OCD after resection of a frontal menengioma.
International Journal of Basic and Clinical Medicine, 2013
Obsessive-compulsive disorder (OCD) is common and frequently disabling psychiatric disorder. The ... more Obsessive-compulsive disorder (OCD) is common and frequently disabling psychiatric disorder. The onset of OCD is usually in adolesence and early adulthood. In literature there are limited case reports which were investigating the association between frontal brain tumors and OCD. In this paper, we report a case who developed late onset OCD after resection of a frontal menengioma
International Journal of Basic and Clinical Medicine, Oct 9, 2015
Delüzyonel Parasitoz (DP) , medikal kanıt olmaksızın kişinin vücudunda parazitlerin bulaştığı şek... more Delüzyonel Parasitoz (DP) , medikal kanıt olmaksızın kişinin vücudunda parazitlerin bulaştığı şeklindeki yanlış inancın olduğu psikiyatrik bozukluktur. Paylaşılmış Psikotik Bozukluk, DP vakalarının %10"unda bildirilmiştir. DP tedavisinde hem tipik hem de atipik antipsikotikler kullanılmaktadır. Atipik antipsikotik grubu ajanların DP'de kullanımına ilişkin literatür bil¬gisi vaka raporları ve vaka serileri ile sınırlıdır ve bilgimize göre bu konuda sistematik bir çalışma yoktur. Risperidonun oral veya intramüsküler depo formları DP tedavisinde en sık kullanılan atipik antipsikotik ajandır. Bu yazıda paylaşılmış psikotik bozukluk şeklinde seyreden iki DP"lu vakanın düşük doz risperidon ile başarılı bir şekilde tedavisini sunmayı amaçladık.
Yeni symposium psikiyatri ve nörolojik bilimler dergisi, 2014
Alopesi areata (AA) genellikle tek, iyi sınırlı yamalarla seyreden yara bırakmayan alopesiler gru... more Alopesi areata (AA) genellikle tek, iyi sınırlı yamalarla seyreden yara bırakmayan alopesiler grubunda yer alan asemptomatik bir saç kaybıdır. AA hastalarında, yüksek oranda psikiyatrik komorbiditeye ait çok sayıda çalışma bulunmaktadır. Ancak literatürde ilk tanı almış alopesi areata hastalarında beyin kaynaklı nörotrofik (BDNF) faktör gibi psikiyatrik belirteçlerin araştırıldığı herhangi bir çalışma bulunmamaktadır. Yöntem: Bu çalışma Namık Kemal Üniversitesi Tıp Fakültesi deri ve zührevi hastalıklar ve psikiyatri bölümlerinde, Mart 2013 ve Eylül 2014 tarihleri arasında gerçekleştirilmiştir. Dışlama kriterleri sonrası herhangi bir psikiyatrik hastalık geçmişi ve muayene bulgusu olmayan, ilk kez AA tanısı almış 60 hasta, yaş ve cinsiyet uyumlu sağlıklı 60 bireyden oluşan kontrolle serum BDNF düzeyleri açısından karşılaştırılmıştır. Bulgular: Gruplar arasında yaş ve kadın/erkek oranları açısından fark saptanmamıştır. AA grubunda serum BDNF düzeyleri 2.13±1.71 ng/dl, sağlıklı grupta 2.32±1.93 ng/dl olarak tespit edilmiştir. Serum BDNF düzeyleri arasında farklılık saptanmamıştır (t=2.76, p=0.61). Sonuçlar: Çalışmamız, ilk kez tanı konulan alopesi areata hastaları ile sağlıklı bireylerin serum BDNF düzeylerinin karşılaştırıldığı ilk çalışmadır. Bu çalışmada normal popülasyon ile alopesi areata serum BDNF düzeyleri arasında fark olmadığı gösterilmiştir. Öte yandan, bu ön çalışmada bildirilen verileri destekleyecek yeni çalışmalara da ihtiyaç olduğunu düşünmekteyiz.
Progress in Neuro-psychopharmacology & Biological Psychiatry, Aug 1, 2013
Introduction: Deficit schizophrenia (DS) is defined for identifying a relatively homogeneous subg... more Introduction: Deficit schizophrenia (DS) is defined for identifying a relatively homogeneous subgroup of patients with diagnosis of schizophrenia, characterized by the presence of primary and enduring negative symptoms. There have been several studies which investigated the status of oxidative stress and total antioxidant level in patients with schizophrenia. However, there is not any study which researched differences between DS and nondeficit schizophrenia (NDS) in terms of status of oxidative stress and antioxidant level. We hypothesized that patients with DS would have different status of oxidative stress and antioxidant levels compared with patients with NDS. Methods: Twenty-three patients with DS, 42 patients with NDS and 31 age, sex and smoking status matched healthy controls (HC) were included to study. Five milliliters of blood was drawn from control subjects and patients for assessing total antioxidant potential (TAOP) and total peroxide levels (TPEROX). The ratio of TPEROX to TAOP is referred as oxidative stress index (OSI). Results: We noticed that serum TAOP level was significantly lower in DS group compared with NDS and HC groups. The OSI was also found to be higher in DS group compared with NDS and HC groups. Furthermore, serum TAOP level and status of OSI were similar between NDS and HC groups. Conclusion: Our study is the first to demonstrate differences between DS and NDS in terms of status of oxidative stress and serum total antioxidant level. We suggest that our study represents novel and important results in terms of supporting provides Q3 and hypothesis which considered DS as a different disease entity with respect to NDS. Further studies are needed for investigating the status of antioxidants and oxidative stress and their clinical implications in deficit schizophrenia.
Paliperidone is a second-generation antipsychotic which is used in the treatment of schizophrenia... more Paliperidone is a second-generation antipsychotic which is used in the treatment of schizophrenia. It is an active metabolite of risperidone and shows almost the same high affinity for dopamine D2 receptor and serotonin 5-HT2 receptor .The data about the association between acute dystonia and paliperidone treatment is restricted in literature. In this paper, we reported two cases who devoloped acute dystonia after initiating of paliperidone treatment. We suggest that paliperidone might acts a potential dopamine D2 receptor blocking agent in some vulnerable patients and acute dystonia should kept in mind as an early side effect of paliperidone even initating with low doses.
Objective: Hyperprolactinemia is an adverse effect, which is related with the use of antipsychoti... more Objective: Hyperprolactinemia is an adverse effect, which is related with the use of antipsychotics. All typical antipsychotics are considered to increase serum prolactin levels. Compared with typical antipsychotics, most of the atypical antipsychotics have a reduced tendency for increasing serum prolactin levels. However, effects of all atypical antipsychotics on serum prolactin levels are not always similar. In the present study, we aimed to compare short-term effects of risperidone and paliperidone, which are two similar atypical antipsychotics in terms of hyperprolactinemia and its associated symptoms. Methods: In this study, we screened data of female patients with diagnosis of schizophrenia and other psychotic disorders, bipolar disorder and who were treated with risperidone or paliperidone. The patients who had adequate sociodemographical and clinical data and who had screened in terms of prolactin levels before and fourth week of the treatment were included to study. Results: Forty-two patients have been treated with risperidone and 36 patients have been treated with paliperidone. Treatment groups were similar in terms of sociodemographic variables. The mean values of serum prolactin levels were significantly increased after four weeks of treatment in both groups (pl0.001). The discontinuation rates because of menstrual irregularities, galactorrhea, sexual dysfunction in risperidone and paliperidone groups were 11.9% and 30.6% respectively, and the rate was significantly higher in paliperidone group (?2=4.13, p=0.04). Conclusion: We suggest that beside its benefits and some superiorities compared to risperidone, paliperidone has no advantage over risperidone in terms of hyperprolactinemia and its associated symptoms. We also suggest that female patients should be monitorized regulary in terms of hyperprolactinemia and its associated symptoms while they are being treated with paliperidone. To our knowledge, the present study is the first to compare and demonstrate the effects of paliperidone and risperidone on serum prolactin levels in Turkey. Further studies with larger sample size are needed to highlight the short term and long term effects of paliperidone on serum prolactin levels in female patients.
The goal of this study was to examine the neuroprotective effect of ebselen against intracerebrov... more The goal of this study was to examine the neuroprotective effect of ebselen against intracerebroventricular streptozotocin (ICV-STZ)-induced oxidative stress and neuronal apoptosis in rat brain. A total of 30 adult male Sprague-Dawley rats were randomly divided into 3 groups of 10 animals each: control, ICV-STZ, and ICV-STZ treated with ebselen. The ICV-STZ group rats were injected bilaterally with ICV-STZ (3 mg/kg) on days 1 and 3, and ebselen (10 mg/kg/day) was administered for 14 days starting from 1st day of ICV-STZ injection to day 14. Rats were killed at the end of the study and brain tissues were removed for biochemical and histopathological investigation. Our results demonstrated, for the first time, the neuroprotective effect of ebselen on Alzheimer’s disease (AD) model in rats. Our present study, in ICV-STZ group, showed significant increase in tissue malondialdehyde levels and significant decrease in enzymatic antioxidants superoxide dismutase and glutathione peroxidase i...
Paliperidone is a second-generation antipsychotic which is used in the treatment of schizophrenia... more Paliperidone is a second-generation antipsychotic which is used in the treatment of schizophrenia. It is an active metabolite of risperidone and shows almost the same high affinity for dopamine D2 receptor and serotonin 5-HT2 receptor .The data about the association between acute dystonia and paliperidone treatment is restricted in literature. In this paper, we reported two cases who devoloped acute dystonia after initiating of paliperidone treatment. We suggest that paliperidone might acts a potential dopamine D2 receptor blocking agent in some vulnerable patients and acute dystonia should kept in mind as an early side effect of paliperidone even initating with low doses.
The purpose of the present investigation was to evaluate cadmium (Cd)-induced neurotoxicity in hi... more The purpose of the present investigation was to evaluate cadmium (Cd)-induced neurotoxicity in hippocampal tissues and beneficial effect of quercetin (QE) against neuronal damage. A total of 30 male rats were divided into 3 groups: control, Cd-treated, and Cd + QE-treated groups. After the treatment, the animals were killed and hippocampal tissues were removed for biochemical and histopathological investigation. Cd significantly increased tissue malondialdehyde (MDA) and protein carbonyl (PC) levels and also decreased superoxide dismutase (SOD) and catalase (CAT) enzyme activities in hippocampal tissue compared with the control. Administration of QE with Cd significantly decreased the levels of MDA and PC and significantly elevated the levels of antioxidant enzymes in hippocampal tissue. In the Cd-treated group, the neurons of both tissues became extensively dark and degenerated with pyknotic nuclei. The morphology of neurons in Cd + QE group was well protected, but not as neurons o...
The present study was carried out to evaluate the neuroprotective effect of quercetin (QE) in pro... more The present study was carried out to evaluate the neuroprotective effect of quercetin (QE) in protecting the cadmium (Cd)-induced neuronal injury in frontal cortex of rats. A total of 30 adult male Sprague-Dawley rats were randomly divided into three groups of 10 animals each: control, Cd treated and Cd treated with QE. The Cd-treated group was injected subcutaneously with cadmium chloride (CdCl2) dissolved in saline at a dose of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd. The rats in QE-treated groups were given QE (15 mg/kg body weight) once a day intraperitoneally starting 2 days prior to Cd injection, during the study period. Rats were sacrificed at the end of the study and the frontal cortex tissues were removed for biochemical and histopathological investigation. To date, there is no available information on the effect of QE on neuronal injury after Cd exposure. Rats intoxicated with Cd for 30 days, significantly increased tissue malondialdehyde (MDA) levels ...
1 , Gülsel Yalç›n ABSTRACT: Behçet's disease and late onset rapidly cycling bipolar affective... more 1 , Gülsel Yalç›n ABSTRACT: Behçet's disease and late onset rapidly cycling bipolar affective disorder: a case report A 48-year old woman who is suffering from Behcet's disease (BD) for 16 years was diagnosed as having bipolar affective disorder (BAD) at the age of 41. Correlative effects of her both illness have been examined when she has been treated in
We compared standard and patient-targeted in-patient education in terms of their effect on patien... more We compared standard and patient-targeted in-patient education in terms of their effect on patients' anxiety. One hundred and ninety-eight patients who were hospitalised for coronary artery bypass surgery were given standard education (group 1) or individualised education (group 2) on the management of their healthcare after discharge. Patients in group 2 were assessed on the patient learning needs scale and were given education according to their individual needs. The level of anxiety was measured by the state-trait anxiety inventory. Anxiety scores were significantly lower in group 2 than group 1 after education (p < 0.001). While state anxiety did not change after education in group 1 (p = 0272), it decreased significantly in group 2 (p < 0.001). For cardiovascular surgery patients, patient-targeted in-patient education was more effective than standard education in decreasing anxiety levels, therefore the content of the education should be individualised according to the patient's particular needs.
OBJECTIVE: The aim of this study is to examine depression and anxiety related arrhytmia risk in f... more OBJECTIVE: The aim of this study is to examine depression and anxiety related arrhytmia risk in fibromyalgia syndrome (FMS). METHODS: Fifty-nine patients with the diagnosis of FMS and 20 control participants were included in the study. Fibromyalgia Impact Questionnaire (FIQ), Visual Pain Scale (VPS) surveys were applied to determine the severity of the disease. Beck Anxiety (BAS) and Beck Depression scales (BDS) were applied to all participants. Electrocardiograms were obtained from all participants. P-wave dispersions (Pd) were estimated to determine the risk of the atrial arrhythmia, and QT wave dispersion (QTd) and corrected QT(QTdd) values were used to predict the risk of ventricular arrhythmia. RESULTS: BAS and BDS results were significantly higher in the patient group compared to the control group (p˂0001). In the patient group, Pd was significantly longer (p=0.034). Other clinical, and demographic data did not differ significantly between groups. CONCLUSION: In this study, the risk of arrhythmia in FMS was evaluated and increased Pd in patients with FMS compared to the control group was detected. This finding shows increased risk of atrial fibrilation (AF) in patients with FMS. If we consider that patients with fibromyalgia consist relatively of young patients together with the increased risk of AF with age, it is important to follow-up these patients in later ages for AF risk.
The aim of this study was to investigate the relationship between plasma glutamate, glutamine and... more The aim of this study was to investigate the relationship between plasma glutamate, glutamine and gamma-aminobutyric acid (GABA) levels in female patients with major depression treated with S-citalopram or fluoxetine. The patients were assigned into S-citalopram (10 mg/day) or fluoxetine (20 mg/day) groups (n = 15 per group). The Hamilton and Beck Depression Inventory Scales were performed on all study participants, and blood samples were collected. The same procedures were repeated 10 days following the onset of therapy. Fifteen female healthy volunteers were also included in the study for the evaluation of normal plasma levels. The plasma GABA levels of the healthy volunteers were higher whereas those for glutamate and glutamine were lower than the day zero samples of the patients. An increase in plasma GABA levels and a decrease in glutamate and glutamine levels were observed on the 10th day of treatment. No difference was detected between the drug treatments. Our findings may suggest that GABA, glutamate and glutamine play a role in depression and that plasma GABA may be used as a biomarker for treatment control.
International Journal of Basic and Clinical Medicine, Oct 9, 2015
Obsessive-compulsive disorder (OCD) is common and frequently disabling psychiatric disorder. The ... more Obsessive-compulsive disorder (OCD) is common and frequently disabling psychiatric disorder. The onset of OCD is usually in adolesence and early adulthood. In literature there are limited case reports which were investigating the association between frontal brain tumors and OCD. In this paper, we report a case who developed late onset OCD after resection of a frontal menengioma.
International Journal of Basic and Clinical Medicine, 2013
Obsessive-compulsive disorder (OCD) is common and frequently disabling psychiatric disorder. The ... more Obsessive-compulsive disorder (OCD) is common and frequently disabling psychiatric disorder. The onset of OCD is usually in adolesence and early adulthood. In literature there are limited case reports which were investigating the association between frontal brain tumors and OCD. In this paper, we report a case who developed late onset OCD after resection of a frontal menengioma
International Journal of Basic and Clinical Medicine, Oct 9, 2015
Delüzyonel Parasitoz (DP) , medikal kanıt olmaksızın kişinin vücudunda parazitlerin bulaştığı şek... more Delüzyonel Parasitoz (DP) , medikal kanıt olmaksızın kişinin vücudunda parazitlerin bulaştığı şeklindeki yanlış inancın olduğu psikiyatrik bozukluktur. Paylaşılmış Psikotik Bozukluk, DP vakalarının %10"unda bildirilmiştir. DP tedavisinde hem tipik hem de atipik antipsikotikler kullanılmaktadır. Atipik antipsikotik grubu ajanların DP'de kullanımına ilişkin literatür bil¬gisi vaka raporları ve vaka serileri ile sınırlıdır ve bilgimize göre bu konuda sistematik bir çalışma yoktur. Risperidonun oral veya intramüsküler depo formları DP tedavisinde en sık kullanılan atipik antipsikotik ajandır. Bu yazıda paylaşılmış psikotik bozukluk şeklinde seyreden iki DP"lu vakanın düşük doz risperidon ile başarılı bir şekilde tedavisini sunmayı amaçladık.
Yeni symposium psikiyatri ve nörolojik bilimler dergisi, 2014
Alopesi areata (AA) genellikle tek, iyi sınırlı yamalarla seyreden yara bırakmayan alopesiler gru... more Alopesi areata (AA) genellikle tek, iyi sınırlı yamalarla seyreden yara bırakmayan alopesiler grubunda yer alan asemptomatik bir saç kaybıdır. AA hastalarında, yüksek oranda psikiyatrik komorbiditeye ait çok sayıda çalışma bulunmaktadır. Ancak literatürde ilk tanı almış alopesi areata hastalarında beyin kaynaklı nörotrofik (BDNF) faktör gibi psikiyatrik belirteçlerin araştırıldığı herhangi bir çalışma bulunmamaktadır. Yöntem: Bu çalışma Namık Kemal Üniversitesi Tıp Fakültesi deri ve zührevi hastalıklar ve psikiyatri bölümlerinde, Mart 2013 ve Eylül 2014 tarihleri arasında gerçekleştirilmiştir. Dışlama kriterleri sonrası herhangi bir psikiyatrik hastalık geçmişi ve muayene bulgusu olmayan, ilk kez AA tanısı almış 60 hasta, yaş ve cinsiyet uyumlu sağlıklı 60 bireyden oluşan kontrolle serum BDNF düzeyleri açısından karşılaştırılmıştır. Bulgular: Gruplar arasında yaş ve kadın/erkek oranları açısından fark saptanmamıştır. AA grubunda serum BDNF düzeyleri 2.13±1.71 ng/dl, sağlıklı grupta 2.32±1.93 ng/dl olarak tespit edilmiştir. Serum BDNF düzeyleri arasında farklılık saptanmamıştır (t=2.76, p=0.61). Sonuçlar: Çalışmamız, ilk kez tanı konulan alopesi areata hastaları ile sağlıklı bireylerin serum BDNF düzeylerinin karşılaştırıldığı ilk çalışmadır. Bu çalışmada normal popülasyon ile alopesi areata serum BDNF düzeyleri arasında fark olmadığı gösterilmiştir. Öte yandan, bu ön çalışmada bildirilen verileri destekleyecek yeni çalışmalara da ihtiyaç olduğunu düşünmekteyiz.
Progress in Neuro-psychopharmacology & Biological Psychiatry, Aug 1, 2013
Introduction: Deficit schizophrenia (DS) is defined for identifying a relatively homogeneous subg... more Introduction: Deficit schizophrenia (DS) is defined for identifying a relatively homogeneous subgroup of patients with diagnosis of schizophrenia, characterized by the presence of primary and enduring negative symptoms. There have been several studies which investigated the status of oxidative stress and total antioxidant level in patients with schizophrenia. However, there is not any study which researched differences between DS and nondeficit schizophrenia (NDS) in terms of status of oxidative stress and antioxidant level. We hypothesized that patients with DS would have different status of oxidative stress and antioxidant levels compared with patients with NDS. Methods: Twenty-three patients with DS, 42 patients with NDS and 31 age, sex and smoking status matched healthy controls (HC) were included to study. Five milliliters of blood was drawn from control subjects and patients for assessing total antioxidant potential (TAOP) and total peroxide levels (TPEROX). The ratio of TPEROX to TAOP is referred as oxidative stress index (OSI). Results: We noticed that serum TAOP level was significantly lower in DS group compared with NDS and HC groups. The OSI was also found to be higher in DS group compared with NDS and HC groups. Furthermore, serum TAOP level and status of OSI were similar between NDS and HC groups. Conclusion: Our study is the first to demonstrate differences between DS and NDS in terms of status of oxidative stress and serum total antioxidant level. We suggest that our study represents novel and important results in terms of supporting provides Q3 and hypothesis which considered DS as a different disease entity with respect to NDS. Further studies are needed for investigating the status of antioxidants and oxidative stress and their clinical implications in deficit schizophrenia.
Paliperidone is a second-generation antipsychotic which is used in the treatment of schizophrenia... more Paliperidone is a second-generation antipsychotic which is used in the treatment of schizophrenia. It is an active metabolite of risperidone and shows almost the same high affinity for dopamine D2 receptor and serotonin 5-HT2 receptor .The data about the association between acute dystonia and paliperidone treatment is restricted in literature. In this paper, we reported two cases who devoloped acute dystonia after initiating of paliperidone treatment. We suggest that paliperidone might acts a potential dopamine D2 receptor blocking agent in some vulnerable patients and acute dystonia should kept in mind as an early side effect of paliperidone even initating with low doses.
Objective: Hyperprolactinemia is an adverse effect, which is related with the use of antipsychoti... more Objective: Hyperprolactinemia is an adverse effect, which is related with the use of antipsychotics. All typical antipsychotics are considered to increase serum prolactin levels. Compared with typical antipsychotics, most of the atypical antipsychotics have a reduced tendency for increasing serum prolactin levels. However, effects of all atypical antipsychotics on serum prolactin levels are not always similar. In the present study, we aimed to compare short-term effects of risperidone and paliperidone, which are two similar atypical antipsychotics in terms of hyperprolactinemia and its associated symptoms. Methods: In this study, we screened data of female patients with diagnosis of schizophrenia and other psychotic disorders, bipolar disorder and who were treated with risperidone or paliperidone. The patients who had adequate sociodemographical and clinical data and who had screened in terms of prolactin levels before and fourth week of the treatment were included to study. Results: Forty-two patients have been treated with risperidone and 36 patients have been treated with paliperidone. Treatment groups were similar in terms of sociodemographic variables. The mean values of serum prolactin levels were significantly increased after four weeks of treatment in both groups (pl0.001). The discontinuation rates because of menstrual irregularities, galactorrhea, sexual dysfunction in risperidone and paliperidone groups were 11.9% and 30.6% respectively, and the rate was significantly higher in paliperidone group (?2=4.13, p=0.04). Conclusion: We suggest that beside its benefits and some superiorities compared to risperidone, paliperidone has no advantage over risperidone in terms of hyperprolactinemia and its associated symptoms. We also suggest that female patients should be monitorized regulary in terms of hyperprolactinemia and its associated symptoms while they are being treated with paliperidone. To our knowledge, the present study is the first to compare and demonstrate the effects of paliperidone and risperidone on serum prolactin levels in Turkey. Further studies with larger sample size are needed to highlight the short term and long term effects of paliperidone on serum prolactin levels in female patients.
The goal of this study was to examine the neuroprotective effect of ebselen against intracerebrov... more The goal of this study was to examine the neuroprotective effect of ebselen against intracerebroventricular streptozotocin (ICV-STZ)-induced oxidative stress and neuronal apoptosis in rat brain. A total of 30 adult male Sprague-Dawley rats were randomly divided into 3 groups of 10 animals each: control, ICV-STZ, and ICV-STZ treated with ebselen. The ICV-STZ group rats were injected bilaterally with ICV-STZ (3 mg/kg) on days 1 and 3, and ebselen (10 mg/kg/day) was administered for 14 days starting from 1st day of ICV-STZ injection to day 14. Rats were killed at the end of the study and brain tissues were removed for biochemical and histopathological investigation. Our results demonstrated, for the first time, the neuroprotective effect of ebselen on Alzheimer’s disease (AD) model in rats. Our present study, in ICV-STZ group, showed significant increase in tissue malondialdehyde levels and significant decrease in enzymatic antioxidants superoxide dismutase and glutathione peroxidase i...
Paliperidone is a second-generation antipsychotic which is used in the treatment of schizophrenia... more Paliperidone is a second-generation antipsychotic which is used in the treatment of schizophrenia. It is an active metabolite of risperidone and shows almost the same high affinity for dopamine D2 receptor and serotonin 5-HT2 receptor .The data about the association between acute dystonia and paliperidone treatment is restricted in literature. In this paper, we reported two cases who devoloped acute dystonia after initiating of paliperidone treatment. We suggest that paliperidone might acts a potential dopamine D2 receptor blocking agent in some vulnerable patients and acute dystonia should kept in mind as an early side effect of paliperidone even initating with low doses.
The purpose of the present investigation was to evaluate cadmium (Cd)-induced neurotoxicity in hi... more The purpose of the present investigation was to evaluate cadmium (Cd)-induced neurotoxicity in hippocampal tissues and beneficial effect of quercetin (QE) against neuronal damage. A total of 30 male rats were divided into 3 groups: control, Cd-treated, and Cd + QE-treated groups. After the treatment, the animals were killed and hippocampal tissues were removed for biochemical and histopathological investigation. Cd significantly increased tissue malondialdehyde (MDA) and protein carbonyl (PC) levels and also decreased superoxide dismutase (SOD) and catalase (CAT) enzyme activities in hippocampal tissue compared with the control. Administration of QE with Cd significantly decreased the levels of MDA and PC and significantly elevated the levels of antioxidant enzymes in hippocampal tissue. In the Cd-treated group, the neurons of both tissues became extensively dark and degenerated with pyknotic nuclei. The morphology of neurons in Cd + QE group was well protected, but not as neurons o...
The present study was carried out to evaluate the neuroprotective effect of quercetin (QE) in pro... more The present study was carried out to evaluate the neuroprotective effect of quercetin (QE) in protecting the cadmium (Cd)-induced neuronal injury in frontal cortex of rats. A total of 30 adult male Sprague-Dawley rats were randomly divided into three groups of 10 animals each: control, Cd treated and Cd treated with QE. The Cd-treated group was injected subcutaneously with cadmium chloride (CdCl2) dissolved in saline at a dose of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd. The rats in QE-treated groups were given QE (15 mg/kg body weight) once a day intraperitoneally starting 2 days prior to Cd injection, during the study period. Rats were sacrificed at the end of the study and the frontal cortex tissues were removed for biochemical and histopathological investigation. To date, there is no available information on the effect of QE on neuronal injury after Cd exposure. Rats intoxicated with Cd for 30 days, significantly increased tissue malondialdehyde (MDA) levels ...
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