Papers by Cristina Matushita
O objetivo deste estudo foi avaliar o desempenho diagnostico da tomografia por emissao de positro... more O objetivo deste estudo foi avaliar o desempenho diagnostico da tomografia por emissao de positrons (PET) com antigeno de membrana especifico da Prostata (PSMA) para deteccao de câncer de prostata e câncer de prostata recorrente. Metodos: uma pesquisa sistematica foi realizada em PubMed, Cochrane e Embase para identificar estudos relevantes publicados que relatam o desempenho do PSMA PET marcado com 68Ga em pacientes com câncer de prostata suspeito, confirmado, nao tratado ou recorrente. Um composto padronizado incluiu alteracao nos valores de PSA, acompanhamento clinico e achados histopatologicos como padrao de referencia. Resultados: trinta e cinco estudos, que incluiram no total 3532 pacientes submetidos a um PET de 68Ga-PSMA, atendiam aos criterios de inclusao. Obtivemos uma razao de verossimilhanca positiva combinada (LR) de 1,81 (0,75 a 4,36) com 0% de heterogeneidade. Para pacientes com PSA <0,5ng/mL, a estimativa de LR combinada positiva foi de 1,17 (0,37-3,73) e a sensibilidade foi de 56% (0,42-0,68). Conclusao: Esta meta-analise de estudos disponiveis demonstra que o PET de 68Ga-PSMA parece fornecer boa sensibilidade e especificidade.
Rev. méd. Minas Gerais, 2014
Objective: to demonstrate the findings of isthmian nodosa salpingitis (SIN) through histero-salpi... more Objective: to demonstrate the findings of isthmian nodosa salpingitis (SIN) through histero-salpingography and evaluate the site of involvement and its impact on female infertility. Patients and Methods: a total of 2,800 histero-salpingographies were reviewed in a retrospective study between January of 1987 and January of 2007 in patients with a clinical history of female infertility. Of these, four patients presented radiological diagnosis of SIN; their main radiographic aspects, sites of involvement, and impact on infertility were analyzed. Results: out of the four patients in which the studied disease was found through the histero-salpingography infertility research, three had a history of tubal pregnancy, all with cornual isthmian involvement; bilateral in three of them and unilateral in one. One of them showed evidence of positive bilateral Cotte, two showed evidence of negative bilateral Cotte, and one bilateral with right positive tubal and left negative tubal. Conclusion: the diagnosis of SIN is achieved based on histero-salpingography, characterized by the accumulation of contrast medium on the tubal wall, distributed in the cornual or ampolar isthmian portion, uni- or bilaterally, and accompanied by clinical history of infertility, tubal pregnancy, spontaneous abortion, and tubal obstruction.
Revista Da Associacao Medica Brasileira, Apr 1, 2019
The information provided through this project must be assessed and criticized by the physician re... more The information provided through this project must be assessed and criticized by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical status of each patient.
Radiologia Brasileira, Aug 1, 2013
The authors report the case of a giant cell tumor of the frontal sinus in a 54-year-old male pati... more The authors report the case of a giant cell tumor of the frontal sinus in a 54-year-old male patient. This tumor location is rare, and this is the third case reported in the literature with radiographic documentation and histopathological confirmation. The patient underwent surgery, with curettage of frontal sinus and placement of a prosthesis. He died because a voluntary abrupt discontinuation of corticosteroids.
European Journal of Nuclear Medicine and Molecular Imaging, Feb 22, 2021
Integrated PET/MR is an imaging technique that combines the strengths of its constituent modaliti... more Integrated PET/MR is an imaging technique that combines the strengths of its constituent modalities and is uniquely suited for evaluation of skeletal metastatic disease. MR can contribute high soft tissue contrast and multiparametric anatomic imaging and has become the imaging modality of choice for assessment of musculoskeletal malignancies. PET provides quantitative molecular and physiologic information and has become a critical tool in the diagnosis and staging of malignancies. In this article, we will provide a brief overview of technical considerations for simultaneous PET/MR acquisition and their relevance to the detection and characterization of osseous metastases. We will also discuss principles for PET/MR protocol development that can optimize detection of skeletal metastatic lesions with a focus on technique for both 18F-FDG and non 18F-FDG radiopharmaceuticals. Lastly, we will review current evidence and provide recommendations for the use of PET/MR in patients for whom there is suspicion for skeletal metastatic disease.
Physica Medica, Aug 1, 2023
Rev. méd. Minas Gerais, 2013
Objective: The purpose of this paper is to analyze the sonographic changes that characterize the ... more Objective: The purpose of this paper is to analyze the sonographic changes that characterize the Cruveilhier-Baumgarten syndrome and its clinical charactheristics. CruveilhierBaumgartem syndrome is characterized by a prominent paraumbilical vein, with dilatated superficial veins of the abdominal wall radiating from the umbilicus of patients with chronic liver disease and portal hypertension. Patients and methods: In a sonographic evaluation of 60 patients diagnosed with chronic liver disease with portal hypertension we found 4 cases of Cruveilhier-Baumgarten syndrome, which we studied with color doppler sonography. Results: All patients were male, in their third decade of life, with a clinical history of splenomegaly and varicose abdominal wall veins. Patients had schistosomiasis and micronodular cirrhosis on hystopathological examination. We also evaluated two patients with esophageal varices without hemathemesis. All patients had ultrasound signs of splenomegaly and chronic liver disease, with hepatopetal flow in all segments of the portal vein and hepatofugal flow in the efferent veins of the liver (paraumbilical vein in the falciform ligament and the anterior abdominal wall surface veins). Conclusion: CBS is charactherized by the association of signs of chronic liver damage with splenomegaly, distention of paraumbilical veins (portal hypertension) and blood flow towards the superficial abdominal wall veins, which are Cruveilhier-Baugarten syndrome: sonographic aspects
Revista Médica de Minas Gerais, 2015
Objective: to identify the radiological findings of salpingitis isthmica nodosa (SIN) through hys... more Objective: to identify the radiological findings of salpingitis isthmica nodosa (SIN) through hysterosalpingography and evaluate the site of involvement and its impact on infertility. Methods: 2,800 protocols were reviewed in a retrospective study between January of 1987 and January of 1997, in patients with a clinical history of female infertility; four of them with a radiological diagnosis of SIN. Ethnicity, age, marital status, current clinical complaints, medical history, location, and side of involvement were analyzed. Results: among the four patients with SIN, three were dark-skin, and one was Caucasian, with an average age of 35 years at diagnosis, two single, one married, and one divorcee. Three patients presented complaints of secondary infertility with previous tubal pregnancy history, and another with primary infertility without pregnancy history. In the four patients with SIN, the tubal portion affected was the cornual isthmian, bilateral tubal in three, and unilateral in one. Regarding peritonization, one showed positive bilateral Cotte proof, two with complete bilateral obstruction, and one with positive Cotte in one of the tubes. Conclusion: SIN is more common in dark-skin patients, in the mean age of 35 years, with a clinical history of infertility, with initial and recurrent tubal pregnancy, and subsequent tubal obstruction characterized by lesion in the Isthmian cornual portion of the fallopian tube, usually with bilateral involvement.
Revista Da Associacao Medica Brasileira, Apr 1, 2019
The information provided through this project must be assessed and criticized by the physician re... more The information provided through this project must be assessed and criticized by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical status of each patient.
Haemophilia, 2011
Recurrent haemarthroses often lead to chronic synovitis in patients with haemophilia and von Will... more Recurrent haemarthroses often lead to chronic synovitis in patients with haemophilia and von Willebrand disease. Radioactive synovectomy with yttrium-90 (90 Y) citrate is frequently used to treat this complication, usually with good results. Since 2006, the Nuclear Energy Research Institute (IPEN, Sao Paulo, Brazil) has produced hydroxyapatite particles labelled with 90 Y for radioactive synovectomy. The aim of this study was to compare the results achieved by both forms of 90 Y in the treatment of haemophilic synovitis. We included 221 joints from 136 patients (age range: 6-20 years), treated by one of the two radiopharmaceuticals, at the Hemocenter of Mato Grosso, Brazil. The outcomes analysed were the annual frequency of haemarthrosis, articular pain and joint range of motion before and 1 year after RS. Similar results were achieved regardless of whether 90 Y hydroxyapatite or 90 Y citrate was used, and results were independent of the joint type, age, gender, radiologic stage and presence of inhibitors. 90 Y hydroxyapatite appears to be equivalent to the reference product 90 Y citrate in the treatment of chronic synovitis associated with bleeding disorders.
Guideline Authors: Ana Cristina Lopes Albricker,1 Cláudia Maria Vilas Freire,2 Simone Nascimento ... more Guideline Authors: Ana Cristina Lopes Albricker,1 Cláudia Maria Vilas Freire,2 Simone Nascimento dos Santos,3 Monica Luiza de Alcantara,4 Mohamed Hassan Saleh,5 Armando Luis Cantisano,6,7 José Aldo Ribeiro Teodoro,8 Carmen Lucia Lascasas Porto,9 Salomon Israel do Amaral,10 Orlando Carlos Gloria Veloso,11 Ana Cláudia Gomes Pereira Petisco,5 Fanilda Souto Barros,12 Márcio Vinícius Lins de Barros,13 Adriano José de Souza,14 Marcone Lima Sobreira,15 Robson Barbosa de Miranda,16 Domingos de Moraes,17 † Carlos Gustavo Yuji Verrastro,18 Alexandre Dias Mançano,19 Ronaldo de Souza Leão Lima,20 Valdair Francisco Muglia,21 Cristina Sebastião Matushita,22,23 Rafael Willain Lopes,24 Artur Martins Novaes Coutinho,25 Diego Bromfman Pianta,22 Alair Augusto Sarmet Moreira Damas dos Santos,26 Bruno de Lima Naves,27 Marcelo Luiz Campos Vieira,28,29 Carlos Eduardo Rochitte24,29,30 Centro Universitário de Belo Horizonte (UniBH),1 Belo Horizonte, MG – Brazil Universidade Federal de Minas Gerais (UFMG),2 ...
Journal of the American College of Cardiology
Arquivos Brasileiros de Cardiologia
Alzheimer's & Dementia, 2021
Abstract
Propose: This study aims to explore the use of the Centiloid (CL) method in amyloid-β P... more Abstract
Propose: This study aims to explore the use of the Centiloid (CL) method in amyloid-β PET quantifcation to evaluate distinct cognitive aging stages, investigating subjects’ mismatch classifcation using
diferent cut-points for amyloid-β positivity.
Procedures: The CL equation was applied in four groups of individuals: SuperAgers (SA), healthy
age-matched controls (AC), healthy middle-aged controls (MC), and Alzheimer’s disease (AD). The
amyloid-β burden was calculated and compared between groups and quantitative variables. Three
diferent cut-points (Jack CR, Wiste HJ, Weigand SD, et al., Alzheimer’s Dement 13:205–216, 2017; Salvadó G, Molinuevo JL, Brugulat-Serrat A, et al., Alzheimer’s Res Ther 11:27, 2019; and Amadoru S, Doré
V, McLean CA, et al., Alzheimer’s Res Ther 12:22, 2020) were applied in CL values to diferentiate the
earliest abnormal pathophysiological accumulation of Aβ and the established Aβ pathology.
Results: The AD group exhibited a signifcantly increased Aβ burden compared to the MC, but not
AC groups. Both healthy control (MC and AC) groups were not signifcantly diferent. Visually, the SA
group showed a diverse distribution of CL values compared with MC; however, the diference was not
signifcant. The CL values have a moderate and signifcant relationship between Aβ visual read, RAVLT
DR and MMSE. Depending on the cut-point used, 10 CL, 19 CL, or 30 CL, 7.5% of our individuals had
a diferent classifcation in the Aβ positivity. For the AC group, we obtained about 40 to 60% of the
individuals classifed as positive.
Conclusion: SuperAgers exhibited a similar Aβ load to AC and MC, difering in cognitive performance.
Independently of cut-point used (10 CL, 19 CL, or 30 CL), three SA individuals were classifed as Aβ positive, showing the duality between the individual’s clinics and the biological defnition of Alzheimer’s.
Diferent cut-points lead to Aβ positivity classifcation mismatch in individuals, and an extra care is
needed for individuals who have a CL value between 10 and 30 CL.
The authors report a case of a newborn term infant with horseshoe lung associated with supracardi... more The authors report a case of a newborn term infant with horseshoe lung associated with supracardiac total anomalous pulmonary venous drainage; such association remains unreported in the Western literature.
Revista Médica de Minas Gerais, 2014
Objective: to demonstrate the findings of isthmian nodosa salpingitis (SIN) through histero-salpi... more Objective: to demonstrate the findings of isthmian nodosa salpingitis (SIN) through histero-salpingography and evaluate the site of involvement and its impact on female infertility. Patients and Methods: a total of 2,800 histero-salpingographies were reviewed in a retrospective study between January of 1987 and January of 2007 in patients with a clinical history of female infertility. Of these, four patients presented radiological diagnosis of SIN; their main radiographic aspects, sites of involvement, and impact on infertility were analyzed. Results: out of the four patients in which the studied disease was found through the histero-salpingography infertility research, three had a history of tubal pregnancy, all with cornual isthmian involvement; bilateral in three of them and unilateral in one. One of them showed evidence of positive bilateral Cotté, two showed evidence of negative bilateral Cotté, and one bilateral with right positive tubal and left negative tubal. Conclusion: the diagnosis of SIN is achieved based on histero-salpingography, characterized by the accumulation of contrast medium on the tubal wall, distributed in the cornual or ampolar isthmian portion, uni-or bilaterally, and accompanied by clinical history of infertility, tubal pregnancy, spontaneous abortion, and tubal obstruction.
JACC: Cardiovascular Imaging
O objetivo deste estudo foi avaliar o desempenho diagnostico da tomografia por emissao de positro... more O objetivo deste estudo foi avaliar o desempenho diagnostico da tomografia por emissao de positrons (PET) com antigeno de membrana especifico da Prostata (PSMA) para deteccao de câncer de prostata e câncer de prostata recorrente. Metodos: uma pesquisa sistematica foi realizada em PubMed, Cochrane e Embase para identificar estudos relevantes publicados que relatam o desempenho do PSMA PET marcado com 68Ga em pacientes com câncer de prostata suspeito, confirmado, nao tratado ou recorrente. Um composto padronizado incluiu alteracao nos valores de PSA, acompanhamento clinico e achados histopatologicos como padrao de referencia. Resultados: trinta e cinco estudos, que incluiram no total 3532 pacientes submetidos a um PET de 68Ga-PSMA, atendiam aos criterios de inclusao. Obtivemos uma razao de verossimilhanca positiva combinada (LR) de 1,81 (0,75 a 4,36) com 0% de heterogeneidade. Para pacientes com PSA <0,5ng/mL, a estimativa de LR combinada positiva foi de 1,17 (0,37-3,73) e a sensib...
Uploads
Papers by Cristina Matushita
Propose: This study aims to explore the use of the Centiloid (CL) method in amyloid-β PET quantifcation to evaluate distinct cognitive aging stages, investigating subjects’ mismatch classifcation using
diferent cut-points for amyloid-β positivity.
Procedures: The CL equation was applied in four groups of individuals: SuperAgers (SA), healthy
age-matched controls (AC), healthy middle-aged controls (MC), and Alzheimer’s disease (AD). The
amyloid-β burden was calculated and compared between groups and quantitative variables. Three
diferent cut-points (Jack CR, Wiste HJ, Weigand SD, et al., Alzheimer’s Dement 13:205–216, 2017; Salvadó G, Molinuevo JL, Brugulat-Serrat A, et al., Alzheimer’s Res Ther 11:27, 2019; and Amadoru S, Doré
V, McLean CA, et al., Alzheimer’s Res Ther 12:22, 2020) were applied in CL values to diferentiate the
earliest abnormal pathophysiological accumulation of Aβ and the established Aβ pathology.
Results: The AD group exhibited a signifcantly increased Aβ burden compared to the MC, but not
AC groups. Both healthy control (MC and AC) groups were not signifcantly diferent. Visually, the SA
group showed a diverse distribution of CL values compared with MC; however, the diference was not
signifcant. The CL values have a moderate and signifcant relationship between Aβ visual read, RAVLT
DR and MMSE. Depending on the cut-point used, 10 CL, 19 CL, or 30 CL, 7.5% of our individuals had
a diferent classifcation in the Aβ positivity. For the AC group, we obtained about 40 to 60% of the
individuals classifed as positive.
Conclusion: SuperAgers exhibited a similar Aβ load to AC and MC, difering in cognitive performance.
Independently of cut-point used (10 CL, 19 CL, or 30 CL), three SA individuals were classifed as Aβ positive, showing the duality between the individual’s clinics and the biological defnition of Alzheimer’s.
Diferent cut-points lead to Aβ positivity classifcation mismatch in individuals, and an extra care is
needed for individuals who have a CL value between 10 and 30 CL.
Propose: This study aims to explore the use of the Centiloid (CL) method in amyloid-β PET quantifcation to evaluate distinct cognitive aging stages, investigating subjects’ mismatch classifcation using
diferent cut-points for amyloid-β positivity.
Procedures: The CL equation was applied in four groups of individuals: SuperAgers (SA), healthy
age-matched controls (AC), healthy middle-aged controls (MC), and Alzheimer’s disease (AD). The
amyloid-β burden was calculated and compared between groups and quantitative variables. Three
diferent cut-points (Jack CR, Wiste HJ, Weigand SD, et al., Alzheimer’s Dement 13:205–216, 2017; Salvadó G, Molinuevo JL, Brugulat-Serrat A, et al., Alzheimer’s Res Ther 11:27, 2019; and Amadoru S, Doré
V, McLean CA, et al., Alzheimer’s Res Ther 12:22, 2020) were applied in CL values to diferentiate the
earliest abnormal pathophysiological accumulation of Aβ and the established Aβ pathology.
Results: The AD group exhibited a signifcantly increased Aβ burden compared to the MC, but not
AC groups. Both healthy control (MC and AC) groups were not signifcantly diferent. Visually, the SA
group showed a diverse distribution of CL values compared with MC; however, the diference was not
signifcant. The CL values have a moderate and signifcant relationship between Aβ visual read, RAVLT
DR and MMSE. Depending on the cut-point used, 10 CL, 19 CL, or 30 CL, 7.5% of our individuals had
a diferent classifcation in the Aβ positivity. For the AC group, we obtained about 40 to 60% of the
individuals classifed as positive.
Conclusion: SuperAgers exhibited a similar Aβ load to AC and MC, difering in cognitive performance.
Independently of cut-point used (10 CL, 19 CL, or 30 CL), three SA individuals were classifed as Aβ positive, showing the duality between the individual’s clinics and the biological defnition of Alzheimer’s.
Diferent cut-points lead to Aβ positivity classifcation mismatch in individuals, and an extra care is
needed for individuals who have a CL value between 10 and 30 CL.