Papers by Consuelo Chang Rueda
Revista Mesoamericana de Investigación
Como resultado de su ciclo evolutivo, el virus SARS-CoV-2, agente causal de COVID-19, ha sufrido ... more Como resultado de su ciclo evolutivo, el virus SARS-CoV-2, agente causal de COVID-19, ha sufrido mutaciones genéticas durante el transcurso de la pandemia, originando diferentes variantes. Las variantes que presentan un potencial de riesgo para la salud pública son denominadas como Variantes de Preocupación (VOC) por la Organización Mundial de la Salud (OMS). Dentro de esta clasificación se encuentra la variante Delta (B.1.617.2) debido a su capacidad de escapar de la inmunidad, ya sea de manera natural o inducida por las vacunas, lo que puede generar reinfecciones, mayor transmisibilidad y gravedad. Esta variante fue identificada por primera vez en octubre de 2020 en India. En México, se reconoció como variante circulante el 18 de abril de 2021, mientras que en Chiapas fue el 16 de julio del mismo año. Con base en ello, se realizó la vigilancia de las variantes epidemiológicamente relevantes Alfa, Beta, Gamma y Delta en un grupo de 117 pacientes diagnosticados con SARS-CoV-2 que ac...
Healthcare
Selenium (Se) is an essential trace element that by its antioxidant properties has been studied t... more Selenium (Se) is an essential trace element that by its antioxidant properties has been studied to elucidate its participation in the development of obesity and type 2 diabetes. We evaluated the association between cardiometabolic traits and serum Se levels in a sample of adults from southern Mexico. In 96 nondiabetic individuals, anthropometric data and clinical biochemistry measurements were analyzed. Serum total Se levels were measured with inductively coupled plasma mass spectrometry (ICP-MS). Serum Se level in the whole sample was 10.309 ± 3.031 μg mL−1 and no difference between the women and men was observed (p = 0.09). Additionally, fasting plasma glucose (FPG) was significantly associated with serum Se level (β = −0.07 ± 0.03, p = 0.02, analysis adjusted for age, sex and BMI). Furthermore, sex shows significant interaction with FPG on the serum Se levels (p = 0.01). A follow-up analysis revealed the particular association between FPG and Se levels in women (β = −0.10 ± 0.04,...
Journal of Trace Elements in Medicine and Biology
Journal of Trace Elements in Medicine and Biology
BACKGROUND Lead (Pb) exposure has been associated with cardiovascular diseases and metabolic synd... more BACKGROUND Lead (Pb) exposure has been associated with cardiovascular diseases and metabolic syndrome, nevertheless its association with obesity, type 2 diabetes, and dyslipidemia markers has been little explored in Mexico. Therefore, we evaluated the association of serum Pb levels (Pb-S), with body mass index (BMI), fasting plasma glucose (FPG), total cholesterol (TC), and triglycerides (TG). METHODS A cross-sectional study was performed on 85 Mexican adults (57 women and 28 men). BMI was calculated, while FPG, TC, and TG were measured by the enzymatic colorimetric method. Total Pb-S levels were measured using inductively coupled plasma mass spectrometry (ICP-MS). RESULTS The study population was 20.3 ± 1.9 years old, showed an average of Pb-S of 0.0982 ± 0.068 μg dL-1, and presented a frequency of overweight (OW) and obesity (OB) of 50.5% and 18.8%, respectively. Men had higher average FPG than women (Women= 83.930 ± 5.662 vs Men= 84.953 ± 6.495; p = 0.037). When we analyzed anthropometric and clinical variables, Pb-S and frequency of OW and OB were observed to increase within the categories of Pb-S tertiles (<0.001). The averages of Pb-S were 0.051 ± 0.035 µg dL-1, 0.107 ± 0.067 µg dL-1, and 0.151 ± 0.063 µg dL-1 for individuals with normal weight (NW), OW, and OB, respectively. In addition, an analysis adjusted for age and sex shows Pb-S is positively associated with BMI (β = 2.76 ± 0.498, p = <0.001). CONCLUSION Our results evidence a significant association between Pb-S and the increase of BMI in Mexican adults and highlight the important health impact that may represent environmental Pb exposure.
Revista de la Facultad de Medicina, 2019
Introduction: Insulin resistance (IR) is a major risk factor for developing diabetes mellitus typ... more Introduction: Insulin resistance (IR) is a major risk factor for developing diabetes mellitus type 2 and cardiovascular diseases. In pediatrics, morbidity and mortality associated with these diseases highlights the diagnostic importance of IR for primary care.Objective: To determine Homeostatic Model Assessment Insulin Resistance (HOMA-IR) values and their correlation with BMI-for-age percentile in children and adolescents of the Soconusco region of Chiapas, Mexico.Materials and methods: Cross-sectional study. Overweight and obesity prevalence was determined based on the Body Mass Index (BMI) percentile of 112 children (5-19 years old). Glucose and fasting insulin values were quantified and used for estimation of HOMA-IR.Results: The combined prevalence of obesity and overweight was 66%, with insulin (p=0.010) and HOMA-IR (p=0.015) values higher than those of the normal weight group. The HOMA-IR values correlated positively with age (r=0.636), weight (r=0.569), height (r=0.578) and ...
Biological Trace Element Research
In Mexico, few studies have analyzed the associations between toxic elements and metabolic diseas... more In Mexico, few studies have analyzed the associations between toxic elements and metabolic diseases. In the present study, we analyzed the associations between serum arsenic (As), cadmium (Cd), and mercury (Hg) levels and body mass index (BMI) and fasting plasma glucose (FPG) in a Mexican adult population. Anthropometric data corresponding to 86 Mexican healthy adults (59 females and 27 men) were analyzed. FPG was analyzed by an enzymatic colorimetric method, and serum As, Cd, and Hg levels were analyzed by inductively coupled plasma-mass spectrometry (ICP-MS). The data show that the median serum As, Cd, and Hg levels were relatively higher in females (As = 1.78 ng mL −1 , Cd = 1.00 ng mL −1 , Hg = 0.96 ng mL −1) than those in males (As = 1.22 ng mL −1 , Cd = 0.91 ng mL −1 , Hg = 0.95 ng mL −1). However, these differences were not statistically significant (p ≥ 0.097). We also found that the median level of As significantly increased with an increase in the body weight categories (normal weight = 1.08; overweight = 1.50; obesity = 2.75; p < 0.001). In addition, a positive association between serum As levels and FPG before and after adjustment for BMI was demonstrated (Rho Unadjusted = 0.012; (RhoA djusted = 0.243, p = 0.032). Serum As levels are positively associated with BMI and FPG in the adult population of Mexico. Nevertheless, these results need to be replicated and confirmed with a larger sample size.
MEMORIAS PROGRAMA www.medigraphic.com QC-2 EVALUACION DEL FUNCIONAMIENTO HEPATICO EN PACIENTES CO... more MEMORIAS PROGRAMA www.medigraphic.com QC-2 EVALUACION DEL FUNCIONAMIENTO HEPATICO EN PACIENTES CON VIH, DEL HOSPITAL GENERAL DE TAPACHULA CHIAPAS, QUE ESTAN BAJO TRATAMIENTO ANTIRRETROVIRAL Chang Rueda Consuelo, Garcia Hernandez Refugio Fabian, Maldonado de Leon Maynor A, Silva Villarreal Emilse C, Ramirez Aguilar Francisco J. Cuerpo Academico de Medicina y Ciencia de la Salud de la Universidad Autonoma de Chiapas, Facultad de Ciencias Quimicas. Campus IV, Carretera a Puerto Madero KM. 2.0, Tapachula, Chiapas., E-mail: [email protected]
Cardiovascular disease (CVD) is one of the main consequences of diabetes which accounts for prema... more Cardiovascular disease (CVD) is one of the main consequences of diabetes which accounts for premature death risk in 50% of diabetic patients. This study reports the importance of lipoprotein A (Lp A) and high sensitive c-reactive protein (HS-CRP) as clinical tests for the early detection of CVD risk in patients with diabetes since 65% of the studied patients was found to be predisposed to atherosclerotic CVD (altered Lp A lab values) without traces of endothelial injury and 4% was found with traces of probable vascular injury (altered HS-CRP lab values). Based on these results it is sugested that through LpA and HS-CPR testing, a proportion of 6 out of 10 patients could avoid severe stages of CVD.
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Papers by Consuelo Chang Rueda