Supplemental material, MSJ-18-0794.R1_Supplementary_material for Reduced dynamics of functional c... more Supplemental material, MSJ-18-0794.R1_Supplementary_material for Reduced dynamics of functional connectivity and cognitive impairment in multiple sclerosis by Alessandro d'Ambrosio, Paola Valsasina, Antonio Gallo, Nicola De Stefano, Deborah Pareto, Frederik Barkhof, Olga Ciccarelli, Christian Enzinger, Gioacchino Tedeschi, M Laura Stromillo, Maria J Arévalo, Hanneke E Hulst, Nils Muhlert, Marisa Koini, Massimo Filippi and Maria A Rocca in Multiple Sclerosis Journal
Background: In multiple sclerosis (MS), abnormalities of brain network dynamics and their relevan... more Background: In multiple sclerosis (MS), abnormalities of brain network dynamics and their relevance for cognitive impairment have never been investigated. Objectives: The aim of this study was to assess the dynamic resting state (RS) functional connectivity (FC) on 62 relapsing-remitting MS patients and 65 sex-matched healthy controls enrolled at 7 European sites. Methods: MS patients underwent clinical and cognitive evaluation. Between-group network FC differences were evaluated using a dynamic approach (based on sliding-window correlation analysis) and grouping correlation matrices into recurrent FC states. Results: Dynamic FC analysis revealed, in healthy controls and MS patients, three recurrent FC states: two characterized by strong intra- and inter-network connectivity and one characterized by weak inter-network connectivity (State 3). A total of 23 MS patients were cognitively impaired (CI). Compared to cognitively preserved (CP), CI-MS patients had reduced RS-FC between subc...
Supplemental material, MSJ-18-0794.R1_Supplementary_material for Reduced dynamics of functional c... more Supplemental material, MSJ-18-0794.R1_Supplementary_material for Reduced dynamics of functional connectivity and cognitive impairment in multiple sclerosis by Alessandro d'Ambrosio, Paola Valsasina, Antonio Gallo, Nicola De Stefano, Deborah Pareto, Frederik Barkhof, Olga Ciccarelli, Christian Enzinger, Gioacchino Tedeschi, M Laura Stromillo, Maria J Arévalo, Hanneke E Hulst, Nils Muhlert, Marisa Koini, Massimo Filippi and Maria A Rocca in Multiple Sclerosis Journal
Background: In multiple sclerosis (MS), abnormalities of brain network dynamics and their relevan... more Background: In multiple sclerosis (MS), abnormalities of brain network dynamics and their relevance for cognitive impairment have never been investigated. Objectives: The aim of this study was to assess the dynamic resting state (RS) functional connectivity (FC) on 62 relapsing-remitting MS patients and 65 sex-matched healthy controls enrolled at 7 European sites. Methods: MS patients underwent clinical and cognitive evaluation. Between-group network FC differences were evaluated using a dynamic approach (based on sliding-window correlation analysis) and grouping correlation matrices into recurrent FC states. Results: Dynamic FC analysis revealed, in healthy controls and MS patients, three recurrent FC states: two characterized by strong intra- and inter-network connectivity and one characterized by weak inter-network connectivity (State 3). A total of 23 MS patients were cognitively impaired (CI). Compared to cognitively preserved (CP), CI-MS patients had reduced RS-FC between subc...
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Papers by Maria Arévalo