Papers by Anuradha Sawant
Current Pain and Headache Reports, 2011
Fibromyalgia syndrome, a chronic condition typically characterized by widespread pain, nonrestora... more Fibromyalgia syndrome, a chronic condition typically characterized by widespread pain, nonrestorative sleep, fatigue, cognitive dysfunction, and other somatic symptoms, negatively impacts physical and emotional function and reduces quality of life. Exercise is commonly recommended in the management of people with fibromyalgia, and interest in examining exercise benefits for those with the syndrome has grown substantially over the past 25 years. Research supports aerobic and strength training to improve physical fitness and function, reduce fibromyalgia symptoms, and improve quality of life. However, other forms of exercise (e.g., tai chi, yoga, Nordic walking, vibration techniques) and lifestyle physical activity also have been investigated to determine their effects. This paper highlights findings from recent randomized controlled trials and reviews of exercise for people with fibromyalgia, and includes information regarding factors that influence response and adherence to exercise to assist clinicians with exercise and physical activity prescription decision-making to optimize health and well-being.
Current Pain and Headache Reports, 2011
Fibromyalgia syndrome, a chronic condition typically characterized by widespread pain, nonrestora... more Fibromyalgia syndrome, a chronic condition typically characterized by widespread pain, nonrestorative sleep, fatigue, cognitive dysfunction, and other somatic symptoms, negatively impacts physical and emotional function and reduces quality of life. Exercise is commonly recommended in the management of people with fibromyalgia, and interest in examining exercise benefits for those with the syndrome has grown substantially over the past 25 years. Research supports aerobic and strength training to improve physical fitness and function, reduce fibromyalgia symptoms, and improve quality of life. However, other forms of exercise (e.g., tai chi, yoga, Nordic walking, vibration techniques) and lifestyle physical activity also have been investigated to determine their effects. This paper highlights findings from recent randomized controlled trials and reviews of exercise for people with fibromyalgia, and includes information regarding factors that influence response and adherence to exercise to assist clinicians with exercise and physical activity prescription decision-making to optimize health and well-being.
International Studies, 1991
Multiple Sclerosis and Related Disorders, 2015
Physiotherapy Canada, 2004
Physiology Journal, 2013
properly cited.
Physiological reports, 2015
Establishing the effect of fluctuating extracellular fluid (ECF) volume on muscle strength in peo... more Establishing the effect of fluctuating extracellular fluid (ECF) volume on muscle strength in people with end-stage renal disease (ESRD) on hemodialysis (HD) is essential, as inadequate hydration of the skeletal muscles impacts its strength and endurance. Bioelectrical impedance spectroscopy (BIS) has been a widely used method for estimating ECF volume of a limb or calf segment. Magnetic resonance imaging (MRI)-acquired transverse relaxation times (T2) has also been used for estimating ECF volumes of individual skeletal muscles. The purpose of this study was to determine the association between T2 (gold standard) of tibialis anterior (TA), medial (MG), and lateral gastrocnemius (LG), and soleus muscles and calf BIS ECF, in healthy and in people with ESRD/HD. Calf BIS and MRI measures were collected on two occasions before and after HD session in people with ESRD/HD and on a single occasion for the healthy participants. Linear regression analysis was used to establish the association...
Physiotherapy Canada, 2011
Purpose: Fatigue is one of the most frequent debilitating symptoms reported by people with end-st... more Purpose: Fatigue is one of the most frequent debilitating symptoms reported by people with end-stage renal disease (ESRD) on haemodialysis (HD) therapy. A wide range of underlying abnormalities, including skeletal muscle weakness, have been implicated as causes of this fatigue. Skeletal muscle weakness is well established in this population, and such muscle weakness is amenable to physical therapy treatment. The purpose of this review was to identify morphological, electrophysiological, and metabolic characteristics of skeletal muscles in people with ESRD/HD that may cause skeletal muscle weakness. Method: Electronic databases were searched for relevant literature from inception to March 2010. Inclusion criteria were English language; adult subjects with ESRD/HD; and the use of muscle biopsy, electromyography, and nuclear magnetic spectroscopy ( 31 P-NMRS) techniques to evaluate muscle characteristics. Results: In total, 38 studies were included. All studies of morphological characteristics reported type II fibre atrophy. Electrophysiological characteristics included both neuropathic and myopathic skeletal muscle changes. Studies of metabolic characteristics revealed higher cytosolic inorganic phosphate levels and reduced effective muscle mass.
Physiotherapy Canada, 2010
Purpose: End-stage renal disease (ESRD) is a condition affecting multiple physiological systems, ... more Purpose: End-stage renal disease (ESRD) is a condition affecting multiple physiological systems, leading to a decline in physical function. Effectiveness of therapeutic interventions in people with ESRD has been assessed using various functional and activity outcome measures. The purpose of this study was to determine the relative and absolute reliability of the 6-minute walk test (6MWT), timed sit-to-stand in 30 seconds (TSS30), and maximal and adjusted activity scores (MAS-HAP, AAS-HAP) of the Human Activity Profile (HAP) in people with ESRD. Method: A convenience sample of 25 participants (67.2e14.2 years) was recruited from an outpatient dialysis unit. Relative reliability was determined using the intraclass correlation coefficient (ICC 2,1 ), and absolute test-retest reliability with the standard error of measurement (SEM) and minimal detectable change at the 95% confidence interval (MDC 95 ) statistics, respectively. The test-retest interval was 1 week. Results: Relative reliability (ICC 2,1 ) was 0.93 for both the 6MWT and the TSS30, 0.92 for the AAS-HAP, and 0.76 for the MAS-HAP. Absolute reliability (SEM and MDC 95 ) values for the 6MWT, AAS-HAP, and TSS30 were 28 m and 77 m, 4.1 and 11.4, and 0.9 and 2.6 repetitions, respectively. Conclusions: Our results suggest that the 6MWT, TSS30, and AAS-HAP are reliable physical function and activity outcome measures in people with ESRD. However, the magnitude of the absolute reliability statistics suggests significant within-participant variability on repeat testing in this population. Overend T, Anderson C, Sawant A, Perryman B, Locking-Cusolito H. Relative and absolute reliability of physical function measures in people with end-stage renal disease. Physiother Can. 2010;62:122-128. RÉ SUMÉ Objectif : L'insuffisance ré nale chronique au stade ultime (IRSU) est un problè me qui affecte de multiples systè mes physiologiques et qui conduit à un dé clin des fonctions physiques. L'efficacité des interventions thé rapeutiques chez les personnes atteintes d'IRSU a é té é valué e à l'aide de divers indicateurs fonctionnels et indicateurs d'activité . L'objectif de cette é tude é tait de dé terminer la fiabilité relative et absolue d'un test de marche de 6 minutes (TM6), d'un test assis à debout de 30 secondes (TSS30) et des scores d'activité maximale et adapté e (MAS-HAP, AAS-HAP) de l'é chelle d'activité (HAP) chez les personnes atteintes d'IRSU. Mé thode : Un é chantillon de commodité composé de 25 participants (67,2 e 14,2 ans) a é té recruté à partir d'une unité de dialyse pour patients externes. La fiabilité relative a é té é valué e à l'aide d'un coefficient de corré lation intraclasse (ICC 2,1 ) et d'une mesure de fiabilité test-retest avec statistiques d'erreur de mesure standard (EMS) et changement minimal dé tectable (CMD 95 ), respectivement. L'intervalle test-retest é tait d'une semaine. Ré sultats : La fiabilité relative (ICC 2,1 ) é tait de 0,93 pour le TM6 comme pour le TSS30, de 0,92 pour l'AAS-HAP et de 0,76 pour le MAS-HAP. Les valeurs de fiabilité absolue (EMS et CMD 95 ) pour le TM6, l'AAS-HAP et le TSS30 é taient de 28 m et de 77 m, de 4,1, de 11,4 et de 0,9, respectivement.
Current Pain and Headache Reports, 2011
Fibromyalgia syndrome, a chronic condition typically characterized by widespread pain, nonrestora... more Fibromyalgia syndrome, a chronic condition typically characterized by widespread pain, nonrestorative sleep, fatigue, cognitive dysfunction, and other somatic symptoms, negatively impacts physical and emotional function and reduces quality of life. Exercise is commonly recommended in the management of people with fibromyalgia, and interest in examining exercise benefits for those with the syndrome has grown substantially over the past 25 years. Research supports aerobic and strength training to improve physical fitness and function, reduce fibromyalgia symptoms, and improve quality of life. However, other forms of exercise (e.g., tai chi, yoga, Nordic walking, vibration techniques) and lifestyle physical activity also have been investigated to determine their effects. This paper highlights findings from recent randomized controlled trials and reviews of exercise for people with fibromyalgia, and includes information regarding factors that influence response and adherence to exercise to assist clinicians with exercise and physical activity prescription decision-making to optimize health and well-being.
Physiotherapy Canada, 2014
Purpose: The primary purpose of this systematic review was to evaluate the anabolic effect of exe... more Purpose: The primary purpose of this systematic review was to evaluate the anabolic effect of exercise intervention in adults with end-stage renal disease on hemodialysis (HD). The secondary objectives were to evaluate the influences of participant characteristics and exercise parameters on changes in muscle size. Methods: Electronic databases (Cochrane, CINAHL, EMBASE, PEDro, PubMed and SCOPUS) were searched from inception to November 2012. Randomized clinical trials published in English that included adults on HD undergoing an exercise intervention where muscle mass was measured as an outcome were included in this review. Two reviewers independently selected the studies, extracted data, and assessed risk of bias within the included studies. Results were then combined by meta-analysis. The effect of exercises was determined using a standardized mean difference (SMD), expressed as Hedges' g, computed using a random effects model. Results: Seven SMDs extracted from five studies were included for final analysis. Strength training was used in all studies; one study used aerobic and mixed strength and aerobic training with two subgroups of participants. The overall effect of exercise on muscle mass was statistically significant (SMD: 0.272; 95% CI, 0.020-0.525). Conclusions: Our results confirm a small but significant effect of strengthening exercise as an anabolic intervention to increase muscle mass. Exercise training should be included in routine management of people on maintenance HD. Although current results indicate that one in nine people on HD is likely to benefit from exercise intervention, parameters influencing these results require further research.
Journal of Aging Research, 2012
Objective. This paper analyzes the effects of resistance training (RT) on metabolic, neuromuscula... more Objective. This paper analyzes the effects of resistance training (RT) on metabolic, neuromuscular, and cardiovascular functions in older adults (mean age ≥ 65 years) with type 2 diabetes (T2DM). Research Design and Methods. A systematic review conducted by two reviewers of the published literature produced 3 records based on 2 randomized controlled trials that assessed the effect of RT on disease process measures and musculoskeletal/body composition measures. Statistical, Comprehensive Meta-Analysis (version 2) software was used to compute Hedge's g, and results were calculated using the random effects model to account for methodological differences amongst studies. Results. Largest effect of RT was seen on muscle strength; especially lower body strength, while the point estimate effect on body composition was small and not statistically significant. The cumulative point estimate for the T2DM disease process measures was moderate and statistically significant. Conclusions. RT generally had a positive effect on musculoskeletal, body composition, and T2DM disease processes measures, with tentative conclusions based on a low number of completed RCTs. Thus, more research is needed on such programs for older adults (≥65 years) with T2DM.
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Papers by Anuradha Sawant