Papers by Antonio Tebcherani
Anais Brasileiros de Dermatologia
A síndrome de Sweet é dermatose rara, caracterizada por erupção aguda de placas e nódulos eritêma... more A síndrome de Sweet é dermatose rara, caracterizada por erupção aguda de placas e nódulos eritêmato-edematosos. Relata-se o caso de doente do sexo feminino, de 55 anos, com lesão cutânea compatível com síndrome de Sweet ao redor de cicatriz cirúrgica na face, após exérese de ceratose actínica e ingestão de dipirona. O caso relatado ressalta a possibilidade da ocorrência do fenômeno de Köebner na síndrome de Sweet, provavelmente desencadeado pelo uso da dipirona.
Anais Brasileiros de Dermatologia, 2014
Cutis verticis gyrata is characterized by excessive formation of scalp skin. It may be primary (e... more Cutis verticis gyrata is characterized by excessive formation of scalp skin. It may be primary (essential and nonessential) or secondary. In the primary essential form it presents only folding skin formation on the scalp, mimicking cerebral gyri, without associated comorbidities. We report a rare case of a 28 year-old male patient with primary essential cutis verticis gyrata.
Apresenta-se caso clínico de variante rara de dermatofibroma (tipo aneurismático) em paciente do ... more Apresenta-se caso clínico de variante rara de dermatofibroma (tipo aneurismático) em paciente do sexo feminino de 72 anos de idade, cuja lesão se localizava na dobra flexural do membro superior direito, resultante de proliferação mesenquimal associada à vasos sanguíneos e hemorragia tecidual, com características histológicas próprias e bem definidas. Os objetivos desta descrição foram a raridade da lesão e a importância que ela assume, do ponto de vista histopatológico, quando comparada no diagnóstico diferencial com outros tumores benignos e malignos e a terminologia utilizada atualmente.
Anais brasileiros de dermatologia
Chronic actinic cheilitis is actinic keratosis located on the vermilion border. Treatment is esse... more Chronic actinic cheilitis is actinic keratosis located on the vermilion border. Treatment is essential because of the potential for malignant transformation. To evaluate the aesthetic and functional results of vermilionectomy using the classic and W-plasty techniques in actinic cheilitis. In the classic technique, the scar is linear and in the W-plasty one, it is a broken line. 32 patients with clinical and histopathological diagnosis of actinic cheilitis were treated. Out of the 32 patients, 15 underwent the W-plasty technique and 17 underwent the classic one. We evaluated parameters such as scar retraction and functional changes. A statistically significant association between the technique used and scar retraction was found, which was positive when using the classic technique (p = 0.01 with Yates' correction). The odds ratio was calculated at 11.25, i.e., there was a greater chance of retraction in patients undergoing the classic technique. Both techniques revealed no functio...
4 Resumo: A síndrome de Sweet é dermatose rara, caracterizada por erupção aguda de placas e nódul... more 4 Resumo: A síndrome de Sweet é dermatose rara, caracterizada por erupção aguda de placas e nódulos eritêmato-edematosos. Relata-se o caso de doente do sexo feminino, de 55 anos, com lesão cutânea compatível com síndrome de Sweet ao redor de cicatriz cirúrgica na face, após exérese de ceratose actínica e ingestão de dipirona. O caso relatado ressalta a possibili- dade
Anais brasileiros de dermatologia
Bullous pemphigoid is an autoimmune subepidermal bullous dermatosis more commonly observed in the... more Bullous pemphigoid is an autoimmune subepidermal bullous dermatosis more commonly observed in the elderly (over 70 years old). Autoantibodies are produced for specific antigens of the epidermal basement membrane zone: BP 180 and BP 230 (hemidesmosome proteins). We report three cases of bullous pemphigoid in adults younger than 50 years old, discussing the clinical characteristics of the disease in younger patients.
Anais brasileiros de dermatologia, 2009
Eruptive xanthoma with unexpected granuloma annulare-like microscopic appearance - Case report Ab... more Eruptive xanthoma with unexpected granuloma annulare-like microscopic appearance - Case report Abstract: Eruptive xanthoma and granuloma annulare are dermatological diseases with different clinical findings that, sometimes, exhibit histopathological similarities with potential for misinterpretation. We report a case of an eruption of yellow-orange papules with erythematous borders in a 34-year-old male with high levels of serum triglycerides and cholesterol. The skin biopsy specimen has diagnosed granuloma annulare. Review of the histologic material revealed eruptive xanthoma. Remission of the eruption after treatment of dyslipidemia confirmed the diagnosis of the eruptive xanthoma and motivated research about the histological similarities and differences between these diseases.
Anais brasileiros de dermatologia
We report a case of an inflammatory variant of epidermolysis bullosa acquisita in a 53-year-old m... more We report a case of an inflammatory variant of epidermolysis bullosa acquisita in a 53-year-old male, with itching blistering eruption on the trunk, armpits and limbs for six months. The skin biopsy specimen showed subepidermal blister with neutrophils. Direct immunofluorescence revealed linear depositions of IgG, IgA, IgM and C3 at the basement membrane; indirect immunofluorescence and salt Split Skin were negative. Antinuclear antibodies were also negative. Improvement of the blisters followed treatment with systemic corticotherapy and some lesions healed with milia. This is a rare presentation of epidermolysis bullosa acquisita, with inflammatory lesions at first.
Anais brasileiros de dermatologia
Trichilemmoma is a benign neoplasm from the outer sheath of the pilosebaceous follicle. Desmoplas... more Trichilemmoma is a benign neoplasm from the outer sheath of the pilosebaceous follicle. Desmoplastic trichilemmoma, a rare variant, is histologically characterized by a central area of desmoplasia that can clinically mimic an invasive carcinoma, requiring histopathological examination to define the diagnosis.
Anais Brasileiros de Dermatologia, 2013
Linear immunoglobulin A dermatosis is a rare autoimmune bullous disease, but the most common auto... more Linear immunoglobulin A dermatosis is a rare autoimmune bullous disease, but the most common autoimmune bullous dermatosis in children. We report a typical exuberant case of linear IgA dermatosis in a tenmonth old child, who showed good response to treatment with corticosteroids and dapsone.
Anais Brasileiros de Dermatologia, 2014
A 34-year-old man presented progressive generalized hardening of the body for 3 years. Three mont... more A 34-year-old man presented progressive generalized hardening of the body for 3 years. Three months ago, he experienced difficulty in swallowing and extending his tongue, and several hard nodules were noted progressively on the forehead ( ). Physical examination revealed that the skin on his face and distal extremities was indurated ( ). On the trunk and proximal extremities, the skin was normal in elasticity, but the underlying muscles were indurated, and almost all the joints were restricted in motion. No regional lymph nodes were palpable. Laboratory examination showed no abnormality in routine tests. Serum and urine immunofixation showed a characteristic pattern of monoclonal IgG gammopathy, particularly of λ paraprotein. Some cardiac abnormalities including left ventricular outflow obstruction and right ventricular dysfunction were noted upon echocardiography. Positron emission tomography computed tomography (PET-CT) scan showed multiple areas of abnormal uptake in almost all the joints and some muscles. Bone marrow aspirate revealed active myeloid proliferation and 3% of plasmacyte observed. Flow cytometry showed that CD38 birght CD45 dim/cells occupied 6.5% of all the nucleated cells and the expression of antigen was CD19 (0.7%), CD56 (1.9%), CD20 (1.7%), CD54 (99.9%), CD138 (99.8%), CD49e (2.6%), intracytoplasmic IgM (3.5%), intracytoplasmic IgD (0.5%), intracytoplasmic IgG (12.6%), intracytoplasmic κ paraprotein (0.3%) and intracytoplasmic λ paraprotein (98.5%). There were no remarkable findings in various other studies, including abdominal ultrasonography and chest computer tomography (CT) scan. The skin and muscle biopsy specimens obtained from the nodule on the forehead and inner thigh showed a deposition of amyloid materials in the dermis, subcutaneous tissues, vessel walls and connective tissue sep-DOI: http://dx.
Modern Pathology, 2012
Trichoepithelioma is a benign neoplasm that shares both clinical and histological features with b... more Trichoepithelioma is a benign neoplasm that shares both clinical and histological features with basal cell carcinoma. It is important to distinguish these neoplasms because they require different clinical behavior and therapeutic planning. Many studies have addressed the use of immunohistochemistry to improve the differential diagnosis of these tumors. These studies present conflicting results when addressing the same markers, probably owing to the small number of basaloid tumors that comprised their studies, which generally did not exceed 50 cases. We built a tissue microarray with 162 trichoepithelioma and 328 basal cell carcinoma biopsies and tested a panel of immune markers composed of CD34, CD10, epithelial membrane antigen, Bcl-2, cytokeratins 15 and 20 and D2-40. The results were analyzed using multiple linear and logistic regression models. This analysis revealed a model that could differentiate trichoepithelioma from basal cell carcinoma in 36% of the cases. The panel of immunohistochemical markers required to differentiate between these tumors was composed of CD10, cytokeratin 15, cytokeratin 20 and D2-40. The results obtained in this work were generated from a large number of biopsies and resulted in the confirmation of overlapping epithelial and stromal immunohistochemical profiles from these basaloid tumors. The results also corroborate the point of view that trichoepithelioma and basal cell carcinoma tumors represent two different points in the differentiation of a single cell type. Despite the use of panels of immune markers, histopathological criteria associated with clinical data certainly remain the best guideline for the differential diagnosis of trichoepithelioma and basal cell carcinoma.
Journal of Dermatological Treatment, 2002
Necrobiotic xanthogranuloma (NXG) is a rare non-X histiocytosis with conspicuous lesions on the p... more Necrobiotic xanthogranuloma (NXG) is a rare non-X histiocytosis with conspicuous lesions on the periorbital skin. A diabetic patient presented with NXG and a previous diagnosis of necrobiosis lipoidica on the legs over a period of almost 2 years before the development of the typical lesions of NXG on the periorbital regions, back, thighs and legs. The patient was found also to have developed lambda paraproteinemia. Treatment with melphalan and prednisone resulted in great improvement of cutaneous lesions and paraproteinemia remission. This case report details how melphalan and prednisone can be administered in the successful treatment of necrobiotic xanthogranuloma with lambda paraproteinemia.
Clinical and Experimental Dermatology, 2008
We report a case of a 44-year-old woman with an 8-year history of gnatophyma. Rosacea is a facial... more We report a case of a 44-year-old woman with an 8-year history of gnatophyma. Rosacea is a facial dermatosis that may present as flushing, erythema, telangiectases, papules, pustules and phyma. Phyma is considered the final evolution stage of rosacea and is a rare variant. Treatment of phyma with atypical localization may be a challenge for dermatologists in clinical practice.
Anais Brasileiros de …, 2008
Anais Brasileiros de Dermatologia, 2009
Anais Brasileiros de Dermatologia, 2008
Anais Brasileiros de Dermatologia, 2009
Xantoma eruptivo e granuloma anular são doenças dermatológicas com quadros clínicos distintos que... more Xantoma eruptivo e granuloma anular são doenças dermatológicas com quadros clínicos distintos que, algumas vezes, apresentam semelhanças histopatológicas que podem conduzir a diagnóstico errôneo. Relata-se o caso de paciente do sexo masculino com 34 anos, portador de dislipidemia, com lesões clinicamente características de xantoma eruptivo cujo exame histopatológico foi sugestivo de granuloma anular. No entanto, a revisão da lâmina mostrou tratar-se de xantoma eruptivo. A remissão completa e rápida das lesões após o tratamento da dislipidemia confirmou o diagnóstico de xantoma eruptivo e motivou a pesquisa sobre as semelhanças e diferenças histopatológicas entre essas doenças.
Anais Brasileiros de Dermatologia, 2009
... indireto foram negativos. Logo após o início do tratamento com predni-sona 40mg/dia, houve me... more ... indireto foram negativos. Logo após o início do tratamento com predni-sona 40mg/dia, houve melhora do quadro com cicatri-zação das bolhas e formação de milia sobre algumas cicatrizes (Figura 4). DISCUSSÃO A EBA ...
Anais Brasileiros de Dermatologia, 2012
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Papers by Antonio Tebcherani