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Angela Richard-Londt

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Papers by Angela Richard-Londt

P.99A multiplex in situ hybridisation and immunohistochemical (ISH-IHC) assay to study developmental changes in relation to fibre type and sodium channels in human skeletal muscle and their contribution to disease severity

Neuromuscular Disorders, 2019

Supplementary Table 3 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

XLSX file, 608K, Ranked gene list PNET vs. REST.

Supplementary Figure 6 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 929K, Derivation and testing of a human sPNET-specific gene signature.

Supplementary Figure 7 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 736K, Derivation of a human ATRT-specific gene set.

Supplementary Figure 2 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 871K, Expression patterns of tumours generated in a p53/Rb background.

Supplementary Methods and Figure Legends from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file - 112K

Supplementary Figure 5 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 1105K, Derivation and testing of a human oligodendroglial gene signature.

Supplementary Figure 8 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 1743K, p53 sequencing of Rb/Pten tumours and in vitro recombined Rb/Pten neurospheres.

Supplementary Table 1 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

XLSX file, 433K, 2500 2-fold differentially expressed in vitro vs in vivo genes.

Supplementary Table 4 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

XLSX file, 115K, Oligodendroglioma-specific genes.

Supplementary Figure 3 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 824K, Restricted tumourigenesis in a Rb/Pten background.

Supplementary Table 2 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

XLSX file, 381K, PNET specific genes.

Supplementary Figure 4 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 828K, Tumour incidence in primary and grafted tumours depend on the initial genetic mut... more

Supplementary Figure 1 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 1557K, Expression patterns of tumours generated in a p53/PTEN/Rb background.

Data from Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

Human astrocytomas and oligodendrogliomas are defined by mutations of the metabolic enzymes isoci... more Human astrocytomas and oligodendrogliomas are defined by mutations of the metabolic enzymes isocitrate dehydrogenase (IDH) 1 or 2, resulting in the production of the abnormal metabolite D-2 hydroxyglutarate. Here, we studied the effect of mutant IDH on cell proliferation and apoptosis in a glioma mouse model. Tumors were generated by inactivating Pten and p53 in forebrain progenitors and compared with tumors additionally expressing the Idh1 R132H mutation. Idh-mutant cells proliferated less in vitro and mice with Idh-mutant tumors survived significantly longer compared with Idh-wildtype mice. Comparison of miRNA and RNA expression profiles of Idh-wildtype and Idh-mutant cells and tumors revealed miR-183 was significantly upregulated in IDH-mutant cells. Idh-mutant cells were more sensitive to endoplasmic reticulum (ER) stress, resulting in increased apoptosis and thus reduced cell proliferation and survival. This was mediated by the interaction of miR-183 with the 5′ untranslated re...

Supplementary Data from Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

Additional experiments to support data from the main manuscript

Figure S1 from Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

Cloning vector to generate IDH mutant mouse

Figure S4 from Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

Generation of IDH mutant tumours with adeno Cre mediated recombination

Figure S6 from Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

miR183 and SEMA3E expression in vitro

Figure S5 from Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

Apoptotic response to ER stress in vitro and in vivo

P.99A multiplex in situ hybridisation and immunohistochemical (ISH-IHC) assay to study developmental changes in relation to fibre type and sodium channels in human skeletal muscle and their contribution to disease severity

Neuromuscular Disorders, 2019

Supplementary Table 3 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

XLSX file, 608K, Ranked gene list PNET vs. REST.

Supplementary Figure 6 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 929K, Derivation and testing of a human sPNET-specific gene signature.

Supplementary Figure 7 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 736K, Derivation of a human ATRT-specific gene set.

Supplementary Figure 2 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 871K, Expression patterns of tumours generated in a p53/Rb background.

Supplementary Methods and Figure Legends from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file - 112K

Supplementary Figure 5 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 1105K, Derivation and testing of a human oligodendroglial gene signature.

Supplementary Figure 8 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 1743K, p53 sequencing of Rb/Pten tumours and in vitro recombined Rb/Pten neurospheres.

Supplementary Table 1 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

XLSX file, 433K, 2500 2-fold differentially expressed in vitro vs in vivo genes.

Supplementary Table 4 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

XLSX file, 115K, Oligodendroglioma-specific genes.

Supplementary Figure 3 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 824K, Restricted tumourigenesis in a Rb/Pten background.

Supplementary Table 2 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

XLSX file, 381K, PNET specific genes.

Supplementary Figure 4 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 828K, Tumour incidence in primary and grafted tumours depend on the initial genetic mut... more

Supplementary Figure 1 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

PDF file, 1557K, Expression patterns of tumours generated in a p53/PTEN/Rb background.

Data from Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

Human astrocytomas and oligodendrogliomas are defined by mutations of the metabolic enzymes isoci... more Human astrocytomas and oligodendrogliomas are defined by mutations of the metabolic enzymes isocitrate dehydrogenase (IDH) 1 or 2, resulting in the production of the abnormal metabolite D-2 hydroxyglutarate. Here, we studied the effect of mutant IDH on cell proliferation and apoptosis in a glioma mouse model. Tumors were generated by inactivating Pten and p53 in forebrain progenitors and compared with tumors additionally expressing the Idh1 R132H mutation. Idh-mutant cells proliferated less in vitro and mice with Idh-mutant tumors survived significantly longer compared with Idh-wildtype mice. Comparison of miRNA and RNA expression profiles of Idh-wildtype and Idh-mutant cells and tumors revealed miR-183 was significantly upregulated in IDH-mutant cells. Idh-mutant cells were more sensitive to endoplasmic reticulum (ER) stress, resulting in increased apoptosis and thus reduced cell proliferation and survival. This was mediated by the interaction of miR-183 with the 5′ untranslated re...

Supplementary Data from Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

Additional experiments to support data from the main manuscript

Figure S1 from Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

Cloning vector to generate IDH mutant mouse

Figure S4 from Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

Generation of IDH mutant tumours with adeno Cre mediated recombination

Figure S6 from Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

miR183 and SEMA3E expression in vitro

Figure S5 from Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

Apoptotic response to ER stress in vitro and in vivo