Andrei Laikhter
Chief Scientific Officer. ChemGenes Corporation, 05/2008 – Present.
• Established Oligonucleotide Synthesis laboratory focused primarily on the synthesis of highly modified oligonucleotides.
• Developed and patented a new highly efficient chromophores as a quencher dyes useful in qPCR and other FRET based technologies.
• Developed and patented new CombiClickTM technology based on combinatorial “Click chemistry”.
• Developed novel oligonucleotide – peptide and protein conjugation methods.
Vice President, Chemistry. Integrated DNA Technologies, Inc., 01/2002-05/2008.
Assistant Vice President, Chemistry. Integrated DNA Technologies, Inc., 05/2001- 01/2002.
Director of Chemical Synthesis. Integrated DNA Technologies, Inc., 05/2000-05/2001.
Senior Scientist. Integrated DNA Technologies, Inc., 11/99-05/2000.
• Established Synthetic laboratory focused primarily on Organic Synthesis.
• Synthesized a number of nucleosides and other components for automated oligonucleotide synthesis.
• Improved automated RNA synthesis.
• Improved a number of DNA and RNA purification methods.
Senior Scientist. Cruachem, Inc., 12/96-11/99.
• Established Analytical laboratory focused primary on HPLC.
• Synthesized dinucleotides aminoacylated by non-natural analogs of Aspartic acid and glycosylated amino acids for in vitro protein synthesis of modified enzymes.
• Improved automated RNA synthesis.
• Improved automated amidate oligonucleotide synthesis.
Research Associate. University of Virginia, 01/94-12/96. Research adviser: Professor Sidney M. Hecht.
• Synthesized dinucleotides aminoacylated by non-natural analogs of Aspartic acid and glycoamino acids for in vitro protein synthesis of modified enzymes (HIV protease, DHFR, luciferase, RNAse-B).
• Solid-phase glycopeptide synthesis.
Postdoctoral Fellow. University of Delaware, 02/93 11/93. Research adviser: Professor Dennis H. Evans.
• Developed Electrochemical chiral synthesis of thio- and nitroglycosides.
EDUCATION:
Ph.D. in Synthetic Organic Chemistry. N.D. Zelinsky Institute of Organic Chemistry USSR Academy of Sciences. PhD thesis: "Synthesis of Nitroheterocycles". Research adviser: Prof. A.A. Fainzilberg.
• Designed and synthesized new nitro polyheterocyclic systems.
B.Sc. in Organic and Bioorganic Chemistry. Moscow Institute of Fine Chemical Technology, Diploma work: "Synthesis of the Carotenals." Research advisers: Dr. B.I. Mitzner and Prof. E.N. Zvonkova.
• Synthesis of modified Retinoids and their incorporation into Bacterioopsin.
• Established Oligonucleotide Synthesis laboratory focused primarily on the synthesis of highly modified oligonucleotides.
• Developed and patented a new highly efficient chromophores as a quencher dyes useful in qPCR and other FRET based technologies.
• Developed and patented new CombiClickTM technology based on combinatorial “Click chemistry”.
• Developed novel oligonucleotide – peptide and protein conjugation methods.
Vice President, Chemistry. Integrated DNA Technologies, Inc., 01/2002-05/2008.
Assistant Vice President, Chemistry. Integrated DNA Technologies, Inc., 05/2001- 01/2002.
Director of Chemical Synthesis. Integrated DNA Technologies, Inc., 05/2000-05/2001.
Senior Scientist. Integrated DNA Technologies, Inc., 11/99-05/2000.
• Established Synthetic laboratory focused primarily on Organic Synthesis.
• Synthesized a number of nucleosides and other components for automated oligonucleotide synthesis.
• Improved automated RNA synthesis.
• Improved a number of DNA and RNA purification methods.
Senior Scientist. Cruachem, Inc., 12/96-11/99.
• Established Analytical laboratory focused primary on HPLC.
• Synthesized dinucleotides aminoacylated by non-natural analogs of Aspartic acid and glycosylated amino acids for in vitro protein synthesis of modified enzymes.
• Improved automated RNA synthesis.
• Improved automated amidate oligonucleotide synthesis.
Research Associate. University of Virginia, 01/94-12/96. Research adviser: Professor Sidney M. Hecht.
• Synthesized dinucleotides aminoacylated by non-natural analogs of Aspartic acid and glycoamino acids for in vitro protein synthesis of modified enzymes (HIV protease, DHFR, luciferase, RNAse-B).
• Solid-phase glycopeptide synthesis.
Postdoctoral Fellow. University of Delaware, 02/93 11/93. Research adviser: Professor Dennis H. Evans.
• Developed Electrochemical chiral synthesis of thio- and nitroglycosides.
EDUCATION:
Ph.D. in Synthetic Organic Chemistry. N.D. Zelinsky Institute of Organic Chemistry USSR Academy of Sciences. PhD thesis: "Synthesis of Nitroheterocycles". Research adviser: Prof. A.A. Fainzilberg.
• Designed and synthesized new nitro polyheterocyclic systems.
B.Sc. in Organic and Bioorganic Chemistry. Moscow Institute of Fine Chemical Technology, Diploma work: "Synthesis of the Carotenals." Research advisers: Dr. B.I. Mitzner and Prof. E.N. Zvonkova.
• Synthesis of modified Retinoids and their incorporation into Bacterioopsin.
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