The Pechmann condensation is the formation of coumarin derivatives from phenols and a carboxylic ... more The Pechmann condensation is the formation of coumarin derivatives from phenols and a carboxylic acids or esters containing a β-carbonyl group under acidic conditions. The reaction has attracted a great deal of attention because of the biological significance of coumarins derivatives. As a result, the synthesis of coumarin and its derivatives have been an attractive goal for the chemist. The present review is focused on brief aspects of the synthesis of coumarin derivatives from phenols and a carboxylic acids or esters containing a β-carbonyl group under acidic conditions using various catalysts.
Pfitzinger reaction is the formation of derivative of 4-quinoline carboxylic acids from isatins o... more Pfitzinger reaction is the formation of derivative of 4-quinoline carboxylic acids from isatins or its analogs under alkaline condition. This reaction was first discovered by Pfitzinger at the end of 19 th century hence it is known as Pfitzinger reaction. This reaction has attracted a great deal of attention in the last few decades because of biological significance of quinoline carboxylic acid derivatives. The utility of Pfitzinger reaction has been proved time to time by its involvement in the synthesis of drugs or drug intermediates.
Oxalic acid has been used as a catalyst for intramolecular cyclisation of 2-hydroxychalcones to f... more Oxalic acid has been used as a catalyst for intramolecular cyclisation of 2-hydroxychalcones to form flavones in good yields. The efficiency of the catalyst was proved with a variety of substrates ranging from electron-deficient to electron-rich aryl aldehydes and 2-hydroxychalcone.
4,5,6,7-Tetrahydrothieno pyridine is an important class of heterocyclic nucleus. Various 4,5,6,7-... more 4,5,6,7-Tetrahydrothieno pyridine is an important class of heterocyclic nucleus. Various 4,5,6,7-tetrahydrothieno pyridine derivatives have been synthesized and evaluated for various biological activities in different models with desired findings. Some analogs have shown potent biological activities and may be considered as lead molecule for the development of future drugs. Number of drug molecules are available in the market and many molecules are in clinical development containing 4,5,6,7-tetrahydrothieno pyridine nucleus as an important core. This review is an attempt to organize the chemical and biological aspects of 4,5,6,7-tetrahydrothieno pyridine analogs reported in last 20 year to till date. Review mainly focuses on the important role of the core in synthesis of drug or drug intermediates giving emphasis on synthetic schemes and biological activities of the different 4,5,6,7-tetrahydrothieno pyridine analogs
The Pechmann condensation is the formation of coumarin derivatives from phenols and a carboxylic ... more The Pechmann condensation is the formation of coumarin derivatives from phenols and a carboxylic acids or esters containing a β-carbonyl group under acidic conditions. The reaction has attracted a great deal of attention because of the biological significance of coumarins derivatives. As a result, the synthesis of coumarin and its derivatives have been an attractive goal for the chemist. The present review is focused on brief aspects of the synthesis of coumarin derivatives from phenols and a carboxylic acids or esters containing a β-carbonyl group under acidic conditions using various catalysts.
Pfitzinger reaction is the formation of derivative of 4-quinoline carboxylic acids from isatins o... more Pfitzinger reaction is the formation of derivative of 4-quinoline carboxylic acids from isatins or its analogs under alkaline condition. This reaction was first discovered by Pfitzinger at the end of 19 th century hence it is known as Pfitzinger reaction. This reaction has attracted a great deal of attention in the last few decades because of biological significance of quinoline carboxylic acid derivatives. The utility of Pfitzinger reaction has been proved time to time by its involvement in the synthesis of drugs or drug intermediates.
Oxalic acid has been used as a catalyst for intramolecular cyclisation of 2-hydroxychalcones to f... more Oxalic acid has been used as a catalyst for intramolecular cyclisation of 2-hydroxychalcones to form flavones in good yields. The efficiency of the catalyst was proved with a variety of substrates ranging from electron-deficient to electron-rich aryl aldehydes and 2-hydroxychalcone.
4,5,6,7-Tetrahydrothieno pyridine is an important class of heterocyclic nucleus. Various 4,5,6,7-... more 4,5,6,7-Tetrahydrothieno pyridine is an important class of heterocyclic nucleus. Various 4,5,6,7-tetrahydrothieno pyridine derivatives have been synthesized and evaluated for various biological activities in different models with desired findings. Some analogs have shown potent biological activities and may be considered as lead molecule for the development of future drugs. Number of drug molecules are available in the market and many molecules are in clinical development containing 4,5,6,7-tetrahydrothieno pyridine nucleus as an important core. This review is an attempt to organize the chemical and biological aspects of 4,5,6,7-tetrahydrothieno pyridine analogs reported in last 20 year to till date. Review mainly focuses on the important role of the core in synthesis of drug or drug intermediates giving emphasis on synthetic schemes and biological activities of the different 4,5,6,7-tetrahydrothieno pyridine analogs
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Papers by Abhay Zambare