Acido ribonucleic

Acido ribonucleic
	instantia de: structural class of chemical entities[*]
	subclasse de: nucleic acids[], biopolymer[], gene product[], polyribonucleotide[]
	parte de: RNA binding[], RNA catabolic process[], RNA metabolic process[], RNA phosphodiester bond hydrolysis[], RNA transport[], RNA transmembrane transporter activity[], protein-DNA-RNA complex[], ribosoma, ribonucleoprotein granule[], protein-lipid-RNA complex[], HDL-containing protein-lipid-RNA complex[], LDL-containing protein-lipid-RNA complex[], ribonucleoprotein complex[], RNA import into nucleus[], RNA export from nucleus[], RNA import into mitochondrion[], gene silencing[], RNA biosynthetic process[], ATP-dependent activity, acting on RNA[], catalytic activity, acting on RNA[*]
	;
	Commons: RNA

Acido ribonucleic (ARN o RNA) es un acido nucleic. Isto significa que ille consiste de un catena longe de unitates de nucleotide. Un nucleotide consiste de un basse nitrogenous nominate nucleobasse, un saccharo/sucre de ribose, e un phosphate. ARN es multo similarte con le ADN, ma ha differencias in alicun/pauc importante detailes de structura: in le cellula, ARN es monocatenari (consiste de un filo), durante que ADN es bicatenari; ARN nucleotides contine ribose durante que ADN contine deoxyribose (un typo de ribose ommite uno atomo de oxygeno); e ARN ha le base de uracil e non de thymine que es presente in ADN.

Structura

Watson-Crick base pairs in a siRNA (hydrogen atoms are not shown)

Cate nucleotide in ARN contine un saccharo/sucre de ribose, con carbones numerotate 1' a 5'. Le bases pote formar ligamines de hydrogeno inter cytosine e guanine, inter adenine e uracil e inter guanine e uracil. ligamines de hydrogeno^[1] Altere interactiones es possibile^[2]

Mg²⁺^[3]

Comparition con ADN

ARN e ADN e differite in 3 characteristicas principal.

The 50S ribosomal subunit. RNA is in orange, protein in blue. The active site is in the middle (red).

Typos de ARN

Patrono:Seealso

Structure of a hammerhead ribozyme, a ribozyme that cuts RNA

Historia de discoperta

Le acidos nucleic esseva discoperta in 1868 de Friedrich Miescher, que nominate le material 'nuclein' proque ille esseva trovate in le nucleus.^[4] Le cellules prokaryotic que non ha un nucleus, contine acidos nucleic, es un discoperta tarde. Le role de ARN in le synthese del protein esseva suspectate in 1939.^[5] Severo Ochoa ha ganiate le Premio Nobel in medicina in 1959 dupo illo ha discoperta como ARN es synthesite.^[6]

Vide etiam

Referentias

↑ "Diversity of base-pair conformations and their occurrence in rRNA structure and RNA structural motifs" (December 2004). Journal of Molecular Biology 344 (5): 1225–49. doi:10.1016/j.jmb.2004.09.072. PMID 15561141.
↑ Barciszewski J, Frederic B, Clark C (1999). RNA biochemistry and biotechnology. Springer, 73–87. ISBN 0792358627. OCLC 52403776.
↑ Tan ZJ, Chen SJ (2008). "Salt dependence of nucleic acid hairpin stability". Biophys. J. 95: 738–52. doi:10.1529/biophysj.108.131524. PMID 18424500.
↑ Dahm R (2005). "Friedrich Miescher and the discovery of DNA". Developmental Biology 278 (2): 274–88. doi:10.1016/j.ydbio.2004.11.028. PMID 15680349.
↑ Caspersson T, Schultz J (1939). "Pentose nucleotides in the cytoplasm of growing tissues". Nature 143: 602–3. doi:10.1038/143602c0.
↑ Ochoa S (1959). Enzymatic synthesis of ribonucleic acid. Nobel Lecture.

Ligamines externe

RNA World website Archived 2007-03-14 at the Wayback Machine Collection de ligamines (structures, sequences, utiles, journals)
Nucleic Acid Database Archived 2007-10-12 at the Wayback Machine Imagines de ADN, ARN e complexes.

[pmid15561141-1] "Diversity of base-pair conformations and their occurrence in rRNA structure and RNA structural motifs" (December 2004). Journal of Molecular Biology 344 (5): 1225–49. doi:10.1016/j.jmb.2004.09.072. PMID 15561141.

[2] Barciszewski J, Frederic B, Clark C (1999). RNA biochemistry and biotechnology. Springer, 73–87. ISBN 0792358627. OCLC 52403776.

[3] Tan ZJ, Chen SJ (2008). "Salt dependence of nucleic acid hairpin stability". Biophys. J. 95: 738–52. doi:10.1529/biophysj.108.131524. PMID 18424500.

[4] Dahm R (2005). "Friedrich Miescher and the discovery of DNA". Developmental Biology 278 (2): 274–88. doi:10.1016/j.ydbio.2004.11.028. PMID 15680349.

[5] Caspersson T, Schultz J (1939). "Pentose nucleotides in the cytoplasm of growing tissues". Nature 143: 602–3. doi:10.1038/143602c0.

[6] Ochoa S (1959). Enzymatic synthesis of ribonucleic acid. Nobel Lecture.

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